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HC-Pro_protein

Euk-Vir

Lettuce_mosaic_virus

HC-Pro_protein__NP_734154__Lettuce_mosaic_virus__12202

Identity

Accession:
NP_734154 ↗
Protein ID:
HC-Pro_protein
Kingdom:
euk

Quality

85.6 mean pLDDT

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 29-107
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00851.25 best Peptidase_C6 29.0 7.70e-07 100.0% 15.9%
CATH (56)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3k6tB00 1.20.5.4010 Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › 0.81 42.0 5.22e-01 77.2% 81.6%
3u8vA00 1.20.120.660 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › IL-4 antagonist (De novo design) like domain 0.73 53.0 5.27e-01 96.2% 72.3%
2vxxA00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.71 65.0 4.98e-01 100.0% 82.6%
2gnoA03 1.20.272.10 Mainly Alpha › Up-down Bundle › Zinc Finger, Delta Prime; domain 3 › 0.70 52.0 4.83e-01 79.7% 65.0%
3n71A03 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.69 48.0 3.50e-01 89.9% 26.8%
3bt5A00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.68 60.0 4.86e-01 98.7% 95.4%
2pqrA01 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.68 46.0 4.36e-01 89.9% 59.1%
4dyqA01 1.10.10.60 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Homeodomain-like 0.67 51.0 4.65e-01 79.7% 77.7%
2mtqA00 1.20.58.130 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.67 54.0 5.58e-01 94.9% 93.2%
1gt0D00 1.10.30.10 Mainly Alpha › Orthogonal Bundle › DNA Binding (I), subunit A › High mobility group box domain 0.65 47.0 4.78e-01 77.2% 89.9%
4a25B01 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.65 57.0 4.58e-01 100.0% 88.8%
2ikbC00 1.20.141.10 Mainly Alpha › Up-down Bundle › Chitosanase, subunit A; domain 1 › Chitosanase, subunit A, domain 1 0.64 55.0 4.49e-01 100.0% 88.2%
1nigA00 1.20.1200.10 Mainly Alpha › Up-down Bundle › Hypothetical Protein Ta1238; Chain: A; › Cobalamin adenosyltransferase-like 0.62 54.0 4.44e-01 97.5% 91.1%
3kyiA00 1.20.120.160 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain 0.62 47.0 4.07e-01 88.6% 50.8%
1vdyA00 1.25.40.90 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.62 43.0 3.65e-01 94.9% 41.4%
2clbA01 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.62 53.0 4.35e-01 100.0% 95.6%
2rldA00 1.20.1440.60 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 23S rRNA-intervening sequence 0.62 54.0 4.78e-01 97.5% 75.4%
2v6kA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.61 54.0 4.61e-01 100.0% 73.8%
3onjA00 1.20.58.400 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › t-snare proteins 0.61 53.0 4.94e-01 96.2% 93.8%
4pxoA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.61 54.0 4.57e-01 100.0% 73.3%
5tqbB01 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.60 55.0 3.60e-01 100.0% 71.4%
3nivC02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.60 52.0 4.53e-01 98.7% 77.4%
3zh9B03 1.20.272.10 Mainly Alpha › Up-down Bundle › Zinc Finger, Delta Prime; domain 3 › 0.60 45.0 3.86e-01 79.7% 77.0%
2cz2A02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.60 52.0 4.53e-01 100.0% 69.8%
1siqA03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.59 48.0 3.92e-01 91.1% 72.9%
4oydB00 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.59 51.0 4.55e-01 98.7% 93.2%
4e6hA00 1.25.40.1040 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.59 50.0 3.01e-01 94.9% 13.9%
4nuuB02 1.20.58.830 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.58 51.0 4.42e-01 98.7% 92.7%
2wauA02 1.20.58.830 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.57 50.0 4.41e-01 100.0% 99.2%
1dd5A01 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.57 49.0 4.45e-01 97.5% 91.7%
3t9oB00 1.20.120.30 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Aspartate receptor, ligand-binding domain 0.57 49.0 4.31e-01 96.2% 67.5%
1bc0A03 1.10.220.10 Mainly Alpha › Orthogonal Bundle › Annexin V; domain 1 › Annexin 0.57 43.0 4.19e-01 96.2% 74.4%
6vudA01 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.57 47.0 4.35e-01 96.2% 88.1%
3jrtA00 1.20.120.1060 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › 0.57 46.0 3.60e-01 87.3% 62.0%
6x6nA01 1.20.120.260 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Virulence factor YopE uncharacterised domain 0.57 42.0 3.74e-01 79.7% 94.0%
3pe0A01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.57 50.0 4.59e-01 97.5% 94.1%
3lbxB01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.56 47.0 4.32e-01 93.7% 85.0%
2i2xB01 1.10.1240.10 Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › Methionine synthase domain 0.56 47.0 4.41e-01 96.2% 88.0%
2hydA01 1.20.1560.10 Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain 0.56 40.0 2.70e-01 77.2% 19.2%
4doyA03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.55 47.0 3.66e-01 97.5% 66.7%
3ztaA00 1.10.490.130 Mainly Alpha › Orthogonal Bundle › Globin-like › 0.55 48.0 4.06e-01 100.0% 73.4%
1f14A01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.55 42.0 3.18e-01 83.5% 90.8%
2vixA03 1.20.1280.240 Mainly Alpha › Up-down Bundle › Monooxygenase › 0.54 46.0 4.18e-01 100.0% 92.9%
3lk5A00 1.10.600.10 Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase 0.54 46.0 3.09e-01 100.0% 41.7%
5fmnA00 1.20.58.1000 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Metal-sensitive repressor, helix protomer 0.53 39.0 3.85e-01 79.7% 100.0%
4mduA02 1.10.220.10 Mainly Alpha › Orthogonal Bundle › Annexin V; domain 1 › Annexin 0.53 37.0 3.67e-01 73.4% 68.3%
4xxiA00 1.10.490.20 Mainly Alpha › Orthogonal Bundle › Globin-like › Phycocyanins 0.53 46.0 3.83e-01 100.0% 78.2%
1t98A02 1.20.58.590 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Chromosome partition protein MukF, middle domain 0.53 46.0 3.67e-01 97.5% 72.4%
1htjF00 1.10.167.10 Mainly Alpha › Orthogonal Bundle › Regulator of G-protein Signalling 4; domain 2 › Regulator of G-protein Signalling 4, domain 2 0.53 42.0 3.31e-01 89.9% 86.3%
3bjdA01 1.10.1240.20 Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › Lytic transglycosylase, superhelical linker domain 0.53 40.0 3.90e-01 96.2% 75.0%
3wd6A02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.52 45.0 4.05e-01 100.0% 71.2%
3kn6A02 1.10.510.10 Mainly Alpha › Orthogonal Bundle › Transferase(Phosphotransferase); domain 1 › Transferase(Phosphotransferase) domain 1 0.52 44.0 3.35e-01 100.0% 79.3%
7xpzA01 1.20.1720.10 Mainly Alpha › Up-down Bundle › Multidrug resistance protein D › Multidrug resistance protein D 0.51 43.0 2.86e-01 98.7% 39.3%
3gyuA00 1.10.565.10 Mainly Alpha › Orthogonal Bundle › Retinoid X Receptor › Retinoid X Receptor 0.51 44.0 3.22e-01 100.0% 97.1%
1bd3A00 3.40.50.2020 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.51 44.0 3.22e-01 94.9% 93.3%
2js5A00 1.10.287.660 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin 0.50 39.0 4.11e-01 84.8% 94.4%
ECOD (44)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3522050 109.3.1.131 alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat › INT_SG_DDX_CT_C 0.70 46.0 4.81e-01 93.7% 73.0%
3325610 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.69 53.0 4.77e-01 92.4% 59.1%
3465231 192.15.1.189 alpha bundles › Long alpha-hairpin › Endosomal sorting complex assembly domains › Endosomal sorting complex assembly domains › Frigida 0.67 56.0 5.60e-01 94.9% 91.3%
3605710 604.12.1.0 alpha bundles › Spectrin repeat-like › MIT domain › MIT domain 0.66 54.0 5.56e-01 92.4% 93.3%
7430 235.1.1.13 a+b complex topology › Lysozyme-like › Lysozyme-like › Lysozyme-like › Glyco_hydro_108,PG_binding_3 0.65 56.0 4.55e-01 100.0% 88.3%
3696650 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.65 57.0 3.51e-01 100.0% 16.6%
3582455 3843.1.1.0 alpha complex topology › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K 0.64 50.0 5.11e-01 93.7% 89.3%
3277087 192.4.1.0 alpha bundles › Long alpha-hairpin › Ribosomal protein L29 (L29p) › Ribosomal protein L29 (L29p) 0.64 49.0 4.57e-01 81.0% 80.0%
3277234 604.12.1.0 alpha bundles › Spectrin repeat-like › MIT domain › MIT domain 0.63 56.0 4.27e-01 97.5% 87.2%
4253382 150.3.1.4 alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › 4-helical cytokines › 4-helical cytokine › IFN-gamma 0.63 54.0 4.66e-01 97.5% 60.8%
3367300 101.1.10.7 alpha arrays › HTH › HTH › Cyclin-like › Cyclin_C 0.62 50.0 3.94e-01 86.1% 66.3%
3916833 190.1.1.1 alpha arrays › HMG-box-like › HMG-box › HMG-box › HMG_box 0.62 46.0 4.65e-01 78.5% 90.0%
3271444 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.62 50.0 3.46e-01 88.6% 33.2%
3191246 109.1.1.1 alpha superhelices › Repetitive alpha hairpins › Glutathione S-transferase (GST)-C › Glutathione S-transferase (GST)-C › GST_C 0.62 54.0 4.54e-01 100.0% 72.9%
3640330 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.61 54.0 4.51e-01 100.0% 86.4%
None 0.61 52.0 3.90e-01 97.5% 45.0%
3600217 5054.1.1.0 alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels 0.60 45.0 3.16e-01 79.7% 36.8%
3975479 109.1.1.6 alpha superhelices › Repetitive alpha hairpins › Glutathione S-transferase (GST)-C › Glutathione S-transferase (GST)-C › GST_C_2 0.60 53.0 4.52e-01 100.0% 76.9%
3669720 4967.1.1.16 alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › TERT_C 0.60 50.0 3.75e-01 93.7% 75.4%
3200625 109.4.1.158 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › ERAP1_C 0.60 42.0 2.82e-01 93.7% 18.1%
3645542 150.1.1.0 alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin 0.60 52.0 4.36e-01 97.5% 83.0%
3389546 604.1.1.1 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin 0.59 48.0 4.87e-01 89.9% 87.5%
5023303 601.4.1.0 alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains 0.59 51.0 4.51e-01 96.2% 69.6%
2134378 11.1.1.153 beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › ERAP1_C 0.58 42.0 4.13e-01 75.9% 76.5%
3964840 3636.1.1.0 a+b two layers › XPD arch domain › XPD arch domain › XPD arch domain 0.58 50.0 3.85e-01 97.5% 71.9%
3497641 604.1.1.1 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin 0.58 47.0 4.39e-01 88.6% 90.0%
3319387 2485.1.1.0 a+b three layers › Thioredoxin-like › Thioredoxin-like › Thioredoxin-like 0.58 50.0 3.69e-01 100.0% 42.6%
3301695 603.2.1.0 alpha bundles › STAT-like › STAT › STAT 0.58 50.0 3.63e-01 97.5% 50.0%
4128901 109.4.1.158 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › ERAP1_C 0.58 49.0 3.36e-01 93.7% 35.6%
3368223 192.29.1.0 alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) 0.58 49.0 3.63e-01 96.2% 62.8%
3272035 109.21.1.2 alpha superhelices › Repetitive alpha hairpins › Nucleoporin NUP85/Nucleoporin NUP145 C-terminal domain › Nucleoporin NUP85/Nucleoporin NUP145 C-terminal domain › Nup96 0.57 48.0 2.91e-01 96.2% 58.2%
3872563 604.1.1.1 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin 0.57 49.0 4.33e-01 96.2% 81.7%
1954342 3826.1.1.1 alpha bundles › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) › Trns_repr_metal 0.57 42.0 4.07e-01 79.7% 95.5%
3784566 604.1.1.191 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › PF29057 0.56 45.0 4.23e-01 88.6% 100.0%
4034363 604.12.1.0 alpha bundles › Spectrin repeat-like › MIT domain › MIT domain 0.56 45.0 4.15e-01 92.4% 87.3%
3177741 4006.1.1.1 alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF 0.56 42.0 3.90e-01 79.7% 91.0%
3755130 604.1.1.1 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin 0.56 44.0 4.05e-01 86.1% 81.9%
3601998 101.1.10.0 alpha arrays › HTH › HTH › Cyclin-like 0.56 38.0 3.25e-01 72.2% 99.3%
3453029 611.7.1.16 alpha bundles › N-cbl like › Mixed lineage kinase domain-like (MLKL) N-terminal domain › Mixed lineage kinase domain-like (MLKL) N-terminal domain › PUB2_N 0.55 47.0 3.52e-01 98.7% 44.3%
3909893 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.54 47.0 3.90e-01 96.2% 90.0%
4485359 103.2.1.0 alpha arrays › RuvA-C › ATP cone › ATP cone 0.54 38.0 3.66e-01 98.7% 63.2%
3965294 3558.1.1.0 alpha arrays › HSDR subunit helical domain › HSDR subunit helical domain › HSDR subunit helical domain 0.54 43.0 4.04e-01 86.1% 77.9%
3228275 109.4.1.32 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › MIF4G 0.52 46.0 3.12e-01 100.0% 74.2%
5044421 592.2.1.0 alpha arrays › PWI domain-like › YugE-like › YugE-like 0.51 37.0 3.69e-01 98.7% 75.0%
D2 medium residues 113-171
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00851.25 best Peptidase_C6 34.8 1.30e-08 100.0% 12.5%
D3 medium residues 177-278_321-403
PDB
Pfam (2)
AccessionNameScoreE-valueQ covHMM cov
PF00851.25 best Peptidase_C6 62.4 5.60e-17 54.6% 18.2%
PF00851.25 Peptidase_C6 91.2 1.00e-25 47.6% 18.4%
D4 medium residues 279-320_404-458
PDB
Domain cluster: representative
Pfam (2)
AccessionNameScoreE-valueQ covHMM cov
PF00851.25 best Peptidase_C6 86.1 3.60e-24 61.9% 13.0%
PF00851.25 Peptidase_C6 25.8 7.30e-06 44.3% 9.3%
CATH (1)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3c2qA01 2.40.420.10 Mainly Beta › Beta Barrel › conserved putative lor/sdh protein from methanococcus maripaludis s2 fold › conserved putative lor/sdh protein from methanococcus maripaludis s2 domain 0.50 36.0 3.83e-01 76.3% 97.7%