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IMGVR_UViG_3300011438_000020-3300011438-Ga0137451_100004553

Arc-Vir

IMGVR_UViG_3300011438_000020-3300011438-Ga0137451_100004553

Quality

75.8 mean pLDDT

Cluster

Singleton — not in a non-trivial cluster

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 144-190
PDB
Domain cluster: representative
CATH (39)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2ib0A01 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.93 79.0 5.50e-01 91.5% 32.6%
2y39A00 1.20.120.1490 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › 0.91 83.0 6.18e-01 100.0% 48.2%
1rq0A01 6.10.140.160 Special › Helix non-globular › Helix Hairpins › 0.90 82.0 6.70e-01 100.0% 57.8%
3fseB02 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.90 78.0 5.39e-01 95.7% 31.9%
3m1cB01 3.30.390.170 Alpha Beta › 2-Layer Sandwich › Enolase-like; domain 1 › 0.89 59.0 4.34e-01 74.5% 29.4%
4abmD00 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.89 80.0 6.73e-01 100.0% 64.9%
2qf9A01 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.89 77.0 5.22e-01 95.7% 29.5%
2ic6A00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.88 79.0 6.84e-01 100.0% 81.7%
6whbA01 1.25.10.10 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant 0.88 65.0 3.91e-01 80.9% 13.4%
1x4tA01 1.10.287.660 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin 0.87 73.0 6.84e-01 93.6% 79.3%
3b2eF00 1.10.287.660 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin 0.87 76.0 6.92e-01 97.9% 80.6%
4l0rB00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.87 76.0 6.60e-01 100.0% 65.8%
2nwlC00 1.10.3860.10 Mainly Alpha › Orthogonal Bundle › Proton glutamate symport protein › Sodium:dicarboxylate symporter 0.86 77.0 4.43e-01 100.0% 34.0%
1w63A00 1.25.10.10 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant 0.86 59.0 3.27e-01 72.3% 5.8%
2gv9A05 1.10.287.690 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › B family DNA polymerase, finger domain 0.86 72.0 6.64e-01 97.9% 72.9%
3nyjA00 1.20.120.770 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Amyloid precursor protein, E2 domain 0.86 76.0 5.03e-01 100.0% 32.0%
1yxrA01 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.85 70.0 6.01e-01 91.5% 60.8%
1hqoA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.85 73.0 5.28e-01 97.9% 41.2%
1vw4L01 3.90.1030.10 Alpha Beta › Alpha-Beta Complex › 50s Ribosomal Protein L17; Chain: A, › Ribosomal protein L17 0.84 58.0 4.05e-01 72.3% 25.2%
6a7hA01 1.20.140.180 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › 0.83 63.0 4.50e-01 87.2% 29.5%
2psmA00 1.20.1250.70 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › Interleukin-15/Interleukin-21 0.82 63.0 4.69e-01 87.2% 34.2%
3c5wA00 1.25.10.10 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant 0.82 57.0 3.60e-01 74.5% 15.8%
3hr0B01 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.81 70.0 5.95e-01 100.0% 67.1%
1zhcA00 6.10.280.50 Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.81 70.0 6.01e-01 100.0% 68.4%
7nc3F01 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.80 69.0 5.11e-01 95.7% 43.9%
2b5dX01 3.20.110.10 Alpha Beta › Alpha-Beta Barrel › 7-stranded beta/alpha barrel › Glycoside hydrolase 38, N terminal domain 0.79 70.0 4.01e-01 97.9% 23.5%
3rx6A00 1.20.58.1090 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phage polarity suppression protein monomer 0.77 67.0 4.48e-01 100.0% 28.3%
4o92A02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.77 64.0 4.91e-01 93.6% 44.8%
2lhrA00 1.20.58.1270 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.75 60.0 5.13e-01 93.6% 53.8%
4h63H01 1.20.58.1710 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.75 64.0 5.56e-01 95.7% 68.1%
2clbA01 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.74 65.0 4.52e-01 100.0% 64.2%
1o7dC01 1.20.1270.50 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Glycoside hydrolase family 38, central domain 0.74 60.0 5.66e-01 97.9% 82.0%
4errB00 1.20.58.1190 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.72 60.0 4.99e-01 93.6% 53.0%
7zb5E01 3.40.50.10810 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Tandem AAA-ATPase domain 0.70 56.0 3.36e-01 87.2% 41.6%
3h36A00 1.10.10.400 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Polyribonucleotide nucleotidyltransferase, RNA-binding domain 0.68 54.0 4.65e-01 89.4% 52.6%
4q5rA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.68 58.0 4.48e-01 100.0% 43.8%
2yxlA01 1.10.940.10 Mainly Alpha › Orthogonal Bundle › N-utilizing Substance Protein B Homolog; Chain A › NusB-like 0.67 48.0 3.34e-01 74.5% 33.6%
7a0hA01 3.30.1140.60 Alpha Beta › 2-Layer Sandwich › Ribosomal protein S3 C-terminal domain › F-actin capping protein, alpha subunit 0.63 48.0 3.65e-01 80.9% 59.4%
3bcvA00 3.90.550.10 Alpha Beta › Alpha-Beta Complex › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A 0.60 43.0 2.89e-01 78.7% 17.9%
ECOD (44)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3284609 603.1.1.0 alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.96 89.0 7.10e-01 100.0% 55.3%
3278124 605.1.1.1 alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › HisKA 0.95 89.0 6.37e-01 100.0% 39.2%
5025186 605.1.1.0 alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase 0.93 85.0 6.70e-01 100.0% 52.2%
3309308 611.3.1.1 alpha bundles › N-cbl like › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 › Med26 0.93 79.0 5.92e-01 91.5% 42.9%
4029205 109.4.1.1255 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Adaptin_N, Cnd1 0.93 85.0 4.60e-01 100.0% 6.7%
3541263 604.1.1.227 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › PF27002 0.91 84.0 5.74e-01 100.0% 33.1%
3735169 109.4.1.356 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Fungal_trans 0.91 72.0 4.08e-01 87.2% 8.9%
3585455 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.91 76.0 4.39e-01 91.5% 12.2%
5004228 109.4.1.207 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › HEAT_2 0.90 64.0 3.73e-01 74.5% 10.6%
3889547 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.89 80.0 5.22e-01 100.0% 28.4%
3855328 4006.1.1.1 alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF 0.89 80.0 6.27e-01 100.0% 49.5%
3757869 4006.1.1.0 alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain 0.89 79.0 6.22e-01 100.0% 49.5%
149872 3291.1.1.1 alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Snf7 0.88 79.0 6.61e-01 100.0% 63.3%
4998516 109.4.1.207 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › HEAT_2 0.88 61.0 3.55e-01 72.3% 9.6%
4034260 605.1.1.12 alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › DUF4870 0.88 77.0 5.70e-01 100.0% 39.2%
4015874 3291.1.1.0 alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related 0.88 78.0 5.21e-01 100.0% 26.9%
4405928 5086.1.1.196 alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › HH_YknX 0.87 78.0 6.78e-01 100.0% 67.1%
3906631 4006.1.1.1 alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF 0.87 76.0 5.76e-01 100.0% 42.7%
5027312 604.6.1.0 alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain 0.86 75.0 5.80e-01 100.0% 44.7%
3178086 109.4.1.22 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Adaptin_N 0.86 64.0 3.93e-01 78.7% 15.5%
3470144 109.4.1.1255 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Adaptin_N, Cnd1 0.86 76.0 4.16e-01 100.0% 6.9%
4466948 5060.1.1.2 alpha bundles › V-type ATP synthase subunit C › V-type ATP synthase subunit C › V-type ATP synthase subunit C › DUF2764 0.85 69.0 4.68e-01 89.4% 26.9%
4441546 4006.1.1.1 alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF 0.84 71.0 5.57e-01 95.7% 45.0%
3485099 3937.1.1.2 alpha bundles › Connexin 26 › Connexin 26 › Connexin 26 › Innexin 0.84 76.0 4.70e-01 100.0% 20.0%
2393375 633.16.1.1 alpha bundles › Bromodomain-like › PMT helical bundle domain-like › PMT helical bundle domain-like › MLD 0.84 64.0 5.32e-01 87.2% 48.8%
3503536 3711.1.1.38 alpha bundles › LTXXQ motif family protein › LTXXQ motif family protein › LTXXQ motif family protein › Patched 0.84 76.0 6.03e-01 100.0% 54.4%
3244591 3684.1.1.0 alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like 0.83 74.0 5.05e-01 100.0% 44.4%
2095477 1170.1.2.2 beta barrels › IL8-related › IL8-related › chemokine-related domain in glycoprotein L (gL) 0.83 61.0 4.30e-01 87.2% 26.6%
4027274 273.1.1.2 a+b three layers › PR-1-like › PR-1-like › PR-1-like › CEP76_C 0.83 65.0 4.53e-01 91.5% 27.6%
3297319 611.3.1.1 alpha bundles › N-cbl like › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 › Med26 0.83 74.0 5.71e-01 95.7% 48.4%
4671 192.7.1.2 alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm › Seryl_tRNA_N 0.82 71.0 5.39e-01 100.0% 41.8%
4305528 109.4.1.222 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › DCB 0.82 73.0 4.63e-01 100.0% 21.8%
3971315 4006.1.1.1 alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF 0.82 71.0 5.50e-01 100.0% 44.8%
4826095 5067.1.1.5 alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Sterol-sensing 0.81 75.0 5.84e-01 100.0% 52.7%
3605713 604.12.1.0 alpha bundles › Spectrin repeat-like › MIT domain › MIT domain 0.81 67.0 5.61e-01 95.7% 52.9%
4136151 4006.1.1.1 alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF 0.81 70.0 5.48e-01 100.0% 46.0%
3891904 109.4.1.1608 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › HEAT_Maestro_2, HEAT_MROH2B_1st 0.80 65.0 3.83e-01 91.5% 11.7%
3964469 7023.1.1.0 alpha bundles › helical ridge domain of D-alanyl transfer protein › helical ridge domain of D-alanyl transfer protein › helical ridge domain of D-alanyl transfer protein 0.80 68.0 5.04e-01 93.6% 51.3%
4980470 6155.1.1.0 alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter 0.80 70.0 5.49e-01 97.9% 48.4%
4319295 4006.1.1.1 alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF 0.79 68.0 5.31e-01 100.0% 44.8%
3210434 109.4.1.22 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Adaptin_N 0.77 55.0 3.43e-01 80.9% 14.1%
4147979 4006.1.1.1 alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF 0.76 62.0 4.94e-01 93.6% 44.0%
3717891 109.4.1.22 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Adaptin_N 0.74 67.0 3.64e-01 100.0% 6.6%
4191594 109.4.1.337 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Ipi1_N 0.69 59.0 3.44e-01 100.0% 26.5%
D2 high residues 195-364
PDB
Domain cluster: representative
CATH (25)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3vkgB06 1.20.920.20 Mainly Alpha › Up-down Bundle › Histone Acetyltransferase; Chain A › 0.77 33.0 2.86e-01 78.8% 27.8%
1dbhA01 1.20.900.10 Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain 0.70 42.0 3.86e-01 95.3% 46.9%
7akwA01 1.20.1070.10 Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins 0.66 40.0 3.63e-01 100.0% 44.1%
3mpxA01 1.20.900.10 Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain 0.66 39.0 3.64e-01 95.3% 46.6%
4rm7A03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.60 35.0 3.83e-01 97.6% 68.3%
4hyjA00 1.20.1070.10 Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins 0.60 44.0 3.98e-01 75.3% 85.6%
6q45G01 1.10.287.80 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ATP synthase, gamma subunit, helix hairpin domain 0.58 35.0 3.81e-01 78.8% 69.9%
4p9fA02 1.20.120.530 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › GntR ligand-binding domain-like 0.58 39.0 4.24e-01 99.4% 80.6%
1q16C01 1.20.950.20 Mainly Alpha › Up-down Bundle › Fumarate Reductase Cytochrome B subunit › Transmembrane di-heme cytochromes, Chain C 0.58 37.0 3.47e-01 98.8% 50.9%
2cmrA00 1.20.58.1860 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.57 40.0 3.90e-01 100.0% 63.5%
1c02A00 1.20.120.160 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain 0.57 41.0 4.18e-01 72.9% 93.4%
4xvxA03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.56 34.0 3.63e-01 100.0% 68.0%
3vkgA12 1.10.287.2610 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.56 35.0 3.21e-01 78.8% 49.3%
2l6hA00 1.20.120.330 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 0.56 42.0 4.44e-01 78.8% 87.7%
3t6gB00 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.56 41.0 4.61e-01 77.1% 99.3%
1c17M00 1.20.120.220 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › ATP synthase, F0 complex, subunit A 0.55 37.0 4.07e-01 98.2% 83.1%
1kmiZ02 1.10.287.500 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin 0.53 32.0 3.56e-01 78.2% 75.4%
6t0bc02 1.20.120.80 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c oxidase, subunit III, four-helix bundle 0.53 40.0 3.92e-01 79.4% 72.8%
2b0hA01 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.53 38.0 4.32e-01 75.9% 99.2%
1aepA00 1.20.120.20 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Apolipoprotein 0.52 39.0 4.07e-01 82.9% 84.3%
3hd6A00 1.10.3430.10 Mainly Alpha › Orthogonal Bundle › Ammonium transporter fold › Ammonium transporter AmtB like domains 0.52 42.0 3.17e-01 84.7% 92.1%
1sziA02 1.20.120.340 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Flagellar protein FliS 0.52 37.0 4.10e-01 74.7% 93.4%
2hxoA02 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.51 36.0 3.87e-01 98.8% 83.3%
2l10A00 1.20.1420.10 Mainly Alpha › Up-down Bundle › A middle domain of Talin 1 › Talin, central domain 0.51 43.0 4.47e-01 98.8% 98.1%
4dllB02 1.10.1040.10 Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 0.50 34.0 3.89e-01 94.7% 90.8%
ECOD (30)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4993122 5058.1.1.2 alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › MS_channel_1st 0.71 43.0 4.44e-01 92.9% 62.4%
5047670 3755.3.1.637 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › DUF7121 0.66 34.0 3.10e-01 78.8% 39.1%
3219989 5001.1.1.41 alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7TM_GPCR_Srw 0.64 43.0 3.37e-01 96.5% 33.1%
5056869 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.61 33.0 3.32e-01 78.2% 50.9%
3207569 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.61 35.0 3.36e-01 78.8% 49.5%
3198905 601.19.1.18 alpha bundles › Four-helical up-and-down bundle › Apolipoprotein › Apolipoprotein › Mmc1_C 0.60 39.0 4.12e-01 100.0% 73.3%
5081836 1075.5.1.1 alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › MatE 0.59 37.0 3.56e-01 95.3% 53.9%
5000026 1075.5.1.4 alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › Polysacc_synt 0.57 37.0 3.49e-01 97.6% 51.9%
3374880 3758.1.1.0 alpha bundles › Bacterial hemolysins-like › Bacterial hemolysins › Bacterial hemolysins 0.57 47.0 4.10e-01 85.3% 80.8%
4936792 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.57 33.0 3.23e-01 79.4% 53.0%
3589146 1075.5.1.4 alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › Polysacc_synt 0.56 33.0 3.23e-01 72.4% 50.3%
3621548 5079.1.1.1 alpha duplicates or obligate multimers › Magnesium transporter MgtE membrane domain › Magnesium transporter MgtE membrane domain › Magnesium transporter MgtE membrane domain › MgtE 0.56 44.0 4.03e-01 100.0% 62.8%
3313420 611.9.1.4 alpha bundles › N-cbl like › Resistance protein (Rx) N-terminal domain › Resistance protein (Rx) N-terminal domain › Rx_N 0.56 40.0 4.39e-01 80.6% 89.3%
3770290 4177.1.1.41 alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › EVC2_like 0.56 44.0 4.25e-01 100.0% 72.3%
3482286 192.8.1.0 alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain 0.56 36.0 3.37e-01 78.8% 55.0%
3251840 601.1.3.6 alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › A middle domain of Talin 1 › Talin_IBS2B 0.55 48.0 4.99e-01 100.0% 100.0%
3471896 601.1.1.6 alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › TLN1-like_RS 0.55 49.0 5.03e-01 98.8% 100.0%
3731804 5058.1.1.37 alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › PF25886 0.55 37.0 3.93e-01 95.9% 77.9%
3574609 3755.4.1.0 alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain 0.55 31.0 3.05e-01 78.2% 49.5%
151123 601.1.1.6 alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › TLN1-like_RS 0.55 50.0 5.01e-01 100.0% 98.8%
4387704 601.1.2.5 alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › TLN1-like_RS 0.54 50.0 5.01e-01 99.4% 100.0%
4569106 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.54 35.0 2.48e-01 78.8% 23.4%
3475284 5082.1.1.1 alpha bundles › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation_efflux 0.54 43.0 3.87e-01 82.9% 91.9%
3511483 601.1.3.6 alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › A middle domain of Talin 1 › Talin_IBS2B 0.54 46.0 4.78e-01 96.5% 100.0%
5001190 604.39.1.6 alpha bundles › Spectrin repeat-like › S-component of energy-coupling factor (ECF) transporters › S-component of energy-coupling factor (ECF) transporters › QueT 0.52 41.0 4.06e-01 99.4% 77.2%
3654904 3755.4.1.17 alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Rx_N 0.52 40.0 4.35e-01 79.4% 99.3%
5017125 1075.5.1.4 alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › Polysacc_synt 0.52 41.0 3.90e-01 81.8% 93.5%
3516872 4006.1.1.4 alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › TraG_N 0.51 37.0 3.57e-01 75.9% 92.0%
3863010 4177.1.1.0 alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like 0.50 47.0 3.51e-01 100.0% 46.7%
4663047 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.50 33.0 3.01e-01 78.8% 50.2%
D3 medium residues 25-81
PDB
Domain cluster: representative
CATH (16)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3pr6A00 3.30.450.70 Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › 0.75 59.0 4.38e-01 86.0% 34.5%
4mh6A00 1.10.287.1700 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.74 66.0 4.77e-01 100.0% 77.4%
2e62A01 6.10.140.420 Special › Helix non-globular › Helix Hairpins › 0.74 51.0 5.32e-01 73.7% 84.6%
4l0rB00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.73 54.0 5.05e-01 100.0% 63.0%
4abmD00 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.70 58.0 5.31e-01 100.0% 70.1%
3mhsB00 1.10.246.140 Mainly Alpha › Orthogonal Bundle › Serum Albumin; Chain A, Domain 1 › ENY2/SUS1 0.69 41.0 3.53e-01 86.0% 38.5%
3hr0B01 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.68 59.0 5.33e-01 98.2% 70.9%
6ynwH01 1.20.20.10 Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C 0.68 55.0 5.24e-01 100.0% 77.0%
4okvE00 6.10.140.1890 Special › Helix non-globular › Helix Hairpins › 0.66 51.0 4.96e-01 89.5% 75.4%
2zxqA06 1.20.1270.70 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Designed single chain three-helix bundle 0.66 41.0 3.96e-01 70.2% 54.5%
8sbeA01 1.20.1250.20 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains 0.66 51.0 3.54e-01 86.0% 51.0%
4q20A01 1.10.287.130 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Signal transduction histidine kinase, dimerisation/phosphotransfer (DHp) domain 0.64 52.0 4.78e-01 100.0% 68.3%
3kb9A00 1.10.600.10 Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase 0.63 54.0 3.36e-01 100.0% 17.9%
2x6hA03 1.10.1070.11 Mainly Alpha › Orthogonal Bundle › Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, Domain 5 › Phosphatidylinositol 3-/4-kinase, catalytic domain 0.62 48.0 3.37e-01 86.0% 77.0%
2xmoA02 1.10.246.180 Mainly Alpha › Orthogonal Bundle › Serum Albumin; Chain A, Domain 1 › 0.61 43.0 3.85e-01 78.9% 51.2%
3j27B00 1.10.8.970 Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Flavivirus envelope glycoprotein M-like 0.57 43.0 4.00e-01 82.5% 81.9%
ECOD (31)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3579493 5054.1.1.0 alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels 0.80 68.0 5.53e-01 100.0% 50.5%
3222805 5054.1.1.8 alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels › Ion_trans_2 0.79 67.0 4.25e-01 100.0% 19.6%
3570117 375.6.1.2 few secondary structure elements › Rubredoxin-like › FlhC-like › FlhC-like › PF31275 0.79 62.0 6.13e-01 89.5% 80.0%
3167091 148.1.1.12 alpha arrays › Histone-like › Histone-related › Histone › Bromo_TP 0.79 64.0 5.47e-01 91.2% 56.7%
4031490 632.2.1.5 alpha bundles › immunoglobulin/albumin-binding domain-like › Bacterial immunoglobulin/albumin-binding domains › Bacterial immunoglobulin/albumin-binding domains › DUF1542 0.78 59.0 5.35e-01 91.2% 61.3%
3500715 633.24.1.2 alpha bundles › Bromodomain-like › RABEX-5 helical domain › RABEX-5 helical domain › DUF5601 0.77 55.0 4.97e-01 80.7% 55.0%
3952366 4970.1.1.0 alpha bundles › fingers domain in bacteriophage RB69-like DNA polymerase I › fingers domain in bacteriophage RB69-like DNA polymerase I › fingers domain in bacteriophage RB69-like DNA polymerase I 0.76 55.0 5.47e-01 78.9% 73.3%
3506727 142.1.1.0 alpha complex topology › Sigma2 domain-like › Sigma2 domain of RNA polymerase sigma factors › Sigma2 domain of RNA polymerase sigma factors 0.76 66.0 5.25e-01 100.0% 51.7%
None 0.75 65.0 3.74e-01 98.2% 10.1%
3931714 3826.1.1.46 alpha bundles › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) › L27_1 0.75 65.0 5.69e-01 98.2% 64.7%
3642400 3711.1.1.4 alpha bundles › LTXXQ motif family protein › LTXXQ motif family protein › LTXXQ motif family protein › DOG1 0.74 65.0 4.37e-01 100.0% 28.2%
3863657 192.29.1.26 alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › BAG6 0.74 56.0 4.30e-01 78.9% 43.5%
5052222 3812.1.1.0 alpha bundles › Type III secretion protein YscE › Type III secretion protein YscE › Type III secretion protein YscE 0.74 61.0 5.38e-01 100.0% 61.2%
3754907 192.29.1.1 alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB_dom 0.73 66.0 5.64e-01 100.0% 84.4%
3991663 4336.2.1.1 alpha duplicates or obligate multimers › YheA/YmcA-like › Protein SUS1 › Protein SUS1 › EnY2 0.73 44.0 3.67e-01 82.5% 35.8%
3174635 4207.1.1.102 alpha duplicates or obligate multimers › Mediator hinge subcomplex-like › Mediator hinge subcomplex-like › RNA polymerase II holoenzyme component SRB7 (MED21) › PF29925 0.71 57.0 4.91e-01 89.5% 57.8%
3596713 633.1.1.0 alpha bundles › Bromodomain-like › Bromodomain › Bromodomain 0.70 56.0 4.23e-01 91.2% 37.0%
3574981 604.12.1.91 alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › RSLD_CPSF6 0.69 46.0 4.32e-01 75.4% 55.7%
2833339 3826.1.1.1 alpha bundles › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) › Trns_repr_metal 0.69 59.0 5.27e-01 100.0% 67.5%
5057941 1075.5.1.0 alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter 0.68 58.0 4.12e-01 94.7% 35.9%
4963338 605.1.1.0 alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase 0.68 53.0 5.22e-01 91.2% 81.7%
3535346 2004.1.1.184 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_11 0.67 53.0 3.14e-01 87.7% 11.7%
3245804 223.2.1.43 a+b three layers › Profilin-like › profilin-like › profilin-like › FNIP_M 0.67 49.0 3.54e-01 78.9% 28.3%
3883169 5001.1.1.3 alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_2 0.66 60.0 3.79e-01 100.0% 55.9%
3680632 603.1.1.0 alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.66 57.0 4.61e-01 98.2% 50.0%
3847053 192.15.1.0 alpha bundles › Long alpha-hairpin › Endosomal sorting complex assembly domains › Endosomal sorting complex assembly domains 0.66 50.0 4.60e-01 82.5% 62.7%
4174713 192.1.1.2 alpha bundles › Long alpha-hairpin › GreA transcript cleavage protein, N-terminal domain › GreA transcript cleavage protein, N-terminal domain › GreA_GreB_N 0.63 51.0 4.52e-01 94.7% 62.5%
138005 141.1.1.8 alpha bundles › Terpenoid synthases › Terpenoid synthases › Terpenoid synthases › Terpene_syn_C_2 0.63 54.0 3.35e-01 100.0% 17.9%
4488970 148.1.3.328 alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain › InvH 0.63 43.0 4.16e-01 71.9% 86.2%
3582573 192.24.1.0 alpha bundles › Long alpha-hairpin › RPC62 helical hairpin domain › RPC62 helical hairpin domain 0.61 54.0 4.40e-01 100.0% 77.3%
4283877 230.3.1.1 a+b two layers › T-fold › Elongation factor Ts (EF-Ts), dimerisation domain › Elongation factor Ts (EF-Ts), dimerisation domain › EF_TS 0.59 49.0 3.60e-01 94.7% 58.1%
D4 medium residues 365-432
PDB
Domain cluster: representative
CATH (11)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3lcvB02 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.57 43.0 3.18e-01 83.8% 62.9%
5k8bA01 3.40.640.10 Alpha Beta › 3-Layer(aba) Sandwich › Aspartate Aminotransferase; domain 2 › Type I PLP-dependent aspartate aminotransferase-like (Major domain) 0.55 45.0 3.22e-01 100.0% 58.6%
1xnfA00 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.54 42.0 2.98e-01 92.6% 37.1%
3hdtA00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.53 40.0 3.06e-01 98.5% 32.7%
2i6jA00 3.90.190.10 Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily 0.53 42.0 3.40e-01 95.6% 86.3%
1y89A00 3.40.50.1360 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.53 43.0 3.10e-01 97.1% 69.2%
4wutA02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.52 39.0 3.17e-01 85.3% 59.2%
1o94A03 3.50.50.60 Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain 0.52 41.0 3.34e-01 92.6% 90.8%
5j60B02 3.50.50.60 Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain 0.52 42.0 3.59e-01 92.6% 80.8%
4kp1A02 3.30.499.10 Alpha Beta › 2-Layer Sandwich › Aconitase; domain 3 › Aconitase, domain 3 0.52 43.0 3.36e-01 92.6% 56.8%
1fs5A00 3.40.50.1360 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.51 41.0 2.89e-01 97.1% 66.2%
ECOD (13)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4147293 2007.1.3.0 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › CheY-like 0.57 46.0 3.60e-01 91.2% 85.0%
5068423 2004.1.1.146 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ATPase 0.54 45.0 3.06e-01 100.0% 78.7%
5056515 2004.1.1.146 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ATPase 0.54 44.0 3.19e-01 100.0% 63.3%
5030434 2006.1.4.0 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like 0.53 38.0 2.99e-01 80.9% 43.8%
156554 2003.1.7.4 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NagB/RpiA/CoA transferase-like › Glucosamine_iso 0.53 43.0 3.10e-01 97.1% 68.9%
3283354 2007.1.2.11 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › Peripla_BP_4 0.52 39.0 3.13e-01 85.3% 60.0%
4934037 7542.1.1.7 a/b three-layered sandwiches › Aconitase iron-sulfur domain › Aconitase iron-sulfur domain › Aconitase iron-sulfur domain › PF28406 0.52 40.0 3.33e-01 86.8% 59.2%
5002228 2004.1.1.146 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ATPase 0.51 40.0 2.92e-01 92.6% 37.4%
3630159 2007.2.3.3 a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › Syja_N 0.51 41.0 2.82e-01 98.5% 45.5%
5036873 2006.1.4.12 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like › PIN_6 0.51 41.0 3.42e-01 91.2% 63.2%
4390520 2003.1.7.10 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NagB/RpiA/CoA transferase-like › Rib_5-P_isom_A 0.51 39.0 3.01e-01 82.4% 44.3%
4929198 7542.1.1.7 a/b three-layered sandwiches › Aconitase iron-sulfur domain › Aconitase iron-sulfur domain › Aconitase iron-sulfur domain › PF28406 0.50 38.0 3.28e-01 86.8% 63.4%
5032659 2004.1.1.146 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ATPase 0.50 40.0 2.80e-01 94.1% 24.6%