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HNH_nuclease
Euk-VirChrysochromulina_ericina_virus
HNH_nuclease__YP_009173567__Chrysochromulina_ericina_virus__455364
Identity
- Accession:
- YP_009173567 ↗
- Protein ID:
- HNH_nuclease
- Kingdom:
- euk
Quality
65.4
mean pLDDT
Taxonomy
Bamfordvirae›
Nucleocytoviricota›
Megaviricetes›
Algavirales›
Phycodnaviridae›
Chrysochromulina_ericina_virus
TaxID: 455364
Cluster
Singleton — not in a non-trivial cluster
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 123-183
Domain cluster:
rep: SR-VP_0-2_scaffold_141_4556078_prodigal-single.1__X__X__00088__D33-109
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01844.30 best | HNH | 39.8 | 5.70e-10 | 73.8% | 97.9% |
CATH (18)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2qgpA00 | 1.10.30.50 | Mainly Alpha › Orthogonal Bundle › DNA Binding (I), subunit A › | 0.79 | 71.0 | 6.37e-01 | 98.4% | 73.5% |
| 1e7lA01 | 3.40.1800.10 | Alpha Beta › 3-Layer(aba) Sandwich › His-Me finger endonuclease fold › His-Me finger endonucleases | 0.79 | 72.0 | 6.54e-01 | 100.0% | 77.5% |
| 3t7lA00 | 3.30.40.10 | Alpha Beta › 2-Layer Sandwich › Herpes Virus-1 › Zinc/RING finger domain, C3HC4 (zinc finger) | 0.73 | 49.0 | 4.62e-01 | 80.3% | 58.1% |
| 3m7kA00 | 3.30.40.220 | Alpha Beta › 2-Layer Sandwich › Herpes Virus-1 › | 0.69 | 60.0 | 4.59e-01 | 98.4% | 64.1% |
| 1jm7A00 | 3.30.40.10 | Alpha Beta › 2-Layer Sandwich › Herpes Virus-1 › Zinc/RING finger domain, C3HC4 (zinc finger) | 0.66 | 43.0 | 3.62e-01 | 86.9% | 39.8% |
| 1wfkA01 | 3.30.40.10 | Alpha Beta › 2-Layer Sandwich › Herpes Virus-1 › Zinc/RING finger domain, C3HC4 (zinc finger) | 0.66 | 45.0 | 4.20e-01 | 80.3% | 57.1% |
| 1z2qA00 | 3.30.40.10 | Alpha Beta › 2-Layer Sandwich › Herpes Virus-1 › Zinc/RING finger domain, C3HC4 (zinc finger) | 0.63 | 50.0 | 4.47e-01 | 95.1% | 61.9% |
| 2m6mA00 | 3.30.40.10 | Alpha Beta › 2-Layer Sandwich › Herpes Virus-1 › Zinc/RING finger domain, C3HC4 (zinc finger) | 0.63 | 46.0 | 4.21e-01 | 93.4% | 57.8% |
| 3lrqB00 | 3.30.40.10 | Alpha Beta › 2-Layer Sandwich › Herpes Virus-1 › Zinc/RING finger domain, C3HC4 (zinc finger) | 0.60 | 46.0 | 4.23e-01 | 88.5% | 63.7% |
| 1xx6A02 | 3.30.60.20 | Alpha Beta › 2-Layer Sandwich › Wheat Germ Agglutinin (Isolectin 2); domain 1 › | 0.60 | 42.0 | 4.67e-01 | 88.5% | 100.0% |
| 2xzmZ00 | 3.30.1230.20 | Alpha Beta › 2-Layer Sandwich › Hypothetical Cytosolic Protein; Chain: A; › Ribosomal protein S21 | 0.57 | 43.0 | 3.74e-01 | 82.0% | 58.8% |
| 2vp7A00 | 3.30.40.10 | Alpha Beta › 2-Layer Sandwich › Herpes Virus-1 › Zinc/RING finger domain, C3HC4 (zinc finger) | 0.57 | 41.0 | 4.02e-01 | 96.7% | 71.2% |
| 2y43A00 | 3.30.40.10 | Alpha Beta › 2-Layer Sandwich › Herpes Virus-1 › Zinc/RING finger domain, C3HC4 (zinc finger) | 0.57 | 43.0 | 3.81e-01 | 86.9% | 56.8% |
| 1a73A00 | 3.90.75.10 | Alpha Beta › Alpha-Beta Complex › Homing Intron 3 (I-Ppo) Encoded Endonuclease; Chain A › Homing Intron 3 (I-ppo) Encoded Endonuclease; Chain A | 0.55 | 45.0 | 3.47e-01 | 100.0% | 50.6% |
| 4ijjB00 | 1.20.120.910 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › DksA, coiled-coil domain | 0.55 | 50.0 | 3.84e-01 | 100.0% | 79.2% |
| 3j7aZ00 | 3.30.1230.20 | Alpha Beta › 2-Layer Sandwich › Hypothetical Cytosolic Protein; Chain: A; › Ribosomal protein S21 | 0.54 | 43.0 | 4.07e-01 | 85.2% | 80.6% |
| 4fo9A02 | 3.30.40.10 | Alpha Beta › 2-Layer Sandwich › Herpes Virus-1 › Zinc/RING finger domain, C3HC4 (zinc finger) | 0.51 | 44.0 | 3.60e-01 | 100.0% | 59.8% |
| 2x5rA01 | 3.30.470.40 | Alpha Beta › 2-Layer Sandwich › D-amino Acid Aminotransferase; Chain A, domain 1 › | 0.50 | 38.0 | 3.30e-01 | 91.8% | 55.7% |
ECOD (60)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4951302 | 378.1.1.2 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases › HNH | 0.89 | 81.0 | 7.93e-01 | 98.4% | 95.4% |
| 5070853 | 378.1.1.2 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases › HNH | 0.87 | 77.0 | 6.84e-01 | 98.4% | 69.4% |
| 4959591 | 378.1.1.2 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases › HNH | 0.86 | 79.0 | 7.76e-01 | 100.0% | 95.4% |
| 4999440 | 378.1.1.27 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases › HNH_5 | 0.85 | 73.0 | 6.50e-01 | 98.4% | 67.1% |
| 4937899 | 378.1.1.2 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases › HNH | 0.85 | 73.0 | 6.37e-01 | 95.1% | 63.3% |
| 3950953 | 377.1.1.78 ↗ | few secondary structure elements › Glucocorticoid receptor-like › LIM domain-like › LIM domain-like › HNH_5 | 0.84 | 71.0 | 6.81e-01 | 96.7% | 80.0% |
| 3952818 | 378.1.1.27 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases › HNH_5 | 0.83 | 71.0 | 6.64e-01 | 96.7% | 75.7% |
| 3963404 | 377.1.1.88 ↗ | few secondary structure elements › Glucocorticoid receptor-like › LIM domain-like › LIM domain-like › HNH | 0.83 | 76.0 | 6.46e-01 | 100.0% | 82.1% |
| 5019258 | 378.1.1.2 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases › HNH | 0.83 | 74.0 | 6.73e-01 | 98.4% | 81.2% |
| 3965880 | 378.1.1.2 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases › HNH | 0.83 | 72.0 | 6.35e-01 | 96.7% | 87.6% |
| 3277754 | 377.1.1.88 ↗ | few secondary structure elements › Glucocorticoid receptor-like › LIM domain-like › LIM domain-like › HNH | 0.83 | 70.0 | 6.69e-01 | 96.7% | 80.0% |
| 4998487 | 378.1.1.2 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases › HNH | 0.82 | 69.0 | 5.98e-01 | 98.4% | 60.0% |
| 4949181 | 378.1.1.2 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases › HNH | 0.81 | 70.0 | 6.51e-01 | 100.0% | 76.0% |
| 4941657 | 377.1.1.88 ↗ | few secondary structure elements › Glucocorticoid receptor-like › LIM domain-like › LIM domain-like › HNH | 0.81 | 70.0 | 6.54e-01 | 95.1% | 84.0% |
| 3587782 | 378.1.1.0 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases | 0.81 | 70.0 | 5.75e-01 | 96.7% | 65.5% |
| 4932123 | 377.7.1.2 ↗ | few secondary structure elements › Glucocorticoid receptor-like › 82 prophage-derived uncharacterized protein ybcO › 82 prophage-derived uncharacterized protein ybcO › HNH | 0.80 | 72.0 | 6.87e-01 | 98.4% | 85.7% |
| 3278018 | 378.1.1.2 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases › HNH | 0.80 | 66.0 | 6.88e-01 | 93.4% | 100.0% |
| 3317146 | 378.1.1.2 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases › HNH | 0.80 | 70.0 | 5.49e-01 | 96.7% | 62.9% |
| 2628026 | 378.1.1.0 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases | 0.80 | 72.0 | 4.94e-01 | 100.0% | 64.4% |
| 3440476 | 378.1.1.10 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases › HNH_4 | 0.79 | 69.0 | 5.52e-01 | 96.7% | 64.7% |
| 3590055 | 378.1.1.2 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases › HNH | 0.79 | 69.0 | 5.63e-01 | 98.4% | 89.6% |
| 3307439 | 378.1.1.0 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases | 0.79 | 68.0 | 5.44e-01 | 96.7% | 63.9% |
| 3952892 | 378.1.1.2 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases › HNH | 0.79 | 67.0 | 5.30e-01 | 96.7% | 46.4% |
| 3955812 | 378.1.1.2 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases › HNH | 0.79 | 67.0 | 5.79e-01 | 98.4% | 61.3% |
| 8235 | 378.1.1.3 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases › Endonuclease_7 | 0.79 | 72.0 | 5.97e-01 | 100.0% | 60.2% |
| 5080086 | 378.1.1.0 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases | 0.78 | 72.0 | 6.50e-01 | 100.0% | 78.8% |
| 5049537 | 378.1.1.2 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases › HNH | 0.78 | 68.0 | 5.86e-01 | 98.4% | 62.8% |
| 4943720 | 378.1.1.0 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases | 0.78 | 67.0 | 5.27e-01 | 98.4% | 46.4% |
| 185780 | 378.1.1.2 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases › HNH | 0.77 | 69.0 | 5.85e-01 | 98.4% | 62.9% |
| 5016552 | 378.1.1.10 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases › HNH_4 | 0.77 | 68.0 | 5.53e-01 | 96.7% | 57.3% |
| 3952776 | 377.1.1.88 ↗ | few secondary structure elements › Glucocorticoid receptor-like › LIM domain-like › LIM domain-like › HNH | 0.77 | 66.0 | 6.52e-01 | 96.7% | 90.8% |
| 4989310 | 378.1.1.27 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases › HNH_5 | 0.77 | 58.0 | 4.01e-01 | 82.0% | 25.9% |
| 2859872 | 378.1.1.10 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases › HNH_4 | 0.77 | 68.0 | 4.76e-01 | 98.4% | 32.8% |
| 3953218 | 378.1.1.23 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases › DUF222 | 0.76 | 67.0 | 4.95e-01 | 98.4% | 38.7% |
| 2485694 | 378.1.1.2 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases › HNH | 0.76 | 66.0 | 5.15e-01 | 98.4% | 51.5% |
| 4986026 | 378.1.1.2 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases › HNH | 0.75 | 57.0 | 3.97e-01 | 82.0% | 26.5% |
| 3957069 | 378.1.1.0 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases | 0.75 | 66.0 | 4.89e-01 | 100.0% | 73.1% |
| 4966182 | 378.1.1.9 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases › HNH_2 | 0.75 | 65.0 | 5.19e-01 | 98.4% | 94.4% |
| 4839749 | 3821.1.1.0 ↗ | a+b complex topology › CRISPR-associated endonuclease Cas9 beta-hairpin domain › CRISPR-associated endonuclease Cas9 beta-hairpin domain › CRISPR-associated endonuclease Cas9 beta-hairpin domain | 0.75 | 51.0 | 5.72e-01 | 70.5% | 95.6% |
| 3952923 | 378.1.1.2 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases › HNH | 0.75 | 63.0 | 5.40e-01 | 98.4% | 58.0% |
| 3952384 | 378.1.1.0 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases | 0.75 | 65.0 | 5.64e-01 | 98.4% | 63.2% |
| 3953059 | 378.1.1.0 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases | 0.75 | 64.0 | 5.64e-01 | 98.4% | 65.6% |
| 3953524 | 378.1.1.23 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases › DUF222 | 0.75 | 65.0 | 4.82e-01 | 98.4% | 39.4% |
| 3948700 | 378.1.1.9 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases › HNH_2 | 0.72 | 64.0 | 5.07e-01 | 100.0% | 98.4% |
| 5000599 | 378.1.1.0 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases | 0.72 | 65.0 | 4.61e-01 | 100.0% | 53.9% |
| 4966684 | 377.1.1.0 ↗ | few secondary structure elements › Glucocorticoid receptor-like › LIM domain-like › LIM domain-like | 0.72 | 57.0 | 5.74e-01 | 98.4% | 86.7% |
| 3249964 | 378.1.1.0 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases | 0.71 | 63.0 | 5.76e-01 | 100.0% | 97.5% |
| 2462317 | 4205.1.1.2 ↗ | a+b two layers › SMI1/KNR4-like › SMI1/KNR4-like › SMI1/KNR4-like › GAD-like,T6SS_Tdi1_C | 0.71 | 53.0 | 3.63e-01 | 100.0% | 22.6% |
| 4981807 | 378.1.1.9 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases › HNH_2 | 0.70 | 61.0 | 4.57e-01 | 100.0% | 76.8% |
| 3328297 | 376.1.1.0 ↗ | few secondary structure elements › RING/U-box-like › RING/U-box-like › RING/U-box | 0.67 | 54.0 | 5.14e-01 | 85.2% | 74.3% |
| 3780266 | 376.1.3.32 ↗ | few secondary structure elements › RING/U-box-like › RING/U-box-like › FYVE/PHD zinc finger › RH_dom | 0.64 | 58.0 | 4.95e-01 | 98.4% | 78.9% |
| 3642367 | 377.1.1.0 ↗ | few secondary structure elements › Glucocorticoid receptor-like › LIM domain-like › LIM domain-like | 0.64 | 45.0 | 5.15e-01 | 80.3% | 100.0% |
| 3869753 | 101.1.2.602 ↗ | alpha arrays › HTH › HTH › winged helix domain › RH_dom | 0.64 | 58.0 | 5.12e-01 | 98.4% | 88.2% |
| 3199832 | 377.1.1.0 ↗ | few secondary structure elements › Glucocorticoid receptor-like › LIM domain-like › LIM domain-like | 0.61 | 44.0 | 4.34e-01 | 75.4% | 89.2% |
| 3697192 | 377.1.1.5 ↗ | few secondary structure elements › Glucocorticoid receptor-like › LIM domain-like › LIM domain-like › LIM | 0.61 | 48.0 | 4.76e-01 | 83.6% | 92.3% |
| 3543123 | 4044.1.1.12 ↗ | alpha bundles › Helical bundle domain in prismane-like proteins › Helical bundle domain in prismane-like proteins › Helical bundle domain in prismane-like proteins › RH_dom | 0.60 | 53.0 | 4.61e-01 | 95.1% | 81.1% |
| 3695527 | 378.1.1.6 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases › zf-His_Me_endon | 0.57 | 48.0 | 3.95e-01 | 100.0% | 57.5% |
| 3204200 | 376.1.1.0 ↗ | few secondary structure elements › RING/U-box-like › RING/U-box-like › RING/U-box | 0.55 | 45.0 | 4.43e-01 | 93.4% | 84.6% |
| 3702432 | 221.1.1.0 ↗ | a+b two layers › beta-Grasp › Ubiquitin-related › Ubiquitin-like | 0.51 | 37.0 | 3.32e-01 | 82.0% | 67.4% |
| 119292 | 3149.1.1.1 ↗ | a+b complex topology › Hypothetical protein ORF126 › Hypothetical protein ORF126 › Hypothetical protein ORF126 › ORF126-like | 0.50 | 38.0 | 3.23e-01 | 91.8% | 51.6% |
D2
medium
residues 3-111