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IMGVR_UViG_3300002120_000001-3300002120-C687J26616_10000003141

Arc-Vir

IMGVR_UViG_3300002120_000001-3300002120-C687J26616_10000003141

Quality

81.3 mean pLDDT

Cluster

Singleton — not in a non-trivial cluster

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 3-44
PDB
Domain cluster: representative
CATH (14)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2nnwA01 3.30.420.220 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › 0.66 51.0 3.86e-01 95.2% 45.9%
2lydA00 2.30.29.30 Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) 0.64 50.0 3.58e-01 100.0% 28.4%
2wdtC02 3.30.1490.420 Alpha Beta › 2-Layer Sandwich › Dna Ligase; domain 1 › Ubiquitin carboxyl-terminal hydrolase, domain 2 0.62 49.0 3.91e-01 100.0% 45.5%
3us4A00 3.30.505.10 Alpha Beta › 2-Layer Sandwich › SHC Adaptor Protein › SH2 domain 0.59 47.0 3.80e-01 100.0% 57.7%
3tdnA00 3.40.50.12600 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.59 44.0 3.34e-01 100.0% 29.8%
2riqA02 2.20.25.630 Mainly Beta › Single Sheet › N-terminal domain of TfIIb › 0.58 40.0 3.60e-01 78.6% 51.7%
3hr8A02 3.30.250.10 Alpha Beta › 2-Layer Sandwich › Rec A Protein; domain 2 › RecA protein, C-terminal domain 0.57 45.0 3.88e-01 95.2% 56.0%
2yyzA02 2.40.50.100 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain 0.55 42.0 3.81e-01 92.9% 62.1%
6bq9A02 3.30.1360.40 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › 0.54 42.0 3.48e-01 100.0% 87.2%
4o2zA01 3.30.200.20 Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › Phosphorylase Kinase; domain 1 0.54 46.0 3.20e-01 100.0% 56.9%
2cr4A01 3.30.505.10 Alpha Beta › 2-Layer Sandwich › SHC Adaptor Protein › SH2 domain 0.54 43.0 3.46e-01 100.0% 56.6%
1o22A00 3.90.1000.10 Alpha Beta › Alpha-Beta Complex › Orphan Protein Tm0875; Chain: A; › Hypothetical protein TM0875 0.54 47.0 3.24e-01 100.0% 60.4%
4fo0A01 3.30.420.40 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain 0.54 39.0 2.88e-01 97.6% 39.8%
4ri1C00 3.40.630.30 Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) 0.52 40.0 2.69e-01 88.1% 52.6%
ECOD (13)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3722097 386.1.1.1 few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › zf-C2H2 0.76 51.0 4.07e-01 85.7% 36.3%
3203292 386.1.1.0 few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers 0.65 50.0 5.13e-01 88.1% 92.5%
5067408 219.1.1.97 a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › CEPT76_peptidase 0.64 53.0 3.55e-01 100.0% 22.8%
3421203 386.1.1.20 few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › zf-met 0.64 49.0 4.44e-01 100.0% 61.7%
4964626 101.1.2.931 alpha arrays › HTH › HTH › winged helix domain › DUF7528 0.61 50.0 3.68e-01 100.0% 63.1%
4983508 101.1.2.0 alpha arrays › HTH › HTH › winged helix domain 0.59 45.0 3.78e-01 100.0% 50.0%
4173879 2003.1.3.1 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › Nucleotide-binding domain › DAO 0.58 43.0 2.51e-01 81.0% 14.8%
1187384 2484.1.1.0 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.56 36.0 3.68e-01 73.8% 100.0%
3265851 64.1.1.1 beta meanders › WW domain-like › WW domain › WW domain › WW 0.54 37.0 3.76e-01 97.6% 77.5%
3579412 386.1.1.0 few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers 0.53 42.0 3.82e-01 100.0% 84.6%
4973804 220.1.1.0 beta barrels › PH domain-like › PH domain-like › PH domain-like 0.52 43.0 3.66e-01 100.0% 57.3%
3987501 222.1.1.4 a+b two layers › Thioesterase/thiol ester dehydrase-isomerase-like › Thioesterase/thiol ester dehydrase-isomerase › Thioesterase/thiol ester dehydrase-isomerase › 4HBT 0.52 41.0 2.97e-01 100.0% 32.2%
3896583 109.4.1.198 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_12 0.51 41.0 2.71e-01 88.1% 34.3%
D2 high residues 71-191
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF10123.15 best Mu-like_Pro 32.0 1.30e-07 83.5% 23.4%
CATH (22)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1at3A00 3.20.16.10 Alpha Beta › Alpha-Beta Barrel › Serine Protease, Human Cytomegalovirus Protease; Chain A › Herpesvirus/Caudovirus protease domain 0.70 63.0 5.12e-01 100.0% 53.9%
1o6eA00 3.20.16.10 Alpha Beta › Alpha-Beta Barrel › Serine Protease, Human Cytomegalovirus Protease; Chain A › Herpesvirus/Caudovirus protease domain 0.66 62.0 4.95e-01 100.0% 60.4%
2sfaA01 2.40.10.10 Mainly Beta › Beta Barrel › Thrombin, subunit H › Trypsin-like serine proteases 0.63 29.0 3.33e-01 72.7% 56.0%
2zzeA03 2.40.30.130 Mainly Beta › Beta Barrel › Elongation Factor Tu (Ef-tu); domain 3 › 0.61 33.0 3.69e-01 96.7% 65.3%
2yweA04 3.30.70.240 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.59 31.0 3.18e-01 80.2% 51.8%
2f1lA01 2.40.30.60 Mainly Beta › Beta Barrel › Elongation Factor Tu (Ef-tu); domain 3 › RimM 0.58 36.0 4.06e-01 92.6% 84.3%
5fiiB00 3.30.70.260 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain 0.56 32.0 3.85e-01 79.3% 85.9%
2ynaA02 2.40.10.10 Mainly Beta › Beta Barrel › Thrombin, subunit H › Trypsin-like serine proteases 0.56 34.0 3.79e-01 72.7% 79.5%
5suvC00 3.90.470.20 Alpha Beta › Alpha-Beta Complex › Ribosomal Protein L22; Chain A › 4'-phosphopantetheinyl transferase domain 0.56 37.0 3.76e-01 72.7% 66.4%
3mahA02 3.30.70.260 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain 0.55 29.0 3.63e-01 79.3% 85.5%
5xuhA00 3.90.470.20 Alpha Beta › Alpha-Beta Complex › Ribosomal Protein L22; Chain A › 4'-phosphopantetheinyl transferase domain 0.55 37.0 3.74e-01 72.7% 68.0%
3og5A01 3.10.20.310 Alpha Beta › Roll › Ubiquitin-like (UB roll) › membrane protein fhac 0.54 35.0 4.01e-01 80.2% 95.3%
3cnrB00 2.40.10.220 Mainly Beta › Beta Barrel › Thrombin, subunit H › predicted glycosyltransferase like domains 0.53 32.0 3.55e-01 75.2% 75.3%
4k3cA01 3.10.20.310 Alpha Beta › Roll › Ubiquitin-like (UB roll) › membrane protein fhac 0.53 34.0 3.95e-01 74.4% 95.1%
1rzmA01 3.30.70.1140 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Phospho-2-dehydro-3-deoxyheptonate aldolase; domain 1 0.53 28.0 3.31e-01 80.2% 73.8%
5lt5A02 3.30.70.1710 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › BMC (bacterial microcompartment) domain 0.53 28.0 3.02e-01 80.2% 57.8%
1dn0D02 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.53 33.0 3.68e-01 100.0% 80.9%
2bddA00 3.90.470.20 Alpha Beta › Alpha-Beta Complex › Ribosomal Protein L22; Chain A › 4'-phosphopantetheinyl transferase domain 0.52 35.0 3.50e-01 72.7% 65.4%
2wdoA00 3.90.470.20 Alpha Beta › Alpha-Beta Complex › Ribosomal Protein L22; Chain A › 4'-phosphopantetheinyl transferase domain 0.52 36.0 3.60e-01 76.0% 69.1%
4bd4A00 2.60.40.200 Mainly Beta › Sandwich › Immunoglobulin-like › Superoxide dismutase, copper/zinc binding domain 0.52 33.0 3.43e-01 100.0% 69.7%
2rdeA02 2.40.10.220 Mainly Beta › Beta Barrel › Thrombin, subunit H › predicted glycosyltransferase like domains 0.51 35.0 3.61e-01 100.0% 74.8%
3c1mA02 3.30.2130.10 Alpha Beta › 2-Layer Sandwich › VC0802-like › VC0802-like 0.50 30.0 2.77e-01 80.2% 43.3%
ECOD (39)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3165956 2007.2.4.10 a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › Phosphoinositide phosphatase › Mu-like_Pro 0.79 74.0 6.96e-01 98.3% 92.9%
3957158 1.1.16.1 beta barrels › cradle loop barrel › RIFT-related › Mammalian cell entry (MCE) domain › MlaD 0.77 46.0 4.91e-01 100.0% 68.6%
3959024 1.1.16.0 beta barrels › cradle loop barrel › RIFT-related › Mammalian cell entry (MCE) domain 0.77 46.0 4.90e-01 100.0% 68.6%
3602442 1.1.16.0 beta barrels › cradle loop barrel › RIFT-related › Mammalian cell entry (MCE) domain 0.76 64.0 6.65e-01 100.0% 97.3%
3964748 1.1.7.0 beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C 0.75 54.0 5.81e-01 95.9% 86.7%
3290923 1.1.16.1 beta barrels › cradle loop barrel › RIFT-related › Mammalian cell entry (MCE) domain › MlaD 0.74 45.0 4.31e-01 100.0% 53.3%
3957231 1.1.16.0 beta barrels › cradle loop barrel › RIFT-related › Mammalian cell entry (MCE) domain 0.74 45.0 4.69e-01 100.0% 65.5%
3347366 1.1.16.1 beta barrels › cradle loop barrel › RIFT-related › Mammalian cell entry (MCE) domain › MlaD 0.74 45.0 4.62e-01 100.0% 63.5%
3964948 1.1.16.4 beta barrels › cradle loop barrel › RIFT-related › Mammalian cell entry (MCE) domain › Peptidase_S78 0.73 63.0 6.23e-01 100.0% 88.0%
3945977 50.1.1.4 beta barrels › Herpes virus serine proteinase, assemblin › Herpes virus serine proteinase, assemblin › Herpes virus serine proteinase, assemblin › DUF2213 0.73 68.0 6.09e-01 100.0% 88.5%
4654097 1.1.16.1 beta barrels › cradle loop barrel › RIFT-related › Mammalian cell entry (MCE) domain › MlaD 0.73 44.0 4.04e-01 100.0% 47.1%
5004197 1.1.16.0 beta barrels › cradle loop barrel › RIFT-related › Mammalian cell entry (MCE) domain 0.72 56.0 6.11e-01 81.8% 98.0%
3166306 50.1.1.4 beta barrels › Herpes virus serine proteinase, assemblin › Herpes virus serine proteinase, assemblin › Herpes virus serine proteinase, assemblin › DUF2213 0.72 67.0 6.19e-01 100.0% 88.9%
3954964 50.1.1.3 beta barrels › Herpes virus serine proteinase, assemblin › Herpes virus serine proteinase, assemblin › Herpes virus serine proteinase, assemblin › Peptidase_S78 0.72 67.0 6.26e-01 100.0% 86.2%
5003309 50.1.1.0 beta barrels › Herpes virus serine proteinase, assemblin › Herpes virus serine proteinase, assemblin › Herpes virus serine proteinase, assemblin 0.71 66.0 6.43e-01 100.0% 91.5%
4995675 50.1.1.0 beta barrels › Herpes virus serine proteinase, assemblin › Herpes virus serine proteinase, assemblin › Herpes virus serine proteinase, assemblin 0.71 66.0 5.90e-01 100.0% 81.2%
5083161 50.1.1.3 beta barrels › Herpes virus serine proteinase, assemblin › Herpes virus serine proteinase, assemblin › Herpes virus serine proteinase, assemblin › Peptidase_S78 0.71 66.0 6.21e-01 100.0% 85.5%
4960055 1.1.16.0 beta barrels › cradle loop barrel › RIFT-related › Mammalian cell entry (MCE) domain 0.69 64.0 6.14e-01 99.2% 89.9%
5051893 1.1.7.20 beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C › Gar1 0.69 38.0 4.49e-01 95.9% 80.0%
3585229 50.1.1.2 beta barrels › Herpes virus serine proteinase, assemblin › Herpes virus serine proteinase, assemblin › Herpes virus serine proteinase, assemblin › Peptidase_S77 0.68 63.0 6.02e-01 100.0% 91.4%
5059785 1.1.7.0 beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C 0.68 37.0 4.45e-01 96.7% 80.0%
5041953 1.1.7.0 beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C 0.66 35.0 4.62e-01 96.7% 100.0%
3410506 304.9.1.95 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › DUF4780 0.65 38.0 4.40e-01 80.2% 81.2%
4005635 1.1.16.1 beta barrels › cradle loop barrel › RIFT-related › Mammalian cell entry (MCE) domain › MlaD 0.63 46.0 4.57e-01 100.0% 72.8%
4107133 304.24.1.1 a+b two layers › Alpha-beta plaits › EF-G C-terminal domain-like › EF-G C-terminal domain-like › EFG_C 0.62 31.0 3.83e-01 80.2% 76.0%
3943528 1.1.16.0 beta barrels › cradle loop barrel › RIFT-related › Mammalian cell entry (MCE) domain 0.62 46.0 4.62e-01 100.0% 76.7%
3982061 1.1.16.1 beta barrels › cradle loop barrel › RIFT-related › Mammalian cell entry (MCE) domain › MlaD 0.62 46.0 4.55e-01 100.0% 73.6%
5023825 304.24.1.0 a+b two layers › Alpha-beta plaits › EF-G C-terminal domain-like › EF-G C-terminal domain-like 0.62 29.0 3.86e-01 78.5% 84.1%
1150480 50.1.1.1 beta barrels › Herpes virus serine proteinase, assemblin › Herpes virus serine proteinase, assemblin › Herpes virus serine proteinase, assemblin › Peptidase_S21 0.60 47.0 5.08e-01 81.0% 96.1%
5052672 304.8.1.0 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.59 33.0 4.20e-01 79.3% 94.3%
3797683 11.1.1.0 beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like 0.59 40.0 4.05e-01 100.0% 68.0%
4951601 304.24.1.37 a+b two layers › Alpha-beta plaits › EF-G C-terminal domain-like › EF-G C-terminal domain-like › MCR_C 0.58 29.0 3.78e-01 80.2% 86.2%
4913403 1.1.16.0 beta barrels › cradle loop barrel › RIFT-related › Mammalian cell entry (MCE) domain 0.58 44.0 4.68e-01 100.0% 90.4%
4913412 1.1.16.0 beta barrels › cradle loop barrel › RIFT-related › Mammalian cell entry (MCE) domain 0.58 45.0 4.47e-01 100.0% 78.4%
3316720 304.9.1.47 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › DUF4283 0.57 31.0 3.58e-01 80.2% 72.9%
5080814 304.8.1.5 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › NIL 0.56 30.0 3.75e-01 78.5% 87.1%
3838338 1.1.5.0 beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel 0.56 36.0 4.18e-01 74.4% 91.8%
4937870 1036.1.1.1 a+b two layers › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › 60S ribosomal export protein NMD3 a+b domain › NMD3 0.53 28.0 3.17e-01 79.3% 65.3%
3413297 11.2.1.1 beta sandwiches › Immunoglobulin-like beta-sandwich › C2 domain › C2 domain › C2 0.52 34.0 3.36e-01 100.0% 60.0%
D3 high residues 218-303
PDB
Domain cluster: representative
CATH (21)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
7odyC01 1.10.287.1080 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › MazG-like 0.70 41.0 4.00e-01 91.9% 54.3%
2vf8B02 1.20.1580.10 Mainly Alpha › Up-down Bundle › ABC transporter ATPase like fold › ABC transporter ATPase like domain 0.63 52.0 4.27e-01 90.7% 78.0%
7utzR02 1.20.1070.10 Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins 0.62 47.0 3.35e-01 82.6% 66.7%
1uw4B00 1.25.40.180 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.61 43.0 3.15e-01 75.6% 51.2%
1mhyG01 1.20.1280.10 Mainly Alpha › Up-down Bundle › Monooxygenase › Methane monooxygenase, gamma chain, domain 1 0.60 38.0 4.19e-01 86.0% 80.9%
2bskB00 1.10.287.810 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Mitochondrial import inner membrane translocase subunit tim13 like domains 0.60 30.0 3.39e-01 93.0% 63.1%
2vf7B01 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.58 48.0 3.26e-01 90.7% 25.3%
1qlbA03 1.20.58.100 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain 0.58 46.0 4.07e-01 82.6% 63.6%
6b8hO01 1.10.520.20 Mainly Alpha › Orthogonal Bundle › Peroxidase; domain 1 › N-terminal domain of the delta subunit of the F1F0-ATP synthase 0.58 37.0 3.57e-01 80.2% 55.6%
2a3qA00 1.10.287.1080 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › MazG-like 0.58 43.0 3.90e-01 90.7% 59.3%
3rjvA02 1.25.40.740 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.58 35.0 3.93e-01 87.2% 81.2%
1dtoA01 1.10.287.30 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › E2 (early) protein, N terminal domain, subdomain 1 0.57 43.0 4.08e-01 100.0% 66.7%
2gsvA00 6.10.140.40 Special › Helix non-globular › Helix Hairpins › 0.55 40.0 4.41e-01 89.5% 97.0%
3rzeA01 1.20.1070.10 Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins 0.55 45.0 3.22e-01 91.9% 70.9%
2qkdA04 2.60.120.1040 Mainly Beta › Sandwich › Jelly Rolls › ZPR1, A/B domain 0.55 43.0 3.76e-01 97.7% 56.7%
1g2rA00 3.30.1230.10 Alpha Beta › 2-Layer Sandwich › Hypothetical Cytosolic Protein; Chain: A; › YlxR-like 0.54 48.0 4.70e-01 98.8% 92.6%
1i6zA00 1.20.58.120 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain 0.53 41.0 3.54e-01 83.7% 67.4%
5jj6B01 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.51 39.0 3.82e-01 83.7% 82.3%
2ds2D01 1.10.110.10 Mainly Alpha › Orthogonal Bundle › Hydrophobic Seed Protein › Plant lipid-transfer and hydrophobic proteins 0.50 33.0 3.73e-01 90.7% 100.0%
2jexA01 1.10.287.30 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › E2 (early) protein, N terminal domain, subdomain 1 0.50 39.0 3.78e-01 100.0% 75.0%
1vw4T01 6.10.330.20 Special › Helix non-globular › Monooxygenase › 0.50 39.0 3.55e-01 84.9% 62.5%
ECOD (26)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3395965 1134.1.1.0 alpha bundles › C-terminal helical domain of alanine-tRNA ligase › C-terminal helical domain of alanine-tRNA ligase › Eukaryotic C-Ala helical domain 0.73 43.0 5.31e-01 89.5% 92.7%
4927922 604.12.1.0 alpha bundles › Spectrin repeat-like › MIT domain › MIT domain 0.68 42.0 4.99e-01 94.2% 90.0%
3610141 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.66 49.0 3.19e-01 79.1% 38.6%
5054405 606.1.1.1 alpha complex topology › Nop N-terminal domain › Nop N-terminal domain › Nop N-terminal domain › Nop 0.65 44.0 4.23e-01 89.5% 61.0%
3516873 159.1.1.3 alpha bundles › all-alpha NTP pyrophosphatases › all-alpha NTP pyrophosphatases › Hypothetical protein AF_0060 › DUF1599 0.62 43.0 4.52e-01 91.9% 77.5%
4011610 109.4.1.2614 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Ank_4 0.62 47.0 3.10e-01 81.4% 38.9%
3390877 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.61 46.0 3.23e-01 82.6% 33.3%
4015907 601.33.1.14 alpha bundles › Four-helical up-and-down bundle › CHAD domain › CHAD domain › Erg28 0.60 45.0 4.61e-01 80.2% 89.3%
3673003 3922.1.1.254 alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › NET2A_C 0.59 47.0 4.14e-01 84.9% 80.8%
3938116 5001.1.1.1 alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1 0.59 50.0 3.55e-01 91.9% 58.4%
3328692 7015.1.1.0 alpha bundles › Palmitoyltransferase DHHC transmembrane domain › Palmitoyltransferase DHHC transmembrane domain › Palmitoyltransferase DHHC transmembrane domain 0.57 47.0 4.01e-01 90.7% 75.2%
3957336 604.5.1.2 alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › PhoU 0.55 44.0 4.23e-01 86.0% 84.0%
3505043 102.1.3.0 alpha arrays › HhH/H2TH › SAM/DNA-glycosylase › PAP/OAS1 substrate-binding domain 0.55 48.0 3.99e-01 100.0% 73.1%
3787068 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.54 48.0 3.52e-01 100.0% 62.0%
3170875 5051.1.1.6 alpha complex topology › Sodium:neurotransmitter symporter family (SNF)-like › Sodium:neurotransmitter symporter family (SNF)-like › Sodium:neurotransmitter symporter family (SNF)-like › Aa_trans 0.54 47.0 3.07e-01 100.0% 95.3%
3251538 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.54 43.0 2.87e-01 96.5% 22.1%
3409557 5001.1.1.5 alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_3 0.54 46.0 3.27e-01 93.0% 49.2%
3636524 192.4.1.13 alpha bundles › Long alpha-hairpin › Ribosomal protein L29 (L29p) › Ribosomal protein L29 (L29p) › Cactin_mid 0.54 49.0 3.67e-01 100.0% 43.3%
4150217 633.2.1.1 alpha bundles › Bromodomain-like › Carnobacteriocin B2 immunity protein › Carnobacteriocin B2 immunity protein › EntA_Immun 0.54 44.0 4.40e-01 90.7% 92.2%
4018439 633.23.1.22 alpha bundles › Bromodomain-like › Claudin › Claudin › MARVEL 0.53 43.0 3.58e-01 89.5% 92.3%
3629550 5054.1.1.8 alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels › Ion_trans_2 0.53 37.0 2.48e-01 90.7% 16.8%
3480976 601.1.2.100 alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › PF31009 0.53 43.0 3.41e-01 90.7% 78.9%
3890937 109.3.1.0 alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat 0.52 45.0 3.35e-01 100.0% 62.5%
3417527 109.4.1.11 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PI3Ka 0.51 46.0 3.53e-01 100.0% 59.0%
3634185 5059.1.1.23 alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › DUF2418 0.51 39.0 3.51e-01 83.7% 73.6%
5059804 633.21.1.0 alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 0.50 40.0 3.85e-01 89.5% 93.3%
D4 high residues 310-363
PDB
Domain cluster: representative
CATH (8)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1ab5A00 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.67 47.0 3.63e-01 75.9% 94.4%
3nz4B03 1.10.274.20 Mainly Alpha › Orthogonal Bundle › Enzyme I; Chain A, domain 2 › Phenylalanine ammonia-lyase 1; domain 3 0.66 50.0 4.12e-01 85.2% 68.3%
7tj9A01 1.20.120.350 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Voltage-gated potassium channels. Chain C 0.62 43.0 3.61e-01 77.8% 43.4%
2b3yA01 3.30.499.10 Alpha Beta › 2-Layer Sandwich › Aconitase; domain 3 › Aconitase, domain 3 0.60 42.0 2.81e-01 75.9% 16.7%
2c5zA00 1.10.1740.100 Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › Set2, Rpb1 interacting domain 0.58 42.0 3.72e-01 85.2% 83.9%
7r8bB01 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.55 41.0 2.57e-01 79.6% 28.4%
7jplA01 1.10.287.70 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.53 40.0 3.34e-01 92.6% 74.4%
2z3xA00 6.10.10.80 Special › Helix non-globular › Helicase, Ruva Protein; domain 3 › Small, acid-soluble spore protein, alpha/beta type-like 0.51 39.0 3.90e-01 83.3% 100.0%
ECOD (10)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3813129 3787.3.1.1 alpha bundles › HAD superfamily helical bundle insertion domain › Insertion domain in cytosolic IMP-GMP specific 5'-nucleotidase › Insertion domain in cytosolic IMP-GMP specific 5'-nucleotidase › 5_nucleotid 0.73 55.0 3.93e-01 81.5% 91.6%
4928145 547.1.1.1 alpha duplicates or obligate multimers › Glutamyl tRNA-reductase dimerization domain › Glutamyl tRNA-reductase dimerization domain › Glutamyl tRNA-reductase dimerization domain › GlutR_dimer 0.67 50.0 4.53e-01 85.2% 70.0%
5061943 101.11.1.0 alpha arrays › HTH › Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 › Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 0.66 50.0 3.84e-01 83.3% 88.8%
4115098 3121.1.1.1 a+b duplicates or obligate multimers › Polypeptide transport-associated (POTRA) domain › Polypeptide transport-associated (POTRA) domain › Polypeptide transport-associated (POTRA) domain › POTRA 0.65 48.0 4.16e-01 79.6% 95.3%
3252664 130.1.1.31 alpha arrays › LEM/SAP HeH motif-like › LEM/SAP HeH motif › LEM/SAP HeH motif › RNF34L-like_3rd 0.65 45.0 4.55e-01 74.1% 70.9%
3965239 3121.1.1.3 a+b duplicates or obligate multimers › Polypeptide transport-associated (POTRA) domain › Polypeptide transport-associated (POTRA) domain › Polypeptide transport-associated (POTRA) domain › POTRA_2 0.62 43.0 3.83e-01 74.1% 68.8%
1837963 1038.1.1.2 alpha complex topology › Pre-mRNA-splicing factor 8 N-terminal domain › Pre-mRNA-splicing factor 8 N-terminal domain › Pre-mRNA-splicing factor 8 N-terminal domain › PROCN 0.56 48.0 3.65e-01 100.0% 45.9%
3173138 192.4.1.0 alpha bundles › Long alpha-hairpin › Ribosomal protein L29 (L29p) › Ribosomal protein L29 (L29p) 0.54 38.0 3.30e-01 75.9% 48.9%
4949212 7541.1.1.1 a/b three-layered sandwiches › Molybdenum cofactor biosynthesis proteins › Molybdenum cofactor biosynthesis proteins › Molybdenum cofactor biosynthesis proteins › MoCF_biosynth 0.54 41.0 2.85e-01 85.2% 52.1%
4929521 101.1.1.0 alpha arrays › HTH › HTH › Three-helical HTH 0.52 39.0 3.15e-01 81.5% 39.1%
D5 high residues 367-449
PDB
Domain cluster: representative
CATH (21)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
7dwqL01 1.20.1240.10 Mainly Alpha › Up-down Bundle › Photosystem 1 Reaction Centre Subunit Xi; Chain: L; › Photosystem I PsaL, reaction centre subunit XI 0.69 44.0 3.79e-01 73.5% 42.4%
2p0tA02 1.10.60.30 Mainly Alpha › Orthogonal Bundle › Diphtheria Toxin Repressor; domain 2 › PSPTO4464-like domains 0.66 43.0 4.57e-01 74.7% 75.0%
5xfaA04 1.20.1440.230 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain 0.65 44.0 4.43e-01 78.3% 68.2%
1kxpD01 1.10.246.10 Mainly Alpha › Orthogonal Bundle › Serum Albumin; Chain A, Domain 1 › 0.62 48.0 4.81e-01 85.5% 83.7%
4rm7A03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.61 44.0 3.68e-01 75.9% 82.7%
1gzsB00 1.10.4120.10 Mainly Alpha › Orthogonal Bundle › SopE-like GEF fold › SopE-like, GEF domain 0.60 42.0 3.39e-01 86.7% 37.0%
5d0yA00 1.10.1760.20 Mainly Alpha › Orthogonal Bundle › Arp2/3 complex 21 kDa subunit ARPC3 › 0.60 46.0 3.81e-01 84.3% 51.0%
3t9oB00 1.20.120.30 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Aspartate receptor, ligand-binding domain 0.60 45.0 3.97e-01 79.5% 66.7%
1v9vA01 1.20.1480.20 Mainly Alpha › Up-down Bundle › hypothetical protein mp506/mpn330, domain 1 › MAST3 pre-PK domain-like 0.58 43.0 4.17e-01 79.5% 77.9%
3himA00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.58 50.0 3.88e-01 97.6% 85.8%
2kseA00 1.20.5.1040 Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › Sensor protein qsec. 0.56 36.0 3.74e-01 73.5% 70.1%
4cy8A01 3.50.50.60 Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain 0.55 44.0 3.16e-01 86.7% 88.5%
4iggB06 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.55 39.0 2.85e-01 74.7% 30.2%
4hs5A00 3.30.920.10 Alpha Beta › 2-Layer Sandwich › Metal Transport, Frataxin; Chain A › Frataxin/CyaY 0.54 45.0 4.15e-01 90.4% 94.3%
4y9jA01 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.54 43.0 3.52e-01 85.5% 75.8%
6q9jB02 1.20.1440.230 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain 0.53 37.0 3.72e-01 83.1% 69.3%
3mfqA01 3.40.50.1980 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Nitrogenase molybdenum iron protein domain 0.53 41.0 3.52e-01 85.5% 66.0%
2hfiA00 1.20.120.440 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › YppE-like 0.52 40.0 3.58e-01 85.5% 61.0%
6cy5A01 1.20.120.140 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › SRP54, nucleotide-binding domain 0.50 35.0 3.49e-01 91.6% 69.7%
7xinA03 3.90.1150.10 Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1 0.50 42.0 3.82e-01 90.4% 100.0%
2qv6B02 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.50 35.0 3.16e-01 74.7% 51.6%
ECOD (30)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3638065 101.1.2.98 alpha arrays › HTH › HTH › winged helix domain › CDT1 0.73 38.0 3.22e-01 81.9% 31.9%
3511397 5067.1.1.3 alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Patched 0.69 57.0 4.18e-01 92.8% 74.5%
3636365 5051.1.1.10 alpha complex topology › Sodium:neurotransmitter symporter family (SNF)-like › Sodium:neurotransmitter symporter family (SNF)-like › Sodium:neurotransmitter symporter family (SNF)-like › AA_permease_2 0.68 50.0 3.05e-01 77.1% 56.6%
4003744 5067.1.1.3 alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Patched 0.66 57.0 3.35e-01 100.0% 21.8%
5028061 192.2.1.1 alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin › Prefoldin_2 0.64 40.0 3.89e-01 100.0% 56.7%
4025349 3567.1.1.0 a+b duplicates or obligate multimers › MPER trimer › MPER trimer › MPER trimer 0.64 40.0 3.39e-01 94.0% 40.8%
5046473 601.3.1.0 alpha bundles › Four-helical up-and-down bundle › Histidine-containing phosphotransfer domain, HPT domain › Histidine-containing phosphotransfer domain, HPT domain 0.63 35.0 3.47e-01 72.3% 51.1%
None 0.62 48.0 3.02e-01 81.9% 60.5%
4978506 3714.1.1.0 a+b two layers › Lon-like protease MtaLonC helical domain › Lon-like protease MtaLonC helical domain › Lon-like protease MtaLonC helical domain 0.62 50.0 3.85e-01 88.0% 45.3%
4965834 605.4.1.0 alpha duplicates or obligate multimers › ROP-like › ROP protein › ROP protein 0.62 44.0 4.45e-01 74.7% 91.8%
4057499 3681.1.1.0 a+b complex topology › Helical hairpin insertion in E. coli DNA-directed RNA polymerase beta subunit › Helical hairpin insertion in E. coli DNA-directed RNA polymerase beta subunit › Helical hairpin insertion in E. coli DNA-directed RNA polymerase beta subunit 0.61 43.0 3.86e-01 73.5% 85.2%
4654615 325.1.7.2 a+b complex topology › alpha/beta-Hammerhead/Barrel-sandwich hybrid › alpha/beta-Hammerhead/Barrel-sandwich hybrid › Single hybrid motif › RNA_pol_Rpb2_6 0.61 43.0 3.10e-01 73.5% 43.0%
4457710 192.2.1.1 alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin › Prefoldin_2 0.60 39.0 3.49e-01 100.0% 45.8%
3972594 3714.1.1.1 a+b two layers › Lon-like protease MtaLonC helical domain › Lon-like protease MtaLonC helical domain › Lon-like protease MtaLonC helical domain › LonC_helical 0.59 49.0 3.55e-01 95.2% 32.2%
3416820 5054.1.1.1 alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels › Lig_chan 0.58 46.0 3.68e-01 88.0% 43.0%
4208825 3896.1.1.0 alpha duplicates or obligate multimers › Intramembrane CDP-DAG synthetase-related › Intramembrane CDP-DAG synthetase-related › Intramembrane CDP-DAG synthetase 0.58 47.0 3.55e-01 91.6% 38.1%
3391689 5054.1.1.1 alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels › Lig_chan 0.58 46.0 3.54e-01 88.0% 39.4%
4976626 3714.1.1.0 a+b two layers › Lon-like protease MtaLonC helical domain › Lon-like protease MtaLonC helical domain › Lon-like protease MtaLonC helical domain 0.57 47.0 3.50e-01 94.0% 72.4%
4954786 605.1.1.0 alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase 0.55 39.0 3.96e-01 74.7% 78.8%
4952130 3714.1.1.1 a+b two layers › Lon-like protease MtaLonC helical domain › Lon-like protease MtaLonC helical domain › Lon-like protease MtaLonC helical domain › LonC_helical 0.55 46.0 3.39e-01 94.0% 70.4%
3614763 192.2.1.1 alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin › Prefoldin_2 0.55 40.0 3.50e-01 75.9% 56.7%
3472968 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.54 44.0 2.85e-01 92.8% 81.8%
4061614 3016.1.1.0 a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases 0.54 38.0 3.60e-01 74.7% 69.5%
4075938 604.39.1.2 alpha bundles › Spectrin repeat-like › S-component of energy-coupling factor (ECF) transporters › S-component of energy-coupling factor (ECF) transporters › BioY 0.54 43.0 3.41e-01 91.6% 68.0%
3594508 213.1.1.0 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) 0.53 45.0 3.19e-01 94.0% 60.5%
3274487 605.1.1.155 alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › Gpi1 0.53 42.0 3.38e-01 88.0% 50.9%
3991594 601.42.1.0 alpha bundles › Four-helical up-and-down bundle › Helical bundle in ROQ domain › Helical bundle in ROQ domain 0.53 39.0 3.04e-01 77.1% 37.6%
3839738 327.11.1.0 a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Prokaryotic type KH domain (KH-domain type II) 0.52 38.0 3.71e-01 75.9% 77.8%
1842585 1.1.13.0 beta barrels › cradle loop barrel › RIFT-related › Phage tail proteins 0.52 38.0 3.08e-01 77.1% 55.4%
4475462 3075.1.1.1 a+b two layers › ubiquitin-binding domain from PLAA › ubiquitin-binding domain from PLAA › ubiquitin-binding domain from PLAA › PFU 0.50 31.0 3.17e-01 88.0% 60.0%
D6 high residues 468-508
PDB
Domain cluster: representative
CATH (49)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1oaiA00 1.10.8.10 Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Ubiquitin-associated (UBA) domain 0.82 59.0 5.23e-01 78.0% 55.9%
6wshA02 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.81 63.0 5.73e-01 85.4% 72.7%
1qo0D02 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.81 64.0 6.16e-01 85.4% 87.0%
2f4lA03 3.10.28.20 Alpha Beta › Roll › Endonuclease I-creI › Acetamidase/Formamidase-like domains 0.80 66.0 5.20e-01 90.2% 56.2%
1s8nA02 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.79 62.0 5.50e-01 85.4% 69.0%
3vdpA01 1.10.8.420 Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › RecR Domain 1 0.79 59.0 5.44e-01 80.5% 63.5%
3w0lD01 1.10.8.1080 Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › 0.78 64.0 4.71e-01 95.1% 36.6%
4didB01 1.20.58.450 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Cell division control protein 42 homolog 0.78 57.0 4.16e-01 80.5% 31.6%
2d6fC03 1.10.150.380 Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › GatB domain, N-terminal subdomain 0.76 52.0 4.81e-01 70.7% 59.6%
1lzwA00 3.30.1390.10 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein L30; Chain: A, › Ribosomal protein L7/L12, C-terminal domain/Adaptor protein ClpS 0.76 56.0 4.32e-01 80.5% 36.3%
2hg2A01 3.40.605.10 Alpha Beta › 3-Layer(aba) Sandwich › Aldehyde Dehydrogenase; Chain A, domain 1 › Aldehyde Dehydrogenase; Chain A, domain 1 0.75 51.0 3.08e-01 80.5% 10.5%
3fdiB00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.75 53.0 3.46e-01 75.6% 25.1%
3ousA00 1.10.287.70 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.74 62.0 5.02e-01 97.6% 82.9%
3pqaB01 3.40.605.10 Alpha Beta › 3-Layer(aba) Sandwich › Aldehyde Dehydrogenase; Chain A, domain 1 › Aldehyde Dehydrogenase; Chain A, domain 1 0.74 51.0 3.08e-01 80.5% 11.0%
1owfA00 4.10.520.10 Few Secondary Structures › Irregular › HU Protein; Chain A › IHF-like DNA-binding proteins 0.74 52.0 3.96e-01 80.5% 32.3%
2oq1A02 1.10.930.10 Mainly Alpha › Orthogonal Bundle › Syk Kinase; Chain A, domain 2 › Syk Kinase; Chain A, domain 2 0.74 55.0 5.39e-01 82.9% 77.8%
1f20A01 3.40.50.80 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module 0.73 63.0 4.18e-01 97.6% 25.8%
4ki9A00 3.90.190.10 Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily 0.73 59.0 3.96e-01 100.0% 23.6%
2bpoA04 3.40.50.80 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module 0.73 65.0 4.25e-01 100.0% 25.3%
4i8qA01 3.40.605.10 Alpha Beta › 3-Layer(aba) Sandwich › Aldehyde Dehydrogenase; Chain A, domain 1 › Aldehyde Dehydrogenase; Chain A, domain 1 0.72 49.0 2.94e-01 80.5% 9.9%
4d3pA00 3.90.190.10 Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily 0.71 58.0 3.99e-01 100.0% 25.9%
8ctsB01 1.10.287.70 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.70 57.0 4.62e-01 97.6% 79.3%
3aqlA02 1.10.3090.10 Mainly Alpha › Orthogonal Bundle › cca-adding enzyme, domain 2 › cca-adding enzyme, domain 2 0.70 60.0 3.70e-01 100.0% 33.5%
6rxaA01 1.10.40.30 Mainly Alpha › Orthogonal Bundle › Ribonucleotide Reductase Protein R1; domain 1 › Fumarase/aspartase (C-terminal domain) 0.70 52.0 4.15e-01 90.2% 39.1%
4h8aB01 1.10.1530.10 Mainly Alpha › Orthogonal Bundle › Hypothetical Oxidoreductase Yiak; Chain: A, domain 1 › Malate/L-lactate/L-sulpholactate dehydrogenase, four-helix barrel 0.70 52.0 4.66e-01 82.9% 56.7%
1rykA00 1.10.1470.10 Mainly Alpha › Orthogonal Bundle › Protein Yjbj; Chain: A; › YjbJ 0.70 56.0 4.75e-01 90.2% 97.1%
7w5lA01 3.40.605.10 Alpha Beta › 3-Layer(aba) Sandwich › Aldehyde Dehydrogenase; Chain A, domain 1 › Aldehyde Dehydrogenase; Chain A, domain 1 0.69 47.0 2.92e-01 80.5% 11.8%
3keyA01 1.10.10.1080 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Stn1, N-terminal wHTH domain 0.68 49.0 4.01e-01 80.5% 46.0%
6oh6A00 1.10.600.10 Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase 0.66 57.0 3.42e-01 100.0% 26.7%
8h72B01 1.10.600.10 Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase 0.66 56.0 3.34e-01 100.0% 27.3%
1mjtB01 3.90.340.10 Alpha Beta › Alpha-Beta Complex › Nitric Oxide Synthase; Chain A, domain 1 › Nitric Oxide Synthase; Chain A, domain 1 0.65 48.0 3.40e-01 80.5% 29.5%
1n1bB02 1.10.600.10 Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase 0.65 53.0 3.24e-01 100.0% 24.6%
8gr7A01 1.10.600.10 Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase 0.65 55.0 3.27e-01 100.0% 26.5%
1zymA02 1.10.274.10 Mainly Alpha › Orthogonal Bundle › Enzyme I; Chain A, domain 2 › PtsI, HPr-binding domain 0.65 53.0 3.81e-01 95.1% 41.3%
4fjqA01 1.10.600.10 Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase 0.64 53.0 3.15e-01 100.0% 19.6%
3g36B00 1.20.890.10 Mainly Alpha › Up-down Bundle › cAMP-dependent Protein Kinase, Chain A › cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain 0.64 49.0 4.65e-01 90.2% 72.5%
1dcnA03 1.10.40.30 Mainly Alpha › Orthogonal Bundle › Ribonucleotide Reductase Protein R1; domain 1 › Fumarase/aspartase (C-terminal domain) 0.64 47.0 4.12e-01 95.1% 50.0%
8h6qD01 1.10.600.10 Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase 0.63 54.0 3.23e-01 100.0% 27.7%
2rinA01 3.40.190.10 Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II 0.62 49.0 3.40e-01 97.6% 23.6%
4mfiA00 3.40.190.10 Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II 0.61 47.0 2.71e-01 100.0% 8.7%
3uorB02 3.40.190.10 Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II 0.61 52.0 3.29e-01 97.6% 20.4%
3bruB00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.59 46.0 2.98e-01 87.8% 19.0%
2py5A04 1.10.287.690 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › B family DNA polymerase, finger domain 0.57 40.0 4.18e-01 87.8% 86.1%
4cc9B00 1.20.5.4730 Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › 0.56 44.0 3.52e-01 97.6% 39.8%
2c5iT00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.55 47.0 3.65e-01 100.0% 43.6%
2i7uA00 6.10.250.1010 Special › Helix non-globular › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › 0.55 46.0 4.09e-01 97.6% 72.6%
3c24A02 1.10.3640.10 Mainly Alpha › Orthogonal Bundle › putative oxidoreductase fold › Semialdehyde dehydrogenase-like, C-terminal 0.55 44.0 3.44e-01 97.6% 39.0%
3fvvA02 1.20.1440.100 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › SG protein - dephosphorylation function 0.54 39.0 3.39e-01 87.8% 46.7%
6ygiB01 1.10.4090.10 Mainly Alpha › Orthogonal Bundle › Hepatitis B viral capsid (hbcag) fold › Viral capsid, core domain supefamily, Hepatitis B virus 0.53 46.0 3.18e-01 100.0% 30.8%
ECOD (42)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
145389 2003.1.1.7 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › ELFV_dehydrog 0.88 64.0 3.93e-01 78.0% 14.6%
5014846 148.1.3.0 alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain 0.87 62.0 5.02e-01 75.6% 42.7%
3183328 103.12.1.13 alpha arrays › RuvA-C › ANTAR domain › ANTAR domain › DUF2015 0.86 66.0 5.52e-01 80.5% 52.3%
5077269 2006.1.4.2 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like › PIN 0.82 59.0 4.02e-01 80.5% 23.3%
3589629 307.1.1.3 a+b two layers › Hedgehog/DD-peptidase › Hedgehog/DD-peptidase › Hedgehog/DD-peptidase › VanY 0.81 72.0 4.48e-01 100.0% 20.1%
4936146 101.35.1.0 alpha arrays › HTH › DNA repair regulatory protein RecX › DNA repair regulatory protein RecX 0.80 59.0 5.40e-01 80.5% 65.5%
3503552 5054.1.1.0 alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels 0.80 58.0 4.04e-01 80.5% 25.9%
3784553 592.1.1.6 alpha arrays › PWI domain-like › PWI domain › PWI domain › Nab2 0.80 58.0 4.64e-01 80.5% 43.5%
3514292 2007.2.3.2 a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › DSPc 0.79 63.0 4.36e-01 95.1% 26.7%
4967548 2006.1.4.0 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like 0.79 58.0 4.20e-01 78.0% 29.1%
3799156 101.1.1.0 alpha arrays › HTH › HTH › Three-helical HTH 0.79 58.0 4.79e-01 80.5% 45.9%
3651776 4106.1.1.1 few secondary structure elements › Zinc hairpin stack › Zinc hairpin stack › Zinc hairpin stack › DHHC 0.79 64.0 4.09e-01 100.0% 19.5%
5009535 148.1.3.410 alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain › DUF6955 0.78 60.0 4.52e-01 87.8% 35.0%
185681 3413.1.1.1 alpha bundles › Inositol phosphate phosphatase sopB N-terminal domain › Inositol phosphate phosphatase sopB N-terminal domain › Inositol phosphate phosphatase sopB N-terminal domain › IpgD 0.78 57.0 4.04e-01 80.5% 28.3%
4959424 103.6.1.0 alpha arrays › RuvA-C › FGAM synthase PurL, linker domain › FGAM synthase PurL, linker domain 0.76 56.0 5.16e-01 80.5% 61.8%
4274974 101.17.1.1 alpha arrays › HTH › IHF-like DNA-binding proteins › IHF-like DNA-binding proteins › Bac_DNA_binding 0.76 56.0 4.17e-01 82.9% 33.0%
4888660 5067.1.1.1 alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › ACR_tran 0.75 64.0 3.92e-01 100.0% 30.6%
4344448 2004.1.1.0 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.75 55.0 3.71e-01 82.9% 23.7%
3915218 5076.2.1.9 alpha complex topology › Mitochondrial ADP/ATP carrier-like › Putative sulfate permease CysZ › Putative sulfate permease CysZ › Choline_transpo 0.74 59.0 3.53e-01 90.2% 13.9%
4984680 3962.1.1.1 alpha arrays › N-terminal helical domain in restriction-modification system methylation subunit-like › N-terminal helical domain in restriction-modification system methylation subunit › N-terminal helical domain in restriction-modification system methylation subunit › HsdM_N 0.72 61.0 4.06e-01 100.0% 27.1%
4510528 4953.1.1.4 beta barrels › L-aspartase C-terminal domain-like › L-aspartase C-terminal domain-like › L-aspartase C-terminal domain-like › ASL_C2 0.72 53.0 4.18e-01 82.9% 42.2%
4134287 131.2.1.2 alpha complex topology › PDEase-like › Poly A polymerase C-terminal region-like › Poly A polymerase C-terminal region-like › PolyA_pol_arg_C,PolyA_pol_RNAbd 0.71 61.0 3.77e-01 100.0% 32.2%
4433737 5067.1.1.1 alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › ACR_tran 0.71 60.0 3.78e-01 100.0% 33.9%
5057411 4953.1.1.4 beta barrels › L-aspartase C-terminal domain-like › L-aspartase C-terminal domain-like › L-aspartase C-terminal domain-like › ASL_C2 0.69 52.0 4.22e-01 82.9% 48.8%
5003091 103.1.1.0 alpha arrays › RuvA-C › RuvA-C, UBA, CRAL/TRIO-N, HBS1 › UBA-like domain 0.69 50.0 4.55e-01 82.9% 58.3%
3678066 101.1.11.40 alpha arrays › HTH › HTH › Ribbon-helix-helix › DUF1677 0.68 53.0 4.48e-01 87.8% 80.0%
4954174 103.2.1.2 alpha arrays › RuvA-C › ATP cone › ATP cone › ATP-cone 0.67 50.0 3.97e-01 82.9% 51.1%
4042981 4953.1.1.4 beta barrels › L-aspartase C-terminal domain-like › L-aspartase C-terminal domain-like › L-aspartase C-terminal domain-like › ASL_C2 0.67 50.0 4.01e-01 90.2% 40.0%
5036826 4953.1.1.4 beta barrels › L-aspartase C-terminal domain-like › L-aspartase C-terminal domain-like › L-aspartase C-terminal domain-like › ASL_C2 0.67 55.0 4.51e-01 95.1% 51.2%
4022241 141.1.1.8 alpha bundles › Terpenoid synthases › Terpenoid synthases › Terpenoid synthases › Terpene_syn_C_2 0.67 57.0 3.62e-01 100.0% 38.8%
4534032 4953.1.1.0 beta barrels › L-aspartase C-terminal domain-like › L-aspartase C-terminal domain-like › L-aspartase C-terminal domain-like 0.66 49.0 4.38e-01 82.9% 66.7%
3923696 198.1.1.0 alpha arrays › Saposin-like › Saposin-like › Saposin-like 0.65 50.0 3.94e-01 90.2% 38.9%
3837790 284.1.3.0 a+b two layers › FKBP-like › FKBP-like › WNK1 autoinhibitory domain 0.65 47.0 3.56e-01 80.5% 37.3%
5058985 7064.1.1.1 alpha bundles › Transmembrane domain of VIT1 › Transmembrane domain of VIT1 › Transmembrane domain of VIT1 › VIT1 0.64 52.0 3.60e-01 100.0% 43.1%
3925672 101.1.1.0 alpha arrays › HTH › HTH › Three-helical HTH 0.63 52.0 4.32e-01 100.0% 62.5%
5064002 7523.1.1.17 a/b three-layered sandwiches › Periplasmic binding protein-like II › Periplasmic binding protein-like II › Periplasmic binding protein-like II › OpuAC 0.63 51.0 3.64e-01 97.6% 29.0%
3253152 198.1.1.3 alpha arrays › Saposin-like › Saposin-like › Saposin-like › SapB_1 0.62 47.0 3.78e-01 90.2% 38.9%
3484301 102.1.1.0 alpha arrays › HhH/H2TH › SAM/DNA-glycosylase › SAM domain-like 0.62 44.0 3.10e-01 82.9% 27.5%
4596871 5065.1.1.1 alpha bundles › Type II ABC importer transmembrane domain fold › Type II ABC importer transmembrane domain fold › Type II ABC importer transmembrane domain fold › ABC-3 0.61 49.0 2.99e-01 100.0% 41.0%
3979831 148.1.3.0 alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain 0.60 45.0 4.01e-01 87.8% 55.4%
4999398 1075.5.1.1 alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › MatE 0.60 51.0 3.12e-01 100.0% 15.7%
5065662 5058.1.1.0 alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region 0.59 48.0 4.16e-01 100.0% 55.7%