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IMGVR_UViG_3300025288_001461-3300025288-Ga0210044_10000075100
Arc-VirIMGVR_UViG_3300025288_001461-3300025288-Ga0210044_10000075100
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 1-138
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00233.26 best | PDEase_I | 38.0 | 2.10e-09 | 53.6% | 27.7% |
CATH (16)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3v93F01 | 1.10.1300.10 | Mainly Alpha › Orthogonal Bundle › Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b › 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain | 0.80 | 75.0 | 5.68e-01 | 100.0% | 51.8% |
| 2o8hA00 | 1.10.1300.10 | Mainly Alpha › Orthogonal Bundle › Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b › 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain | 0.80 | 74.0 | 5.60e-01 | 99.3% | 49.2% |
| 1zklA00 | 1.10.1300.10 | Mainly Alpha › Orthogonal Bundle › Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b › 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain | 0.79 | 74.0 | 5.56e-01 | 100.0% | 49.8% |
| 3ecmA00 | 1.10.1300.10 | Mainly Alpha › Orthogonal Bundle › Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b › 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain | 0.78 | 73.0 | 5.36e-01 | 100.0% | 47.9% |
| 6mzbB03 | 1.10.1300.10 | Mainly Alpha › Orthogonal Bundle › Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b › 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain | 0.78 | 73.0 | 5.27e-01 | 100.0% | 43.5% |
| 3dynA00 | 1.10.1300.10 | Mainly Alpha › Orthogonal Bundle › Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b › 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain | 0.78 | 72.0 | 5.38e-01 | 100.0% | 47.6% |
| 2lseA00 | 1.20.120.1360 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › | 0.55 | 35.0 | 3.97e-01 | 76.8% | 86.1% |
| 2bl2A00 | 1.20.120.610 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › lithium bound rotor ring of v- atpase | 0.53 | 38.0 | 3.74e-01 | 76.1% | 88.5% |
| 1sj8A02 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.52 | 37.0 | 3.97e-01 | 73.9% | 97.5% |
| 4at7A01 | 1.10.1410.40 | Mainly Alpha › Orthogonal Bundle › Poly(a)-polymerase, middle domain › | 0.52 | 38.0 | 3.47e-01 | 97.1% | 57.1% |
| 4hzuS00 | 1.10.1760.20 | Mainly Alpha › Orthogonal Bundle › Arp2/3 complex 21 kDa subunit ARPC3 › | 0.51 | 44.0 | 4.21e-01 | 96.4% | 93.3% |
| 1navA00 | 1.10.565.10 | Mainly Alpha › Orthogonal Bundle › Retinoid X Receptor › Retinoid X Receptor | 0.51 | 44.0 | 3.68e-01 | 96.4% | 93.7% |
| 1u89A00 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.51 | 37.0 | 3.76e-01 | 75.4% | 77.0% |
| 2btdA00 | 1.25.40.340 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › DhaL domain | 0.51 | 38.0 | 3.31e-01 | 77.5% | 100.0% |
| 2p9xA00 | 1.10.1200.200 | Mainly Alpha › Orthogonal Bundle › Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein; Chain A › Protein of unknown function DUF3227 | 0.50 | 33.0 | 3.77e-01 | 79.7% | 92.9% |
| 3ikhA00 | 3.40.1190.20 | Alpha Beta › 3-Layer(aba) Sandwich › UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase › Ribokinase | 0.50 | 39.0 | 3.07e-01 | 81.2% | 95.5% |
ECOD (11)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3480803 | 131.1.1.1 ↗ | alpha complex topology › PDEase-like › HD-domain/PDEase-like › HD-domain/PDEase-like › PDEase_I | 0.79 | 73.0 | 6.03e-01 | 100.0% | 67.1% |
| 3487911 | 3954.1.1.0 ↗ | alpha arrays › Phosphodiesterase 4 upstream conserved regions (UCR) › Phosphodiesterase 4 upstream conserved regions (UCR) › Phosphodiesterase 4 upstream conserved regions (UCR) | 0.79 | 73.0 | 5.50e-01 | 100.0% | 50.3% |
| 3586513 | 131.1.1.1 ↗ | alpha complex topology › PDEase-like › HD-domain/PDEase-like › HD-domain/PDEase-like › PDEase_I | 0.79 | 73.0 | 5.93e-01 | 100.0% | 65.2% |
| 3909429 | 131.1.1.0 ↗ | alpha complex topology › PDEase-like › HD-domain/PDEase-like › HD-domain/PDEase-like | 0.78 | 72.0 | 5.52e-01 | 100.0% | 53.6% |
| 3177188 | 131.1.1.1 ↗ | alpha complex topology › PDEase-like › HD-domain/PDEase-like › HD-domain/PDEase-like › PDEase_I | 0.75 | 70.0 | 5.05e-01 | 99.3% | 41.4% |
| 4010621 | 1075.5.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › MatE | 0.61 | 44.0 | 3.77e-01 | 74.6% | 90.0% |
| 5037027 | 5041.1.1.1 ↗ | extended segments › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C › ATP-synt_C | 0.58 | 42.0 | 4.08e-01 | 74.6% | 93.3% |
| 3294231 | 5050.1.1.26 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › UVB_sens_prot | 0.56 | 41.0 | 3.28e-01 | 75.4% | 85.5% |
| 3646192 | 611.7.1.11 ↗ | alpha bundles › N-cbl like › Mixed lineage kinase domain-like (MLKL) N-terminal domain › Mixed lineage kinase domain-like (MLKL) N-terminal domain › DUF7032 | 0.52 | 38.0 | 3.89e-01 | 75.4% | 83.1% |
| 4945564 | 590.1.1.1 ↗ | alpha bundles › Citrobacter dihydroxyacetone kinase extra ATP-binding domain › Citrobacter dihydroxyacetone kinase extra ATP-binding domain › Citrobacter dihydroxyacetone kinase extra ATP-binding domain › Dak2 | 0.52 | 38.0 | 3.40e-01 | 77.5% | 97.1% |
| 4319172 | 604.39.1.15 ↗ | alpha bundles › Spectrin repeat-like › S-component of energy-coupling factor (ECF) transporters › S-component of energy-coupling factor (ECF) transporters › DUF2232 | 0.50 | 46.0 | 3.56e-01 | 100.0% | 82.3% |
D2
high
residues 195-278
D3
medium
residues 139-194
Domain cluster:
representative
CATH (28)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1vf7A03 | 1.10.287.470 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.65 | 43.0 | 4.27e-01 | 78.6% | 63.3% |
| 3bulA01 | 1.10.1240.10 | Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › Methionine synthase domain | 0.65 | 50.0 | 4.44e-01 | 87.5% | 58.6% |
| 3zukA01 | 3.40.390.10 | Alpha Beta › 3-Layer(aba) Sandwich › Collagenase (Catalytic Domain) › Collagenase (Catalytic Domain) | 0.63 | 52.0 | 3.32e-01 | 100.0% | 87.9% |
| 3k62A00 | 1.25.10.10 | Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant | 0.62 | 49.0 | 2.99e-01 | 94.6% | 12.7% |
| 4ri6A02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.61 | 49.0 | 3.96e-01 | 92.9% | 68.9% |
| 3nowA02 | 1.25.10.10 | Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant | 0.61 | 53.0 | 3.16e-01 | 100.0% | 31.5% |
| 1j1jA02 | 1.20.58.200 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 2 | 0.61 | 47.0 | 4.19e-01 | 87.5% | 78.8% |
| 3rmqA02 | 6.10.140.1650 | Special › Helix non-globular › Helix Hairpins › | 0.60 | 42.0 | 4.25e-01 | 85.7% | 76.8% |
| 2gtsA00 | 1.10.287.850 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HP0062-like domain | 0.59 | 42.0 | 3.87e-01 | 76.8% | 88.3% |
| 1t10A01 | 3.40.50.10490 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Glucose-6-phosphate isomerase like protein; domain 1 | 0.59 | 47.0 | 2.95e-01 | 94.6% | 89.6% |
| 4am6A03 | 3.30.420.580 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › | 0.59 | 49.0 | 3.22e-01 | 96.4% | 44.2% |
| 3n5lA03 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.59 | 41.0 | 4.13e-01 | 75.0% | 73.7% |
| 3mekA04 | 1.25.40.970 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.58 | 43.0 | 3.91e-01 | 82.1% | 66.3% |
| 1e1hB01 | 1.20.58.540 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.58 | 43.0 | 3.61e-01 | 91.1% | 44.7% |
| 4hfvA02 | 6.10.280.170 | Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Substrate of the Dot/Icm secretion system | 0.58 | 44.0 | 4.13e-01 | 83.9% | 69.0% |
| 4l0rB00 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.58 | 42.0 | 3.86e-01 | 76.8% | 63.0% |
| 2wjnM01 | 1.20.85.10 | Mainly Alpha › Up-down Bundle › Photosynthetic Reaction Center, subunit M; domain 1 › Photosystem II protein D1-like | 0.58 | 42.0 | 3.14e-01 | 78.6% | 52.4% |
| 6g85A01 | 3.90.190.10 | Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily | 0.57 | 49.0 | 3.73e-01 | 100.0% | 46.9% |
| 2aqwA00 | 3.20.20.70 | Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Aldolase class I | 0.57 | 46.0 | 2.96e-01 | 94.6% | 16.8% |
| 1vkeB00 | 1.20.1290.10 | Mainly Alpha › Up-down Bundle › AhpD-like › AhpD-like | 0.56 | 45.0 | 3.90e-01 | 100.0% | 59.4% |
| 4rw0A00 | 3.40.50.1110 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › SGNH hydrolase | 0.55 | 45.0 | 3.22e-01 | 92.9% | 31.0% |
| 2pmbA01 | 3.30.1850.10 | Alpha Beta › 2-Layer Sandwich › MCP/YpsA-like › MoCo carrier protein-like | 0.55 | 37.0 | 3.04e-01 | 71.4% | 67.3% |
| 2bskB00 | 1.10.287.810 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Mitochondrial import inner membrane translocase subunit tim13 like domains | 0.54 | 37.0 | 3.52e-01 | 71.4% | 69.2% |
| 3hsqA02 | 1.20.1180.10 | Mainly Alpha › Up-down Bundle › Udp N-acetylglucosamine O-acyltransferase; Domain 2 › Udp N-acetylglucosamine O-acyltransferase, C-terminal domain | 0.52 | 40.0 | 3.92e-01 | 98.2% | 79.4% |
| 2g8lB01 | 1.10.8.380 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Uncharacterised protein PF01937, DUF89, domain 1 | 0.52 | 46.0 | 4.39e-01 | 100.0% | 94.0% |
| 2fgyA01 | 1.20.120.1310 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Carboxysome Shell Carbonic Anhydrase, N-terminal helical domain | 0.52 | 39.0 | 3.27e-01 | 85.7% | 50.5% |
| 3tthB00 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.51 | 42.0 | 3.09e-01 | 98.2% | 32.9% |
| 3cs1A02 | 1.10.238.10 | Mainly Alpha › Orthogonal Bundle › Recoverin; domain 1 › EF-hand | 0.50 | 39.0 | 3.38e-01 | 82.1% | 90.4% |
ECOD (26)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3945351 | 605.1.1.128 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › DUF485 | 0.72 | 49.0 | 4.29e-01 | 71.4% | 52.9% |
| 3697097 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.69 | 47.0 | 3.23e-01 | 71.4% | 26.7% |
| 3696650 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.68 | 55.0 | 3.26e-01 | 94.6% | 14.5% |
| 3971928 | 3567.1.1.0 ↗ | a+b duplicates or obligate multimers › MPER trimer › MPER trimer › MPER trimer | 0.67 | 47.0 | 4.34e-01 | 75.0% | 62.7% |
| 3626374 | 150.5.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › ESAT-6 like › ESAT-6 like | 0.66 | 47.0 | 4.01e-01 | 75.0% | 91.1% |
| 3731364 | 3922.1.1.137 ↗ | alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › HisKA | 0.65 | 45.0 | 4.32e-01 | 75.0% | 63.1% |
| 4984136 | 5051.1.1.0 ↗ | alpha complex topology › Sodium:neurotransmitter symporter family (SNF)-like › Sodium:neurotransmitter symporter family (SNF)-like › Sodium:neurotransmitter symporter family (SNF)-like | 0.65 | 54.0 | 3.21e-01 | 100.0% | 38.1% |
| 3296104 | 2004.1.1.1 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA | 0.62 | 51.0 | 3.39e-01 | 92.9% | 25.8% |
| 3575609 | 103.1.1.0 ↗ | alpha arrays › RuvA-C › RuvA-C, UBA, CRAL/TRIO-N, HBS1 › UBA-like domain | 0.62 | 53.0 | 5.02e-01 | 92.9% | 100.0% |
| 4937093 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.61 | 43.0 | 3.43e-01 | 75.0% | 36.7% |
| 5012473 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.60 | 43.0 | 3.46e-01 | 76.8% | 80.9% |
| 3674276 | 603.1.1.161 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins › DUF212 | 0.60 | 50.0 | 3.85e-01 | 100.0% | 78.6% |
| 3721415 | 608.1.1.0 ↗ | alpha arrays › AhpD-like › AhpD-like › AhpD-like | 0.60 | 48.0 | 3.49e-01 | 96.4% | 30.6% |
| 5012567 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.59 | 43.0 | 3.16e-01 | 76.8% | 28.7% |
| 3584822 | 3291.1.1.147 ↗ | alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › MT | 0.59 | 42.0 | 3.30e-01 | 75.0% | 74.2% |
| 4949876 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.59 | 40.0 | 3.85e-01 | 75.0% | 61.5% |
| 3645906 | 2004.1.1.508 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD_C, UvrD_C_2 | 0.58 | 50.0 | 3.04e-01 | 98.2% | 15.3% |
| 3260777 | 109.3.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat | 0.56 | 47.0 | 3.11e-01 | 100.0% | 38.1% |
| 4363614 | 601.25.1.1 ↗ | alpha bundles › Four-helical up-and-down bundle › TrmE connector domain › TrmE connector domain › MnmE_helical | 0.56 | 42.0 | 3.11e-01 | 85.7% | 56.4% |
| 3494375 | 2006.1.4.10 ↗ | a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like › PIN_4 | 0.55 | 40.0 | 2.83e-01 | 92.9% | 23.1% |
| 4271959 | 108.1.1.71 ↗ | alpha arrays › EF-hand › EF-hand-related › EF-hand › DUF5580_M | 0.54 | 43.0 | 3.59e-01 | 98.2% | 89.6% |
| 3970898 | 6119.1.1.0 ↗ | alpha bundles › Helical bundle domain in CusB › Helical bundle domain in CusB › Helical bundle domain in CusB | 0.54 | 38.0 | 4.02e-01 | 75.0% | 84.0% |
| 3797432 | 130.1.1.0 ↗ | alpha arrays › LEM/SAP HeH motif-like › LEM/SAP HeH motif › LEM/SAP HeH motif | 0.53 | 32.0 | 3.30e-01 | 82.1% | 60.4% |
| 3635675 | 2008.1.1.144 ↗ | a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › PF27653 | 0.53 | 42.0 | 3.04e-01 | 96.4% | 60.0% |
| 4443506 | 101.1.2.517 ↗ | alpha arrays › HTH › HTH › winged helix domain › RNA_pol_Rpc82, HTH_9, POLR3C_WHD | 0.51 | 40.0 | 2.47e-01 | 89.3% | 37.6% |
| 3633384 | 101.1.2.359 ↗ | alpha arrays › HTH › HTH › winged helix domain › GPIID_WHD | 0.50 | 40.0 | 3.74e-01 | 94.6% | 96.0% |