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HC-Pro_protein

Euk-Vir

Potato_virus_A

HC-Pro_protein__NP_734360__Potato_virus_A__12215

Identity

Accession:
NP_734360 ↗
Protein ID:
HC-Pro_protein
Kingdom:
euk

Quality

83.4 mean pLDDT

Taxonomy

Orthornavirae› Pisuviricota› Stelpaviricetes› Patatavirales› Potyviridae› Potyvirus› Potato_virus_A

TaxID: 12215

Cluster

View cluster (80 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 28-104
PDB
Domain cluster: rep: HC-Pro__YP_009252411__Tobacco_mosqueado_virus__1792583__D31-64_66-104
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00851.25 best Peptidase_C6 29.7 4.60e-07 98.7% 15.2%
CATH (33)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2gnoA03 1.20.272.10 Mainly Alpha › Up-down Bundle › Zinc Finger, Delta Prime; domain 3 › 0.69 52.0 4.74e-01 79.2% 63.0%
2pqrA01 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.69 46.0 4.35e-01 89.6% 57.0%
3oxfA05 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.69 46.0 4.74e-01 89.6% 72.0%
2d2sA01 1.20.58.1210 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Exo84p, N-terminal helical domain 0.68 51.0 4.50e-01 100.0% 54.3%
4a25B01 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.67 60.0 4.71e-01 98.7% 87.0%
1s3qG00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.66 57.0 4.53e-01 97.4% 81.0%
4y6cA00 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.66 49.0 3.55e-01 92.2% 28.8%
2pftA00 1.20.1280.170 Mainly Alpha › Up-down Bundle › Monooxygenase › Exocyst complex component Exo70 0.65 58.0 3.49e-01 100.0% 26.2%
2cz2A02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.64 57.0 4.82e-01 100.0% 68.3%
2yfaA02 1.20.1440.210 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 0.63 56.0 4.91e-01 100.0% 69.0%
2v6kA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.63 56.0 4.72e-01 100.0% 72.3%
2ra1A01 1.20.58.790 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.63 53.0 4.90e-01 93.5% 88.8%
1yxrA01 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.62 46.0 4.68e-01 88.3% 82.4%
3nivC02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.62 54.0 4.67e-01 100.0% 75.8%
1dk8A02 1.10.167.10 Mainly Alpha › Orthogonal Bundle › Regulator of G-protein Signalling 4; domain 2 › Regulator of G-protein Signalling 4, domain 2 0.61 46.0 4.46e-01 88.3% 71.8%
4oydB00 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.61 54.0 4.68e-01 98.7% 92.3%
3axjB02 1.20.58.200 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 2 0.60 47.0 4.59e-01 89.6% 77.6%
1ugoA00 1.20.58.120 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain 0.59 53.0 4.91e-01 100.0% 83.8%
4ap2B01 1.20.1310.10 Mainly Alpha › Up-down Bundle › 5 helical Cullin repeat like › Cullin Repeats 0.59 53.0 4.42e-01 100.0% 91.0%
1cunA01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.59 51.0 4.68e-01 96.1% 91.2%
6vudA01 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.58 49.0 4.42e-01 97.4% 89.0%
2hisA00 3.20.20.80 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Glycosidases 0.58 51.0 3.40e-01 100.0% 58.3%
3pe0A01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.57 49.0 4.51e-01 96.1% 92.1%
4nuuB02 1.20.58.830 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.57 50.0 4.31e-01 98.7% 91.9%
1ux8A00 1.10.490.10 Mainly Alpha › Orthogonal Bundle › Globin-like › Globins 0.55 47.0 4.17e-01 100.0% 94.1%
4uurA00 1.10.490.10 Mainly Alpha › Orthogonal Bundle › Globin-like › Globins 0.54 46.0 4.06e-01 100.0% 93.5%
1zeeA01 1.20.58.600 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.53 45.0 3.91e-01 93.5% 71.2%
4hehA01 1.10.1240.10 Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › Methionine synthase domain 0.53 40.0 3.97e-01 83.1% 80.7%
1np7A02 1.25.40.80 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.53 41.0 3.58e-01 92.2% 54.6%
3kbbA02 1.10.150.240 Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 0.52 36.0 3.74e-01 71.4% 100.0%
4u72A01 1.20.58.480 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.52 45.0 3.26e-01 97.4% 87.4%
3zilA00 1.25.10.60 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Rad61, Wapl domain 0.52 44.0 2.89e-01 97.4% 50.8%
2oerA00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.51 42.0 3.32e-01 94.8% 42.5%
ECOD (28)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3773905 604.3.1.33 ↗ alpha bundles › Spectrin repeat-like › BAG domain › BAG domain › RSLD_CPSF6 0.73 59.0 5.98e-01 96.1% 88.0%
3997799 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.71 50.0 3.12e-01 72.7% 29.6%
3924801 109.4.1.1643 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › RSLD_CPSF6 0.70 57.0 5.32e-01 97.4% 71.6%
4579290 4156.1.1.6 ↗ alpha arrays › Sec63 N-terminal subdomain-like › Sec63 N-terminal subdomain-like › Sec63 N-terminal subdomain-like › Helicase_dom4_arc 0.67 56.0 4.73e-01 92.2% 88.5%
3200625 109.4.1.158 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › ERAP1_C 0.66 43.0 2.85e-01 93.5% 16.2%
3229748 1134.1.1.9 ↗ alpha bundles › C-terminal helical domain of alanine-tRNA ligase › C-terminal helical domain of alanine-tRNA ligase › Eukaryotic C-Ala helical domain › RSLD_CPSF6 0.66 54.0 5.22e-01 98.7% 80.0%
3605710 604.12.1.0 ↗ alpha bundles › Spectrin repeat-like › MIT domain › MIT domain 0.65 54.0 5.46e-01 92.2% 90.7%
3391259 604.6.1.0 ↗ alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain 0.65 54.0 5.14e-01 96.1% 77.8%
4491518 7516.1.1.153 ↗ a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Glycos_transf_2, Glyco_transf_8 0.64 53.0 3.14e-01 89.6% 17.7%
3581268 604.1.1.104 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › ANC1_spectrin 0.63 54.0 5.06e-01 93.5% 92.6%
3640330 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.63 55.0 4.60e-01 100.0% 86.4%
3345666 109.1.1.7 ↗ alpha superhelices › Repetitive alpha hairpins › Glutathione S-transferase (GST)-C › Glutathione S-transferase (GST)-C › GST_C_3 0.63 56.0 4.65e-01 100.0% 67.4%
4879561 626.1.1.1 ↗ alpha complex topology › Formin homology 2 domain (FH2 domain) › Formin homology 2 domain (FH2 domain) › Formin homology 2 domain (FH2 domain) › FH2 0.63 55.0 3.46e-01 96.1% 55.2%
3255703 310.2.1.0 ↗ a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF 0.63 55.0 4.91e-01 97.4% 87.2%
3574981 604.12.1.91 ↗ alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › RSLD_CPSF6 0.62 46.0 4.78e-01 92.2% 88.6%
4936739 3921.1.1.1 ↗ alpha complex topology › Na(+)-translocating NADH-quinone reductase subunit D › Na(+)-translocating NADH-quinone reductase subunit D › Na(+)-translocating NADH-quinone reductase subunit D › Rnf-Nqr 0.62 54.0 3.95e-01 98.7% 36.5%
3784313 103.2.1.2 ↗ alpha arrays › RuvA-C › ATP cone › ATP cone › ATP-cone 0.59 39.0 3.73e-01 90.9% 56.7%
3750000 604.1.1.1 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin 0.59 51.0 4.62e-01 96.1% 87.6%
4485359 103.2.1.0 ↗ alpha arrays › RuvA-C › ATP cone › ATP cone 0.58 41.0 3.89e-01 98.7% 61.1%
2051524 2007.1.14.4 ↗ a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Chelatase-like › ZnuA 0.58 51.0 4.10e-01 97.4% 87.8%
5001522 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.57 48.0 4.40e-01 93.5% 88.3%
3841673 604.1.1.1 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin 0.57 49.0 4.51e-01 96.1% 92.0%
3755130 604.1.1.1 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin 0.56 48.0 4.37e-01 96.1% 87.6%
4128901 109.4.1.158 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › ERAP1_C 0.56 46.0 3.20e-01 93.5% 34.8%
3757581 604.1.1.1 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin 0.55 48.0 4.33e-01 96.1% 87.6%
3909893 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.55 47.0 3.92e-01 96.1% 69.3%
3559937 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.55 46.0 4.22e-01 94.8% 88.6%
3240658 109.4.1.409 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Arm,IBB,Arm_3 0.50 43.0 3.06e-01 100.0% 53.5%
D2 high residues 269-456
PDB
Domain cluster: rep: HC-Pro_protein__YP_006590094__Chinese_yam_necrotic_mosaic_virus__128818__D95-261
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00851.25 best Peptidase_C6 268.7 1.40e-79 100.0% 42.5%
D3 medium residues 112-173
PDB
Domain cluster: rep: HC-Pro_protein__YP_006405405__Basella_rugose_mosaic_virus__373398__D110-165
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00851.25 best Peptidase_C6 31.8 1.10e-07 100.0% 13.4%
D4 medium residues 207-268
PDB
Domain cluster: rep: HC-Pro_protein__NP_871739__Onion_yellow_dwarf_virus__43130__D203-269
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00851.25 best Peptidase_C6 33.4 3.60e-08 100.0% 13.2%