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IMGVR_UViG_3300007863_000693-3300007863-Ga0105744_10018317
Arc-VirIMGVR_UViG_3300007863_000693-3300007863-Ga0105744_10018317
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 1-37_328-427
Domain cluster:
representative
CATH (24)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 8e9gK01 | 1.10.287.3510 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.68 | 39.0 | 4.68e-01 | 78.8% | 83.5% |
| 2wdqC00 | 1.20.1300.10 | Mainly Alpha › Up-down Bundle › 3 helical TM bundles of succinate and fumarate reductases › Fumarate reductase/succinate dehydrogenase, transmembrane subunit | 0.67 | 47.0 | 5.01e-01 | 75.9% | 81.8% |
| 1w9rA00 | 1.20.58.440 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › choline binding protein A | 0.65 | 43.0 | 4.57e-01 | 78.1% | 75.6% |
| 3pvlA03 | 1.20.80.10 | Mainly Alpha › Up-down Bundle › Acyl-CoA Binding Protein › | 0.64 | 31.0 | 3.38e-01 | 75.2% | 52.5% |
| 6lumG01 | 1.20.1300.10 | Mainly Alpha › Up-down Bundle › 3 helical TM bundles of succinate and fumarate reductases › Fumarate reductase/succinate dehydrogenase, transmembrane subunit | 0.64 | 45.0 | 4.95e-01 | 74.5% | 88.4% |
| 3rkoG00 | 1.10.287.3510 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.60 | 42.0 | 4.83e-01 | 86.9% | 99.0% |
| 1rzhL01 | 1.20.85.10 | Mainly Alpha › Up-down Bundle › Photosynthetic Reaction Center, subunit M; domain 1 › Photosystem II protein D1-like | 0.59 | 47.0 | 4.48e-01 | 84.7% | 88.3% |
| 7f16R01 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.59 | 45.0 | 3.59e-01 | 81.8% | 41.5% |
| 7cafA01 | 1.10.3720.10 | Mainly Alpha › Orthogonal Bundle › MetI-like fold › MetI-like | 0.58 | 42.0 | 3.41e-01 | 76.6% | 58.8% |
| 2wdqD00 | 1.20.1300.10 | Mainly Alpha › Up-down Bundle › 3 helical TM bundles of succinate and fumarate reductases › Fumarate reductase/succinate dehydrogenase, transmembrane subunit | 0.57 | 42.0 | 4.69e-01 | 78.1% | 99.0% |
| 3cf6E03 | 1.20.870.10 | Mainly Alpha › Up-down Bundle › Son of sevenless (SoS) protein; Chain S, domain 1 › Son of sevenless (SoS) protein Chain: S domain 1 | 0.56 | 29.0 | 3.02e-01 | 81.0% | 51.1% |
| 8a1gC01 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.56 | 42.0 | 3.82e-01 | 77.4% | 85.6% |
| 1jadA00 | 1.20.1230.10 | Mainly Alpha › Up-down Bundle › Phospholipase C Beta; Chain: A › Phospholipase C beta, distal C-terminal domain | 0.56 | 46.0 | 3.87e-01 | 89.1% | 89.7% |
| 3mcpA02 | 3.30.420.40 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain | 0.55 | 38.0 | 3.14e-01 | 70.1% | 49.8% |
| 2qr4A01 | 1.20.140.70 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Oligopeptidase f, N-terminal domain | 0.55 | 44.0 | 4.24e-01 | 85.4% | 79.5% |
| 4ysxC00 | 1.20.1300.10 | Mainly Alpha › Up-down Bundle › 3 helical TM bundles of succinate and fumarate reductases › Fumarate reductase/succinate dehydrogenase, transmembrane subunit | 0.54 | 41.0 | 3.99e-01 | 79.6% | 69.9% |
| 2j0jA02 | 1.20.80.10 | Mainly Alpha › Up-down Bundle › Acyl-CoA Binding Protein › | 0.54 | 29.0 | 3.11e-01 | 78.8% | 57.4% |
| 3mpxA01 | 1.20.900.10 | Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain | 0.53 | 36.0 | 3.18e-01 | 74.5% | 45.6% |
| 3i3lA01 | 3.50.50.60 | Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain | 0.53 | 43.0 | 3.07e-01 | 86.1% | 96.9% |
| 6xj1A01 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.52 | 38.0 | 3.09e-01 | 75.2% | 83.7% |
| 4xt1A00 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.52 | 42.0 | 3.28e-01 | 86.1% | 64.9% |
| 1s35A02 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.51 | 38.0 | 4.17e-01 | 85.4% | 95.5% |
| 2lqgA00 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.50 | 36.0 | 3.64e-01 | 79.6% | 73.2% |
| 7nc3F01 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.50 | 33.0 | 3.63e-01 | 79.6% | 80.7% |
ECOD (23)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3915925 | 5069.1.3.98 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Fumarate reductase respiratory complex transmembrane subunits › ARL6IP6 | 0.75 | 52.0 | 6.03e-01 | 80.3% | 98.0% |
| 3376682 | 5069.1.3.88 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Fumarate reductase respiratory complex transmembrane subunits › PGG | 0.68 | 48.0 | 5.45e-01 | 77.4% | 95.2% |
| 5063352 | 5060.2.1.1 ↗ | alpha bundles › V-type ATP synthase subunit C › Toxin coregulated pilus biosynthesis protein E cytoplasmic domain › Toxin coregulated pilus biosynthesis protein E cytoplasmic domain › T2SSF | 0.65 | 35.0 | 3.58e-01 | 85.4% | 53.1% |
| 3949246 | 601.4.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains | 0.65 | 39.0 | 3.66e-01 | 71.5% | 49.7% |
| 4987764 | 601.2.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Cytochromes › Cytochromes | 0.62 | 42.0 | 4.24e-01 | 84.7% | 67.9% |
| 4855948 | 5001.1.1.1 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1 | 0.62 | 37.0 | 4.06e-01 | 71.5% | 71.7% |
| None | — | 0.61 | 51.0 | 3.87e-01 | 88.3% | 75.2% | |
| 3601466 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.61 | 46.0 | 2.79e-01 | 78.1% | 20.0% |
| 3238246 | 150.1.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin | 0.60 | 35.0 | 3.89e-01 | 77.4% | 70.9% |
| 4020912 | 5001.1.1.85 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Fung_rhodopsin | 0.59 | 47.0 | 3.76e-01 | 83.9% | 77.4% |
| 3920855 | 3861.1.1.3 ↗ | alpha bundles › Mitochondrial translocator protein (TSPO) › Mitochondrial translocator protein (TSPO) › Mitochondrial translocator protein (TSPO) › PF30661 | 0.58 | 45.0 | 3.64e-01 | 81.8% | 68.0% |
| 3371343 | 3755.4.1.0 ↗ | alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain | 0.56 | 46.0 | 4.16e-01 | 85.4% | 85.0% |
| 3276672 | 604.3.1.1 ↗ | alpha bundles › Spectrin repeat-like › BAG domain › BAG domain › BAG | 0.56 | 40.0 | 4.15e-01 | 83.2% | 77.7% |
| 3742906 | 6155.1.1.2 ↗ | alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter › PQ-loop | 0.55 | 38.0 | 3.94e-01 | 86.1% | 76.0% |
| 3601767 | 601.1.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin | 0.55 | 42.0 | 4.03e-01 | 83.2% | 69.7% |
| 3965811 | 3711.1.1.0 ↗ | alpha bundles › LTXXQ motif family protein › LTXXQ motif family protein › LTXXQ motif family protein | 0.54 | 36.0 | 4.05e-01 | 73.7% | 86.2% |
| 3589541 | 5082.1.1.1 ↗ | alpha bundles › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation_efflux | 0.54 | 44.0 | 3.94e-01 | 86.1% | 77.9% |
| 4556307 | 3563.1.1.1 ↗ | alpha bundles › Twin arginine protein translocation system component TatC › Twin arginine protein translocation system component TatC › Twin arginine protein translocation system component TatC › TatC | 0.52 | 46.0 | 3.88e-01 | 97.1% | 64.3% |
| 3605145 | 603.1.1.97 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins › Syntaxin, SNARE | 0.52 | 43.0 | 3.47e-01 | 86.9% | 93.6% |
| 3621149 | 4177.1.1.0 ↗ | alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like | 0.51 | 38.0 | 3.30e-01 | 79.6% | 75.1% |
| 1140569 | 101.34.1.1 ↗ | alpha arrays › HTH › Transcription factor LEAFY › Transcription factor LEAFY › C_LFY_FLO | 0.50 | 38.0 | 3.64e-01 | 78.8% | 82.3% |
| 4024773 | 633.10.1.0 ↗ | alpha bundles › Bromodomain-like › IVS-encoded protein-like › IVS-encoded protein-like | 0.50 | 40.0 | 3.78e-01 | 86.1% | 96.5% |
| 3483996 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.50 | 36.0 | 3.93e-01 | 81.0% | 90.9% |
D2
medium
residues 38-118_428-441
Domain cluster:
representative
CATH (53)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1sziA02 | 1.20.120.340 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Flagellar protein FliS | 0.69 | 57.0 | 5.03e-01 | 100.0% | 62.0% |
| 3kavA00 | 1.20.1270.360 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.69 | 53.0 | 5.19e-01 | 98.9% | 75.5% |
| 4bg5B00 | 1.10.3160.10 | Mainly Alpha › Orthogonal Bundle › Bbcrasp-1 › Bbcrasp-1 | 0.69 | 61.0 | 4.77e-01 | 97.9% | 55.8% |
| 4o6yB00 | 1.20.120.1770 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › | 0.68 | 62.0 | 4.75e-01 | 100.0% | 48.8% |
| 1qdbA02 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.67 | 56.0 | 4.93e-01 | 100.0% | 60.8% |
| 1jmwA00 | 1.20.120.30 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Aspartate receptor, ligand-binding domain | 0.67 | 56.0 | 4.84e-01 | 100.0% | 58.9% |
| 2yfaB01 | 1.20.1440.210 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › | 0.65 | 54.0 | 5.04e-01 | 100.0% | 73.1% |
| 1zzpA00 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.65 | 51.0 | 4.87e-01 | 97.9% | 73.4% |
| 1oahA02 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.65 | 58.0 | 5.04e-01 | 100.0% | 66.2% |
| 4p9tA01 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.64 | 54.0 | 5.05e-01 | 100.0% | 73.3% |
| 1oj7A02 | 1.20.1090.10 | Mainly Alpha › Up-down Bundle › Dehydroquinate synthase-like, alpha domain › Dehydroquinate synthase-like - alpha domain | 0.64 | 49.0 | 3.83e-01 | 98.9% | 37.7% |
| 3lmfA00 | 1.20.1270.360 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.64 | 52.0 | 5.04e-01 | 100.0% | 78.0% |
| 1avoB00 | 1.20.120.180 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Proteasome activator pa28, C-terminal domain | 0.63 | 57.0 | 4.99e-01 | 100.0% | 87.9% |
| 1y4cA03 | 1.20.120.660 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › IL-4 antagonist (De novo design) like domain | 0.63 | 48.0 | 4.62e-01 | 100.0% | 70.8% |
| 2z1qB04 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.63 | 54.0 | 4.80e-01 | 100.0% | 66.2% |
| 2kmfA01 | 1.20.58.810 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Photosystem II Pbs27 | 0.62 | 49.0 | 4.81e-01 | 100.0% | 77.5% |
| 8gi9A01 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.62 | 54.0 | 4.18e-01 | 100.0% | 97.0% |
| 3pwxA01 | 1.20.1330.10 | Mainly Alpha › Up-down Bundle › f41 fragment of flagellin, N-terminal domain › f41 fragment of flagellin, N-terminal domain | 0.62 | 51.0 | 4.14e-01 | 100.0% | 46.7% |
| 3t6gB00 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.62 | 53.0 | 4.75e-01 | 100.0% | 67.2% |
| 6l1kA02 | 1.20.1090.10 | Mainly Alpha › Up-down Bundle › Dehydroquinate synthase-like, alpha domain › Dehydroquinate synthase-like - alpha domain | 0.62 | 47.0 | 3.73e-01 | 94.7% | 39.1% |
| 1w9rA00 | 1.20.58.440 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › choline binding protein A | 0.62 | 49.0 | 4.62e-01 | 87.4% | 70.6% |
| 4gycA00 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.61 | 53.0 | 4.12e-01 | 100.0% | 97.7% |
| 7zxkC01 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.61 | 46.0 | 3.95e-01 | 94.7% | 50.7% |
| 8g59R01 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.61 | 54.0 | 3.94e-01 | 100.0% | 100.0% |
| 4jvsA01 | 1.20.120.1700 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › | 0.60 | 53.0 | 4.90e-01 | 98.9% | 96.0% |
| 2yyiA03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.60 | 54.0 | 4.18e-01 | 100.0% | 47.4% |
| 1u7lA02 | 1.20.1460.10 | Mainly Alpha › Up-down Bundle › subunit c (vma5p) of the yeast v-atpase, domain 2 › subunit c (vma5p) of the yeast v-atpase, domain 2 | 0.60 | 43.0 | 3.48e-01 | 74.7% | 73.2% |
| 4hr1A00 | 1.20.1270.410 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.60 | 53.0 | 4.97e-01 | 98.9% | 82.2% |
| 8b70A01 | 1.20.1740.10 | Mainly Alpha › Up-down Bundle › Amino acid/polyamine transporter I › Amino acid/polyamine transporter I | 0.60 | 50.0 | 3.31e-01 | 93.7% | 78.0% |
| 8etcb01 | 1.20.120.1190 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › | 0.59 | 52.0 | 4.57e-01 | 100.0% | 74.0% |
| 1aepA00 | 1.20.120.20 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Apolipoprotein | 0.59 | 51.0 | 4.44e-01 | 97.9% | 98.0% |
| 2d4uB00 | 1.20.120.30 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Aspartate receptor, ligand-binding domain | 0.59 | 51.0 | 4.46e-01 | 100.0% | 69.7% |
| 3nf2A00 | 1.10.600.10 | Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase | 0.59 | 48.0 | 3.32e-01 | 89.5% | 32.2% |
| 7eq1R01 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.59 | 52.0 | 3.77e-01 | 100.0% | 90.4% |
| 4m70I00 | 1.20.5.4130 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › | 0.58 | 47.0 | 4.51e-01 | 92.6% | 75.9% |
| 1yo7A00 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.58 | 52.0 | 4.86e-01 | 100.0% | 81.7% |
| 1kqfC00 | 1.20.950.20 | Mainly Alpha › Up-down Bundle › Fumarate Reductase Cytochrome B subunit › Transmembrane di-heme cytochromes, Chain C | 0.58 | 51.0 | 4.01e-01 | 100.0% | 56.9% |
| 3ajmB02 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.58 | 50.0 | 4.51e-01 | 100.0% | 69.2% |
| 1yjgA00 | 1.20.120.240 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Lipoprotein, type 6 | 0.58 | 52.0 | 4.44e-01 | 100.0% | 65.6% |
| 6lumD01 | 1.20.1300.10 | Mainly Alpha › Up-down Bundle › 3 helical TM bundles of succinate and fumarate reductases › Fumarate reductase/succinate dehydrogenase, transmembrane subunit | 0.58 | 47.0 | 4.31e-01 | 88.4% | 83.2% |
| 2oezA02 | 1.10.3900.10 | Mainly Alpha › Orthogonal Bundle › YacF-like › YacF-like | 0.58 | 49.0 | 4.22e-01 | 98.9% | 76.7% |
| 3pltA00 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.57 | 50.0 | 3.94e-01 | 100.0% | 76.2% |
| 1xfiA02 | 1.20.1700.10 | Mainly Alpha › Up-down Bundle › AF1104-like › AF1104-like | 0.55 | 43.0 | 4.40e-01 | 98.9% | 87.8% |
| 4g12A02 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.55 | 39.0 | 3.43e-01 | 83.2% | 48.3% |
| 4id0A02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.54 | 38.0 | 3.67e-01 | 73.7% | 63.4% |
| 2m6uA00 | 1.20.81.20 | Mainly Alpha › Up-down Bundle › Receptor-associated Protein › | 0.54 | 43.0 | 4.60e-01 | 100.0% | 100.0% |
| 4nqiD00 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.54 | 47.0 | 3.61e-01 | 100.0% | 78.9% |
| 5tj5E00 | 1.20.120.610 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › lithium bound rotor ring of v- atpase | 0.54 | 47.0 | 4.21e-01 | 100.0% | 74.6% |
| 3fedA03 | 1.20.930.40 | Mainly Alpha › Up-down Bundle › Transcription Elongation Factor S-II; Chain A › Transferrin receptor-like, dimerisation domain | 0.53 | 48.0 | 4.06e-01 | 100.0% | 78.1% |
| 4bejB02 | 1.20.120.1240 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Dynamin, middle domain | 0.52 | 42.0 | 3.16e-01 | 85.3% | 49.8% |
| 1kxpD02 | 1.10.246.10 | Mainly Alpha › Orthogonal Bundle › Serum Albumin; Chain A, Domain 1 › | 0.52 | 41.0 | 4.20e-01 | 100.0% | 94.3% |
| 2wdqD00 | 1.20.1300.10 | Mainly Alpha › Up-down Bundle › 3 helical TM bundles of succinate and fumarate reductases › Fumarate reductase/succinate dehydrogenase, transmembrane subunit | 0.51 | 43.0 | 4.20e-01 | 95.8% | 96.2% |
| 1zylA03 | 1.20.1270.170 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.50 | 41.0 | 4.02e-01 | 94.7% | 84.5% |
ECOD (63)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3215515 | 632.1.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain | 0.70 | 58.0 | 5.97e-01 | 100.0% | 93.3% |
| 3336154 | 3562.1.1.11 ↗ | alpha bundles › Calcium release-activated calcium channel protein 1 › Calcium release-activated calcium channel protein 1 › Calcium release-activated calcium channel protein 1 › PGG | 0.70 | 58.0 | 5.25e-01 | 100.0% | 65.4% |
| 3422266 | 3562.1.1.0 ↗ | alpha bundles › Calcium release-activated calcium channel protein 1 › Calcium release-activated calcium channel protein 1 › Calcium release-activated calcium channel protein 1 | 0.70 | 64.0 | 5.82e-01 | 100.0% | 78.4% |
| 3312652 | 633.21.1.18 ↗ | alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 › CASP_dom | 0.69 | 59.0 | 5.07e-01 | 100.0% | 58.7% |
| 4013272 | 5001.1.1.85 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Fung_rhodopsin | 0.69 | 62.0 | 4.92e-01 | 100.0% | 93.3% |
| 3210375 | 5001.1.1.85 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Fung_rhodopsin | 0.69 | 62.0 | 4.56e-01 | 100.0% | 94.8% |
| 5018554 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.69 | 60.0 | 5.97e-01 | 94.7% | 96.0% |
| 3258488 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.68 | 47.0 | 4.70e-01 | 72.6% | 100.0% |
| 3689697 | 605.4.1.8 ↗ | alpha duplicates or obligate multimers › ROP-like › ROP protein › ROP protein › MARVEL | 0.68 | 58.0 | 5.94e-01 | 97.9% | 98.9% |
| 3253784 | 4177.1.1.0 ↗ | alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like | 0.67 | 61.0 | 4.65e-01 | 100.0% | 71.8% |
| 4261813 | 4177.2.1.4 ↗ | alpha duplicates or obligate multimers › BAR/IMD domain-like › Inhibitor of kappaB kinase beta dimerization domain › Inhibitor of kappaB kinase beta dimerization domain › ATG17_like | 0.67 | 62.0 | 4.19e-01 | 100.0% | 69.8% |
| 4026761 | 5001.1.1.31 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › GPR180-TMEM145_TM | 0.67 | 60.0 | 4.39e-01 | 100.0% | 90.8% |
| 4138735 | 632.22.1.1 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats › EzrA | 0.66 | 59.0 | 5.88e-01 | 100.0% | 99.0% |
| 4175767 | 632.22.1.1 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats › EzrA | 0.66 | 59.0 | 5.76e-01 | 100.0% | 94.3% |
| 3249357 | 611.8.1.1 ↗ | alpha bundles › N-cbl like › C-terminal domain of E3 ubiquitin-protein ligase ARIH1 › C-terminal domain of E3 ubiquitin-protein ligase ARIH1 › Ariadne | 0.66 | 60.0 | 5.07e-01 | 100.0% | 64.5% |
| 3189881 | 3562.1.1.34 ↗ | alpha bundles › Calcium release-activated calcium channel protein 1 › Calcium release-activated calcium channel protein 1 › Calcium release-activated calcium channel protein 1 › DUF2985 | 0.66 | 59.0 | 4.63e-01 | 100.0% | 58.0% |
| 3216584 | 632.1.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain | 0.66 | 53.0 | 5.34e-01 | 100.0% | 88.4% |
| 3364515 | 611.7.1.11 ↗ | alpha bundles › N-cbl like › Mixed lineage kinase domain-like (MLKL) N-terminal domain › Mixed lineage kinase domain-like (MLKL) N-terminal domain › DUF7032 | 0.65 | 57.0 | 5.13e-01 | 100.0% | 69.6% |
| 5023098 | 632.22.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats | 0.65 | 59.0 | 5.36e-01 | 100.0% | 83.2% |
| 3508301 | 5069.1.3.0 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Fumarate reductase respiratory complex transmembrane subunits | 0.65 | 52.0 | 4.31e-01 | 88.4% | 52.6% |
| 3802240 | 632.1.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain | 0.64 | 58.0 | 5.73e-01 | 100.0% | 97.0% |
| 3573589 | 632.22.1.1 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats › EzrA | 0.64 | 57.0 | 5.67e-01 | 100.0% | 99.0% |
| 3209446 | 632.22.1.131 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats › SOG2 | 0.64 | 57.0 | 5.13e-01 | 100.0% | 73.3% |
| 3445405 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.64 | 56.0 | 5.16e-01 | 100.0% | 75.8% |
| 4020994 | 5069.1.1.0 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes | 0.64 | 57.0 | 4.96e-01 | 100.0% | 67.6% |
| 5018556 | 632.22.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats | 0.64 | 57.0 | 5.35e-01 | 100.0% | 87.8% |
| 4033032 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.64 | 57.0 | 5.03e-01 | 100.0% | 70.0% |
| 4025051 | 601.30.1.1 ↗ | alpha bundles › Four-helical up-and-down bundle › Helical bundle domain in hypothetical protein PH1320 › Helical bundle domain in hypothetical protein PH1320 › NOG1_N | 0.63 | 55.0 | 4.84e-01 | 100.0% | 80.0% |
| 3578008 | 601.1.2.100 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › PF31009 | 0.63 | 55.0 | 4.77e-01 | 100.0% | 72.3% |
| 3479389 | 601.1.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin | 0.63 | 56.0 | 4.54e-01 | 100.0% | 54.6% |
| 3553221 | 632.22.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats | 0.63 | 53.0 | 4.92e-01 | 100.0% | 74.2% |
| 4095048 | 632.7.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Heat shock protein 70kD (HSP70), C-terminal subdomain › Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.63 | 53.0 | 4.91e-01 | 100.0% | 74.2% |
| 3717920 | 150.1.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin | 0.62 | 56.0 | 4.77e-01 | 100.0% | 61.3% |
| 3591756 | 601.29.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › TM1646-like › TM1646-like | 0.62 | 54.0 | 4.89e-01 | 98.9% | 72.6% |
| 3218038 | 632.7.1.25 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Heat shock protein 70kD (HSP70), C-terminal subdomain › Heat shock protein 70kD (HSP70), C-terminal subdomain › PF27508 | 0.62 | 56.0 | 5.63e-01 | 100.0% | 100.0% |
| 4352674 | 632.1.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain | 0.61 | 50.0 | 4.85e-01 | 95.8% | 80.0% |
| 3724548 | 611.7.1.10 ↗ | alpha bundles › N-cbl like › Mixed lineage kinase domain-like (MLKL) N-terminal domain › Mixed lineage kinase domain-like (MLKL) N-terminal domain › Helo_like_N | 0.61 | 55.0 | 4.89e-01 | 100.0% | 77.8% |
| 3649632 | 611.9.1.4 ↗ | alpha bundles › N-cbl like › Resistance protein (Rx) N-terminal domain › Resistance protein (Rx) N-terminal domain › Rx_N | 0.61 | 52.0 | 4.58e-01 | 100.0% | 63.6% |
| 3689908 | 3755.4.1.0 ↗ | alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain | 0.61 | 53.0 | 4.93e-01 | 98.9% | 79.2% |
| 5011612 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.61 | 55.0 | 4.94e-01 | 100.0% | 76.2% |
| 3792421 | 632.7.1.1 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Heat shock protein 70kD (HSP70), C-terminal subdomain › Heat shock protein 70kD (HSP70), C-terminal subdomain › HSP70 | 0.61 | 54.0 | 4.32e-01 | 98.9% | 49.5% |
| 3697868 | 4207.1.1.65 ↗ | alpha duplicates or obligate multimers › Mediator hinge subcomplex-like › Mediator hinge subcomplex-like › RNA polymerase II holoenzyme component SRB7 (MED21) › DUF2985 | 0.61 | 53.0 | 4.12e-01 | 100.0% | 52.7% |
| 3306934 | 632.1.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain | 0.60 | 53.0 | 5.11e-01 | 100.0% | 95.5% |
| 3709603 | 5069.1.1.0 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes | 0.60 | 53.0 | 4.68e-01 | 100.0% | 67.6% |
| 3297061 | 632.1.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain | 0.60 | 53.0 | 5.05e-01 | 100.0% | 85.2% |
| 3315624 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.60 | 52.0 | 4.99e-01 | 96.8% | 87.3% |
| 3862609 | 601.1.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin | 0.60 | 53.0 | 4.82e-01 | 100.0% | 86.9% |
| 3804223 | 633.4.1.1 ↗ | alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI | 0.60 | 53.0 | 4.45e-01 | 100.0% | 58.2% |
| 3484110 | 5001.1.1.0 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like | 0.60 | 52.0 | 3.76e-01 | 100.0% | 92.9% |
| 3775375 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.60 | 52.0 | 4.53e-01 | 97.9% | 68.7% |
| 3423999 | 601.1.2.74 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › Rx_N | 0.60 | 52.0 | 4.67e-01 | 100.0% | 77.1% |
| 3271750 | 601.1.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin | 0.60 | 51.0 | 3.66e-01 | 100.0% | 32.8% |
| 3933742 | 174.1.1.0 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain | 0.59 | 45.0 | 3.83e-01 | 100.0% | 48.8% |
| 3587197 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.59 | 53.0 | 4.54e-01 | 100.0% | 67.3% |
| 4968618 | 611.6.1.0 ↗ | alpha bundles › N-cbl like › PT26-6P helical domain › PT26-6P helical domain | 0.59 | 48.0 | 4.84e-01 | 100.0% | 90.8% |
| 3445666 | 601.1.2.74 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › Rx_N | 0.58 | 49.0 | 4.42e-01 | 95.8% | 83.7% |
| 3377749 | 3843.1.1.15 ↗ | alpha complex topology › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › ETR1_N | 0.58 | 46.0 | 4.61e-01 | 91.6% | 84.0% |
| 4017411 | 3755.4.1.0 ↗ | alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain | 0.57 | 50.0 | 4.39e-01 | 100.0% | 74.7% |
| 3577293 | 633.22.1.0 ↗ | alpha bundles › Bromodomain-like › Vitamin K epoxide reductase (VKOR) › Vitamin K epoxide reductase (VKOR) | 0.55 | 49.0 | 4.00e-01 | 98.9% | 61.1% |
| 4878961 | 5001.1.1.1 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1 | 0.54 | 46.0 | 4.50e-01 | 95.8% | 88.8% |
| 3959034 | 633.6.1.0 ↗ | alpha bundles › Bromodomain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA dehydrogenase C-terminal domain-like | 0.54 | 47.0 | 3.77e-01 | 97.9% | 82.6% |
| 3520876 | 3352.1.1.19 ↗ | alpha bundles › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › Mannosyl_trans2 | 0.52 | 44.0 | 2.90e-01 | 98.9% | 21.4% |
| 3265093 | 5059.1.1.0 ↗ | alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter | 0.52 | 44.0 | 3.06e-01 | 94.7% | 61.3% |
D3
medium
residues 119-142_192-214_248-327
Domain cluster:
representative
CATH (10)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1op1A00 | 1.20.81.10 | Mainly Alpha › Up-down Bundle › Receptor-associated Protein › RAP domain | 0.64 | 34.0 | 4.21e-01 | 79.5% | 81.7% |
| 3fvvA02 | 1.20.1440.100 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › SG protein - dephosphorylation function | 0.57 | 28.0 | 3.50e-01 | 81.1% | 76.0% |
| 4lunU00 | 1.25.40.180 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.56 | 39.0 | 2.93e-01 | 70.9% | 43.7% |
| 4rm7A03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.55 | 35.0 | 3.42e-01 | 70.1% | 59.0% |
| 2rldA00 | 1.20.1440.60 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 23S rRNA-intervening sequence | 0.55 | 34.0 | 3.60e-01 | 85.8% | 69.3% |
| 1tjlA00 | 1.20.120.910 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › DksA, coiled-coil domain | 0.54 | 38.0 | 3.65e-01 | 72.4% | 93.8% |
| 2d4uB00 | 1.20.120.30 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Aspartate receptor, ligand-binding domain | 0.52 | 40.0 | 3.76e-01 | 81.1% | 70.3% |
| 6kd7A00 | 1.10.600.10 | Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase | 0.52 | 41.0 | 3.06e-01 | 84.3% | 44.3% |
| 4xaiB02 | 1.10.565.10 | Mainly Alpha › Orthogonal Bundle › Retinoid X Receptor › Retinoid X Receptor | 0.51 | 43.0 | 3.72e-01 | 90.6% | 76.0% |
| 2om6A02 | 1.10.150.400 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › | 0.50 | 29.0 | 3.69e-01 | 81.9% | 93.7% |
ECOD (3)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 5054079 | 192.4.1.0 ↗ | alpha bundles › Long alpha-hairpin › Ribosomal protein L29 (L29p) › Ribosomal protein L29 (L29p) | 0.64 | 39.0 | 4.75e-01 | 73.2% | 95.0% |
| 4877500 | 5001.1.1.1 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1 | 0.59 | 40.0 | 4.41e-01 | 73.2% | 85.4% |
| 3517291 | 192.29.1.24 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › TMEM237 | 0.53 | 42.0 | 3.71e-01 | 81.9% | 83.9% |