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IMGVR_UViG_3300000341_000011-3300000341-OneHSP_6670CDRAFT_10011901

Arc-Vir

Identity

Accession:: IMGVR_UViG_3300000341_000011-3300000341-OneHSP_6670CDRAFT_10011901 ↗
Kingdom:: archaea

Quality

89.3 mean pLDDT

Cluster

Singleton — not in a non-trivial cluster

3D Structure

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Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 198-374

PDB

Domain cluster: representative

CATH (36)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3zciA00	1.20.58.1660	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.80	61.0	6.01e-01	79.1%	99.0%
2ap3A00	1.20.120.570	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › YkyA-like	0.78	56.0	5.46e-01	73.4%	88.0%
1x8zB00	1.20.140.40	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Invertase/pectin methylesterase inhibitor family protein	0.77	48.0	5.22e-01	72.9%	74.1%
3kbtA00	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.72	61.0	5.17e-01	89.3%	85.9%
2cmrA00	1.20.58.1860	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.72	52.0	5.06e-01	73.4%	92.2%
3i9wA00	1.20.58.920	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.69	52.0	4.53e-01	78.5%	55.9%
3edvA02	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.68	51.0	5.13e-01	78.0%	100.0%
1sziA02	1.20.120.340	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Flagellar protein FliS	0.67	43.0	4.88e-01	72.9%	83.2%
7p3rA01	1.20.1170.10	Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; ›	0.67	58.0	4.68e-01	91.0%	99.1%
2pfdA03	1.20.120.680	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Formiminotetrahydrofolate cyclodeaminase monomer, up-and-down helical bundle	0.65	46.0	4.42e-01	72.9%	66.0%
3i9yA00	1.20.58.920	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.63	47.0	4.25e-01	79.1%	58.5%
2a2fX02	1.20.58.670	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Dsl1p vesicle tethering complex, Tip20p subunit, domain D	0.62	33.0	3.83e-01	82.5%	69.8%
3k66A01	1.20.120.770	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Amyloid precursor protein, E2 domain	0.61	44.0	4.14e-01	71.8%	87.1%
3rauA00	1.25.40.280	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › alix/aip1 like domains	0.61	55.0	4.36e-01	96.6%	85.2%
3r9mA00	1.25.40.280	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › alix/aip1 like domains	0.61	54.0	4.22e-01	96.0%	88.0%
2xs1A01	1.25.40.280	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › alix/aip1 like domains	0.61	53.0	4.28e-01	96.6%	85.4%
1o5hA00	1.20.120.680	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Formiminotetrahydrofolate cyclodeaminase monomer, up-and-down helical bundle	0.61	45.0	4.32e-01	75.7%	79.0%
4oydB00	1.10.132.20	Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor	0.60	39.0	4.82e-01	74.6%	100.0%
1x04A00	1.20.1270.60	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain	0.60	46.0	4.41e-01	89.8%	69.0%
4mt0A01	1.20.1600.10	Mainly Alpha › Up-down Bundle › Outer membrane efflux proteins (OEP) › Outer membrane efflux proteins (OEP)	0.59	48.0	3.78e-01	85.9%	80.3%
2jswA00	1.20.1410.10	Mainly Alpha › Up-down Bundle › I/LWEQ domain › I/LWEQ domain	0.58	43.0	4.25e-01	75.7%	91.5%
1r0dA00	1.20.1410.10	Mainly Alpha › Up-down Bundle › I/LWEQ domain › I/LWEQ domain	0.58	45.0	4.35e-01	79.1%	94.3%
3na7A00	1.10.287.1490	Mainly Alpha › Orthogonal Bundle › Helix Hairpins ›	0.58	36.0	3.23e-01	95.5%	46.0%
1zb1A00	1.25.40.280	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › alix/aip1 like domains	0.58	51.0	4.07e-01	96.6%	87.2%
3vkgA12	1.10.287.2610	Mainly Alpha › Orthogonal Bundle › Helix Hairpins ›	0.57	39.0	3.62e-01	79.1%	56.3%
2v0pA00	1.25.40.540	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › TAP42-like family	0.57	40.0	3.69e-01	70.6%	93.6%
4ke2A00	6.10.140.1860	Special › Helix non-globular › Helix Hairpins ›	0.55	32.0	3.13e-01	78.0%	49.0%
4f4cA01	1.20.1560.10	Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain	0.54	48.0	3.21e-01	96.6%	98.2%
2b5uA02	1.10.287.620	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix Hairpins	0.53	34.0	3.52e-01	97.7%	67.7%
3cazB00	1.20.1270.60	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain	0.53	42.0	3.95e-01	89.3%	70.0%
4nswB01	1.20.1270.60	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain	0.52	42.0	3.71e-01	88.7%	58.2%
3vw7A01	1.20.1070.10	Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins	0.52	45.0	3.82e-01	91.0%	83.3%
2d1lA00	1.20.1270.60	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain	0.51	44.0	3.89e-01	89.8%	67.1%
3ok8A00	1.20.1270.60	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain	0.51	42.0	3.93e-01	89.3%	69.9%
2v0oB00	1.20.1270.60	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain	0.50	44.0	3.78e-01	92.7%	68.6%
4bemJ00	1.20.120.610	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › lithium bound rotor ring of v- atpase	0.50	40.0	4.02e-01	88.7%	82.3%

ECOD (35)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
5021299	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.83	60.0	5.77e-01	72.9%	91.3%
3212207	174.1.1.0 ↗	few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain	0.80	55.0	6.32e-01	74.0%	92.6%
3235363	632.22.1.0 ↗	alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats	0.72	38.0	3.52e-01	78.5%	41.4%
3244449	3755.3.1.408 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › Zw10_N	0.72	54.0	5.39e-01	77.4%	87.8%
3423702	633.4.1.0 ↗	alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor	0.71	46.0	4.82e-01	75.1%	71.2%
3826941	633.4.1.1 ↗	alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI	0.70	51.0	5.16e-01	74.6%	82.7%
4587950	603.1.1.0 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins	0.69	49.0	4.36e-01	71.8%	88.3%
3708240	603.1.1.0 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins	0.69	52.0	4.74e-01	78.0%	94.5%
3620806	604.1.1.1 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin	0.69	53.0	5.43e-01	79.1%	97.1%
4086306	5086.1.1.0 ↗	alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins	0.69	37.0	3.40e-01	78.5%	40.9%
3487517	109.4.1.1375 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_SYVN1_N	0.67	55.0	5.00e-01	89.3%	65.1%
4984022	3755.3.1.0 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin	0.66	41.0	4.96e-01	85.9%	94.7%
3742731	7013.1.1.1 ↗	alpha bundles › Ribosome assembly factor Efg1-like › Ribosome assembly factor Efg1-like › Ribosome assembly factor Efg1-like › Efg1	0.66	38.0	4.05e-01	80.8%	65.2%
3706526	3755.3.1.0 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin	0.65	34.0	3.74e-01	78.5%	59.3%
3207657	3755.4.1.3 ↗	alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Helo_like_N	0.64	45.0	4.22e-01	70.6%	94.0%
3973695	5086.1.1.0 ↗	alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins	0.64	38.0	3.77e-01	78.5%	54.7%
3923874	109.4.1.37 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › BRO1	0.63	57.0	4.46e-01	97.2%	88.5%
5060654	109.4.1.5 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_1	0.63	41.0	3.83e-01	72.3%	53.2%
3393091	109.4.1.37 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › BRO1	0.63	56.0	4.44e-01	97.2%	88.9%
3207001	633.23.1.22 ↗	alpha bundles › Bromodomain-like › Claudin › Claudin › MARVEL	0.62	44.0	4.91e-01	75.1%	91.4%
4955963	3755.3.1.0 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin	0.61	37.0	3.55e-01	78.5%	52.5%
4677488	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.61	42.0	4.16e-01	70.6%	85.8%
3553092	601.1.2.2 ↗	alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › I_LWEQ	0.60	44.0	4.34e-01	75.7%	90.5%
3494149	601.1.2.6 ↗	alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › Talin_IBS2B	0.60	44.0	4.55e-01	88.1%	80.6%
3519973	4177.1.1.0 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like	0.60	35.0	3.15e-01	97.7%	41.2%
3172328	4177.1.1.97 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › PF30147	0.60	46.0	4.09e-01	84.2%	55.4%
5048802	3755.3.1.0 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin	0.59	34.0	3.41e-01	80.2%	55.0%
4988997	192.2.1.0 ↗	alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin	0.58	38.0	3.85e-01	79.1%	65.6%
3919840	3922.1.1.0 ↗	alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3	0.57	37.0	3.46e-01	78.0%	52.7%
3290726	633.6.1.2 ↗	alpha bundles › Bromodomain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA dehydrogenase C-terminal domain-like › ACOX	0.57	40.0	4.14e-01	71.8%	80.0%
3962991	3755.3.1.0 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin	0.55	35.0	3.42e-01	97.7%	57.4%
3168919	4177.1.1.1 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › FCH	0.54	47.0	3.97e-01	91.5%	67.1%
4371230	2004.1.1.615 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N, AAA_21, AAA_23, AAA_29	0.53	36.0	2.36e-01	97.2%	16.6%
4969098	3926.1.1.0 ↗	alpha bundles › V-type proton ATPase subunit D › V-type proton ATPase subunit D › V-type proton ATPase subunit D	0.53	41.0	4.21e-01	97.7%	82.3%
3877875	5001.1.1.1 ↗	alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1	0.50	43.0	3.60e-01	92.1%	74.8%

D2 medium residues 132-197

PDB

Domain cluster: representative

CATH (58)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2xs1A01	1.25.40.280	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › alix/aip1 like domains	0.91	82.0	4.97e-01	95.5%	21.0%
2wmoA01	1.25.40.410	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › DOCK DHR2 domain, lobe A	0.90	77.0	5.91e-01	90.9%	65.7%
3ceqA00	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.88	76.0	4.92e-01	90.9%	25.2%
1a17A00	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.88	72.0	5.25e-01	92.4%	35.8%
2jbwA01	1.20.1440.110	Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › acylaminoacyl peptidase	0.87	74.0	6.26e-01	90.9%	67.0%
3ro3A00	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.87	72.0	5.32e-01	89.4%	38.4%
1xg2B00	1.20.140.40	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Invertase/pectin methylesterase inhibitor family protein	0.87	74.0	5.55e-01	92.4%	51.0%
2ifuD00	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.86	74.0	4.74e-01	90.9%	23.0%
4jhrB00	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.86	73.0	4.66e-01	90.9%	21.5%
2v6yA00	1.20.58.80	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit	0.86	75.0	7.20e-01	95.5%	96.0%
1yxrA01	1.20.58.80	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit	0.86	72.0	6.95e-01	90.9%	100.0%
4aifA00	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.85	74.0	5.57e-01	92.4%	51.4%
2hr2A00	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.85	72.0	5.40e-01	92.4%	41.0%
2crbA00	1.20.58.80	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit	0.85	78.0	6.76e-01	100.0%	87.6%
1x8zB00	1.20.140.40	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Invertase/pectin methylesterase inhibitor family protein	0.84	74.0	5.63e-01	95.5%	53.1%
6fdpA00	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.84	66.0	5.34e-01	89.4%	45.8%
4p3gD00	1.10.3450.40	Mainly Alpha › Orthogonal Bundle › Hyaluronidase domain-like › Signal recognition particle, SRP68 subunit, RNA-binding domain	0.83	72.0	5.06e-01	95.5%	36.4%
1ouvA00	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.83	61.0	3.94e-01	83.3%	19.2%
4yvoA00	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.83	71.0	5.75e-01	92.4%	52.1%
7ru9C01	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.83	69.0	4.47e-01	89.4%	23.6%
4p3fA00	1.10.3450.40	Mainly Alpha › Orthogonal Bundle › Hyaluronidase domain-like › Signal recognition particle, SRP68 subunit, RNA-binding domain	0.82	72.0	5.05e-01	95.5%	37.3%
2fbnA00	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.82	70.0	5.24e-01	92.4%	47.1%
4u7iA00	1.20.58.80	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit	0.81	69.0	6.10e-01	92.4%	89.2%
7c1iA01	1.20.120.160	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain	0.81	67.0	5.84e-01	92.4%	60.0%
2wpvE00	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.81	68.0	4.43e-01	92.4%	23.6%
3lpzA01	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.81	68.0	4.35e-01	92.4%	21.2%
2a9uA01	1.20.58.80	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit	0.81	71.0	5.65e-01	95.5%	64.3%
1j5wA02	1.20.58.180	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Class II aaRS and biotin synthetases; domain 2	0.80	72.0	6.83e-01	98.5%	98.7%
1wfdA00	1.20.58.80	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit	0.79	69.0	6.18e-01	97.0%	83.9%
2yhcA00	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.78	64.0	4.45e-01	92.4%	28.2%
2gscC00	1.20.1440.60	Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 23S rRNA-intervening sequence	0.77	66.0	5.64e-01	97.0%	76.4%
4k51B00	1.25.40.860	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat ›	0.76	64.0	4.81e-01	92.4%	100.0%
3l8rA00	1.20.58.80	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit	0.76	64.0	5.54e-01	92.4%	87.3%
1iygA00	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.75	63.0	4.99e-01	98.5%	45.9%
8hdlA01	1.10.600.10	Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase	0.74	62.0	4.19e-01	92.4%	29.5%
5je8B02	1.10.1040.10	Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2	0.74	65.0	5.10e-01	93.9%	88.3%
3oxfA05	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.74	60.0	5.84e-01	92.4%	89.3%
3g0oA02	1.10.1040.10	Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2	0.74	64.0	5.16e-01	93.9%	90.9%
3ckyA02	1.10.1040.10	Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2	0.73	63.0	4.96e-01	93.9%	82.8%
2gf2A02	1.10.1040.10	Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2	0.73	64.0	4.99e-01	93.9%	88.1%
3gonA02	3.30.70.890	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › GHMP kinase, C-terminal domain	0.73	62.0	4.87e-01	92.4%	61.9%
3w6zA02	1.10.1040.10	Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2	0.73	64.0	5.13e-01	93.9%	91.7%
3ggyA00	1.20.1260.60	Mainly Alpha › Up-down Bundle › Ferritin › Vacuolar protein sorting-associated protein Ist1	0.73	61.0	4.30e-01	89.4%	88.7%
4dllB02	1.10.1040.10	Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2	0.73	63.0	5.03e-01	95.5%	87.7%
2uyyA02	1.10.1040.10	Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2	0.72	62.0	4.99e-01	93.9%	89.4%
1o3uA00	1.20.120.330	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2	0.72	59.0	4.76e-01	87.9%	83.3%
2hsbA00	1.20.120.330	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2	0.71	63.0	4.95e-01	93.9%	77.0%
1ks9A02	1.10.1040.10	Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2	0.71	58.0	4.69e-01	87.9%	98.4%
4uqxA01	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.71	59.0	5.31e-01	97.0%	67.4%
2cvzA02	1.10.1040.10	Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2	0.70	60.0	4.78e-01	93.9%	84.8%
1zbpA01	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.70	57.0	5.29e-01	95.5%	69.4%
2wwxB00	1.20.1260.70	Mainly Alpha › Up-down Bundle › Ferritin ›	0.70	63.0	4.44e-01	100.0%	82.5%
3eslA02	1.25.40.930	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat ›	0.70	58.0	4.76e-01	90.9%	52.1%
1fpoC02	1.20.1280.20	Mainly Alpha › Up-down Bundle › Monooxygenase › HscB, C-terminal domain	0.69	57.0	5.15e-01	92.4%	91.2%
4ioeA00	1.10.287.850	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HP0062-like domain	0.68	48.0	4.41e-01	74.2%	97.7%
7powA01	1.20.120.1760	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › CDP-alcohol phosphotransferase transmembrane (TM) domain	0.68	57.0	4.20e-01	98.5%	63.6%
2hs5A02	1.20.120.530	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › GntR ligand-binding domain-like	0.68	55.0	4.22e-01	86.4%	76.4%
2q00B00	1.20.120.330	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2	0.65	55.0	4.52e-01	95.5%	78.7%

ECOD (63)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3937759	604.12.1.0 ↗	alpha bundles › Spectrin repeat-like › MIT domain › MIT domain	0.93	75.0	7.35e-01	84.8%	100.0%
5045529	604.12.1.0 ↗	alpha bundles › Spectrin repeat-like › MIT domain › MIT domain	0.92	71.0	7.24e-01	81.8%	100.0%
4946564	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.91	77.0	4.82e-01	89.4%	20.3%
3407072	604.12.1.0 ↗	alpha bundles › Spectrin repeat-like › MIT domain › MIT domain	0.90	79.0	7.30e-01	92.4%	93.8%
3614560	604.12.1.0 ↗	alpha bundles › Spectrin repeat-like › MIT domain › MIT domain	0.89	78.0	7.29e-01	93.9%	81.2%
3990212	109.4.1.2733 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_8, ARM_TT21_4th	0.89	78.0	5.84e-01	92.4%	51.7%
4997237	109.4.1.95 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_2	0.89	77.0	6.35e-01	92.4%	68.2%
4654447	109.4.1.95 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_2	0.88	76.0	5.54e-01	92.4%	43.6%
5053124	109.7.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › Cytochrome c oxidase subunit E › Cytochrome c oxidase subunit E	0.88	75.0	7.20e-01	92.4%	85.3%
4307275	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.87	78.0	6.37e-01	97.0%	85.2%
3400367	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.87	75.0	5.61e-01	92.4%	48.0%
3926031	604.12.1.0 ↗	alpha bundles › Spectrin repeat-like › MIT domain › MIT domain	0.87	75.0	6.60e-01	93.9%	83.2%
3665244	109.7.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › Cytochrome c oxidase subunit E › Cytochrome c oxidase subunit E	0.86	72.0	5.35e-01	93.9%	38.1%
3918871	109.4.1.3569 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_12, Consortin_N	0.86	79.0	5.50e-01	100.0%	37.0%
3613056	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.86	79.0	4.68e-01	100.0%	16.4%
4970557	604.12.1.0 ↗	alpha bundles › Spectrin repeat-like › MIT domain › MIT domain	0.86	72.0	7.07e-01	89.4%	100.0%
4144467	109.4.1.192 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_8	0.85	74.0	5.51e-01	92.4%	47.3%
3596017	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.85	76.0	5.41e-01	97.0%	39.4%
3612930	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.85	73.0	4.87e-01	92.4%	26.0%
3506555	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.85	70.0	5.79e-01	89.4%	52.7%
5038830	375.1.1.26 ↗	few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related › Rpr2	0.85	73.0	6.20e-01	90.9%	82.0%
5072449	604.12.1.1 ↗	alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › MIT	0.85	77.0	6.91e-01	100.0%	88.9%
3217195	109.4.1.192 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_8	0.85	74.0	5.51e-01	93.9%	48.4%
3592012	109.4.1.202 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_16	0.85	70.0	5.34e-01	93.9%	41.4%
3306356	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.84	72.0	5.29e-01	92.4%	43.6%
3341387	109.4.1.5 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_1	0.84	72.0	5.33e-01	92.4%	45.0%
3254186	109.4.1.1286 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_8, TPR_12	0.84	76.0	4.62e-01	97.0%	79.7%
5075267	604.12.1.0 ↗	alpha bundles › Spectrin repeat-like › MIT domain › MIT domain	0.84	68.0	6.88e-01	87.9%	87.7%
5076566	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.84	73.0	4.93e-01	93.9%	29.5%
5073700	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.84	72.0	5.09e-01	92.4%	34.1%
3810594	109.4.1.190 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_6	0.84	71.0	5.18e-01	92.4%	42.4%
4013444	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.84	71.0	5.98e-01	90.9%	59.0%
4016538	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.83	70.0	5.79e-01	90.9%	57.0%
3821959	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.83	71.0	5.45e-01	92.4%	45.0%
3581466	604.12.1.1 ↗	alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › MIT	0.83	70.0	6.58e-01	92.4%	90.0%
3892906	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.82	75.0	4.25e-01	100.0%	17.3%
5021300	604.12.1.0 ↗	alpha bundles › Spectrin repeat-like › MIT domain › MIT domain	0.82	68.0	6.35e-01	89.4%	85.0%
4968405	375.1.1.26 ↗	few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related › Rpr2	0.82	71.0	5.82e-01	90.9%	74.5%
3402110	604.12.1.1 ↗	alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › MIT	0.82	74.0	6.54e-01	100.0%	86.3%
5029773	604.12.1.0 ↗	alpha bundles › Spectrin repeat-like › MIT domain › MIT domain	0.82	71.0	6.82e-01	93.9%	97.3%
3414718	109.4.1.339 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TRAPPC-Trs85	0.82	68.0	4.54e-01	90.9%	66.3%
5035450	375.1.1.0 ↗	few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related	0.82	69.0	6.05e-01	90.9%	86.3%
4175679	604.9.1.27 ↗	alpha bundles › Spectrin repeat-like › Ribosomal protein S20 › Ribosomal protein S20 › Zw10_N, Zw10_middle	0.81	74.0	5.67e-01	100.0%	55.2%
4001551	109.4.1.210 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_19	0.81	70.0	5.07e-01	92.4%	41.8%
3695480	109.4.1.1666 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_8, TPR_10	0.81	72.0	4.97e-01	97.0%	97.1%
3935017	604.12.1.0 ↗	alpha bundles › Spectrin repeat-like › MIT domain › MIT domain	0.80	70.0	6.55e-01	95.5%	96.2%
5038668	4266.2.1.0 ↗	alpha bundles › Hyaluronidase domain-like › TTHA0068-like › TTHA0068-like	0.80	67.0	5.99e-01	90.9%	70.0%
3600262	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.80	72.0	4.60e-01	100.0%	24.9%
3189212	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.79	69.0	5.86e-01	95.5%	60.0%
5049221	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.79	66.0	4.55e-01	90.9%	30.9%
5050406	604.12.1.0 ↗	alpha bundles › Spectrin repeat-like › MIT domain › MIT domain	0.79	70.0	6.45e-01	98.5%	94.1%
3901310	109.4.1.819 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Sec8_C	0.79	70.0	3.93e-01	100.0%	13.6%
3413348	109.4.1.3511 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › L27	0.76	67.0	3.84e-01	100.0%	12.4%
3921840	109.4.1.1373 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Syndetin_C, Vps54_N	0.76	67.0	3.87e-01	100.0%	12.0%
3760719	109.4.1.445 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Vps54_N	0.76	67.0	4.37e-01	100.0%	26.9%
3901459	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.76	66.0	3.77e-01	100.0%	12.6%
3936356	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.75	65.0	3.70e-01	98.5%	23.0%
5072892	601.28.1.0 ↗	alpha bundles › Four-helical up-and-down bundle › VPS28 C-terminal domain-like › VPS28 C-terminal domain-like	0.75	63.0	5.55e-01	93.9%	64.2%
3601620	109.2.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › alpha/alpha toroid › alpha/alpha toroid	0.73	62.0	3.95e-01	90.9%	50.3%
5050917	601.28.1.0 ↗	alpha bundles › Four-helical up-and-down bundle › VPS28 C-terminal domain-like › VPS28 C-terminal domain-like	0.71	57.0	5.41e-01	90.9%	75.0%
5050395	601.28.1.0 ↗	alpha bundles › Four-helical up-and-down bundle › VPS28 C-terminal domain-like › VPS28 C-terminal domain-like	0.71	57.0	5.40e-01	93.9%	73.5%
5052083	601.28.1.0 ↗	alpha bundles › Four-helical up-and-down bundle › VPS28 C-terminal domain-like › VPS28 C-terminal domain-like	0.70	58.0	5.46e-01	97.0%	75.3%
4057021	605.4.1.20 ↗	alpha duplicates or obligate multimers › ROP-like › ROP protein › ROP protein › DUF6092	0.56	43.0	3.95e-01	86.4%	82.2%

D3 medium residues 418-518

PDB

Domain cluster: rep: KP238129__AIZ11342.1__X__00008__D443-531

D4 medium residues 519-611

PDB

Domain cluster: representative

CATH (77)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1wp1B01	1.20.1600.10	Mainly Alpha › Up-down Bundle › Outer membrane efflux proteins (OEP) › Outer membrane efflux proteins (OEP)	0.89	68.0	4.34e-01	78.5%	22.3%
2b5uA02	1.10.287.620	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix Hairpins	0.85	68.0	5.54e-01	83.9%	93.2%
3a8pA02	6.10.140.680	Special › Helix non-globular › Helix Hairpins ›	0.85	63.0	5.87e-01	77.4%	64.9%
2v0xA01	1.10.287.3160	Mainly Alpha › Orthogonal Bundle › Helix Hairpins ›	0.84	70.0	5.65e-01	88.2%	71.4%
2ch7A00	1.10.287.950	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Methyl-accepting chemotaxis protein	0.84	64.0	4.30e-01	79.6%	98.7%
3k29A00	1.10.287.1700	Mainly Alpha › Orthogonal Bundle › Helix Hairpins ›	0.82	62.0	5.12e-01	79.6%	67.1%
1y4cA03	1.20.120.660	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › IL-4 antagonist (De novo design) like domain	0.81	66.0	6.14e-01	92.5%	69.9%
1fioA00	1.20.58.70	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.80	60.0	4.71e-01	79.6%	40.0%
1o5hA00	1.20.120.680	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Formiminotetrahydrofolate cyclodeaminase monomer, up-and-down helical bundle	0.79	69.0	5.33e-01	94.6%	50.5%
1w99A01	1.20.190.10	Mainly Alpha › Up-down Bundle › Delta-Endotoxin; domain 1 › Pesticidal crystal protein, N-terminal domain	0.78	69.0	5.53e-01	100.0%	50.9%
6dlzA01	1.20.140.150	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 ›	0.78	73.0	5.72e-01	100.0%	55.8%
2qqyA00	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.78	69.0	5.95e-01	94.6%	96.4%
2v0pA00	1.25.40.540	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › TAP42-like family	0.77	67.0	5.02e-01	93.5%	70.2%
8cdaB03	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.75	57.0	4.72e-01	79.6%	54.1%
3r2kA00	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.75	70.0	5.82e-01	100.0%	92.2%
3kyiA00	1.20.120.160	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain	0.75	54.0	4.79e-01	89.2%	53.9%
5af7B03	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.75	56.0	4.73e-01	78.5%	51.4%
3hr0B01	1.10.287.1060	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like	0.74	56.0	6.00e-01	79.6%	93.7%
3v5uA01	6.10.280.80	Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › NCX, peripheral helical region	0.74	54.0	5.94e-01	76.3%	98.7%
4it4A02	1.20.58.80	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit	0.74	62.0	6.31e-01	100.0%	92.3%
4nwpD00	1.20.1200.10	Mainly Alpha › Up-down Bundle › Hypothetical Protein Ta1238; Chain: A; › Cobalamin adenosyltransferase-like	0.74	66.0	5.50e-01	94.6%	92.6%
2oduA02	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.74	61.0	5.90e-01	90.3%	85.7%
5nl6A02	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.73	64.0	6.16e-01	98.9%	90.7%
4cmyA00	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.73	67.0	5.49e-01	100.0%	86.5%
2d4uB00	1.20.120.30	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Aspartate receptor, ligand-binding domain	0.73	62.0	5.20e-01	92.5%	61.9%
4cybD00	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.73	67.0	5.37e-01	98.9%	86.0%
2jifA03	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.72	55.0	4.59e-01	80.6%	48.1%
4w8pA02	1.20.120.230	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like	0.72	63.0	5.61e-01	94.6%	68.5%
3l9fA02	6.10.140.1570	Special › Helix non-globular › Helix Hairpins ›	0.72	55.0	5.82e-01	80.6%	96.3%
1t72A02	1.20.58.220	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2	0.71	64.0	6.35e-01	100.0%	100.0%
3mq1A01	1.20.58.970	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.71	61.0	6.22e-01	92.5%	100.0%
1xzpA02	1.20.120.430	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › tRNA modification GTPase MnmE domain 2	0.71	61.0	4.99e-01	92.5%	57.8%
1r0dA00	1.20.1410.10	Mainly Alpha › Up-down Bundle › I/LWEQ domain › I/LWEQ domain	0.71	64.0	4.99e-01	100.0%	47.2%
1hciA04	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.71	63.0	5.91e-01	100.0%	89.5%
5j1gA00	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.71	63.0	4.76e-01	100.0%	50.0%
2gl2B00	1.10.287.1700	Mainly Alpha › Orthogonal Bundle › Helix Hairpins ›	0.71	53.0	5.07e-01	79.6%	80.7%
1qdbA02	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.71	49.0	4.21e-01	71.0%	50.3%
1qsdA00	1.20.58.90	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.70	52.0	5.13e-01	79.6%	73.5%
4hr1A00	1.20.1270.410	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 ›	0.70	48.0	4.47e-01	80.6%	56.8%
1hciA03	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.69	62.0	5.73e-01	100.0%	94.2%
1quuA01	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.69	61.0	5.58e-01	100.0%	81.7%
1vcsA00	1.20.58.400	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › t-snare proteins	0.69	60.0	5.84e-01	95.7%	88.2%
3rkgA02	1.20.58.340	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Magnesium transport protein CorA, transmembrane region	0.69	60.0	5.07e-01	100.0%	75.6%
3ck6C02	1.20.58.340	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Magnesium transport protein CorA, transmembrane region	0.69	60.0	5.57e-01	98.9%	85.7%
3kbtA00	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.68	61.0	4.32e-01	100.0%	37.7%
2fji101	1.10.357.50	Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 ›	0.68	58.0	4.54e-01	96.8%	62.7%
2pfdA03	1.20.120.680	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Formiminotetrahydrofolate cyclodeaminase monomer, up-and-down helical bundle	0.68	61.0	4.72e-01	100.0%	46.8%
6xkyA01	1.20.1330.10	Mainly Alpha › Up-down Bundle › f41 fragment of flagellin, N-terminal domain › f41 fragment of flagellin, N-terminal domain	0.67	56.0	4.37e-01	88.2%	51.3%
1br0A00	1.20.58.70	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.67	50.0	4.59e-01	77.4%	61.7%
1sumB02	1.20.58.220	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2	0.67	59.0	5.50e-01	98.9%	82.2%
4l8iB00	1.10.132.20	Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor	0.67	54.0	5.17e-01	90.3%	92.0%
3dbyL00	1.20.1260.120	Mainly Alpha › Up-down Bundle › Ferritin › Protein of unknown function DUF2935	0.66	55.0	4.01e-01	95.7%	33.1%
2iiuA00	1.20.58.220	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2	0.66	56.0	4.37e-01	95.7%	44.7%
1tjoB00	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.66	58.0	4.77e-01	100.0%	85.1%
4oydB00	1.10.132.20	Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor	0.65	58.0	5.38e-01	98.9%	96.6%
2uv8A07	6.10.140.1410	Special › Helix non-globular › Helix Hairpins ›	0.65	46.0	4.77e-01	72.0%	88.2%
4u72A01	1.20.58.480	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.65	55.0	4.09e-01	90.3%	89.2%
4kb2A01	1.10.132.20	Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor	0.65	57.0	5.43e-01	98.9%	97.2%
2chnB03	1.20.58.460	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Hyaluronidase post-catalytic domain-like	0.65	56.0	4.48e-01	94.6%	60.0%
6vudA01	1.10.132.20	Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor	0.65	56.0	5.36e-01	97.8%	97.2%
1v4eA00	1.10.600.10	Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase	0.64	55.0	3.80e-01	90.3%	52.5%
1ux5A03	1.20.58.2220	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Formin, FH2 domain	0.64	57.0	4.24e-01	100.0%	78.2%
2l1lB00	1.20.1440.250	Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) ›	0.64	44.0	4.03e-01	94.6%	52.8%
3lbxB01	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.64	56.0	5.38e-01	98.9%	93.5%
2nwbA02	1.20.58.480	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.63	56.0	4.22e-01	100.0%	97.9%
1yhlA00	1.10.600.10	Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase	0.63	48.0	3.17e-01	80.6%	26.0%
2ntxA01	1.20.58.2010	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › PRONE domain, subdomain 1	0.61	53.0	4.17e-01	100.0%	50.5%
6xxvC00	1.10.132.20	Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor	0.60	53.0	5.00e-01	98.9%	96.4%
3ztaA00	1.10.490.130	Mainly Alpha › Orthogonal Bundle › Globin-like ›	0.59	52.0	4.61e-01	100.0%	90.6%
4rm7A03	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.58	49.0	4.41e-01	97.8%	88.5%
4lunU00	1.25.40.180	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat ›	0.57	51.0	3.54e-01	100.0%	36.7%
1wtyA00	1.20.120.330	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2	0.56	50.0	4.62e-01	96.8%	80.2%
3tp3A02	1.10.357.10	Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2	0.56	46.0	3.96e-01	94.6%	56.1%
3vprA02	1.10.357.10	Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2	0.55	45.0	3.97e-01	98.9%	59.3%
4dloB02	1.25.40.610	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat ›	0.55	41.0	3.89e-01	90.3%	65.0%
1q6aA00	1.10.1240.30	Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › KaiA/RbsU domain	0.53	45.0	4.35e-01	95.7%	86.0%
3c02A00	1.20.1080.10	Mainly Alpha › Up-down Bundle › Glycerol uptake facilitator protein › Glycerol uptake facilitator protein.	0.51	45.0	3.39e-01	100.0%	52.1%

ECOD (97)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3509997	4177.1.1.0 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like	0.89	68.0	5.12e-01	79.6%	46.8%
4110549	192.7.1.2 ↗	alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm › Seryl_tRNA_N	0.88	67.0	6.29e-01	79.6%	70.0%
3967398	3755.1.1.1 ↗	alpha bundles › YscO-like › Putative type III secretion protein YscO-related › Putative type III secretion protein YscO-related › YscO	0.86	66.0	5.49e-01	79.6%	54.0%
3211945	633.23.1.14 ↗	alpha bundles › Bromodomain-like › Claudin › Claudin › Claudin_3	0.85	79.0	6.36e-01	100.0%	63.5%
4234530	192.7.1.2 ↗	alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm › Seryl_tRNA_N	0.85	66.0	6.07e-01	80.6%	84.3%
3598168	3755.1.1.0 ↗	alpha bundles › YscO-like › Putative type III secretion protein YscO-related › Putative type III secretion protein YscO-related	0.83	63.0	5.12e-01	79.6%	44.8%
3724953	150.1.1.0 ↗	alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin	0.82	76.0	6.31e-01	100.0%	67.7%
3722881	633.21.1.0 ↗	alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107	0.82	68.0	5.72e-01	88.2%	66.7%
3516673	601.33.1.2 ↗	alpha bundles › Four-helical up-and-down bundle › CHAD domain › CHAD domain › PPP1R21_helical	0.82	76.0	6.16e-01	100.0%	66.7%
3972084	3755.3.1.0 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin	0.82	62.0	5.58e-01	79.6%	62.4%
3694617	633.23.1.9 ↗	alpha bundles › Bromodomain-like › Claudin › Claudin › SUR7	0.82	75.0	5.63e-01	98.9%	51.9%
4177674	4992.1.1.23 ↗	extended segments › RelB-like › RelB-like › RelB-like › Seryl_tRNA_N	0.81	62.0	5.83e-01	79.6%	70.9%
3413223	633.23.1.1 ↗	alpha bundles › Bromodomain-like › Claudin › Claudin › PMP22_Claudin	0.81	75.0	5.85e-01	100.0%	57.8%
3939162	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.79	74.0	6.69e-01	100.0%	83.3%
4031043	3939.1.1.0 ↗	alpha duplicates or obligate multimers › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain	0.79	71.0	6.55e-01	98.9%	92.5%
3480486	633.23.1.0 ↗	alpha bundles › Bromodomain-like › Claudin › Claudin	0.78	72.0	5.44e-01	100.0%	51.9%
3932692	604.6.1.0 ↗	alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain	0.77	66.0	6.74e-01	91.4%	100.0%
3934928	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.77	65.0	6.54e-01	91.4%	96.8%
3911582	633.21.1.23 ↗	alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 › CD20	0.76	71.0	5.95e-01	100.0%	76.7%
4011777	4121.1.1.0 ↗	a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like	0.76	70.0	4.58e-01	100.0%	71.1%
3228858	603.1.1.1 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins › Syntaxin	0.76	58.0	4.45e-01	79.6%	40.5%
5029293	192.29.1.0 ↗	alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding)	0.76	70.0	5.97e-01	100.0%	65.5%
4213065	150.1.1.0 ↗	alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin	0.75	68.0	5.65e-01	100.0%	61.9%
3587778	3755.3.1.0 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin	0.75	67.0	5.51e-01	97.8%	63.6%
4963655	150.1.1.0 ↗	alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin	0.75	65.0	5.42e-01	93.5%	96.1%
3798353	174.1.1.0 ↗	few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain	0.75	63.0	5.31e-01	90.3%	82.0%
3514684	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.75	68.0	6.30e-01	100.0%	93.0%
3770420	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.74	67.0	6.10e-01	100.0%	83.2%
3740106	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.74	66.0	6.20e-01	100.0%	84.3%
3968997	5086.1.1.0 ↗	alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins	0.74	56.0	4.99e-01	79.6%	59.2%
3998921	633.21.1.0 ↗	alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107	0.74	65.0	5.56e-01	96.8%	70.7%
4959990	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.74	66.0	5.94e-01	100.0%	80.0%
5027312	604.6.1.0 ↗	alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain	0.74	65.0	6.32e-01	95.7%	98.1%
3929376	604.1.1.63 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin_SESTD1	0.74	67.0	4.53e-01	100.0%	32.2%
4024537	603.1.1.0 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins	0.74	66.0	5.07e-01	96.8%	84.0%
3571433	3939.1.1.220 ↗	alpha duplicates or obligate multimers › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain › KIF21A	0.74	55.0	4.61e-01	79.6%	55.0%
3504305	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.73	64.0	6.23e-01	97.8%	93.3%
3513593	174.1.1.0 ↗	few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain	0.73	66.0	5.56e-01	100.0%	67.7%
3925845	109.4.1.192 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_8	0.73	67.0	4.50e-01	100.0%	28.5%
3876247	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.73	65.0	5.97e-01	98.9%	94.2%
3185833	633.23.1.22 ↗	alpha bundles › Bromodomain-like › Claudin › Claudin › MARVEL	0.73	64.0	5.53e-01	100.0%	77.3%
3189104	603.1.1.19 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins › Syntaxin-18_N	0.73	64.0	4.86e-01	100.0%	84.3%
1877523	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.73	64.0	6.08e-01	98.9%	100.0%
4456477	192.29.1.0 ↗	alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding)	0.72	63.0	5.13e-01	95.7%	67.4%
3415238	603.1.1.6 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins › Syntaxin_2	0.72	61.0	4.86e-01	91.4%	74.1%
3764098	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.72	64.0	5.22e-01	100.0%	64.4%
4014229	603.1.1.0 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins	0.72	64.0	4.69e-01	100.0%	41.2%
5083475	4121.1.1.1 ↗	a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like › CorA	0.72	65.0	4.64e-01	100.0%	66.2%
5056108	601.1.2.0 ↗	alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608)	0.72	63.0	5.28e-01	98.9%	66.1%
3662289	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.72	65.0	3.90e-01	100.0%	17.6%
3927597	604.3.1.0 ↗	alpha bundles › Spectrin repeat-like › BAG domain › BAG domain	0.72	65.0	5.96e-01	100.0%	94.2%
3219394	633.23.1.14 ↗	alpha bundles › Bromodomain-like › Claudin › Claudin › Claudin_3	0.72	63.0	5.20e-01	97.8%	62.4%
3876221	5.1.12.5 ↗	beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › PERK and Ire1 luminal domains › KIF21A	0.72	54.0	4.53e-01	79.6%	48.4%
3577620	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.72	64.0	6.00e-01	100.0%	94.8%
3836003	3684.1.1.2 ↗	alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › BPS1	0.72	64.0	4.97e-01	100.0%	52.7%
None	—		0.72	63.0	4.70e-01	100.0%	43.7%
5026989	604.5.1.1 ↗	alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › PhoU_div	0.72	65.0	4.87e-01	100.0%	46.7%
3686783	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.72	60.0	5.77e-01	92.5%	85.7%
3933742	174.1.1.0 ↗	few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain	0.71	67.0	5.47e-01	100.0%	68.1%
3517330	603.2.1.1 ↗	alpha bundles › STAT-like › STAT › STAT › STAT_alpha	0.71	63.0	4.87e-01	100.0%	82.9%
3260458	603.1.1.17 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins › SNARE	0.71	63.0	4.69e-01	100.0%	44.6%
4017168	150.1.1.114 ↗	alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › PF30036	0.71	62.0	5.29e-01	98.9%	68.2%
5075236	603.1.1.0 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins	0.71	64.0	5.90e-01	100.0%	84.2%
3885014	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.70	63.0	5.81e-01	100.0%	89.2%
4995305	604.5.1.2 ↗	alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › PhoU	0.70	61.0	6.13e-01	96.8%	98.9%
3998932	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.70	60.0	4.96e-01	95.7%	55.9%
4244765	1075.4.1.100 ↗	alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › PF27758	0.70	64.0	4.75e-01	98.9%	77.3%
3849331	604.1.1.1 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin	0.69	61.0	5.73e-01	98.9%	88.7%
3915562	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.69	62.0	5.78e-01	100.0%	90.4%
3444721	603.1.1.6 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins › Syntaxin_2	0.69	61.0	4.85e-01	100.0%	54.4%
4026893	603.1.1.0 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins	0.69	61.0	4.75e-01	98.9%	79.0%
3904075	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.69	59.0	5.66e-01	95.7%	94.5%
3746634	604.1.1.1 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin	0.68	58.0	5.32e-01	96.8%	78.4%
3504301	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.68	61.0	5.80e-01	100.0%	96.4%
3491110	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.68	61.0	5.79e-01	100.0%	95.5%
3655	633.7.1.1 ↗	alpha bundles › Bromodomain-like › Bacillus cereus metalloprotein-like › Bacillus cereus metalloprotein-like › DUF2935	0.67	56.0	5.06e-01	92.5%	70.8%
3992691	604.1.1.1 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin	0.67	60.0	5.80e-01	100.0%	97.1%
3580104	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.67	56.0	5.61e-01	92.5%	97.9%
4030233	603.1.1.6 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins › Syntaxin_2	0.67	60.0	4.75e-01	100.0%	80.0%
54242	633.7.1.0 ↗	alpha bundles › Bromodomain-like › Bacillus cereus metalloprotein-like › Bacillus cereus metalloprotein-like	0.67	56.0	5.04e-01	92.5%	70.8%
3882637	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.67	59.0	5.32e-01	100.0%	83.8%
3703409	4163.1.1.1 ↗	alpha bundles › GINS helical bundle-like › GINS helical bundle-like › PSF1 N-terminal domain-like › Sld5	0.67	59.0	4.80e-01	98.9%	70.0%
3516160	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.67	58.0	5.27e-01	98.9%	81.5%
3689455	7087.1.1.1 ↗	alpha bundles › Emopamil binding protein (EBP) transmembrane domain › Emopamil binding protein (EBP) transmembrane domain › Emopamil binding protein (EBP) transmembrane domain › EBP	0.66	57.0	4.23e-01	97.8%	44.3%
3487245	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.66	58.0	5.49e-01	100.0%	90.4%
3398025	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.66	57.0	5.67e-01	100.0%	99.0%
3232821	4106.1.1.1 ↗	few secondary structure elements › Zinc hairpin stack › Zinc hairpin stack › Zinc hairpin stack › DHHC	0.65	53.0	4.21e-01	89.2%	76.9%
3998931	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.65	58.0	5.58e-01	97.8%	90.5%
4261817	5086.1.1.91 ↗	alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › PRM1	0.65	58.0	4.59e-01	100.0%	62.4%
3607674	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.65	57.0	3.97e-01	97.8%	32.5%
3933140	174.1.1.0 ↗	few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain	0.64	57.0	4.59e-01	100.0%	61.6%
4828003	310.2.1.0 ↗	a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF	0.64	56.0	5.21e-01	98.9%	93.4%
3996707	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.64	55.0	5.29e-01	98.9%	92.7%
3505438	604.1.1.67 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin_5	0.64	56.0	5.49e-01	98.9%	96.0%
3701383	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.63	56.0	4.47e-01	100.0%	52.3%
3245526	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.60	47.0	4.60e-01	88.2%	85.7%
4843090	310.2.1.0 ↗	a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF	0.59	51.0	4.87e-01	98.9%	100.0%

D5 medium residues 612-689

PDB

Domain cluster: representative

CATH (86)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4iloA00	1.10.287.1490	Mainly Alpha › Orthogonal Bundle › Helix Hairpins ›	0.92	78.0	5.36e-01	89.7%	30.9%
1fewA00	1.20.58.70	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.91	78.0	5.81e-01	89.7%	43.4%
1wp7A00	1.10.287.770	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › YojJ-like	0.90	70.0	7.75e-01	80.8%	98.4%
4i17A00	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.88	76.0	5.28e-01	91.0%	35.3%
2q0oC00	1.10.287.160	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat	0.87	68.0	6.62e-01	83.3%	83.7%
3lssA01	1.10.287.40	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain	0.87	73.0	6.37e-01	89.7%	66.1%
2b5uA02	1.10.287.620	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix Hairpins	0.87	73.0	5.62e-01	89.7%	50.9%
4ioeA00	1.10.287.850	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HP0062-like domain	0.87	75.0	7.21e-01	92.3%	97.7%
2v0xA01	1.10.287.3160	Mainly Alpha › Orthogonal Bundle › Helix Hairpins ›	0.86	78.0	5.97e-01	98.7%	71.4%
2gl2B00	1.10.287.1700	Mainly Alpha › Orthogonal Bundle › Helix Hairpins ›	0.85	66.0	5.82e-01	89.7%	58.7%
1skvA00	1.10.287.660	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin	0.85	64.0	7.03e-01	79.5%	100.0%
2dq0A01	1.10.287.40	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain	0.84	72.0	6.38e-01	91.0%	71.0%
3k29A00	1.10.287.1700	Mainly Alpha › Orthogonal Bundle › Helix Hairpins ›	0.84	70.0	5.42e-01	89.7%	65.2%
3rq9A00	1.10.287.2500	Mainly Alpha › Orthogonal Bundle › Helix Hairpins ›	0.83	63.0	6.36e-01	83.3%	79.5%
2yevC00	6.10.280.110	Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.83	63.0	7.00e-01	88.5%	100.0%
1qv9A02	6.10.140.120	Special › Helix non-globular › Helix Hairpins ›	0.82	63.0	5.74e-01	82.1%	64.1%
3l9fA02	6.10.140.1570	Special › Helix non-globular › Helix Hairpins ›	0.82	65.0	6.48e-01	84.6%	95.1%
3d36B02	1.10.287.130	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Signal transduction histidine kinase, dimerisation/phosphotransfer (DHp) domain	0.82	58.0	6.55e-01	88.5%	95.1%
1yg2A02	6.10.140.190	Special › Helix non-globular › Helix Hairpins ›	0.80	66.0	6.31e-01	91.0%	75.6%
3r84A00	1.10.287.3490	Mainly Alpha › Orthogonal Bundle › Helix Hairpins ›	0.79	67.0	6.67e-01	91.0%	88.9%
1hciA04	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.79	64.0	5.59e-01	87.2%	63.2%
4hr1A00	1.20.1270.410	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 ›	0.79	60.0	5.20e-01	91.0%	53.4%
3fnbA01	1.20.1440.110	Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › acylaminoacyl peptidase	0.79	64.0	5.57e-01	92.3%	58.8%
4gzrB00	1.10.287.1060	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like	0.79	66.0	6.64e-01	88.5%	98.7%
2ot4A03	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.78	60.0	5.36e-01	88.5%	58.9%
2i0mA01	1.20.58.220	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2	0.77	61.0	5.45e-01	88.5%	62.3%
2q12A00	1.20.1270.60	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain	0.77	63.0	4.46e-01	91.0%	43.4%
3g67A00	1.10.287.950	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Methyl-accepting chemotaxis protein	0.76	62.0	4.54e-01	89.7%	34.3%
4dylA02	1.10.287.160	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat	0.76	63.0	5.92e-01	91.0%	91.5%
7ymiZ01	1.10.287.740	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Photosystem II PsbZ, reaction centre	0.76	54.0	6.06e-01	75.6%	100.0%
1t7sA00	1.20.58.120	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain	0.76	62.0	5.27e-01	91.0%	54.3%
2yf4F00	1.10.3420.10	Mainly Alpha › Orthogonal Bundle › putative ntp pyrophosphohydrolase like fold › putative ntp pyrophosphohydrolase like domain	0.76	55.0	4.44e-01	88.5%	41.3%
2dnxA00	1.20.58.70	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.75	67.0	5.68e-01	100.0%	78.5%
1u7lA02	1.20.1460.10	Mainly Alpha › Up-down Bundle › subunit c (vma5p) of the yeast v-atpase, domain 2 › subunit c (vma5p) of the yeast v-atpase, domain 2	0.75	62.0	4.72e-01	91.0%	41.0%
4cqiA00	1.20.58.90	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.74	62.0	5.55e-01	91.0%	72.9%
1qsdA00	1.20.58.90	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.74	60.0	5.56e-01	89.7%	68.6%
3rx6A00	1.20.58.1090	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phage polarity suppression protein monomer	0.74	60.0	4.58e-01	89.7%	37.4%
1b5lA00	1.20.1250.10	Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; ›	0.74	55.0	4.42e-01	84.6%	40.8%
2a3qA00	1.10.287.1080	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › MazG-like	0.74	58.0	5.08e-01	83.3%	59.3%
3hhcC00	1.20.1250.60	Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › Interferon lambda	0.74	56.0	4.46e-01	83.3%	41.7%
1quuA01	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.73	60.0	5.15e-01	91.0%	56.3%
4mhlA00	1.20.1250.10	Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; ›	0.72	61.0	4.76e-01	91.0%	44.1%
1gaxA05	1.10.287.380	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Valyl-tRNA synthetase, C-terminal domain	0.72	55.0	5.69e-01	84.6%	87.7%
1t72A02	1.20.58.220	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2	0.72	64.0	5.97e-01	98.7%	92.9%
3ismC01	1.25.40.240	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Ku, C-terminal domain	0.72	57.0	4.53e-01	84.6%	52.6%
1owaA02	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.72	61.0	5.51e-01	93.6%	84.9%
1bhaA00	1.10.287.170	Mainly Alpha › Orthogonal Bundle › Helix Hairpins ›	0.72	50.0	5.40e-01	73.1%	85.1%
5jrcA00	1.20.58.2140	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.71	59.0	4.40e-01	88.5%	50.5%
6vq6G02	1.20.1460.10	Mainly Alpha › Up-down Bundle › subunit c (vma5p) of the yeast v-atpase, domain 2 › subunit c (vma5p) of the yeast v-atpase, domain 2	0.71	58.0	4.48e-01	91.0%	41.8%
4qgpB00	1.10.287.1080	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › MazG-like	0.71	54.0	4.86e-01	80.8%	59.8%
3rkgA02	1.20.58.340	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Magnesium transport protein CorA, transmembrane region	0.71	64.0	4.91e-01	97.4%	69.5%
2gtsA00	1.10.287.850	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HP0062-like domain	0.71	56.0	5.70e-01	89.7%	89.6%
3v5uA01	6.10.280.80	Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › NCX, peripheral helical region	0.71	57.0	5.76e-01	88.5%	97.4%
2vs0A00	1.10.287.1060	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like	0.70	58.0	5.71e-01	91.0%	89.0%
1r0dA00	1.20.1410.10	Mainly Alpha › Up-down Bundle › I/LWEQ domain › I/LWEQ domain	0.70	60.0	4.58e-01	97.4%	87.0%
4dyqA01	1.10.10.60	Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Homeodomain-like	0.70	55.0	4.97e-01	83.3%	83.5%
4mh6A00	1.10.287.1700	Mainly Alpha › Orthogonal Bundle › Helix Hairpins ›	0.70	57.0	4.54e-01	89.7%	47.2%
3axjB02	1.20.58.200	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 2	0.70	57.0	5.57e-01	92.3%	81.2%
1sumB02	1.20.58.220	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2	0.69	60.0	5.28e-01	97.4%	86.4%
1m62A00	1.20.58.120	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain	0.69	55.0	5.28e-01	84.6%	75.9%
3hr0B01	1.10.287.1060	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like	0.69	55.0	5.54e-01	89.7%	88.6%
2q5zB00	1.10.287.1080	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › MazG-like	0.68	50.0	4.70e-01	78.2%	63.8%
2iakA01	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.68	59.0	4.49e-01	98.7%	48.4%
2jqqA00	1.20.58.1240	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.68	59.0	4.72e-01	96.2%	87.7%
4ehsA00	1.10.860.10	Mainly Alpha › Orthogonal Bundle › DNAb Helicase; Chain A › DNAb Helicase; Chain A	0.68	51.0	4.40e-01	80.8%	88.7%
7zxkC01	1.20.1250.10	Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; ›	0.68	54.0	4.41e-01	88.5%	48.7%
3layF00	1.20.120.1490	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) ›	0.67	53.0	5.35e-01	87.2%	87.2%
3g80A00	1.10.287.1060	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like	0.67	56.0	5.77e-01	92.3%	100.0%
3mq1A01	1.20.58.970	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.66	58.0	5.55e-01	98.7%	100.0%
3itfA00	1.20.120.1490	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) ›	0.66	49.0	4.42e-01	80.8%	61.3%
3ck6C02	1.20.58.340	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Magnesium transport protein CorA, transmembrane region	0.66	54.0	4.76e-01	92.3%	66.4%
1rcwB00	1.20.910.10	Mainly Alpha › Up-down Bundle › Heme Oxygenase; Chain A › Heme oxygenase-like	0.65	55.0	4.11e-01	97.4%	68.7%
4kb2A01	1.10.132.20	Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor	0.65	57.0	5.14e-01	98.7%	90.8%
1dd5A01	1.10.132.20	Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor	0.64	57.0	5.10e-01	98.7%	91.7%
4okvE00	6.10.140.1890	Special › Helix non-globular › Helix Hairpins ›	0.64	46.0	4.90e-01	79.5%	92.3%
5mlc900	1.10.132.20	Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor	0.63	57.0	5.13e-01	100.0%	92.5%
4oydB00	1.10.132.20	Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor	0.63	56.0	4.96e-01	100.0%	90.6%
4lunU00	1.25.40.180	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat ›	0.61	55.0	3.68e-01	100.0%	46.0%
3u4qA02	1.10.274.50	Mainly Alpha › Orthogonal Bundle › Enzyme I; Chain A, domain 2 ›	0.61	51.0	4.15e-01	92.3%	80.0%
6xxvC00	1.10.132.20	Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor	0.60	53.0	4.76e-01	98.7%	92.8%
3ayhA00	1.20.1250.40	Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › RNA Polymerase II, Rpb4 subunit	0.57	50.0	4.19e-01	97.4%	82.1%
4finB01	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.56	47.0	3.27e-01	93.6%	42.6%
3frqB00	1.10.357.10	Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2	0.56	45.0	3.52e-01	91.0%	57.1%
3dcfA02	1.10.357.10	Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2	0.55	48.0	3.95e-01	97.4%	53.5%
3o60A00	1.10.357.10	Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2	0.55	43.0	3.37e-01	87.2%	55.5%
2x6hA03	1.10.1070.11	Mainly Alpha › Orthogonal Bundle › Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, Domain 5 › Phosphatidylinositol 3-/4-kinase, catalytic domain	0.51	41.0	3.11e-01	88.5%	64.5%

ECOD (85)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4349607	192.7.1.2 ↗	alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm › Seryl_tRNA_N	0.92	78.0	6.85e-01	89.7%	66.4%
3294656	3755.3.1.0 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin	0.91	78.0	4.82e-01	89.7%	43.9%
3341646	5086.1.1.0 ↗	alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins	0.91	78.0	5.07e-01	89.7%	24.1%
3456370	192.2.1.0 ↗	alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin	0.91	77.0	5.96e-01	89.7%	45.2%
4076629	220.1.1.22 ↗	beta barrels › PH domain-like › PH domain-like › PH domain-like › FERM_C	0.90	77.0	5.08e-01	89.7%	25.8%
3706526	3755.3.1.0 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin	0.90	76.0	6.00e-01	89.7%	77.3%
4320014	4177.1.1.0 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like	0.90	76.0	5.07e-01	89.7%	26.3%
3622487	604.7.1.1 ↗	alpha bundles › Spectrin repeat-like › Tubulin chaperone cofactor A › Tubulin chaperone cofactor A › TBCA	0.89	75.0	6.62e-01	89.7%	73.6%
3477880	4177.1.1.1 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › FCH	0.89	76.0	4.95e-01	89.7%	25.9%
3408277	192.2.1.0 ↗	alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin	0.88	76.0	6.54e-01	91.0%	77.4%
3890044	3922.1.1.0 ↗	alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3	0.88	66.0	7.02e-01	78.2%	100.0%
3577907	4177.1.1.0 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like	0.88	74.0	5.00e-01	89.7%	30.2%
3991608	109.4.1.102 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › WAPL	0.88	73.0	4.46e-01	89.7%	17.2%
4324117	3755.4.1.0 ↗	alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain	0.87	74.0	4.66e-01	89.7%	59.4%
4516988	5086.1.1.0 ↗	alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins	0.87	74.0	5.99e-01	91.0%	68.6%
3213281	4177.1.1.1 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › FCH	0.87	73.0	4.87e-01	89.7%	28.9%
3235839	3755.4.1.0 ↗	alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain	0.87	73.0	5.48e-01	89.7%	44.6%
3576467	4177.1.1.1 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › FCH	0.86	72.0	4.72e-01	89.7%	25.6%
3908810	4177.1.1.1 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › FCH	0.86	72.0	4.75e-01	89.7%	26.4%
3620978	2003.1.2.18 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › FAD/NAD(P)-binding domain	0.86	73.0	4.68e-01	89.7%	23.1%
3435097	4177.1.1.11 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › DUF632	0.86	72.0	4.86e-01	89.7%	29.4%
3213527	4177.1.1.1 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › FCH	0.86	72.0	4.78e-01	89.7%	27.4%
5076586	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.86	76.0	6.95e-01	93.6%	85.7%
3364492	603.1.1.0 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins	0.86	67.0	5.27e-01	82.1%	43.3%
4054050	4006.1.1.1 ↗	alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF	0.86	60.0	5.51e-01	87.2%	57.0%
3215465	5086.1.1.0 ↗	alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins	0.86	72.0	5.98e-01	89.7%	56.2%
3519973	4177.1.1.0 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like	0.86	71.0	4.92e-01	89.7%	31.8%
3269524	5001.1.1.81 ↗	alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › THH1_TOM1-3_dom	0.86	76.0	5.03e-01	94.9%	47.8%
3270696	604.7.1.1 ↗	alpha bundles › Spectrin repeat-like › Tubulin chaperone cofactor A › Tubulin chaperone cofactor A › TBCA	0.85	73.0	6.52e-01	91.0%	77.1%
3255232	4177.1.1.0 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like	0.85	72.0	4.90e-01	89.7%	28.4%
3181110	5086.1.1.110 ↗	alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › HisKA	0.85	72.0	6.67e-01	89.7%	87.4%
3896686	192.8.1.36 ↗	alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain › M_domain	0.85	69.0	6.31e-01	85.9%	76.0%
3649758	3755.3.1.0 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin	0.85	72.0	5.07e-01	91.0%	32.9%
4942859	605.4.1.0 ↗	alpha duplicates or obligate multimers › ROP-like › ROP protein › ROP protein	0.85	68.0	6.44e-01	87.2%	73.3%
3735607	192.29.1.0 ↗	alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding)	0.85	71.0	7.10e-01	89.7%	95.0%
3495261	109.4.1.1844 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_1, TPR_10, TPR_12	0.84	71.0	4.35e-01	91.0%	17.2%
3763195	1072.1.1.1 ↗	alpha bundles › Hsp90 co-chaperone Cdc37 N-terminal domain › Hsp90 co-chaperone Cdc37 N-terminal domain › Hsp90 co-chaperone Cdc37 N-terminal domain › CDC37_N	0.84	71.0	5.85e-01	91.0%	58.5%
3692587	7087.1.1.1 ↗	alpha bundles › Emopamil binding protein (EBP) transmembrane domain › Emopamil binding protein (EBP) transmembrane domain › Emopamil binding protein (EBP) transmembrane domain › EBP	0.84	78.0	6.02e-01	100.0%	55.0%
3488631	4177.1.1.0 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like	0.83	70.0	4.71e-01	91.0%	28.4%
3268765	4177.1.1.8 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › BAR_3	0.83	69.0	4.81e-01	89.7%	31.2%
4660205	192.2.1.0 ↗	alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin	0.83	77.0	6.29e-01	100.0%	99.3%
3527998	3755.3.1.386 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › Myo5a	0.83	70.0	5.46e-01	89.7%	52.3%
3824360	1075.4.1.1 ↗	alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane	0.83	75.0	4.85e-01	100.0%	71.9%
5052771	192.29.1.0 ↗	alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding)	0.82	65.0	5.62e-01	88.5%	56.5%
3225544	4006.1.1.0 ↗	alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain	0.82	65.0	5.91e-01	83.3%	67.0%
3631342	3559.1.1.1 ↗	a+b complex topology › Mediator of RNA polymerase II transcription subunit 22 › Mediator of RNA polymerase II transcription subunit 22 › Mediator of RNA polymerase II transcription subunit 22 › Med22	0.82	70.0	6.25e-01	91.0%	70.5%
3933140	174.1.1.0 ↗	few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain	0.81	74.0	5.52e-01	100.0%	55.1%
3440537	109.4.1.91 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Sec10_HB	0.81	67.0	4.54e-01	89.7%	26.3%
4976711	150.1.1.0 ↗	alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin	0.80	66.0	5.22e-01	91.0%	45.6%
3368426	109.4.1.1472 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Tho2, Thoc2, THOC2_N	0.79	70.0	3.90e-01	96.2%	36.3%
3478372	4177.1.1.5 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › Vps5	0.79	65.0	4.67e-01	89.7%	34.5%
3400786	174.1.1.0 ↗	few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain	0.79	69.0	5.59e-01	96.2%	53.8%
3942662	150.5.1.0 ↗	alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › ESAT-6 like › ESAT-6 like	0.79	65.0	6.07e-01	89.7%	74.7%
3687276	150.5.1.0 ↗	alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › ESAT-6 like › ESAT-6 like	0.78	62.0	6.09e-01	84.6%	77.6%
3683912	192.7.1.0 ↗	alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm	0.78	65.0	5.54e-01	88.5%	62.5%
4030523	4177.1.1.0 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like	0.78	64.0	4.63e-01	89.7%	36.7%
3962381	150.5.1.50 ↗	alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › ESAT-6 like › ESAT-6 like › EspA_EspE	0.78	65.0	6.47e-01	89.7%	95.0%
3711125	603.1.1.0 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins	0.78	65.0	4.68e-01	88.5%	56.6%
4013672	3922.1.1.0 ↗	alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3	0.78	68.0	6.22e-01	93.6%	93.0%
3713312	192.29.1.0 ↗	alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding)	0.77	64.0	4.61e-01	88.5%	57.6%
3385727	5086.1.1.0 ↗	alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins	0.77	64.0	4.37e-01	91.0%	71.1%
3939680	4177.1.1.3 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › Arfaptin	0.77	70.0	4.89e-01	100.0%	82.6%
4981185	4121.1.1.0 ↗	a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like	0.76	63.0	4.87e-01	91.0%	41.7%
2970012	150.3.1.0 ↗	alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › 4-helical cytokines › 4-helical cytokine	0.76	61.0	4.58e-01	84.6%	96.6%
5049657	2498.1.1.10 ↗	mixed a+b and a/b › Zincin-like › "Metalloproteases (""zincins"") catalytic domain" › "Metalloproteases (""zincins"") catalytic domain" › Peptidase_M48	0.76	69.0	4.68e-01	98.7%	87.4%
5017743	192.29.1.0 ↗	alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding)	0.76	66.0	6.42e-01	94.9%	94.1%
3571433	3939.1.1.220 ↗	alpha duplicates or obligate multimers › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain › KIF21A	0.75	61.0	4.86e-01	89.7%	54.4%
3594129	4177.1.1.0 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like	0.75	62.0	4.50e-01	91.0%	34.4%
3516673	601.33.1.2 ↗	alpha bundles › Four-helical up-and-down bundle › CHAD domain › CHAD domain › PPP1R21_helical	0.75	66.0	5.22e-01	100.0%	60.6%
3414605	174.1.1.0 ↗	few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain	0.75	69.0	5.66e-01	100.0%	62.2%
3170491	4177.1.1.0 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like	0.75	62.0	4.41e-01	88.5%	35.5%
3288903	150.8.1.1 ↗	alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › PPE › PPE › PPE	0.74	60.0	4.66e-01	89.7%	42.3%
3254000	4177.1.1.8 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › BAR_3	0.74	60.0	4.16e-01	89.7%	27.3%
3189104	603.1.1.19 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins › Syntaxin-18_N	0.74	65.0	4.68e-01	100.0%	95.2%
3892397	4177.1.1.2 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › BAR	0.73	63.0	4.24e-01	96.2%	75.9%
4453815	192.12.1.1 ↗	alpha bundles › Long alpha-hairpin › Transcriptional repressor TraM › Transcriptional repressor TraM › Prok-TraM	0.73	58.0	5.47e-01	87.2%	72.6%
3284573	150.5.1.11 ↗	alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › ESAT-6 like › ESAT-6 like › T7SS_ESX_EspC	0.71	58.0	5.36e-01	89.7%	75.0%
3954841	150.5.1.11 ↗	alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › ESAT-6 like › ESAT-6 like › T7SS_ESX_EspC	0.70	56.0	5.20e-01	89.7%	68.0%
3178532	109.4.1.1764 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PF28917	0.70	60.0	4.33e-01	100.0%	42.0%
3619200	192.15.1.76 ↗	alpha bundles › Long alpha-hairpin › Endosomal sorting complex assembly domains › Endosomal sorting complex assembly domains › CUPID	0.70	60.0	4.84e-01	97.4%	49.0%
3766956	622.4.1.22 ↗	alpha bundles › YvfG-like › Mite allergen Der p 5-related › Mite allergen Der p 5-related › FAM186A-B_N	0.69	56.0	4.92e-01	94.9%	58.3%
3721656	630.1.1.2 ↗	a+b complex topology › RuBisCo LSMT C-terminal, substrate-binding domain › RuBisCo LSMT C-terminal, substrate-binding domain › RuBisCo LSMT C-terminal, substrate-binding domain › PF29521	0.67	53.0	4.50e-01	87.2%	94.8%
3214189	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.66	57.0	5.26e-01	100.0%	96.2%
3915878	3922.1.1.65 ↗	alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › PLC-beta_C	0.61	54.0	3.93e-01	98.7%	100.0%
3290040	174.1.1.61 ↗	few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › PF29531	0.60	49.0	4.33e-01	94.9%	62.4%

D6 medium residues 709-786

PDB

Domain cluster: representative

CATH (56)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2gs4A00	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.89	60.0	4.61e-01	70.5%	34.2%
2c41C01	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.88	64.0	5.02e-01	75.6%	44.3%
4fzsA00	1.20.1270.60	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain	0.88	64.0	4.52e-01	75.6%	30.1%
4iloA00	1.10.287.1490	Mainly Alpha › Orthogonal Bundle › Helix Hairpins ›	0.87	62.0	4.29e-01	74.4%	26.7%
3na7A00	1.10.287.1490	Mainly Alpha › Orthogonal Bundle › Helix Hairpins ›	0.87	61.0	4.20e-01	73.1%	26.2%
3nymA00	6.10.290.10	Special › Helix non-globular › Four Helix Bundle (Hemerythrin (Met), subunit A) ›	0.86	59.0	4.93e-01	70.5%	46.0%
2v6yA00	1.20.58.80	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit	0.84	53.0	5.42e-01	87.2%	66.7%
1x8zB00	1.20.140.40	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Invertase/pectin methylesterase inhibitor family protein	0.82	60.0	4.80e-01	76.9%	42.9%
4ioeA00	1.10.287.850	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HP0062-like domain	0.81	58.0	5.64e-01	75.6%	78.2%
4aflA00	6.10.140.1740	Special › Helix non-globular › Helix Hairpins ›	0.79	55.0	5.04e-01	73.1%	69.6%
2f3oA00	3.20.70.20	Alpha Beta › Alpha-Beta Barrel › Anaerobic Ribonucleotide-triphosphate Reductase Large Chain ›	0.78	65.0	3.64e-01	87.2%	28.6%
1m5iA00	1.10.287.450	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin	0.78	55.0	4.98e-01	74.4%	64.8%
7xxiA01	1.20.1070.10	Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins	0.77	69.0	4.63e-01	100.0%	56.2%
8b70A01	1.20.1740.10	Mainly Alpha › Up-down Bundle › Amino acid/polyamine transporter I › Amino acid/polyamine transporter I	0.77	68.0	4.28e-01	100.0%	73.7%
6f1eA01	1.20.1250.10	Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; ›	0.77	56.0	4.59e-01	91.0%	43.2%
1wa8A00	1.10.287.1060	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like	0.77	54.0	5.04e-01	74.4%	62.6%
2hjmA01	1.20.120.460	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › protein pf1176 like	0.77	55.0	5.30e-01	96.2%	67.4%
1sj7C00	1.20.1420.10	Mainly Alpha › Up-down Bundle › A middle domain of Talin 1 › Talin, central domain	0.76	57.0	4.33e-01	78.2%	39.8%
3axjB01	1.20.58.190	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 1	0.75	55.0	4.31e-01	75.6%	84.5%
2ic6A00	1.20.58.90	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.75	51.0	5.38e-01	70.5%	81.7%
4v1gA00	1.20.20.10	Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C	0.75	52.0	5.07e-01	71.8%	87.1%
3nyjA00	1.20.120.770	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Amyloid precursor protein, E2 domain	0.75	57.0	4.37e-01	82.1%	84.5%
4errB00	1.20.58.1190	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.75	49.0	4.82e-01	87.2%	62.7%
3ajmB02	1.20.120.330	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2	0.75	53.0	4.40e-01	78.2%	43.6%
4oo2A02	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.75	58.0	4.16e-01	98.7%	31.1%
1wdzA00	1.20.1270.60	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain	0.73	65.0	4.62e-01	98.7%	77.5%
2y39A00	1.20.120.1490	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) ›	0.72	57.0	5.10e-01	85.9%	70.9%
2chnB03	1.20.58.460	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Hyaluronidase post-catalytic domain-like	0.72	65.0	4.94e-01	100.0%	46.7%
2fzfA01	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.72	67.0	5.26e-01	100.0%	98.0%
3r6nA02	1.20.58.1060	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.71	63.0	5.09e-01	100.0%	78.1%
3l1nA02	1.20.1280.140	Mainly Alpha › Up-down Bundle › Monooxygenase ›	0.71	48.0	4.70e-01	70.5%	63.2%
8a1gC01	1.20.1270.60	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain	0.71	64.0	4.87e-01	100.0%	79.0%
5b00A00	1.10.600.10	Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase	0.70	60.0	4.11e-01	100.0%	28.0%
3pltA00	1.20.1270.60	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain	0.69	61.0	4.44e-01	98.7%	68.2%
2wdqD00	1.20.1300.10	Mainly Alpha › Up-down Bundle › 3 helical TM bundles of succinate and fumarate reductases › Fumarate reductase/succinate dehydrogenase, transmembrane subunit	0.69	59.0	5.40e-01	97.4%	86.7%
4wpcA00	1.20.1270.60	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain	0.68	60.0	4.07e-01	97.4%	68.6%
4nqiD00	1.20.1270.60	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain	0.68	58.0	4.23e-01	98.7%	71.1%
4w8pA02	1.20.120.230	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like	0.68	60.0	4.98e-01	94.9%	60.8%
3rguB00	1.20.5.420	Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › Immunoglobulin FC, subunit C	0.67	54.0	5.20e-01	97.4%	77.0%
7e4gA01	1.20.1070.10	Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins	0.67	62.0	4.44e-01	100.0%	38.6%
3agtA00	1.20.120.50	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Hemerythrin-like	0.67	57.0	4.75e-01	94.9%	54.1%
8e9gK01	1.10.287.3510	Mainly Alpha › Orthogonal Bundle › Helix Hairpins ›	0.66	51.0	4.94e-01	98.7%	73.6%
5j1hA01	1.20.58.1060	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.66	55.0	4.19e-01	91.0%	65.9%
1nzeA00	1.20.120.290	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Oxygen-evolving enhancer protein 3 (PsbQ), four-helix up-down bundle	0.65	52.0	4.65e-01	98.7%	60.7%
3ug9A02	1.20.1070.10	Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins	0.64	56.0	4.07e-01	100.0%	36.0%
6qelA01	1.10.860.10	Mainly Alpha › Orthogonal Bundle › DNAb Helicase; Chain A › DNAb Helicase; Chain A	0.64	53.0	4.32e-01	93.6%	96.7%
7zm7601	1.20.120.1200	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ	0.63	50.0	3.94e-01	85.9%	82.0%
2gscC00	1.20.1440.60	Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 23S rRNA-intervening sequence	0.61	57.0	4.97e-01	100.0%	73.6%
3k66A01	1.20.120.770	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Amyloid precursor protein, E2 domain	0.60	54.0	3.96e-01	100.0%	56.0%
2wzkA03	1.20.1310.10	Mainly Alpha › Up-down Bundle › 5 helical Cullin repeat like › Cullin Repeats	0.60	47.0	4.17e-01	83.3%	88.2%
3s84A02	1.20.120.20	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Apolipoprotein	0.58	50.0	4.03e-01	97.4%	75.2%
2lqgA00	1.20.120.230	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like	0.57	50.0	4.22e-01	100.0%	63.0%
3e7qA00	1.10.357.10	Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2	0.57	46.0	3.43e-01	89.7%	58.7%
4dwlA00	1.20.1440.60	Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 23S rRNA-intervening sequence	0.56	47.0	4.22e-01	96.2%	65.7%
2khmA01	1.10.10.1350	Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Spidroin domain, C-terminal domain	0.53	39.0	3.48e-01	76.9%	63.9%
1op1A00	1.20.81.10	Mainly Alpha › Up-down Bundle › Receptor-associated Protein › RAP domain	0.51	43.0	4.27e-01	100.0%	91.5%

ECOD (58)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3410475	4177.1.1.5 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › Vps5	0.93	66.0	4.78e-01	73.1%	33.5%
3286104	632.22.1.0 ↗	alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats	0.92	61.0	5.53e-01	70.5%	53.0%
3738484	4177.1.1.0 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like	0.92	67.0	4.32e-01	75.6%	20.4%
3908132	3755.3.1.0 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin	0.89	63.0	4.25e-01	73.1%	61.0%
3215704	5001.1.1.27 ↗	alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Sre	0.87	81.0	5.32e-01	100.0%	44.5%
3788052	3755.3.1.0 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin	0.87	61.0	3.94e-01	73.1%	19.1%
3348566	3291.1.1.106 ↗	alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Chloroplast_duf	0.87	63.0	5.06e-01	75.6%	42.9%
5042399	5001.1.1.0 ↗	alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like	0.84	77.0	5.34e-01	100.0%	60.8%
5012500	3843.1.1.6 ↗	alpha complex topology › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › MrpF_PhaF	0.84	59.0	5.76e-01	73.1%	75.3%
4950702	192.29.1.0 ↗	alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding)	0.83	66.0	5.61e-01	100.0%	53.6%
3366621	3562.1.1.11 ↗	alpha bundles › Calcium release-activated calcium channel protein 1 › Calcium release-activated calcium channel protein 1 › Calcium release-activated calcium channel protein 1 › PGG	0.81	74.0	5.73e-01	98.7%	55.6%
4634678	507.1.1.0 ↗	alpha arrays › DnaB helicase N-terminal domain-related › DnaB helicase N-terminal domain-related › DnaB helicase N-terminal domain-related	0.81	70.0	5.54e-01	94.9%	100.0%
5047181	5001.1.1.0 ↗	alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like	0.81	73.0	5.19e-01	100.0%	56.0%
5075967	3281.1.1.1 ↗	alpha complex topology › Sodium/proton antiporter subunits-like › Sodium/proton antiporter subunits-like › NADH-quinone oxidoreductase subunit L (NuoL)-related › Proton_antipo_M	0.80	71.0	4.54e-01	98.7%	24.3%
4941521	5069.1.3.0 ↗	alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Fumarate reductase respiratory complex transmembrane subunits	0.80	73.0	6.81e-01	100.0%	84.2%
3215082	4177.1.1.0 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like	0.79	57.0	4.67e-01	74.4%	45.9%
4111212	622.4.1.30 ↗	alpha bundles › YvfG-like › Mite allergen Der p 5-related › Mite allergen Der p 5-related › ETR1_N	0.79	67.0	6.22e-01	100.0%	74.0%
5053143	3843.1.1.41 ↗	alpha complex topology › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › PF29293	0.77	59.0	5.67e-01	98.7%	71.1%
3829876	3562.1.1.11 ↗	alpha bundles › Calcium release-activated calcium channel protein 1 › Calcium release-activated calcium channel protein 1 › Calcium release-activated calcium channel protein 1 › PGG	0.77	69.0	5.56e-01	98.7%	61.4%
3302335	109.4.1.634 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › EST1	0.76	68.0	4.79e-01	93.6%	78.1%
4683274	3843.1.1.6 ↗	alpha complex topology › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › MrpF_PhaF	0.76	61.0	6.14e-01	98.7%	83.7%
5035274	632.22.1.0 ↗	alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats	0.75	69.0	5.82e-01	100.0%	63.3%
4467968	605.4.1.0 ↗	alpha duplicates or obligate multimers › ROP-like › ROP protein › ROP protein	0.74	60.0	5.14e-01	98.7%	55.8%
3938853	5082.1.1.1 ↗	alpha bundles › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation_efflux	0.74	65.0	4.67e-01	100.0%	78.7%
3552989	604.8.1.1 ↗	alpha bundles › Spectrin repeat-like › Smac/diablo › Smac/diablo › Smac_DIABLO	0.74	52.0	3.91e-01	73.1%	33.7%
4015874	3291.1.1.0 ↗	alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related	0.73	65.0	4.94e-01	96.2%	77.7%
3204772	192.1.1.31 ↗	alpha bundles › Long alpha-hairpin › GreA transcript cleavage protein, N-terminal domain › GreA transcript cleavage protein, N-terminal domain › Cep57_MT_bd	0.73	64.0	5.83e-01	94.9%	76.0%
3821192	3843.1.1.0 ↗	alpha complex topology › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K	0.72	61.0	6.02e-01	96.2%	87.1%
3372083	605.1.1.0 ↗	alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase	0.71	55.0	5.00e-01	98.7%	60.9%
3805780	4177.1.1.0 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like	0.71	65.0	4.58e-01	100.0%	71.3%
4974234	604.12.1.141 ↗	alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › 8xMP	0.71	52.0	5.09e-01	83.3%	70.6%
4982694	3843.1.1.35 ↗	alpha complex topology › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › DUF1634	0.71	60.0	5.60e-01	94.9%	86.7%
3587749	192.29.1.0 ↗	alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding)	0.70	63.0	5.05e-01	100.0%	64.5%
3694103	5054.1.1.58 ↗	alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels › YVC1_C	0.70	64.0	4.17e-01	100.0%	23.9%
4932209	3843.1.1.6 ↗	alpha complex topology › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › MrpF_PhaF	0.70	55.0	5.55e-01	97.4%	83.7%
3497911	633.23.1.0 ↗	alpha bundles › Bromodomain-like › Claudin › Claudin	0.70	66.0	5.36e-01	100.0%	81.5%
3410541	5054.1.1.8 ↗	alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels › Ion_trans_2	0.70	49.0	3.21e-01	73.1%	26.4%
3345844	605.1.1.270 ↗	alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › Na_Ca_ex	0.70	62.0	5.10e-01	100.0%	71.0%
2527147	4266.1.1.3 ↗	alpha bundles › Hyaluronidase domain-like › Hyaluronidase post-catalytic domain-like › Hyaluronidase post-catalytic domain-like › NagJ_C	0.70	61.0	5.28e-01	98.7%	64.2%
4376234	4070.1.1.2 ↗	alpha arrays › FtsH protease domain-like › FtsH protease domain-like › FtsH protease domain-like › Peptidase_M50	0.69	62.0	4.24e-01	96.2%	32.2%
3673192	192.29.1.0 ↗	alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding)	0.68	62.0	4.66e-01	96.2%	71.2%
3764767	6155.1.1.2 ↗	alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter › PQ-loop	0.68	60.0	5.01e-01	96.2%	58.5%
3475770	5069.1.1.38 ↗	alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes › Frag1	0.68	60.0	4.71e-01	100.0%	50.0%
3724523	4121.1.1.7 ↗	a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like › PF26616	0.68	56.0	3.62e-01	91.0%	58.6%
3969668	3758.2.1.1 ↗	alpha bundles › Bacterial hemolysins-like › Biopolymer transport protein ExbB › Biopolymer transport protein ExbB › MotA_ExbB	0.67	53.0	3.79e-01	85.9%	73.0%
4370184	3758.2.1.1 ↗	alpha bundles › Bacterial hemolysins-like › Biopolymer transport protein ExbB › Biopolymer transport protein ExbB › MotA_ExbB	0.67	53.0	4.01e-01	85.9%	73.9%
3969091	109.4.1.203 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.66	54.0	4.04e-01	88.5%	40.0%
4984355	3843.1.1.1 ↗	alpha complex topology › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › Oxidored_q2	0.65	54.0	5.02e-01	97.4%	73.7%
3801151	7015.1.1.0 ↗	alpha bundles › Palmitoyltransferase DHHC transmembrane domain › Palmitoyltransferase DHHC transmembrane domain › Palmitoyltransferase DHHC transmembrane domain	0.65	60.0	4.36e-01	100.0%	57.8%
4964845	5001.1.1.292 ↗	alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › HisKA_7TM	0.65	55.0	4.11e-01	100.0%	63.7%
3581716	7015.1.1.0 ↗	alpha bundles › Palmitoyltransferase DHHC transmembrane domain › Palmitoyltransferase DHHC transmembrane domain › Palmitoyltransferase DHHC transmembrane domain	0.65	60.0	4.96e-01	100.0%	70.8%
4198477	3758.2.1.1 ↗	alpha bundles › Bacterial hemolysins-like › Biopolymer transport protein ExbB › Biopolymer transport protein ExbB › MotA_ExbB	0.64	53.0	3.83e-01	92.3%	75.1%
5075517	5069.1.1.0 ↗	alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes	0.63	55.0	4.49e-01	100.0%	52.0%
2503462	601.33.1.1 ↗	alpha bundles › Four-helical up-and-down bundle › CHAD domain › CHAD domain › CHAD	0.61	49.0	4.63e-01	100.0%	72.3%
3663121	5069.1.1.62 ↗	alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes › Chloroplast_duf	0.60	47.0	4.32e-01	98.7%	63.8%
3240691	7015.1.1.0 ↗	alpha bundles › Palmitoyltransferase DHHC transmembrane domain › Palmitoyltransferase DHHC transmembrane domain › Palmitoyltransferase DHHC transmembrane domain	0.58	49.0	4.25e-01	100.0%	61.5%
3710351	5086.1.1.0 ↗	alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins	0.58	50.0	3.89e-01	96.2%	67.4%
4322883	601.13.1.11 ↗	alpha bundles › Four-helical up-and-down bundle › Flagellar export chaperone FliS › Flagellar export chaperone FliS › FlaF	0.53	43.0	4.01e-01	96.2%	72.0%