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IMGVR_UViG_3300017910_001187-3300017910-Ga0192369_10652626
Arc-VirIMGVR_UViG_3300017910_001187-3300017910-Ga0192369_10652626
Identity
- Kingdom:
- archaea
Quality
75.6
mean pLDDT
Cluster
Singleton — not in a non-trivial cluster
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 620-701
Domain cluster:
representative
CATH (56)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2wk1A00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.69 | 47.0 | 3.33e-01 | 84.1% | 24.0% |
| 3zihA00 | 3.30.110.150 | Alpha Beta › 2-Layer Sandwich › Translation Initiation Factor IF3 › SepF-like protein | 0.67 | 46.0 | 4.73e-01 | 84.1% | 74.7% |
| 3zieD00 | 3.30.110.150 | Alpha Beta › 2-Layer Sandwich › Translation Initiation Factor IF3 › SepF-like protein | 0.66 | 48.0 | 4.83e-01 | 85.4% | 75.6% |
| 3p04A00 | 3.30.110.150 | Alpha Beta › 2-Layer Sandwich › Translation Initiation Factor IF3 › SepF-like protein | 0.66 | 46.0 | 4.71e-01 | 84.1% | 76.6% |
| 6g80B01 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.66 | 52.0 | 3.73e-01 | 95.1% | 31.2% |
| 6u9hF02 | 3.30.70.1150 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT-like. Chain A, domain 2 | 0.65 | 38.0 | 3.93e-01 | 75.6% | 61.0% |
| 4dcmA01 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.65 | 47.0 | 3.70e-01 | 89.0% | 36.2% |
| 1whrA00 | 3.30.1370.50 | Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › R3H-like domain | 0.64 | 51.0 | 4.44e-01 | 97.6% | 56.5% |
| 1ejcA02 | 3.65.10.10 | Alpha Beta › Alpha-beta prism › UDP-n-acetylglucosamine1-carboxyvinyl-transferase; Chain › Enolpyruvate transferase domain | 0.63 | 45.0 | 3.38e-01 | 100.0% | 29.3% |
| 3tosA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.63 | 44.0 | 3.11e-01 | 84.1% | 23.9% |
| 1jo0A00 | 3.30.110.60 | Alpha Beta › 2-Layer Sandwich › Translation Initiation Factor IF3 › YhbY-like | 0.62 | 42.0 | 4.02e-01 | 84.1% | 58.8% |
| 6az1a00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.62 | 42.0 | 4.44e-01 | 85.4% | 80.6% |
| 6uvuA01 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.62 | 44.0 | 4.14e-01 | 86.6% | 60.6% |
| 5iceA02 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.61 | 48.0 | 3.39e-01 | 85.4% | 35.5% |
| 3jtnB00 | 3.30.70.1950 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.61 | 35.0 | 3.39e-01 | 74.4% | 50.0% |
| 5optn00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.61 | 50.0 | 4.82e-01 | 92.7% | 81.7% |
| 3cuoD00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.61 | 43.0 | 4.20e-01 | 86.6% | 67.0% |
| 2zkzC00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.60 | 43.0 | 4.26e-01 | 86.6% | 71.3% |
| 6i6lA02 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.60 | 46.0 | 3.31e-01 | 84.1% | 35.6% |
| 1p4xA01 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.59 | 47.0 | 4.16e-01 | 93.9% | 57.5% |
| 3jamK00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.59 | 46.0 | 4.46e-01 | 93.9% | 74.0% |
| 1rq8A00 | 3.30.110.60 | Alpha Beta › 2-Layer Sandwich › Translation Initiation Factor IF3 › YhbY-like | 0.59 | 40.0 | 3.86e-01 | 85.4% | 60.4% |
| 4hw0C00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.59 | 45.0 | 4.33e-01 | 92.7% | 72.0% |
| 3hnrA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.59 | 47.0 | 3.58e-01 | 86.6% | 47.2% |
| 2xzn800 | 3.30.63.20 | Alpha Beta › 2-Layer Sandwich › Guanylate Kinase phosphate binding domain › | 0.59 | 42.0 | 4.06e-01 | 85.4% | 66.7% |
| 2v1nA01 | 1.10.10.2030 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › DNA/RNA-binding protein Kin17, conserved domain | 0.58 | 46.0 | 4.33e-01 | 86.6% | 74.3% |
| 4avaA02 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.58 | 43.0 | 3.38e-01 | 93.9% | 36.1% |
| 3m8eA00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.57 | 44.0 | 4.17e-01 | 90.2% | 68.3% |
| 2hgcA00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.57 | 44.0 | 4.48e-01 | 92.7% | 87.2% |
| 1ub9A00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.57 | 45.0 | 4.29e-01 | 92.7% | 72.0% |
| 3fixA00 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.57 | 45.0 | 3.54e-01 | 84.1% | 50.9% |
| 2l48A00 | 3.30.70.2030 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.57 | 34.0 | 3.45e-01 | 81.7% | 57.6% |
| 4xpkA00 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.57 | 45.0 | 3.70e-01 | 84.1% | 58.9% |
| 4ejoA00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.56 | 46.0 | 4.21e-01 | 92.7% | 67.9% |
| 3l7wA00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.56 | 46.0 | 4.29e-01 | 92.7% | 72.4% |
| 2wa0A01 | 1.10.10.1200 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › MAGE homology domain, winged helix WH1 motif | 0.56 | 43.0 | 4.10e-01 | 86.6% | 71.3% |
| 4nzrM03 | 3.30.110.180 | Alpha Beta › 2-Layer Sandwich › Translation Initiation Factor IF3 › | 0.56 | 43.0 | 3.81e-01 | 84.1% | 61.8% |
| 3vgpA00 | 3.40.50.12610 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › | 0.56 | 43.0 | 3.51e-01 | 85.4% | 60.1% |
| 3pieA02 | 3.30.1370.250 | Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › | 0.55 | 48.0 | 4.54e-01 | 98.8% | 90.0% |
| 3c9aA03 | 2.20.20.160 | Mainly Beta › Single Sheet › Anthopleurin-A › | 0.55 | 41.0 | 4.36e-01 | 78.0% | 94.4% |
| 1xviA02 | 3.30.980.20 | Alpha Beta › 2-Layer Sandwich › Threonyl-tRNA Synthetase; Chain A, domain 2 › Putative mannosyl-3-phosphoglycerate phosphatase; domain 2 | 0.54 | 38.0 | 3.68e-01 | 73.2% | 97.9% |
| 2o0bA02 | 3.65.10.10 | Alpha Beta › Alpha-beta prism › UDP-n-acetylglucosamine1-carboxyvinyl-transferase; Chain › Enolpyruvate transferase domain | 0.54 | 47.0 | 3.53e-01 | 98.8% | 98.1% |
| 3dr5A00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.54 | 42.0 | 3.20e-01 | 87.8% | 33.8% |
| 4rayA01 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.54 | 40.0 | 4.00e-01 | 84.1% | 77.6% |
| 2mbfA01 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.54 | 42.0 | 4.00e-01 | 86.6% | 87.6% |
| 2eshA00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.53 | 43.0 | 3.96e-01 | 92.7% | 70.2% |
| 3l9fA01 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.53 | 43.0 | 4.23e-01 | 91.5% | 86.5% |
| 7npaA02 | 3.30.70.3340 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.53 | 37.0 | 3.71e-01 | 81.7% | 70.6% |
| 2yvwA02 | 3.65.10.10 | Alpha Beta › Alpha-beta prism › UDP-n-acetylglucosamine1-carboxyvinyl-transferase; Chain › Enolpyruvate transferase domain | 0.53 | 46.0 | 3.50e-01 | 100.0% | 76.7% |
| 2ph7A01 | 1.10.3400.10 | Mainly Alpha › Orthogonal Bundle › af_2093 domain like fold › af_2093 domain like | 0.52 | 41.0 | 3.60e-01 | 85.4% | 56.5% |
| 2ly1A03 | 3.30.420.610 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › LOTUS domain-like | 0.52 | 41.0 | 4.12e-01 | 90.2% | 87.7% |
| 2d9iA00 | 3.30.1370.110 | Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › | 0.52 | 39.0 | 3.81e-01 | 85.4% | 71.9% |
| 2zihC00 | 1.10.3630.10 | Mainly Alpha › Orthogonal Bundle › yeast vps74-n-term truncation variant fold › yeast vps74-n-term truncation variant domain like | 0.51 | 41.0 | 2.88e-01 | 87.8% | 97.5% |
| 1yk9A00 | 3.30.70.1230 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Nucleotide cyclase, GGDEF domain | 0.51 | 42.0 | 3.23e-01 | 90.2% | 62.0% |
| 4fqdB02 | 3.65.10.10 | Alpha Beta › Alpha-beta prism › UDP-n-acetylglucosamine1-carboxyvinyl-transferase; Chain › Enolpyruvate transferase domain | 0.51 | 44.0 | 3.31e-01 | 100.0% | 75.9% |
| 2qbyA03 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.50 | 40.0 | 3.98e-01 | 92.7% | 87.8% |
ECOD (61)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3489258 | 306.8.1.0 ↗ | a+b two layers › Glucose permease domain IIB-like › TM1457-like › TM1457-like | 0.77 | 55.0 | 5.06e-01 | 74.4% | 98.1% |
| 5026253 | 328.9.1.1 ↗ | a+b two layers › IF3-like › SepF C-terminal domain › SepF C-terminal domain › SepF | 0.68 | 48.0 | 4.85e-01 | 85.4% | 75.0% |
| 4948041 | 328.9.1.0 ↗ | a+b two layers › IF3-like › SepF C-terminal domain › SepF C-terminal domain | 0.67 | 50.0 | 5.05e-01 | 85.4% | 80.0% |
| 5059020 | 328.9.1.1 ↗ | a+b two layers › IF3-like › SepF C-terminal domain › SepF C-terminal domain › SepF | 0.66 | 47.0 | 4.80e-01 | 84.1% | 76.2% |
| 4992707 | 101.1.2.0 ↗ | alpha arrays › HTH › HTH › winged helix domain | 0.66 | 47.0 | 3.96e-01 | 85.4% | 44.3% |
| 3609147 | 320.1.1.0 ↗ | a+b two layers › R3H domain-like › R3H domain › R3H domain | 0.65 | 49.0 | 4.56e-01 | 93.9% | 62.9% |
| None | — | 0.65 | 50.0 | 3.69e-01 | 100.0% | 30.9% | |
| 4640904 | 328.9.1.1 ↗ | a+b two layers › IF3-like › SepF C-terminal domain › SepF C-terminal domain › SepF | 0.65 | 46.0 | 4.56e-01 | 84.1% | 70.6% |
| 3292011 | 2003.1.5.154 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_29, Methyltransf_11 | 0.65 | 56.0 | 3.42e-01 | 97.6% | 15.9% |
| 4926945 | 101.1.2.0 ↗ | alpha arrays › HTH › HTH › winged helix domain | 0.65 | 49.0 | 4.58e-01 | 91.5% | 63.8% |
| 3448558 | 880.1.1.1 ↗ | a+b duplicates or obligate multimers › ADC synthase › ADC synthase › ADC synthase › Chorismate_bind | 0.65 | 48.0 | 2.94e-01 | 78.0% | 31.7% |
| 4090109 | 328.6.1.1 ↗ | a+b two layers › IF3-like › EPT/RTPC-like › EPT/RTPC-like › EPSP_synthase | 0.65 | 47.0 | 3.53e-01 | 100.0% | 29.8% |
| 5056162 | 328.9.1.1 ↗ | a+b two layers › IF3-like › SepF C-terminal domain › SepF C-terminal domain › SepF | 0.65 | 46.0 | 4.72e-01 | 85.4% | 77.5% |
| 4967063 | 2003.1.5.80 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_24 | 0.64 | 44.0 | 3.19e-01 | 86.6% | 25.1% |
| 4395739 | 101.1.2.44 ↗ | alpha arrays › HTH › HTH › winged helix domain › Ribosomal_S25 | 0.63 | 44.0 | 4.18e-01 | 84.1% | 60.0% |
| 2491334 | 101.1.2.0 ↗ | alpha arrays › HTH › HTH › winged helix domain | 0.63 | 50.0 | 4.99e-01 | 86.6% | 82.4% |
| 4957231 | 101.1.2.0 ↗ | alpha arrays › HTH › HTH › winged helix domain | 0.63 | 49.0 | 4.75e-01 | 92.7% | 73.7% |
| 3649264 | 2003.1.5.115 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_29 | 0.63 | 52.0 | 3.18e-01 | 89.0% | 18.3% |
| 3597641 | 304.163.1.0 ↗ | a+b two layers › Alpha-beta plaits › ATP-binding protein TM_1403 insertion domain › ATP-binding protein TM_1403 insertion domain | 0.62 | 37.0 | 3.83e-01 | 73.2% | 64.0% |
| 4966320 | 101.1.2.884 ↗ | alpha arrays › HTH › HTH › winged helix domain › UPF0122 | 0.62 | 48.0 | 4.52e-01 | 91.5% | 68.0% |
| 4663585 | 328.6.1.1 ↗ | a+b two layers › IF3-like › EPT/RTPC-like › EPT/RTPC-like › EPSP_synthase | 0.62 | 47.0 | 3.49e-01 | 100.0% | 30.9% |
| 4565948 | 304.37.1.0 ↗ | a+b two layers › Alpha-beta plaits › Sulfite reductase, domains 1 and 3 › Sulfite reductase, domains 1 and 3 | 0.62 | 38.0 | 3.75e-01 | 75.6% | 56.7% |
| 3168448 | 101.1.2.154 ↗ | alpha arrays › HTH › HTH › winged helix domain › CDT1_C | 0.61 | 54.0 | 4.70e-01 | 100.0% | 65.1% |
| 5008379 | 304.37.1.1 ↗ | a+b two layers › Alpha-beta plaits › Sulfite reductase, domains 1 and 3 › Sulfite reductase, domains 1 and 3 › NIR_SIR_ferr | 0.61 | 36.0 | 3.87e-01 | 74.4% | 67.1% |
| 3598887 | 304.8.1.0 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like | 0.61 | 36.0 | 3.77e-01 | 72.0% | 64.0% |
| 3983904 | 101.1.2.14 ↗ | alpha arrays › HTH › HTH › winged helix domain › HTH_5 | 0.61 | 44.0 | 4.08e-01 | 86.6% | 60.0% |
| 3944893 | 101.1.2.0 ↗ | alpha arrays › HTH › HTH › winged helix domain | 0.60 | 45.0 | 4.29e-01 | 87.8% | 68.4% |
| 4928979 | 101.1.2.0 ↗ | alpha arrays › HTH › HTH › winged helix domain | 0.60 | 53.0 | 4.88e-01 | 100.0% | 91.7% |
| 3528332 | 304.163.1.1 ↗ | a+b two layers › Alpha-beta plaits › ATP-binding protein TM_1403 insertion domain › ATP-binding protein TM_1403 insertion domain › R1_ABCA1 | 0.60 | 35.0 | 3.70e-01 | 73.2% | 62.7% |
| 3432388 | 109.4.1.43 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › SAC3_GANP | 0.60 | 50.0 | 4.17e-01 | 93.9% | 63.3% |
| 5031317 | 101.1.2.0 ↗ | alpha arrays › HTH › HTH › winged helix domain | 0.60 | 47.0 | 4.21e-01 | 91.5% | 59.2% |
| 5040361 | 101.1.2.673 ↗ | alpha arrays › HTH › HTH › winged helix domain › HTH_HVO_0163_N | 0.60 | 42.0 | 3.92e-01 | 85.4% | 58.1% |
| 5040012 | 101.1.2.135 ↗ | alpha arrays › HTH › HTH › winged helix domain › MarR_2 | 0.60 | 47.0 | 4.58e-01 | 91.5% | 78.9% |
| 5025218 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.59 | 47.0 | 3.02e-01 | 85.4% | 40.0% |
| 3704940 | 320.4.1.3 ↗ | a+b two layers › R3H domain-like › PUB domain › PUB domain › PUB | 0.59 | 49.0 | 4.41e-01 | 97.6% | 64.2% |
| 4147372 | 7523.1.1.15 ↗ | a/b three-layered sandwiches › Periplasmic binding protein-like II › Periplasmic binding protein-like II › Periplasmic binding protein-like II › LysR_substrate | 0.59 | 35.0 | 3.21e-01 | 89.0% | 43.6% |
| 3629469 | 304.4.1.53 ↗ | a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel › R1_ABCA1 | 0.59 | 34.0 | 3.43e-01 | 73.2% | 54.1% |
| 3711218 | 320.4.1.3 ↗ | a+b two layers › R3H domain-like › PUB domain › PUB domain › PUB | 0.59 | 52.0 | 3.58e-01 | 100.0% | 29.1% |
| 3390426 | 304.163.1.1 ↗ | a+b two layers › Alpha-beta plaits › ATP-binding protein TM_1403 insertion domain › ATP-binding protein TM_1403 insertion domain › R1_ABCA1 | 0.59 | 36.0 | 3.43e-01 | 73.2% | 51.0% |
| 3993298 | 304.163.1.1 ↗ | a+b two layers › Alpha-beta plaits › ATP-binding protein TM_1403 insertion domain › ATP-binding protein TM_1403 insertion domain › R1_ABCA1 | 0.58 | 36.0 | 3.66e-01 | 73.2% | 62.5% |
| 5018900 | 101.1.2.673 ↗ | alpha arrays › HTH › HTH › winged helix domain › HTH_HVO_0163_N | 0.58 | 41.0 | 3.84e-01 | 85.4% | 58.1% |
| 3404332 | 304.7.1.1 ↗ | a+b two layers › Alpha-beta plaits › Protease propeptides/inhibitors › Protease propeptides/inhibitors › Propep_M14 | 0.57 | 37.0 | 3.60e-01 | 85.4% | 58.9% |
| 2834167 | 304.37.1.1 ↗ | a+b two layers › Alpha-beta plaits › Sulfite reductase, domains 1 and 3 › Sulfite reductase, domains 1 and 3 › NIR_SIR_ferr | 0.57 | 36.0 | 3.66e-01 | 73.2% | 63.4% |
| 3928208 | 304.163.1.0 ↗ | a+b two layers › Alpha-beta plaits › ATP-binding protein TM_1403 insertion domain › ATP-binding protein TM_1403 insertion domain | 0.57 | 34.0 | 3.51e-01 | 75.6% | 61.3% |
| 5048525 | 101.1.2.0 ↗ | alpha arrays › HTH › HTH › winged helix domain | 0.56 | 43.0 | 4.35e-01 | 85.4% | 82.4% |
| 4214782 | 328.6.1.1 ↗ | a+b two layers › IF3-like › EPT/RTPC-like › EPT/RTPC-like › EPSP_synthase | 0.56 | 47.0 | 3.64e-01 | 92.7% | 97.9% |
| 3907766 | 101.1.2.0 ↗ | alpha arrays › HTH › HTH › winged helix domain | 0.56 | 46.0 | 4.27e-01 | 93.9% | 71.8% |
| 3949754 | 213.1.1.0 ↗ | a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) | 0.56 | 49.0 | 3.61e-01 | 100.0% | 44.8% |
| 3268538 | 101.1.2.267 ↗ | alpha arrays › HTH › HTH › winged helix domain › Nse4_C | 0.56 | 41.0 | 3.71e-01 | 87.8% | 56.5% |
| 4363314 | 101.1.2.485 ↗ | alpha arrays › HTH › HTH › winged helix domain › DUF2513 | 0.55 | 49.0 | 4.42e-01 | 100.0% | 86.1% |
| 5064092 | 101.1.2.14 ↗ | alpha arrays › HTH › HTH › winged helix domain › HTH_5 | 0.55 | 42.0 | 3.90e-01 | 92.7% | 63.6% |
| 3624653 | 304.163.1.1 ↗ | a+b two layers › Alpha-beta plaits › ATP-binding protein TM_1403 insertion domain › ATP-binding protein TM_1403 insertion domain › R1_ABCA1 | 0.54 | 33.0 | 3.41e-01 | 75.6% | 62.7% |
| 3961181 | 328.6.1.1 ↗ | a+b two layers › IF3-like › EPT/RTPC-like › EPT/RTPC-like › EPSP_synthase | 0.54 | 48.0 | 3.56e-01 | 100.0% | 95.9% |
| 5082051 | 101.1.2.0 ↗ | alpha arrays › HTH › HTH › winged helix domain | 0.54 | 44.0 | 4.32e-01 | 91.5% | 83.3% |
| 3481408 | 101.1.2.0 ↗ | alpha arrays › HTH › HTH › winged helix domain | 0.54 | 41.0 | 3.21e-01 | 84.1% | 39.0% |
| 3925904 | 101.1.2.57 ↗ | alpha arrays › HTH › HTH › winged helix domain › EAP30 | 0.54 | 41.0 | 3.31e-01 | 85.4% | 42.3% |
| 3285086 | 3268.1.1.0 ↗ | a+b two layers › N-terminal domain in xanthine dehydrogenase › N-terminal domain in xanthine dehydrogenase › N-terminal domain in xanthine dehydrogenase | 0.53 | 41.0 | 4.24e-01 | 81.7% | 97.3% |
| 5053743 | 328.6.1.1 ↗ | a+b two layers › IF3-like › EPT/RTPC-like › EPT/RTPC-like › EPSP_synthase | 0.53 | 46.0 | 3.44e-01 | 100.0% | 40.9% |
| 3743466 | 101.1.2.267 ↗ | alpha arrays › HTH › HTH › winged helix domain › Nse4_C | 0.53 | 40.0 | 3.72e-01 | 89.0% | 63.8% |
| 4891104 | 227.1.1.5 ↗ | a+b two layers › DNA clamp › DNA clamp › DNA clamp › Herpes_UL42 | 0.53 | 43.0 | 3.76e-01 | 100.0% | 57.3% |
| 5035456 | 304.19.1.1 ↗ | a+b two layers › Alpha-beta plaits › eIF-2-alpha, C-terminal domain › eIF-2-alpha, C-terminal domain › EIF_2_alpha | 0.50 | 33.0 | 3.42e-01 | 75.6% | 70.0% |
D2
medium
residues 38-84_289-361
Domain cluster:
representative
CATH (3)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1rl2A01 | 2.40.50.140 | Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins | 0.56 | 24.0 | 3.29e-01 | 82.5% | 80.4% |
| 1ci3M02 | 2.40.50.100 | Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain | 0.54 | 26.0 | 3.46e-01 | 78.3% | 91.4% |
| 2x5cA01 | 3.30.70.3590 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.51 | 26.0 | 2.91e-01 | 76.7% | 59.3% |
ECOD (9)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4117297 | 4.1.1.0 ↗ | beta barrels › SH3 › SH3 › SH3 | 0.62 | 28.0 | 3.58e-01 | 70.8% | 71.4% |
| 4119875 | 325.1.7.0 ↗ | a+b complex topology › alpha/beta-Hammerhead/Barrel-sandwich hybrid › alpha/beta-Hammerhead/Barrel-sandwich hybrid › Single hybrid motif | 0.58 | 28.0 | 3.65e-01 | 75.0% | 84.6% |
| 4456732 | 325.1.7.0 ↗ | a+b complex topology › alpha/beta-Hammerhead/Barrel-sandwich hybrid › alpha/beta-Hammerhead/Barrel-sandwich hybrid › Single hybrid motif | 0.57 | 29.0 | 3.39e-01 | 76.7% | 68.8% |
| 4625348 | 325.1.7.3 ↗ | a+b complex topology › alpha/beta-Hammerhead/Barrel-sandwich hybrid › alpha/beta-Hammerhead/Barrel-sandwich hybrid › Single hybrid motif › Apocytochr_F_C | 0.54 | 26.0 | 3.50e-01 | 78.3% | 90.0% |
| 4056113 | 1.1.7.80 ↗ | beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C › RND-MFP_C | 0.53 | 29.0 | 3.21e-01 | 91.7% | 63.0% |
| 4349950 | 325.1.7.0 ↗ | a+b complex topology › alpha/beta-Hammerhead/Barrel-sandwich hybrid › alpha/beta-Hammerhead/Barrel-sandwich hybrid › Single hybrid motif | 0.53 | 26.0 | 3.44e-01 | 74.2% | 91.7% |
| 4027502 | 4.1.1.0 ↗ | beta barrels › SH3 › SH3 › SH3 | 0.51 | 23.0 | 3.05e-01 | 87.5% | 76.9% |
| 4982354 | 4.7.1.0 ↗ | beta barrels › SH3 › RNase P subunit p29 › RNase P subunit p29 | 0.51 | 26.0 | 3.40e-01 | 85.0% | 90.8% |
| 5077400 | 192.2.1.0 ↗ | alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin | 0.50 | 30.0 | 3.21e-01 | 85.8% | 67.3% |
D3
medium
residues 85-163
Domain cluster:
rep: IMGVR_UViG_3300020477_001803-3300020477-Ga0211585_100181568__D69-141
CATH (2)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1uwvA03 | 2.40.50.1070 | Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › | 0.53 | 40.0 | 3.39e-01 | 81.0% | 67.2% |
| 5c3pD00 | 2.60.120.330 | Mainly Beta › Sandwich › Jelly Rolls › B-lactam Antibiotic, Isopenicillin N Synthase; Chain | 0.52 | 46.0 | 3.10e-01 | 100.0% | 56.4% |
ECOD (9)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4486484 | 2004.1.1.799 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N, AAA_27, AAA_29 | 0.56 | 48.0 | 3.29e-01 | 100.0% | 79.4% |
| 5026249 | 2004.1.1.87 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N | 0.56 | 48.0 | 3.38e-01 | 100.0% | 76.5% |
| 4959079 | 2004.1.1.198 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_23 | 0.56 | 47.0 | 2.89e-01 | 100.0% | 88.3% |
| 2323715 | 1192.1.1.0 ↗ | 0.54 | 38.0 | 3.36e-01 | 74.7% | 63.3% | |
| 3583571 | 833.1.1.0 ↗ | a+b duplicates or obligate multimers › Pepsin inhibitor-3 › Pepsin inhibitor-3 › Pepsin inhibitor-3 | 0.54 | 46.0 | 4.15e-01 | 93.7% | 93.4% |
| 3903430 | 220.1.1.123 ↗ | beta barrels › PH domain-like › PH domain-like › PH domain-like › PH_SSH1-like_1st | 0.53 | 33.0 | 3.28e-01 | 100.0% | 56.5% |
| 4065466 | 220.1.1.150 ↗ | beta barrels › PH domain-like › PH domain-like › PH domain-like › DUF986 | 0.53 | 32.0 | 3.20e-01 | 98.7% | 56.2% |
| 3408734 | 5001.1.1.1 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1 | 0.52 | 43.0 | 2.98e-01 | 97.5% | 74.3% |
| 3788749 | 6109.1.1.0 ↗ | a+b two layers › N-terminal domain of chitin biosynthesis protein CHS6 › N-terminal domain of chitin biosynthesis protein CHS6 › N-terminal domain of chitin biosynthesis protein CHS6 | 0.51 | 43.0 | 3.56e-01 | 96.2% | 72.0% |
D4
medium
residues 164-288
Domain cluster:
representative
D5
medium
residues 362-481
Domain cluster:
representative
CATH (17)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3k1lA01 | 3.30.457.40 | Alpha Beta › 2-Layer Sandwich › Copper Amine Oxidase; Chain A, domain 1 › | 0.65 | 48.0 | 5.32e-01 | 86.7% | 100.0% |
| 2lpuA00 | 3.30.1460.50 | Alpha Beta › 2-Layer Sandwich › Yope Regulator; Chain: A, › | 0.63 | 47.0 | 4.41e-01 | 79.2% | 94.6% |
| 2ymsC00 | 2.40.10.480 | Mainly Beta › Beta Barrel › Thrombin, subunit H › | 0.56 | 32.0 | 3.84e-01 | 80.8% | 88.0% |
| 4irzA01 | 2.130.10.130 | Mainly Beta › 7 Propeller › Methylamine Dehydrogenase; Chain H › Integrin alpha, N-terminal | 0.55 | 48.0 | 3.30e-01 | 96.7% | 89.8% |
| 3w15A01 | 2.130.10.10 | Mainly Beta › 7 Propeller › Methylamine Dehydrogenase; Chain H › YVTN repeat-like/Quinoprotein amine dehydrogenase | 0.55 | 43.0 | 3.18e-01 | 85.8% | 90.4% |
| 5h1kB02 | 2.130.10.10 | Mainly Beta › 7 Propeller › Methylamine Dehydrogenase; Chain H › YVTN repeat-like/Quinoprotein amine dehydrogenase | 0.53 | 43.0 | 3.20e-01 | 89.2% | 81.9% |
| 3odtA00 | 2.130.10.10 | Mainly Beta › 7 Propeller › Methylamine Dehydrogenase; Chain H › YVTN repeat-like/Quinoprotein amine dehydrogenase | 0.53 | 43.0 | 3.28e-01 | 89.2% | 80.4% |
| 4hs5A00 | 3.30.920.10 | Alpha Beta › 2-Layer Sandwich › Metal Transport, Frataxin; Chain A › Frataxin/CyaY | 0.52 | 39.0 | 4.17e-01 | 100.0% | 91.4% |
| 2d4rA00 | 3.30.530.20 | Alpha Beta › 2-Layer Sandwich › Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4 › START domain | 0.52 | 41.0 | 3.89e-01 | 90.8% | 69.2% |
| 4nsxA02 | 2.130.10.10 | Mainly Beta › 7 Propeller › Methylamine Dehydrogenase; Chain H › YVTN repeat-like/Quinoprotein amine dehydrogenase | 0.52 | 43.0 | 3.24e-01 | 90.8% | 95.4% |
| 3mmyA00 | 2.130.10.10 | Mainly Beta › 7 Propeller › Methylamine Dehydrogenase; Chain H › YVTN repeat-like/Quinoprotein amine dehydrogenase | 0.52 | 42.0 | 3.07e-01 | 89.2% | 74.3% |
| 6m90A02 | 2.130.10.10 | Mainly Beta › 7 Propeller › Methylamine Dehydrogenase; Chain H › YVTN repeat-like/Quinoprotein amine dehydrogenase | 0.52 | 43.0 | 3.28e-01 | 92.5% | 81.0% |
| 4ntqA00 | 3.10.380.20 | Alpha Beta › Roll › Ribonuclease domain of colicin e3 (Residues 456-551) › Novel toxin 21 (CdiA), C-terminal domain | 0.51 | 31.0 | 3.76e-01 | 81.7% | 94.7% |
| 8siuA01 | 2.130.10.10 | Mainly Beta › 7 Propeller › Methylamine Dehydrogenase; Chain H › YVTN repeat-like/Quinoprotein amine dehydrogenase | 0.51 | 43.0 | 3.09e-01 | 93.3% | 66.1% |
| 7apkF01 | 2.130.10.10 | Mainly Beta › 7 Propeller › Methylamine Dehydrogenase; Chain H › YVTN repeat-like/Quinoprotein amine dehydrogenase | 0.51 | 41.0 | 3.04e-01 | 88.3% | 69.2% |
| 7d27A02 | 3.40.1190.10 | Alpha Beta › 3-Layer(aba) Sandwich › UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase › Mur-like, catalytic domain | 0.51 | 38.0 | 3.14e-01 | 80.0% | 92.2% |
| 3zl8A02 | 3.40.1190.10 | Alpha Beta › 3-Layer(aba) Sandwich › UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase › Mur-like, catalytic domain | 0.50 | 38.0 | 3.15e-01 | 80.8% | 85.8% |
ECOD (33)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3257727 | 216.1.1.0 ↗ | a+b two layers › UBC-like › UBC-like › UBC-like | 0.67 | 54.0 | 5.26e-01 | 95.0% | 78.5% |
| 383967 | 216.1.1.7 ↗ | a+b two layers › UBC-like › UBC-like › UBC-like › FANCL_d1 | 0.64 | 46.0 | 5.23e-01 | 83.3% | 100.0% |
| 3378755 | 216.1.1.0 ↗ | a+b two layers › UBC-like › UBC-like › UBC-like | 0.63 | 48.0 | 4.76e-01 | 80.8% | 95.2% |
| 3712602 | 216.1.1.4 ↗ | a+b two layers › UBC-like › UBC-like › UBC-like › RWD | 0.62 | 51.0 | 4.91e-01 | 87.5% | 77.8% |
| 4436313 | 295.1.1.0 ↗ | a+b two layers › ssDNA-binding transcriptional regulator domain-like › ssDNA-binding transcriptional regulator domain › ssDNA-binding transcriptional regulator domain | 0.57 | 41.0 | 4.54e-01 | 91.7% | 98.9% |
| 3288281 | 881.1.1.15 ↗ | a+b three layers › Mog1p/PsbP-like › Mog1p/PsbP-like › Mog1p/PsbP-like › DUF3558 | 0.56 | 35.0 | 3.38e-01 | 73.3% | 53.5% |
| 3174260 | 5.1.3.147 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 6-bladed › Kelch_1, Beta-prop_ATRN-LZTR1 | 0.56 | 47.0 | 3.26e-01 | 92.5% | 93.6% |
| 3799341 | 3297.1.1.25 ↗ | extended segments › Helical hairpin in Ndc80 › Helical hairpin in Ndc80 › Helical hairpin in Ndc80 › WD40_RFWD3 | 0.55 | 44.0 | 3.18e-01 | 87.5% | 72.1% |
| 4081842 | 192.8.1.0 ↗ | alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain | 0.55 | 39.0 | 3.23e-01 | 80.8% | 41.4% |
| 3441395 | 5.1.3.159 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 6-bladed › DUF7595 | 0.54 | 43.0 | 3.18e-01 | 85.0% | 69.0% |
| 3706670 | 292.2.1.6 ↗ | a+b two layers › RIP/Polo-box domain › Polo-box domain › Polo-box domain › DUF4520 | 0.54 | 32.0 | 3.39e-01 | 80.8% | 64.5% |
| 3490808 | 5.1.4.139 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › WD40_2 | 0.53 | 45.0 | 3.18e-01 | 93.3% | 76.4% |
| 3816594 | 1.1.17.0 ↗ | beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel 2 | 0.53 | 40.0 | 3.22e-01 | 79.2% | 97.5% |
| 3255634 | 5.1.3.0 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 6-bladed | 0.53 | 46.0 | 3.24e-01 | 97.5% | 89.8% |
| 3713007 | 5.1.4.164 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › Beta-prop_VPS8 | 0.53 | 44.0 | 3.08e-01 | 91.7% | 63.2% |
| 3595178 | 219.1.1.0 ↗ | a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases | 0.53 | 42.0 | 2.62e-01 | 85.0% | 37.2% |
| 3784858 | 5.1.4.362 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › WD40, Beta-prop_VPS8 | 0.53 | 41.0 | 2.79e-01 | 83.3% | 62.8% |
| 4952972 | 7520.1.1.2 ↗ | a/b three-layered sandwiches › CinA-like › CinA-like › CinA-like › HcgF | 0.53 | 40.0 | 3.53e-01 | 80.8% | 94.4% |
| 3629868 | 5.1.4.223 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › Beta-prop_RIC1_2nd | 0.52 | 46.0 | 2.82e-01 | 100.0% | 69.7% |
| 3399261 | 5.1.4.371 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › Frtz | 0.52 | 38.0 | 2.61e-01 | 77.5% | 44.6% |
| 3225979 | 5.1.4.1 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › WD40 | 0.52 | 40.0 | 2.89e-01 | 82.5% | 45.5% |
| 3175498 | 5.1.4.332 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › PF29748 | 0.52 | 41.0 | 2.96e-01 | 85.0% | 70.4% |
| 3809547 | 5.1.4.297 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › WD40, NBCH_WD40 | 0.52 | 43.0 | 3.09e-01 | 90.8% | 47.3% |
| 4336238 | 241.2.1.1 ↗ | a+b two layers › Type III secretory system chaperone-like › Frataxin-like › Frataxin-like › Frataxin_Cyay | 0.52 | 39.0 | 4.17e-01 | 99.2% | 95.0% |
| 3205589 | 5.1.11.10 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 9-bladed › Rrn6_beta-prop | 0.52 | 42.0 | 2.95e-01 | 89.2% | 66.6% |
| 3413200 | 2484.1.1.0 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like | 0.51 | 37.0 | 2.59e-01 | 75.8% | 90.5% |
| 4028247 | 5.1.4.1 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › WD40 | 0.51 | 44.0 | 3.15e-01 | 96.7% | 68.3% |
| 3469033 | 1.1.5.0 ↗ | beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel | 0.51 | 39.0 | 3.12e-01 | 80.8% | 94.4% |
| 3436009 | 5.1.4.101 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › DUF1618 | 0.51 | 41.0 | 3.22e-01 | 86.7% | 76.5% |
| 3517217 | 5.1.4.1 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › WD40 | 0.51 | 41.0 | 2.94e-01 | 87.5% | 67.2% |
| 3827487 | 5.1.4.0 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed | 0.50 | 41.0 | 2.96e-01 | 88.3% | 69.3% |
| 4001980 | 4099.1.1.21 ↗ | a+b two layers › Kinetochore globular domain-like › Kinetochore globular domain-like › Kinetochore globular domain-like › RM3_Med14 | 0.50 | 40.0 | 4.05e-01 | 90.8% | 85.8% |
| 395916 | 883.1.1.6 ↗ | a+b complex topology › Aha1/BPI domain-like › Aha1/BPI domain-like › Aha1/BPI domain-like › Aha1_N | 0.50 | 34.0 | 3.28e-01 | 70.0% | 88.4% |
D6
medium
residues 482-538