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IMGVR_UViG_2918192969_000001-2918192969-2918194543
Arc-VirIMGVR_UViG_2918192969_000001-2918192969-2918194543
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 4-119
Domain cluster:
representative
CATH (34)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1y4cA03 | 1.20.120.660 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › IL-4 antagonist (De novo design) like domain | 0.78 | 50.0 | 5.08e-01 | 70.7% | 65.5% |
| 4yjwA00 | 1.20.120.930 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Uncharacterised protein PF12889, N-terminal DUF3829 | 0.75 | 58.0 | 5.22e-01 | 80.2% | 68.0% |
| 1qdbA02 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.74 | 51.0 | 4.77e-01 | 71.6% | 58.0% |
| 1yo7A00 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.73 | 49.0 | 4.87e-01 | 73.3% | 65.8% |
| 2rldA00 | 1.20.1440.60 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 23S rRNA-intervening sequence | 0.69 | 47.0 | 4.81e-01 | 74.1% | 71.1% |
| 1kxpD02 | 1.10.246.10 | Mainly Alpha › Orthogonal Bundle › Serum Albumin; Chain A, Domain 1 › | 0.69 | 45.0 | 5.04e-01 | 76.7% | 87.5% |
| 3t9oB00 | 1.20.120.30 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Aspartate receptor, ligand-binding domain | 0.69 | 48.0 | 4.75e-01 | 74.1% | 69.2% |
| 2ap3A00 | 1.20.120.570 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › YkyA-like | 0.67 | 53.0 | 4.51e-01 | 84.5% | 64.6% |
| 4hr1A00 | 1.20.1270.410 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.66 | 48.0 | 4.85e-01 | 75.0% | 81.4% |
| 4m70I00 | 1.20.5.4130 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › | 0.66 | 48.0 | 5.02e-01 | 75.9% | 89.8% |
| 2hujA00 | 1.20.120.440 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › YppE-like | 0.66 | 46.0 | 4.56e-01 | 77.6% | 67.2% |
| 8hk0B03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.65 | 47.0 | 4.48e-01 | 75.0% | 65.2% |
| 1zvzA02 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.65 | 50.0 | 4.96e-01 | 81.9% | 80.6% |
| 1x8zB00 | 1.20.140.40 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Invertase/pectin methylesterase inhibitor family protein | 0.64 | 43.0 | 4.03e-01 | 71.6% | 54.4% |
| 1k90B03 | 1.20.140.60 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › | 0.64 | 39.0 | 3.97e-01 | 87.9% | 61.7% |
| 2okuA00 | 1.20.120.470 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Acyl-CoA dehydrogenase, C-terminal domain | 0.62 | 45.0 | 4.52e-01 | 76.7% | 87.7% |
| 3eabE00 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.62 | 42.0 | 4.89e-01 | 84.5% | 94.2% |
| 1bgcA00 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.60 | 47.0 | 4.22e-01 | 81.9% | 62.7% |
| 1w9rA00 | 1.20.58.440 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › choline binding protein A | 0.60 | 49.0 | 4.90e-01 | 88.8% | 89.1% |
| 2wzkA03 | 1.20.1310.10 | Mainly Alpha › Up-down Bundle › 5 helical Cullin repeat like › Cullin Repeats | 0.58 | 33.0 | 3.37e-01 | 88.8% | 57.3% |
| 1r0dA00 | 1.20.1410.10 | Mainly Alpha › Up-down Bundle › I/LWEQ domain › I/LWEQ domain | 0.57 | 51.0 | 4.36e-01 | 100.0% | 94.8% |
| 3ztaA00 | 1.10.490.130 | Mainly Alpha › Orthogonal Bundle › Globin-like › | 0.57 | 50.0 | 4.74e-01 | 96.6% | 96.4% |
| 7csoA01 | 1.20.900.10 | Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain | 0.55 | 49.0 | 3.87e-01 | 94.8% | 85.5% |
| 3bt5A00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.55 | 45.0 | 4.17e-01 | 89.7% | 90.1% |
| 4u7iA00 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.54 | 40.0 | 4.42e-01 | 90.5% | 95.7% |
| 3fnbA01 | 1.20.1440.110 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › acylaminoacyl peptidase | 0.54 | 39.0 | 3.94e-01 | 75.0% | 97.4% |
| 7zxkC01 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.54 | 44.0 | 4.03e-01 | 87.9% | 67.3% |
| 2clbA01 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.54 | 43.0 | 3.95e-01 | 87.9% | 86.2% |
| 4rfsS00 | 1.10.1760.20 | Mainly Alpha › Orthogonal Bundle › Arp2/3 complex 21 kDa subunit ARPC3 › | 0.53 | 41.0 | 3.48e-01 | 81.0% | 52.4% |
| 1jnrA03 | 1.20.58.100 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain | 0.52 | 37.0 | 3.73e-01 | 82.8% | 72.7% |
| 7dluA01 | 1.10.287.1260 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.51 | 38.0 | 3.94e-01 | 81.0% | 85.7% |
| 2yw6B00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.51 | 42.0 | 3.93e-01 | 91.4% | 89.3% |
| 3ck6C02 | 1.20.58.340 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Magnesium transport protein CorA, transmembrane region | 0.51 | 44.0 | 4.41e-01 | 94.0% | 91.6% |
| 2nrlA00 | 1.10.490.10 | Mainly Alpha › Orthogonal Bundle › Globin-like › Globins | 0.51 | 41.0 | 3.82e-01 | 86.2% | 93.8% |
ECOD (46)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3227678 | 632.1.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain | 0.83 | 56.0 | 6.03e-01 | 70.7% | 80.0% |
| 5037413 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.80 | 58.0 | 5.11e-01 | 75.0% | 77.0% |
| 4968618 | 611.6.1.0 ↗ | alpha bundles › N-cbl like › PT26-6P helical domain › PT26-6P helical domain | 0.79 | 56.0 | 6.06e-01 | 73.3% | 85.7% |
| 5052771 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.76 | 56.0 | 5.69e-01 | 75.9% | 79.1% |
| 3700730 | 601.1.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin | 0.74 | 54.0 | 4.96e-01 | 75.9% | 63.3% |
| 3990896 | 5050.1.1.1 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Sugar_tr | 0.74 | 52.0 | 4.13e-01 | 72.4% | 84.1% |
| 3612019 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.74 | 52.0 | 5.84e-01 | 71.6% | 95.6% |
| 4137645 | 5069.1.1.0 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes | 0.74 | 53.0 | 4.90e-01 | 73.3% | 73.6% |
| 3684359 | 604.7.1.0 ↗ | alpha bundles › Spectrin repeat-like › Tubulin chaperone cofactor A › Tubulin chaperone cofactor A | 0.73 | 51.0 | 4.68e-01 | 70.7% | 65.5% |
| 3393952 | 7515.1.1.6 ↗ | a/b three-layered sandwiches › Alkaline phosphatase-like › Alkaline phosphatase-like › Alkaline phosphatase-like › Phosphodiest | 0.73 | 54.0 | 3.68e-01 | 75.9% | 97.0% |
| 4030302 | 7015.1.1.0 ↗ | alpha bundles › Palmitoyltransferase DHHC transmembrane domain › Palmitoyltransferase DHHC transmembrane domain › Palmitoyltransferase DHHC transmembrane domain | 0.73 | 51.0 | 4.85e-01 | 71.6% | 68.9% |
| 3629841 | 5050.1.1.8 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › FPN1 | 0.72 | 52.0 | 4.03e-01 | 74.1% | 54.6% |
| 4662540 | 633.31.1.0 ↗ | alpha bundles › Bromodomain-like › Four-helical bundle insertion domain in pyruvate-ferredoxin oxidoreductase › Four-helical bundle insertion domain in pyruvate-ferredoxin oxidoreductase | 0.72 | 37.0 | 4.50e-01 | 74.1% | 76.0% |
| 4428399 | 632.11.1.10 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like › EzrA | 0.72 | 52.0 | 5.40e-01 | 77.6% | 79.1% |
| 3388493 | 633.10.1.15 ↗ | alpha bundles › Bromodomain-like › IVS-encoded protein-like › IVS-encoded protein-like › Transmemb_17 | 0.71 | 50.0 | 4.81e-01 | 71.6% | 67.7% |
| 3199087 | 5038.2.1.1 ↗ | alpha superhelices › Cytochrome c oxidase subunit I-like › MAPEG domain-like › MAPEG domain-like › MAPEG | 0.71 | 52.0 | 4.88e-01 | 75.9% | 91.4% |
| 3313420 | 611.9.1.4 ↗ | alpha bundles › N-cbl like › Resistance protein (Rx) N-terminal domain › Resistance protein (Rx) N-terminal domain › Rx_N | 0.71 | 53.0 | 4.98e-01 | 78.4% | 86.4% |
| 4423640 | 5059.1.1.5 ↗ | alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › UAA | 0.70 | 58.0 | 4.02e-01 | 87.1% | 49.9% |
| 4025746 | 4106.1.1.1 ↗ | few secondary structure elements › Zinc hairpin stack › Zinc hairpin stack › Zinc hairpin stack › DHHC | 0.70 | 52.0 | 4.54e-01 | 77.6% | 68.2% |
| 3656892 | 611.9.1.4 ↗ | alpha bundles › N-cbl like › Resistance protein (Rx) N-terminal domain › Resistance protein (Rx) N-terminal domain › Rx_N | 0.69 | 51.0 | 4.92e-01 | 76.7% | 94.6% |
| 3949780 | 3883.1.1.1 ↗ | alpha bundles › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-OH_P_transf | 0.68 | 56.0 | 4.73e-01 | 87.1% | 81.6% |
| 3377749 | 3843.1.1.15 ↗ | alpha complex topology › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › ETR1_N | 0.68 | 51.0 | 5.44e-01 | 80.2% | 90.0% |
| 3988974 | 604.5.1.0 ↗ | alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) | 0.68 | 55.0 | 5.62e-01 | 85.3% | 92.7% |
| 3436259 | 632.15.1.5 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Staphylococcal complement inhibitor (SCIN) › Staphylococcal complement inhibitor (SCIN) › Rx_N | 0.67 | 46.0 | 4.63e-01 | 70.7% | 69.2% |
| 3939680 | 4177.1.1.3 ↗ | alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › Arfaptin | 0.67 | 57.0 | 4.54e-01 | 93.1% | 88.1% |
| 3767 | 601.26.1.1 ↗ | alpha bundles › Four-helical up-and-down bundle › YppE-like › YppE-like › DUF1798 | 0.66 | 46.0 | 4.58e-01 | 75.9% | 68.3% |
| 3988973 | 601.1.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin | 0.65 | 52.0 | 5.14e-01 | 84.5% | 86.7% |
| 5001811 | 632.1.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain | 0.65 | 46.0 | 5.11e-01 | 73.3% | 94.4% |
| 5014025 | 1076.1.1.4 ↗ | alpha bundles › Intramembrane protease Rce1-related › Intramembrane protease Rce1-related › Intramembrane protease Rce1-related › PrsW-protease | 0.65 | 53.0 | 4.26e-01 | 87.9% | 72.4% |
| 4934670 | 601.33.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › CHAD domain › CHAD domain | 0.64 | 43.0 | 5.05e-01 | 79.3% | 100.0% |
| 4438700 | 622.1.1.0 ↗ | alpha bundles › YvfG-like › HSC20 (HSCB), C-terminal oligomerisation domain › HSC20 (HSCB), C-terminal oligomerisation domain | 0.63 | 37.0 | 4.37e-01 | 80.2% | 82.4% |
| 3230341 | 5054.1.1.17 ↗ | alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels › TRAM_LAG1_CLN8 | 0.62 | 55.0 | 4.36e-01 | 96.6% | 79.1% |
| 3404270 | 377.1.1.0 ↗ | few secondary structure elements › Glucocorticoid receptor-like › LIM domain-like › LIM domain-like | 0.61 | 42.0 | 4.07e-01 | 71.6% | 63.8% |
| None | — | 0.60 | 45.0 | 3.31e-01 | 78.4% | 51.1% | |
| 3486435 | 5059.1.1.0 ↗ | alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter | 0.60 | 44.0 | 3.31e-01 | 77.6% | 57.5% |
| 3624728 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.59 | 41.0 | 4.73e-01 | 94.8% | 96.5% |
| 3568926 | 7515.1.1.6 ↗ | a/b three-layered sandwiches › Alkaline phosphatase-like › Alkaline phosphatase-like › Alkaline phosphatase-like › Phosphodiest | 0.58 | 50.0 | 3.43e-01 | 93.1% | 94.3% |
| 3282593 | 4121.1.1.1 ↗ | a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like › CorA | 0.58 | 54.0 | 4.19e-01 | 100.0% | 84.6% |
| 4019091 | 3755.4.1.0 ↗ | alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain | 0.58 | 42.0 | 4.04e-01 | 77.6% | 70.7% |
| 3666876 | 5058.1.1.0 ↗ | alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region | 0.58 | 50.0 | 4.79e-01 | 93.1% | 89.2% |
| 3441289 | 3684.1.1.19 ↗ | alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › DUF1110 | 0.56 | 51.0 | 4.35e-01 | 94.8% | 71.4% |
| 3724548 | 611.7.1.10 ↗ | alpha bundles › N-cbl like › Mixed lineage kinase domain-like (MLKL) N-terminal domain › Mixed lineage kinase domain-like (MLKL) N-terminal domain › Helo_like_N | 0.56 | 41.0 | 3.94e-01 | 76.7% | 66.7% |
| 3370265 | 604.3.1.1 ↗ | alpha bundles › Spectrin repeat-like › BAG domain › BAG domain › BAG | 0.56 | 36.0 | 3.52e-01 | 73.3% | 57.7% |
| 3176050 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.55 | 49.0 | 3.77e-01 | 94.8% | 84.1% |
| 4597634 | 632.19.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Choline binding protein A › Choline binding protein A | 0.52 | 35.0 | 4.02e-01 | 83.6% | 100.0% |
| 3815122 | 604.12.1.68 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › DUF6857 | 0.52 | 45.0 | 3.81e-01 | 90.5% | 76.1% |