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HC-Pro_protein
Euk-VirLeek_yellow_stripe_virus
HC-Pro_protein__NP_734094__Leek_yellow_stripe_virus__42004
Identity
- Accession:
- NP_734094 ↗
- Protein ID:
- HC-Pro_protein
- Kingdom:
- euk
Quality
85.6
mean pLDDT
Taxonomy
Orthornavirae›
Pisuviricota›
Stelpaviricetes›
Patatavirales›
Potyviridae›
Potyvirus›
Leek_yellow_stripe_virus
TaxID: 42004
Cluster
View cluster (80 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 23-103
Domain cluster:
rep: HC-Pro__YP_009252411__Tobacco_mosqueado_virus__1792583__D31-64_66-104
D2
high
residues 110-178
Domain cluster:
representative
CATH (44)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4abmD00 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.85 | 62.0 | 5.93e-01 | 75.4% | 75.3% |
| 4q20A01 | 1.10.287.130 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Signal transduction histidine kinase, dimerisation/phosphotransfer (DHp) domain | 0.83 | 60.0 | 5.66e-01 | 75.4% | 67.1% |
| 4aflA00 | 6.10.140.1740 | Special › Helix non-globular › Helix Hairpins › | 0.83 | 60.0 | 5.18e-01 | 75.4% | 58.8% |
| 1z0jB00 | 4.10.860.20 | Few Secondary Structures › Irregular › DNA Excision Repair, Uvrb; Chain A › Rabenosyn, Rab binding domain | 0.83 | 50.0 | 5.68e-01 | 71.0% | 82.4% |
| 6r1nA01 | 1.10.287.40 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain | 0.82 | 59.0 | 5.10e-01 | 75.4% | 54.4% |
| 4a17U01 | 1.10.287.310 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.79 | 56.0 | 5.44e-01 | 75.4% | 68.8% |
| 4rngC00 | 1.20.1280.290 | Mainly Alpha › Up-down Bundle › Monooxygenase › | 0.78 | 48.0 | 4.54e-01 | 72.5% | 51.8% |
| 1ydxA02 | 1.10.287.1120 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Bipartite methylase S protein | 0.78 | 56.0 | 5.09e-01 | 75.4% | 64.4% |
| 1m5iA00 | 1.10.287.450 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.77 | 57.0 | 4.88e-01 | 76.8% | 90.5% |
| 2ic6A00 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.76 | 55.0 | 5.45e-01 | 75.4% | 74.6% |
| 2xokP00 | 1.20.20.10 | Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C | 0.75 | 51.0 | 5.06e-01 | 71.0% | 70.3% |
| 1ku9A02 | 1.10.287.450 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.75 | 52.0 | 5.39e-01 | 72.5% | 78.1% |
| 4dciA00 | 6.10.140.1110 | Special › Helix non-globular › Helix Hairpins › | 0.75 | 51.0 | 3.99e-01 | 71.0% | 34.0% |
| 4ijjB00 | 1.20.120.910 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › DksA, coiled-coil domain | 0.73 | 54.0 | 4.35e-01 | 78.3% | 60.0% |
| 2fb5A01 | 1.10.287.770 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › YojJ-like | 0.72 | 52.0 | 5.15e-01 | 75.4% | 80.6% |
| 3ehmA01 | 1.25.40.390 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.72 | 51.0 | 3.27e-01 | 73.9% | 61.8% |
| 1a36A04 | 1.10.132.10 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › | 0.72 | 52.0 | 3.86e-01 | 75.4% | 30.3% |
| 3v5uA01 | 6.10.280.80 | Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › NCX, peripheral helical region | 0.71 | 50.0 | 4.89e-01 | 75.4% | 80.3% |
| 3dyjA02 | 1.20.1420.10 | Mainly Alpha › Up-down Bundle › A middle domain of Talin 1 › Talin, central domain | 0.71 | 59.0 | 4.65e-01 | 95.7% | 98.0% |
| 4lwsA00 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.70 | 49.0 | 4.41e-01 | 73.9% | 69.0% |
| 8gi9A01 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.70 | 60.0 | 4.20e-01 | 97.1% | 41.6% |
| 2c2aA01 | 1.10.287.130 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Signal transduction histidine kinase, dimerisation/phosphotransfer (DHp) domain | 0.70 | 48.0 | 4.42e-01 | 72.5% | 55.6% |
| 3b2eF00 | 1.10.287.660 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.69 | 49.0 | 5.14e-01 | 76.8% | 83.9% |
| 2gtsA00 | 1.10.287.850 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HP0062-like domain | 0.68 | 49.0 | 4.75e-01 | 76.8% | 68.8% |
| 1z0pA00 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.66 | 47.0 | 4.64e-01 | 75.4% | 75.3% |
| 2ke4A00 | 6.10.140.470 | Special › Helix non-globular › Helix Hairpins › | 0.66 | 47.0 | 4.25e-01 | 76.8% | 94.9% |
| 3hl6A02 | 1.20.58.700 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.64 | 50.0 | 4.29e-01 | 87.0% | 52.2% |
| 3nrxA00 | 1.20.58.1520 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.64 | 46.0 | 3.89e-01 | 78.3% | 47.2% |
| 2kg7B00 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.64 | 44.0 | 3.91e-01 | 71.0% | 54.6% |
| 4i1mB01 | 1.20.120.1700 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › | 0.63 | 56.0 | 4.60e-01 | 100.0% | 69.0% |
| 2crbA00 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.63 | 45.0 | 4.10e-01 | 76.8% | 72.2% |
| 1j1jA02 | 1.20.58.200 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 2 | 0.63 | 42.0 | 4.03e-01 | 78.3% | 57.6% |
| 1b06A01 | 1.10.287.990 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Fe,Mn superoxide dismutase (SOD) domain | 0.63 | 43.0 | 4.37e-01 | 72.5% | 80.6% |
| 2lhrA00 | 1.20.58.1270 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.62 | 43.0 | 4.17e-01 | 75.4% | 64.1% |
| 2rkkA01 | 1.25.40.270 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Vacuolar protein sorting-associated protein vta1 | 0.61 | 51.0 | 4.01e-01 | 95.7% | 99.4% |
| 8e9gK01 | 1.10.287.3510 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.61 | 53.0 | 4.87e-01 | 100.0% | 97.8% |
| 3rpmA02 | 1.20.1270.90 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › AF1782-like | 0.61 | 41.0 | 3.86e-01 | 73.9% | 56.5% |
| 6m9sB01 | 1.20.910.10 | Mainly Alpha › Up-down Bundle › Heme Oxygenase; Chain A › Heme oxygenase-like | 0.61 | 52.0 | 3.68e-01 | 95.7% | 67.7% |
| 7zm7601 | 1.20.120.1200 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ | 0.59 | 51.0 | 3.94e-01 | 100.0% | 46.7% |
| 3lvyE01 | 1.20.1290.10 | Mainly Alpha › Up-down Bundle › AhpD-like › AhpD-like | 0.58 | 43.0 | 3.29e-01 | 79.7% | 66.1% |
| 1k04A02 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.56 | 47.0 | 4.19e-01 | 98.6% | 92.3% |
| 6b8hO01 | 1.10.520.20 | Mainly Alpha › Orthogonal Bundle › Peroxidase; domain 1 › N-terminal domain of the delta subunit of the F1F0-ATP synthase | 0.55 | 34.0 | 3.02e-01 | 81.2% | 42.4% |
| 2k6hA01 | 3.40.420.10 | Alpha Beta › 3-Layer(aba) Sandwich › Ricin (A subunit); domain 1 › Ricin (A subunit), domain 1 | 0.55 | 40.0 | 3.04e-01 | 78.3% | 63.3% |
| 3ecsC01 | 1.20.120.1070 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Translation initiation factor eIF-2B, N-terminal domain | 0.54 | 37.0 | 3.36e-01 | 72.5% | 100.0% |
ECOD (37)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4943532 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.88 | 64.0 | 6.36e-01 | 75.4% | 78.6% |
| 3400926 | 3758.1.1.45 ↗ | alpha bundles › Bacterial hemolysins-like › Bacterial hemolysins › Bacterial hemolysins › Not3 | 0.86 | 63.0 | 5.22e-01 | 76.8% | 58.3% |
| 3593844 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.86 | 62.0 | 4.68e-01 | 75.4% | 35.3% |
| None | — | 0.85 | 58.0 | 4.04e-01 | 75.4% | 24.5% | |
| 4961508 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.83 | 60.0 | 5.82e-01 | 75.4% | 73.3% |
| 5076024 | 633.21.1.0 ↗ | alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 | 0.82 | 58.0 | 4.83e-01 | 73.9% | 49.6% |
| 3925617 | 192.5.1.14 ↗ | alpha bundles › Long alpha-hairpin › HR1 repeat › HR1 repeat › HR1_TOCA | 0.81 | 58.0 | 5.41e-01 | 75.4% | 70.6% |
| 3626769 | 192.5.1.14 ↗ | alpha bundles › Long alpha-hairpin › HR1 repeat › HR1 repeat › HR1_TOCA | 0.81 | 58.0 | 5.28e-01 | 75.4% | 66.7% |
| 3567670 | 192.5.1.14 ↗ | alpha bundles › Long alpha-hairpin › HR1 repeat › HR1 repeat › HR1_TOCA | 0.80 | 58.0 | 5.26e-01 | 75.4% | 66.7% |
| 4303085 | 3755.3.1.467 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › DRC7_C | 0.80 | 58.0 | 4.80e-01 | 76.8% | 50.8% |
| 3437925 | 605.1.1.132 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › DUF641 | 0.80 | 59.0 | 5.30e-01 | 78.3% | 63.2% |
| 3315495 | 192.8.1.0 ↗ | alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain | 0.80 | 57.0 | 5.34e-01 | 75.4% | 62.4% |
| 3999274 | 5086.1.1.102 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › PTHB1_hp | 0.79 | 57.0 | 4.89e-01 | 75.4% | 57.1% |
| 3488979 | 192.5.1.0 ↗ | alpha bundles › Long alpha-hairpin › HR1 repeat › HR1 repeat | 0.79 | 58.0 | 4.73e-01 | 78.3% | 52.8% |
| 3853458 | 192.29.1.1 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB_dom | 0.78 | 64.0 | 5.67e-01 | 87.0% | 75.8% |
| 3331938 | 192.8.1.0 ↗ | alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain | 0.78 | 55.0 | 5.29e-01 | 76.8% | 63.7% |
| 3738041 | 192.5.1.1 ↗ | alpha bundles › Long alpha-hairpin › HR1 repeat › HR1 repeat › HR1 | 0.78 | 56.0 | 5.21e-01 | 75.4% | 68.2% |
| 315449 | 192.8.1.2 ↗ | alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain › Hanta_nucleocap | 0.77 | 55.0 | 5.36e-01 | 75.4% | 69.7% |
| 3215306 | 3826.1.1.0 ↗ | alpha bundles › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) | 0.77 | 53.0 | 4.98e-01 | 72.5% | 62.4% |
| 4162727 | 5086.1.1.12 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › Uds1 | 0.76 | 54.0 | 4.24e-01 | 75.4% | 39.3% |
| 3636894 | 630.1.1.1 ↗ | a+b complex topology › RuBisCo LSMT C-terminal, substrate-binding domain › RuBisCo LSMT C-terminal, substrate-binding domain › RuBisCo LSMT C-terminal, substrate-binding domain › Rubis-subs-bind | 0.76 | 57.0 | 4.10e-01 | 79.7% | 86.5% |
| 3902100 | 3291.1.1.0 ↗ | alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related | 0.75 | 53.0 | 4.97e-01 | 73.9% | 72.9% |
| 3487862 | 212.1.1.0 ↗ | a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like | 0.75 | 53.0 | 3.63e-01 | 75.4% | 23.7% |
| 3732358 | 604.12.1.42 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › DUF202 | 0.75 | 54.0 | 4.69e-01 | 76.8% | 60.0% |
| 3690520 | 192.29.1.128 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › DUF202 | 0.74 | 54.0 | 4.78e-01 | 76.8% | 63.0% |
| 3258925 | 192.8.1.0 ↗ | alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain | 0.74 | 53.0 | 5.30e-01 | 75.4% | 75.7% |
| 3829849 | 7566.1.1.2 ↗ | a/b three-layered sandwiches › HflX family GTPase N-terminal domain › HflX family GTPase N-terminal domain › HflX family GTPase N-terminal domain › GTP-bdg_N | 0.73 | 62.0 | 4.53e-01 | 95.7% | 46.7% |
| 3503444 | 192.8.1.0 ↗ | alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain | 0.72 | 52.0 | 4.77e-01 | 75.4% | 58.9% |
| 4959236 | 601.7.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain | 0.72 | 52.0 | 4.96e-01 | 75.4% | 70.0% |
| 5053143 | 3843.1.1.41 ↗ | alpha complex topology › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › PF29293 | 0.72 | 61.0 | 5.65e-01 | 97.1% | 92.2% |
| 3423387 | 611.9.1.0 ↗ | alpha bundles › N-cbl like › Resistance protein (Rx) N-terminal domain › Resistance protein (Rx) N-terminal domain | 0.71 | 60.0 | 5.12e-01 | 92.8% | 80.0% |
| 2323907 | 212.1.1.24 ↗ | a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Morc6_S5 | 0.69 | 49.0 | 3.43e-01 | 75.4% | 23.3% |
| 4218502 | 605.1.1.279 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › Spo7 | 0.67 | 52.0 | 4.45e-01 | 81.2% | 57.1% |
| 3504421 | 4177.1.1.2 ↗ | alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › BAR | 0.66 | 56.0 | 3.89e-01 | 94.2% | 80.0% |
| 3957407 | 2004.1.1.430 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ABC_tran, ABC_tran_Xtn | 0.65 | 53.0 | 3.48e-01 | 87.0% | 45.1% |
| 3213526 | 192.5.1.14 ↗ | alpha bundles › Long alpha-hairpin › HR1 repeat › HR1 repeat › HR1_TOCA | 0.65 | 46.0 | 4.12e-01 | 76.8% | 64.8% |
| 3826428 | 109.4.1.420 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR | 0.54 | 37.0 | 2.94e-01 | 71.0% | 54.1% |
D3
medium
residues 188-206_222-266_305-338
Domain cluster:
rep: HC-Pro__YP_001936179__Verbena_virus_Y__515446__D186-209_223-267_313-337
D4
medium
residues 207-221_339-456
Domain cluster:
rep: HC-Pro_protein__YP_006590094__Chinese_yam_necrotic_mosaic_virus__128818__D95-261
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00851.25 best | Peptidase_C6 | 169.6 | 1.70e-49 | 100.0% | 28.4% |