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IMGVR_UViG_3300029303_000321-3300029303-Ga0168703_100019323
Arc-VirIMGVR_UViG_3300029303_000321-3300029303-Ga0168703_100019323
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 1-74
Domain cluster:
representative
CATH (28)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2uv8A07 | 6.10.140.1410 | Special › Helix non-globular › Helix Hairpins › | 0.72 | 55.0 | 5.31e-01 | 82.4% | 82.4% |
| 4ev6A03 | 1.20.58.340 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Magnesium transport protein CorA, transmembrane region | 0.72 | 51.0 | 5.69e-01 | 75.7% | 96.6% |
| 1lvlA01 | 3.50.50.60 | Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain | 0.69 | 49.0 | 3.55e-01 | 75.7% | 46.5% |
| 7s0rB01 | 1.20.81.20 | Mainly Alpha › Up-down Bundle › Receptor-associated Protein › | 0.68 | 49.0 | 4.89e-01 | 78.4% | 75.0% |
| 3favD00 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.67 | 47.0 | 4.70e-01 | 74.3% | 79.5% |
| 4m70I00 | 1.20.5.4130 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › | 0.67 | 47.0 | 4.09e-01 | 73.0% | 57.4% |
| 4okvE00 | 6.10.140.1890 | Special › Helix non-globular › Helix Hairpins › | 0.65 | 48.0 | 5.06e-01 | 78.4% | 87.7% |
| 2vkzA02 | 3.40.47.10 | Alpha Beta › 3-Layer(aba) Sandwich › Peroxisomal Thiolase; Chain A, domain 1 › Thiolase/Chalcone synthase | 0.65 | 57.0 | 3.87e-01 | 97.3% | 43.5% |
| 4wzxA01 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.63 | 39.0 | 3.89e-01 | 71.6% | 61.3% |
| 3h6pC00 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.63 | 43.0 | 4.81e-01 | 73.0% | 94.6% |
| 4m70B00 | 1.10.246.200 | Mainly Alpha › Orthogonal Bundle › Serum Albumin; Chain A, Domain 1 › WPP domain | 0.62 | 51.0 | 4.80e-01 | 90.5% | 73.6% |
| 1sg6A02 | 1.20.1090.10 | Mainly Alpha › Up-down Bundle › Dehydroquinate synthase-like, alpha domain › Dehydroquinate synthase-like - alpha domain | 0.62 | 39.0 | 2.95e-01 | 74.3% | 24.4% |
| 5xtck00 | 1.10.287.3510 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.61 | 43.0 | 3.99e-01 | 74.3% | 60.8% |
| 3owaB04 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.60 | 41.0 | 3.24e-01 | 70.3% | 77.1% |
| 2rdcA00 | 1.10.287.800 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › protein ne1242 | 0.60 | 41.0 | 3.43e-01 | 71.6% | 39.8% |
| 3fhnA01 | 6.10.280.210 | Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Dsl1p vesicle tethering complex, Tip20p subunit, domain A | 0.60 | 41.0 | 3.10e-01 | 71.6% | 28.8% |
| 3cazB00 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.59 | 45.0 | 3.25e-01 | 81.1% | 77.6% |
| 4dciA00 | 6.10.140.1110 | Special › Helix non-globular › Helix Hairpins › | 0.59 | 40.0 | 3.28e-01 | 71.6% | 38.1% |
| 5b1oA00 | 1.10.287.130 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Signal transduction histidine kinase, dimerisation/phosphotransfer (DHp) domain | 0.57 | 39.0 | 4.10e-01 | 70.3% | 81.5% |
| 4xvxA03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.56 | 41.0 | 3.41e-01 | 81.1% | 86.4% |
| 2y39A00 | 1.20.120.1490 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › | 0.56 | 45.0 | 3.97e-01 | 87.8% | 75.5% |
| 4dwlA00 | 1.20.1440.60 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 23S rRNA-intervening sequence | 0.56 | 39.0 | 3.54e-01 | 75.7% | 96.3% |
| 2xubA05 | 6.10.140.1450 | Special › Helix non-globular › Helix Hairpins › | 0.55 | 39.0 | 3.60e-01 | 74.3% | 67.7% |
| 1zhcA00 | 6.10.280.50 | Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.55 | 46.0 | 4.62e-01 | 93.2% | 96.1% |
| 4aflA00 | 6.10.140.1740 | Special › Helix non-globular › Helix Hairpins › | 0.55 | 39.0 | 3.47e-01 | 74.3% | 58.8% |
| 3euaA02 | 1.10.10.2240 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › | 0.53 | 35.0 | 3.75e-01 | 86.5% | 79.7% |
| 4iggA01 | 1.10.287.160 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat | 0.53 | 40.0 | 4.19e-01 | 78.4% | 100.0% |
| 3nbxX03 | 1.20.58.1510 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.51 | 40.0 | 3.62e-01 | 97.3% | 61.4% |
ECOD (27)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4937584 | 5058.1.1.0 ↗ | alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region | 0.73 | 56.0 | 5.61e-01 | 81.1% | 84.0% |
| 3282873 | 5042.1.1.1 ↗ | extended segments › Magnesium transport protein CorA, transmembrane region › Magnesium transport protein CorA, transmembrane region › Magnesium transport protein CorA, transmembrane region › CorA | 0.72 | 52.0 | 5.54e-01 | 75.7% | 90.5% |
| 3771990 | 3567.1.1.6 ↗ | a+b duplicates or obligate multimers › MPER trimer › MPER trimer › MPER trimer › DGCR6 | 0.71 | 50.0 | 4.17e-01 | 73.0% | 73.6% |
| 5036615 | 5058.1.1.0 ↗ | alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region | 0.69 | 54.0 | 4.99e-01 | 83.8% | 76.8% |
| 3212581 | 148.1.3.289 ↗ | alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain › PKK | 0.69 | 49.0 | 5.25e-01 | 75.7% | 91.7% |
| 3756047 | 192.29.1.243 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › Fy-3 | 0.68 | 50.0 | 4.73e-01 | 78.4% | 98.9% |
| 3957435 | 5058.1.1.2 ↗ | alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › MS_channel_1st | 0.67 | 48.0 | 4.11e-01 | 75.7% | 60.0% |
| 4965530 | 5058.1.1.0 ↗ | alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region | 0.66 | 51.0 | 4.74e-01 | 83.8% | 71.6% |
| 3528691 | 601.19.1.20 ↗ | alpha bundles › Four-helical up-and-down bundle › Apolipoprotein › Apolipoprotein › Fy-3 | 0.66 | 54.0 | 4.60e-01 | 93.2% | 90.4% |
| 3800210 | 3826.1.1.0 ↗ | alpha bundles › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) | 0.65 | 50.0 | 5.25e-01 | 87.8% | 100.0% |
| 1746028 | 7581.1.1.7 ↗ | a/b three-layered sandwiches › Thiolase-like › Thiolase-like › Thiolase-like › Ketoacyl-synt_C | 0.63 | 54.0 | 3.52e-01 | 97.3% | 33.5% |
| 3717860 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.63 | 45.0 | 4.32e-01 | 77.0% | 78.9% |
| 4287749 | 150.5.1.110 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › ESAT-6 like › ESAT-6 like › PRESAN | 0.63 | 50.0 | 4.79e-01 | 90.5% | 92.2% |
| 3785340 | 7581.1.1.3 ↗ | a/b three-layered sandwiches › Thiolase-like › Thiolase-like › Thiolase-like › ketoacyl-synt,Ketoacyl-synt_C | 0.63 | 55.0 | 3.15e-01 | 97.3% | 68.4% |
| 4954658 | 632.19.1.7 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Choline binding protein A › Choline binding protein A › PF27212 | 0.61 | 45.0 | 4.75e-01 | 81.1% | 92.3% |
| 3988791 | 192.8.1.0 ↗ | alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain | 0.61 | 42.0 | 4.37e-01 | 71.6% | 80.0% |
| 3221921 | 3939.1.1.0 ↗ | alpha duplicates or obligate multimers › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain | 0.60 | 42.0 | 3.81e-01 | 73.0% | 62.0% |
| 4116779 | 603.1.1.174 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins › HisKA | 0.60 | 42.0 | 4.23e-01 | 73.0% | 73.3% |
| 5030302 | 3922.1.1.0 ↗ | alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 | 0.58 | 40.0 | 3.70e-01 | 70.3% | 55.8% |
| 3251379 | 605.1.1.1 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › HisKA | 0.57 | 41.0 | 3.95e-01 | 75.7% | 68.2% |
| 4219465 | 192.7.1.2 ↗ | alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm › Seryl_tRNA_N | 0.56 | 42.0 | 3.67e-01 | 78.4% | 93.6% |
| 5014863 | 3755.3.1.524 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › AI-2E_transport | 0.56 | 47.0 | 3.16e-01 | 94.6% | 88.4% |
| 3982352 | 4207.1.2.90 ↗ | alpha duplicates or obligate multimers › Mediator hinge subcomplex-like › Mediator hinge subcomplex-like › MED7 hinge region › FxsA | 0.55 | 46.0 | 4.17e-01 | 100.0% | 90.0% |
| 3832264 | 2004.1.1.184 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_11 | 0.54 | 44.0 | 2.70e-01 | 91.9% | 66.9% |
| 3968484 | 605.1.1.1 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › HisKA | 0.54 | 38.0 | 3.95e-01 | 75.7% | 88.6% |
| 3270180 | 5063.1.1.0 ↗ | alpha bundles › Photosystem I reaction center subunit X, PsaK › Photosystem I reaction center subunit X, PsaK › Photosystem I reaction center subunit X, PsaK | 0.53 | 42.0 | 4.04e-01 | 91.9% | 77.8% |
| 3236471 | 5054.1.1.8 ↗ | alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels › Ion_trans_2 | 0.52 | 43.0 | 3.09e-01 | 100.0% | 78.2% |
D2
medium
residues 75-272
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF09913.16 best | DUF2142 | 83.9 | 1.40e-23 | 96.0% | 48.4% |
CATH (5)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3vr4B04 | 1.10.1140.10 | Mainly Alpha › Orthogonal Bundle › Bovine Mitochondrial F1-ATPase, ATP Synthase Beta Chain; Chain D, domain3 › Bovine Mitochondrial F1-atpase; Atp Synthase Beta Chain; Chain D, domain 3 | 0.65 | 35.0 | 3.96e-01 | 90.4% | 67.5% |
| 2no4A02 | 1.10.150.240 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 | 0.57 | 21.0 | 3.25e-01 | 81.3% | 84.0% |
| 2fx0A02 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.54 | 28.0 | 3.39e-01 | 72.7% | 73.5% |
| 3v5uA01 | 6.10.280.80 | Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › NCX, peripheral helical region | 0.52 | 21.0 | 3.39e-01 | 91.9% | 97.4% |
| 2oh3A01 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.51 | 31.0 | 3.49e-01 | 100.0% | 79.2% |
ECOD (15)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4954029 | 3352.1.1.7 ↗ | alpha bundles › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › DUF2142 | 0.99 | 76.0 | 5.78e-01 | 100.0% | 39.7% |
| 4954264 | 3352.1.1.7 ↗ | alpha bundles › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › DUF2142 | 0.98 | 85.0 | 6.34e-01 | 100.0% | 42.2% |
| 4952898 | 3352.1.1.7 ↗ | alpha bundles › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › DUF2142 | 0.97 | 96.0 | 6.88e-01 | 100.0% | 42.8% |
| 3281331 | 3352.1.1.7 ↗ | alpha bundles › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › DUF2142 | 0.85 | 82.0 | 5.98e-01 | 100.0% | 43.0% |
| 4959788 | 3352.1.1.2 ↗ | alpha bundles › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › PMT_2 | 0.76 | 58.0 | 4.49e-01 | 100.0% | 37.1% |
| 5055260 | 3352.1.1.0 ↗ | alpha bundles › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain | 0.76 | 59.0 | 4.59e-01 | 100.0% | 39.3% |
| 4341144 | 3352.1.1.6 ↗ | alpha bundles › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › Glyco_transf_22 | 0.75 | 60.0 | 4.75e-01 | 100.0% | 43.4% |
| 4958183 | 3352.1.1.0 ↗ | alpha bundles › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain | 0.75 | 58.0 | 4.58e-01 | 100.0% | 40.8% |
| 4997137 | 3352.1.1.0 ↗ | alpha bundles › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain | 0.70 | 62.0 | 4.92e-01 | 100.0% | 47.9% |
| 3493364 | 3352.1.1.6 ↗ | alpha bundles › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › Glyco_transf_22 | 0.68 | 58.0 | 4.46e-01 | 99.5% | 42.2% |
| 5019226 | 3352.1.1.1 ↗ | alpha bundles › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › STT3 | 0.66 | 62.0 | 4.50e-01 | 100.0% | 39.4% |
| 3281663 | 3352.1.1.9 ↗ | alpha bundles › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › Mannosyl_trans | 0.66 | 56.0 | 4.28e-01 | 100.0% | 40.9% |
| 4605882 | 3352.1.1.1 ↗ | alpha bundles › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › STT3 | 0.62 | 58.0 | 4.23e-01 | 100.0% | 38.8% |
| 4965359 | 3352.1.1.51 ↗ | alpha bundles › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › AglB_core-like | 0.62 | 58.0 | 3.80e-01 | 100.0% | 25.0% |
| 3841126 | 5038.2.1.0 ↗ | alpha superhelices › Cytochrome c oxidase subunit I-like › MAPEG domain-like › MAPEG domain-like | 0.57 | 38.0 | 3.98e-01 | 96.5% | 72.4% |
D3
medium
residues 273-335
Domain cluster:
representative
CATH (34)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1k04A02 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.72 | 58.0 | 4.94e-01 | 88.9% | 58.7% |
| 1m5iA00 | 1.10.287.450 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.71 | 58.0 | 4.93e-01 | 92.1% | 95.2% |
| 4kb2A01 | 1.10.132.20 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor | 0.71 | 61.0 | 5.19e-01 | 100.0% | 92.7% |
| 2vixA03 | 1.20.1280.240 | Mainly Alpha › Up-down Bundle › Monooxygenase › | 0.70 | 56.0 | 4.70e-01 | 90.5% | 53.1% |
| 3lssA01 | 1.10.287.40 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain | 0.68 | 56.0 | 4.68e-01 | 92.1% | 57.1% |
| 4l0rB00 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.67 | 52.0 | 4.96e-01 | 92.1% | 74.0% |
| 1ykhA00 | 6.10.140.200 | Special › Helix non-globular › Helix Hairpins › | 0.66 | 54.0 | 4.70e-01 | 93.7% | 60.0% |
| 1lrzA03 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.65 | 51.0 | 5.20e-01 | 87.3% | 91.9% |
| 4it4A02 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.64 | 54.0 | 4.93e-01 | 100.0% | 82.4% |
| 2efkA01 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.64 | 53.0 | 3.51e-01 | 92.1% | 22.9% |
| 1x4tA01 | 1.10.287.660 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.64 | 48.0 | 5.00e-01 | 88.9% | 89.7% |
| 4iggA01 | 1.10.287.160 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat | 0.64 | 48.0 | 4.78e-01 | 82.5% | 95.5% |
| 4e6nA02 | 6.10.140.1010 | Special › Helix non-globular › Helix Hairpins › | 0.64 | 49.0 | 4.84e-01 | 82.5% | 80.3% |
| 1urfA00 | 1.10.287.160 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat | 0.64 | 53.0 | 4.92e-01 | 93.7% | 75.3% |
| 2uv8A07 | 6.10.140.1410 | Special › Helix non-globular › Helix Hairpins › | 0.63 | 47.0 | 4.37e-01 | 85.7% | 81.2% |
| 2gl2B00 | 1.10.287.1700 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.61 | 50.0 | 4.23e-01 | 92.1% | 54.1% |
| 1b5lA00 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.61 | 46.0 | 3.53e-01 | 84.1% | 59.9% |
| 4aflA00 | 6.10.140.1740 | Special › Helix non-globular › Helix Hairpins › | 0.61 | 48.0 | 4.17e-01 | 90.5% | 98.0% |
| 4h63H01 | 1.20.58.1710 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.60 | 45.0 | 4.42e-01 | 84.1% | 79.2% |
| 3hmfA00 | 1.20.920.10 | Mainly Alpha › Up-down Bundle › Histone Acetyltransferase; Chain A › Bromodomain-like | 0.60 | 48.0 | 4.00e-01 | 90.5% | 90.5% |
| 1i6zA00 | 1.20.58.120 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain | 0.60 | 51.0 | 4.09e-01 | 100.0% | 73.3% |
| 2vkzA02 | 3.40.47.10 | Alpha Beta › 3-Layer(aba) Sandwich › Peroxisomal Thiolase; Chain A, domain 1 › Thiolase/Chalcone synthase | 0.60 | 45.0 | 3.06e-01 | 85.7% | 21.4% |
| 4dkcB00 | 1.20.1250.80 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › Interleukin-34 | 0.60 | 46.0 | 3.50e-01 | 85.7% | 68.1% |
| 2xokP00 | 1.20.20.10 | Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C | 0.59 | 45.0 | 4.38e-01 | 87.3% | 74.3% |
| 2jaeA03 | 1.20.1440.240 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › | 0.59 | 44.0 | 3.86e-01 | 84.1% | 63.4% |
| 4mk3A02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.58 | 48.0 | 3.98e-01 | 92.1% | 53.0% |
| 1j1jA02 | 1.20.58.200 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 2 | 0.58 | 51.0 | 4.64e-01 | 100.0% | 85.9% |
| 4id0A02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.58 | 47.0 | 3.90e-01 | 88.9% | 50.9% |
| 2yqyA00 | 1.20.120.450 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › dinb family like domain | 0.58 | 47.0 | 3.83e-01 | 92.1% | 67.5% |
| 3nnrA00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.57 | 47.0 | 3.38e-01 | 96.8% | 38.1% |
| 1t98A02 | 1.20.58.590 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Chromosome partition protein MukF, middle domain | 0.56 | 47.0 | 3.60e-01 | 98.4% | 90.2% |
| 3lphC00 | 6.10.140.630 | Special › Helix non-globular › Helix Hairpins › | 0.56 | 40.0 | 4.14e-01 | 82.5% | 86.2% |
| 4gf0A02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.55 | 41.0 | 3.50e-01 | 84.1% | 52.2% |
| 2wzkA01 | 1.20.1310.10 | Mainly Alpha › Up-down Bundle › 5 helical Cullin repeat like › Cullin Repeats | 0.53 | 46.0 | 3.71e-01 | 100.0% | 53.5% |
ECOD (39)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4952898 | 3352.1.1.7 ↗ | alpha bundles › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › DUF2142 | 0.94 | 84.0 | 4.83e-01 | 93.7% | 12.7% |
| 4954264 | 3352.1.1.7 ↗ | alpha bundles › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › DUF2142 | 0.87 | 81.0 | 4.80e-01 | 100.0% | 15.9% |
| 3233696 | 4970.1.1.0 ↗ | alpha bundles › fingers domain in bacteriophage RB69-like DNA polymerase I › fingers domain in bacteriophage RB69-like DNA polymerase I › fingers domain in bacteriophage RB69-like DNA polymerase I | 0.74 | 58.0 | 5.95e-01 | 87.3% | 93.3% |
| 4951260 | 601.14.1.1 ↗ | alpha bundles › Four-helical up-and-down bundle › Hemerythrin › Hemerythrin › Hemerythrin | 0.72 | 57.0 | 4.45e-01 | 88.9% | 82.1% |
| 3736652 | 192.29.1.102 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › Fung_rhodopsin | 0.71 | 56.0 | 5.24e-01 | 87.3% | 81.2% |
| 4935676 | 604.5.1.2 ↗ | alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › PhoU | 0.71 | 61.0 | 5.11e-01 | 98.4% | 80.9% |
| 4941353 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.71 | 55.0 | 4.53e-01 | 85.7% | 48.7% |
| 3364683 | 192.8.1.0 ↗ | alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain | 0.70 | 48.0 | 4.30e-01 | 76.2% | 51.1% |
| 4848262 | 109.3.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat | 0.69 | 55.0 | 4.68e-01 | 88.9% | 53.3% |
| 3978380 | 5069.1.1.0 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes | 0.68 | 54.0 | 4.20e-01 | 90.5% | 43.4% |
| 4016292 | 192.2.1.18 ↗ | alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin › ING | 0.68 | 55.0 | 4.36e-01 | 92.1% | 49.6% |
| 3766883 | 604.5.1.34 ↗ | alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › ELO | 0.67 | 58.0 | 3.86e-01 | 100.0% | 36.0% |
| 5053661 | 2011.1.1.8 ↗ | a/b three-layered sandwiches › Phosphorylase/hydrolase-like › Zn-dependent exopeptidases › Zn-dependent exopeptidases › Peptidase_M28 | 0.67 | 53.0 | 3.32e-01 | 88.9% | 43.2% |
| 3729252 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.67 | 55.0 | 4.55e-01 | 92.1% | 67.0% |
| 3782284 | 223.2.1.0 ↗ | a+b three layers › Profilin-like › profilin-like › profilin-like | 0.67 | 52.0 | 3.64e-01 | 85.7% | 26.7% |
| 4928305 | 7566.1.1.2 ↗ | a/b three-layered sandwiches › HflX family GTPase N-terminal domain › HflX family GTPase N-terminal domain › HflX family GTPase N-terminal domain › GTP-bdg_N | 0.66 | 53.0 | 3.84e-01 | 92.1% | 35.6% |
| 4581983 | 5086.1.1.13 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › T3SSipB | 0.66 | 52.0 | 4.12e-01 | 90.5% | 59.3% |
| 5048590 | 192.7.1.2 ↗ | alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm › Seryl_tRNA_N | 0.65 | 52.0 | 4.47e-01 | 92.1% | 56.4% |
| 1566346 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.65 | 48.0 | 4.68e-01 | 81.0% | 74.6% |
| 3182561 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.65 | 53.0 | 3.94e-01 | 92.1% | 37.0% |
| 5052036 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.64 | 50.0 | 4.78e-01 | 85.7% | 81.3% |
| None | — | 0.64 | 52.0 | 3.63e-01 | 92.1% | 30.0% | |
| 5069548 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.64 | 51.0 | 5.14e-01 | 92.1% | 100.0% |
| 3990854 | 192.7.1.0 ↗ | alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm | 0.63 | 50.0 | 4.51e-01 | 88.9% | 67.8% |
| 4014485 | 5044.1.1.0 ↗ | extended segments › PsbZ-like › PsbZ-like › PsbZ-like | 0.63 | 50.0 | 4.52e-01 | 92.1% | 76.8% |
| 3273217 | 604.12.1.0 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain | 0.63 | 54.0 | 4.77e-01 | 98.4% | 86.3% |
| 3188064 | 605.1.1.133 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › OST3_OST6 | 0.62 | 47.0 | 3.89e-01 | 85.7% | 44.0% |
| 3374304 | 601.33.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › CHAD domain › CHAD domain | 0.62 | 50.0 | 4.77e-01 | 96.8% | 98.8% |
| 5028289 | 7516.1.1.2 ↗ | a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Glycos_transf_2 | 0.62 | 51.0 | 3.35e-01 | 98.4% | 26.8% |
| 3398929 | 5041.1.1.32 ↗ | extended segments › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C › TMEM141 | 0.62 | 47.0 | 4.30e-01 | 87.3% | 81.1% |
| 3698165 | 192.15.1.77 ↗ | alpha bundles › Long alpha-hairpin › Endosomal sorting complex assembly domains › Endosomal sorting complex assembly domains › OST3_OST6 | 0.61 | 46.0 | 3.93e-01 | 85.7% | 47.8% |
| 3731535 | 150.1.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin | 0.61 | 48.0 | 4.29e-01 | 92.1% | 73.0% |
| 3934928 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.61 | 51.0 | 4.54e-01 | 98.4% | 91.6% |
| 3639616 | 109.4.1.158 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › ERAP1_C | 0.60 | 49.0 | 3.20e-01 | 95.2% | 79.1% |
| 3236866 | 1135.1.1.3 ↗ | a+b complex topology › Immune Mapped Protein 2 (IMP2) › Immune Mapped Protein 2 (IMP2) › Immune Mapped Protein 2 (IMP2) › CytochromB561_N | 0.60 | 50.0 | 4.35e-01 | 92.1% | 64.2% |
| 4496489 | 2498.4.1.0 ↗ | mixed a+b and a/b › Zincin-like › HSP90 C-terminal domain (C-terminal part of Pfam 00183) › HSP90 C-terminal domain (C-terminal part of Pfam 00183) | 0.59 | 48.0 | 3.41e-01 | 92.1% | 30.2% |
| 3857804 | 3567.1.1.0 ↗ | a+b duplicates or obligate multimers › MPER trimer › MPER trimer › MPER trimer | 0.59 | 44.0 | 4.02e-01 | 84.1% | 81.1% |
| 3648687 | 604.12.1.89 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › CDP-OH_P_transf | 0.57 | 45.0 | 4.12e-01 | 96.8% | 88.4% |
| 1222635 | 109.1.1.6 ↗ | alpha superhelices › Repetitive alpha hairpins › Glutathione S-transferase (GST)-C › Glutathione S-transferase (GST)-C › GST_C_2 | 0.55 | 41.0 | 3.38e-01 | 84.1% | 46.5% |
D4
medium
residues 336-477
Domain cluster:
representative
CATH (7)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2l7nA00 | 1.20.1420.10 | Mainly Alpha › Up-down Bundle › A middle domain of Talin 1 › Talin, central domain | 0.57 | 36.0 | 3.43e-01 | 71.8% | 53.6% |
| 6z01B03 | 1.10.132.10 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › | 0.56 | 34.0 | 3.30e-01 | 71.1% | 54.5% |
| 1nktA04 | 1.10.3060.10 | Mainly Alpha › Orthogonal Bundle › Helical scaffold and wing domains of SecA › Helical scaffold and wing domains of SecA | 0.54 | 43.0 | 4.04e-01 | 85.9% | 100.0% |
| 2fsfB04 | 1.10.3060.10 | Mainly Alpha › Orthogonal Bundle › Helical scaffold and wing domains of SecA › Helical scaffold and wing domains of SecA | 0.52 | 42.0 | 3.77e-01 | 88.0% | 86.8% |
| 7p2yC03 | 1.20.150.20 | Mainly Alpha › Up-down Bundle › Lysin › ATP synthase alpha/beta chain, C-terminal domain | 0.52 | 29.0 | 3.11e-01 | 75.4% | 58.3% |
| 3nc3B00 | 1.10.630.10 | Mainly Alpha › Orthogonal Bundle › Cytochrome p450 › Cytochrome P450 | 0.51 | 42.0 | 3.13e-01 | 88.7% | 93.0% |
| 3r4iA02 | 6.10.140.960 | Special › Helix non-globular › Helix Hairpins › | 0.51 | 19.0 | 2.90e-01 | 71.1% | 80.0% |
ECOD (10)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4954029 | 3352.1.1.7 ↗ | alpha bundles › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › DUF2142 | 0.92 | 73.0 | 5.12e-01 | 100.0% | 30.1% |
| 4954264 | 3352.1.1.7 ↗ | alpha bundles › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › DUF2142 | 0.91 | 77.0 | 5.29e-01 | 100.0% | 29.9% |
| 3281331 | 3352.1.1.7 ↗ | alpha bundles › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › DUF2142 | 0.82 | 77.0 | 5.24e-01 | 100.0% | 71.3% |
| 4952898 | 3352.1.1.7 ↗ | alpha bundles › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › DUF2142 | 0.80 | 77.0 | 5.15e-01 | 100.0% | 64.5% |
| 3987419 | 140.1.1.7 ↗ | alpha bundles › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › DALR_2 | 0.56 | 35.0 | 3.84e-01 | 71.8% | 75.7% |
| 3223750 | 601.1.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin | 0.56 | 35.0 | 3.43e-01 | 72.5% | 56.8% |
| 3282500 | 5065.1.1.3 ↗ | alpha bundles › Type II ABC importer transmembrane domain fold › Type II ABC importer transmembrane domain fold › Type II ABC importer transmembrane domain fold › BPD_transp_2 | 0.54 | 42.0 | 3.31e-01 | 83.1% | 76.7% |
| 3685239 | 4323.1.1.2 ↗ | alpha bundles › helical bundle domain in vacuolar ATP synthase subunit C › helical bundle domain in vacuolar ATP synthase subunit C › helical bundle domain in vacuolar ATP synthase subunit C › V-ATPase_C | 0.53 | 40.0 | 3.76e-01 | 78.2% | 85.3% |
| 3723912 | 5050.1.1.1 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Sugar_tr | 0.52 | 38.0 | 3.36e-01 | 77.5% | 51.8% |
| 4302432 | 5065.1.1.3 ↗ | alpha bundles › Type II ABC importer transmembrane domain fold › Type II ABC importer transmembrane domain fold › Type II ABC importer transmembrane domain fold › BPD_transp_2 | 0.51 | 41.0 | 3.25e-01 | 88.7% | 72.6% |