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IMGVR_UViG_3300031861_000370-3300031861-Ga0315319_100075455
Arc-VirIMGVR_UViG_3300031861_000370-3300031861-Ga0315319_100075455
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 590-653
Domain cluster:
representative
CATH (11)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2ve3B00 | 1.10.630.10 | Mainly Alpha › Orthogonal Bundle › Cytochrome p450 › Cytochrome P450 | 0.60 | 50.0 | 3.10e-01 | 100.0% | 56.4% |
| 1wgwA00 | 1.20.120.140 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › SRP54, nucleotide-binding domain | 0.58 | 45.0 | 3.96e-01 | 87.5% | 80.8% |
| 2gttC01 | 1.10.3570.10 | Mainly Alpha › Orthogonal Bundle › Rhabdovirus nucleoprotein-like fold › Rhabdovirus nucleocapsid protein like domain | 0.55 | 47.0 | 3.44e-01 | 100.0% | 37.1% |
| 3oqvA00 | 3.40.50.11710 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Cyclodipeptide synthase | 0.55 | 42.0 | 3.04e-01 | 87.5% | 46.0% |
| 2jaeA03 | 1.20.1440.240 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › | 0.54 | 43.0 | 3.76e-01 | 89.1% | 83.2% |
| 1eb7A01 | 1.10.760.10 | Mainly Alpha › Orthogonal Bundle › Cytochrome Bc1 Complex; Chain D, domain 2 › Cytochrome c-like domain | 0.54 | 47.0 | 3.64e-01 | 100.0% | 96.6% |
| 3fedA03 | 1.20.930.40 | Mainly Alpha › Up-down Bundle › Transcription Elongation Factor S-II; Chain A › Transferrin receptor-like, dimerisation domain | 0.53 | 36.0 | 2.77e-01 | 70.3% | 90.3% |
| 3qdkA02 | 3.30.420.40 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain | 0.52 | 43.0 | 2.94e-01 | 98.4% | 61.6% |
| 3smtA02 | 3.90.1420.10 | Alpha Beta › Alpha-Beta Complex › set domain protein methyltransferase, domain 2 › Rubisco LSMT, substrate-binding domain | 0.51 | 39.0 | 3.06e-01 | 89.1% | 92.1% |
| 3tahA02 | 1.10.287.1770 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.50 | 38.0 | 3.55e-01 | 87.5% | 86.4% |
| 4acoA02 | 1.10.443.20 | Mainly Alpha › Orthogonal Bundle › hpI Integrase; Chain A › Centromere DNA-binding protein complex CBF3 subunit, domain 2 | 0.50 | 38.0 | 2.48e-01 | 85.9% | 64.0% |
ECOD (5)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3180486 | 601.1.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin | 0.60 | 47.0 | 3.61e-01 | 87.5% | 68.8% |
| 4270602 | 2003.1.2.18 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › FAD/NAD(P)-binding domain | 0.54 | 46.0 | 2.90e-01 | 100.0% | 24.1% |
| 4945392 | 2002.1.1.50 ↗ | a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels › F_bP_aldolase | 0.53 | 44.0 | 2.80e-01 | 100.0% | 47.3% |
| 3169408 | 101.1.17.2 ↗ | alpha arrays › HTH › HTH › FF domain › FF | 0.53 | 40.0 | 3.97e-01 | 92.2% | 78.6% |
| 3837821 | 5050.1.1.1 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Sugar_tr | 0.53 | 44.0 | 2.98e-01 | 93.8% | 71.2% |
D2
high
residues 980-1060
Domain cluster:
representative
CATH (8)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1zbuB01 | 1.10.720.30 | Mainly Alpha › Orthogonal Bundle › Transcription Termination Factor Rho, Rna-binding Domain; Chain A, Domain 1 › SAP domain | 0.81 | 47.0 | 4.90e-01 | 70.4% | 63.5% |
| 1qo0D02 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.73 | 36.0 | 4.69e-01 | 75.3% | 84.8% |
| 2m4eA00 | 1.20.120.1930 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Uncharacterised protein PF16691 family | 0.63 | 44.0 | 4.33e-01 | 72.8% | 90.7% |
| 1d3yA01 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.61 | 35.0 | 3.76e-01 | 75.3% | 64.8% |
| 2btoA01 | 3.40.50.1440 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Tubulin/FtsZ, GTPase domain | 0.55 | 42.0 | 3.00e-01 | 82.7% | 94.7% |
| 3vfcA01 | 3.30.390.10 | Alpha Beta › 2-Layer Sandwich › Enolase-like; domain 1 › Enolase-like, N-terminal domain | 0.53 | 35.0 | 2.82e-01 | 70.4% | 36.9% |
| 5ucoA02 | 3.40.47.10 | Alpha Beta › 3-Layer(aba) Sandwich › Peroxisomal Thiolase; Chain A, domain 1 › Thiolase/Chalcone synthase | 0.51 | 36.0 | 3.04e-01 | 75.3% | 47.1% |
| 1werA02 | 1.10.506.10 | Mainly Alpha › Orthogonal Bundle › GTPase Activation - p120GAP; domain 1 › GTPase Activation - p120gap; domain 1 | 0.50 | 37.0 | 3.08e-01 | 79.0% | 100.0% |
ECOD (4)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1168191 | 130.1.1.1 ↗ | alpha arrays › LEM/SAP HeH motif-like › LEM/SAP HeH motif › LEM/SAP HeH motif › SAP | 0.81 | 47.0 | 4.87e-01 | 70.4% | 62.7% |
| 3463447 | 210.2.1.1 ↗ | a+b four layers › Ntn/PP2C › Protein serine/threonine phosphatase 2C, catalytic domain › Protein serine/threonine phosphatase 2C, catalytic domain › PP2C | 0.65 | 46.0 | 2.92e-01 | 74.1% | 93.5% |
| 4445092 | 130.1.2.0 ↗ | alpha arrays › LEM/SAP HeH motif-like › LEM/SAP HeH motif › ribosome-binding domain of Mdm38 | 0.60 | 54.0 | 3.62e-01 | 95.1% | 66.5% |
| 3979217 | 3576.1.1.1 ↗ | a+b complex topology › Cas8-like › Cascade subunit CasA/Cse1/Cas8 › Cascade subunit CasA/Cse1/Cas8 › CRISPR_Cse1 | 0.51 | 43.0 | 2.67e-01 | 96.3% | 79.2% |
D3
medium
residues 1-175
Domain cluster:
representative
CATH (19)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4rs8A00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.78 | 31.0 | 4.46e-01 | 91.4% | 77.4% |
| 2xubA01 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.77 | 28.0 | 4.13e-01 | 89.1% | 73.1% |
| 2mlgA00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.75 | 29.0 | 4.31e-01 | 88.0% | 80.5% |
| 5dcaA11 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.73 | 40.0 | 5.08e-01 | 96.0% | 89.5% |
| 2v79A00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.72 | 33.0 | 4.01e-01 | 92.0% | 64.3% |
| 3bj6B00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.71 | 32.0 | 3.43e-01 | 96.0% | 49.0% |
| 5xnsC00 | 1.10.10.580 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Structural maintenance of chromosome 1. Chain E | 0.70 | 28.0 | 4.30e-01 | 86.9% | 91.4% |
| 1sfxB00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.69 | 28.0 | 3.63e-01 | 91.4% | 62.5% |
| 2jtvA00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.67 | 26.0 | 4.18e-01 | 96.0% | 95.4% |
| 5eriA00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.65 | 31.0 | 3.33e-01 | 97.1% | 50.3% |
| 2p4wA01 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.63 | 31.0 | 3.93e-01 | 92.6% | 78.6% |
| 7dklA01 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.61 | 32.0 | 3.97e-01 | 90.3% | 78.1% |
| 3bg2A03 | 1.10.3410.10 | Mainly Alpha › Orthogonal Bundle › putative deoxyguanosinetriphosphate triphosphohydrolase fold › putative deoxyguanosinetriphosphate triphosphohydrolase like domain | 0.60 | 27.0 | 3.52e-01 | 89.7% | 74.0% |
| 2fbiA00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.57 | 33.0 | 3.72e-01 | 100.0% | 73.5% |
| 2mh9A00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.56 | 33.0 | 3.84e-01 | 91.4% | 79.5% |
| 1jgsA00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.56 | 33.0 | 3.76e-01 | 100.0% | 75.4% |
| 3k8pC01 | 1.20.58.1440 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.55 | 28.0 | 3.43e-01 | 84.6% | 77.1% |
| 6ldiF01 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.53 | 23.0 | 2.97e-01 | 93.1% | 69.8% |
| 6pcoC00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.52 | 30.0 | 3.48e-01 | 100.0% | 75.8% |
ECOD (16)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 5051484 | 101.1.2.30 ↗ | alpha arrays › HTH › HTH › winged helix domain › TrmB | 0.74 | 36.0 | 3.92e-01 | 91.4% | 55.2% |
| 5007853 | 101.1.2.192 ↗ | alpha arrays › HTH › HTH › winged helix domain › B_lactamase-like_C | 0.68 | 29.0 | 4.51e-01 | 88.0% | 100.0% |
| 5014584 | 101.1.2.932 ↗ | alpha arrays › HTH › HTH › winged helix domain › wHTH-PRTase_assc | 0.67 | 32.0 | 4.62e-01 | 90.3% | 95.3% |
| 3265825 | 101.1.2.65 ↗ | alpha arrays › HTH › HTH › winged helix domain › Rad21_Rec8 | 0.66 | 32.0 | 4.43e-01 | 90.9% | 91.1% |
| 4999991 | 101.1.2.0 ↗ | alpha arrays › HTH › HTH › winged helix domain | 0.64 | 36.0 | 4.30e-01 | 100.0% | 81.7% |
| 4026870 | 101.1.2.111 ↗ | alpha arrays › HTH › HTH › winged helix domain › RQC | 0.64 | 35.0 | 4.39e-01 | 91.4% | 86.4% |
| 3657252 | 101.1.2.0 ↗ | alpha arrays › HTH › HTH › winged helix domain | 0.63 | 33.0 | 3.21e-01 | 91.4% | 45.3% |
| 3171534 | 3470.1.1.46 ↗ | extended segments › Glycophorin-A transmembrane domain › Glycophorin-A transmembrane domain › Glycophorin-A transmembrane domain › VanZ | 0.63 | 29.0 | 3.78e-01 | 81.1% | 75.8% |
| 3275333 | 101.1.2.37 ↗ | alpha arrays › HTH › HTH › winged helix domain › E2F_TDP | 0.62 | 36.0 | 3.08e-01 | 96.0% | 35.1% |
| 3194261 | 101.1.1.0 ↗ | alpha arrays › HTH › HTH › Three-helical HTH | 0.62 | 26.0 | 3.21e-01 | 94.3% | 57.4% |
| 4996241 | 101.1.2.0 ↗ | alpha arrays › HTH › HTH › winged helix domain | 0.58 | 34.0 | 4.09e-01 | 95.4% | 85.0% |
| 5036014 | 192.2.1.0 ↗ | alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin | 0.53 | 29.0 | 3.84e-01 | 70.9% | 97.9% |
| 4940192 | 192.2.1.1 ↗ | alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin › Prefoldin_2 | 0.52 | 29.0 | 3.51e-01 | 70.3% | 81.6% |
| 3816176 | 5041.1.1.0 ↗ | extended segments › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C | 0.52 | 31.0 | 3.89e-01 | 81.7% | 99.0% |
| 3614366 | 101.1.2.0 ↗ | alpha arrays › HTH › HTH › winged helix domain | 0.51 | 36.0 | 3.61e-01 | 92.0% | 69.7% |
| 4129936 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.51 | 27.0 | 3.47e-01 | 82.3% | 89.5% |
D4
medium
residues 176-240_321-355_471-521_714-755_887-979
Domain cluster:
representative
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00940.25 best | RNA_pol | 68.7 | 6.20e-19 | 35.0% | 16.0% |
| PF00940.25 | RNA_pol | 44.6 | 1.30e-11 | 28.3% | 12.2% |
CATH (5)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1aroP03 | 3.30.70.370 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.83 | 40.0 | 5.62e-01 | 73.8% | 89.3% |
| 3q23A02 | 3.30.70.2440 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.79 | 42.0 | 5.90e-01 | 86.7% | 100.0% |
| 4hkqA01 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.71 | 26.0 | 3.68e-01 | 72.7% | 66.7% |
| 1vq8E02 | 3.90.930.12 | Alpha Beta › Alpha-Beta Complex › Outer Surface Protein A; domain 3 › Ribosomal protein L6 | 0.51 | 18.0 | 2.89e-01 | 87.1% | 84.9% |
| 4m5bA00 | 1.10.1760.20 | Mainly Alpha › Orthogonal Bundle › Arp2/3 complex 21 kDa subunit ARPC3 › | 0.51 | 29.0 | 3.37e-01 | 83.2% | 73.8% |
ECOD (7)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4035959 | 306.2.1.1 ↗ | a+b two layers › Glucose permease domain IIB-like › arginine repressor C terminal domain-related › C-terminal domain of arginine repressor › Arg_repressor_C | 0.55 | 17.0 | 3.23e-01 | 71.3% | 94.1% |
| 3983816 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.54 | 33.0 | 3.56e-01 | 78.0% | 68.0% |
| 3571315 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.54 | 28.0 | 3.10e-01 | 78.0% | 58.3% |
| 4977732 | 304.48.1.0 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like | 0.53 | 34.0 | 3.81e-01 | 77.6% | 79.6% |
| 5044377 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.52 | 35.0 | 3.83e-01 | 75.5% | 80.0% |
| 3265942 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.51 | 26.0 | 3.28e-01 | 77.6% | 77.7% |
| 4649506 | 3239.1.1.1 ↗ | alpha complex topology › Cas1 › Cas1 › Cas1 › Cas_Cas1 | 0.51 | 35.0 | 3.38e-01 | 95.8% | 60.0% |
D5
medium
residues 356-470
Domain cluster:
rep: IMGVR_UViG_3300037808_002181-3300037808-Ga0427880_006200_5315_7366__D597-683
CATH (9)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2e9xB02 | 1.20.58.1020 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.54 | 33.0 | 3.43e-01 | 80.0% | 63.3% |
| 2gscC00 | 1.20.1440.60 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 23S rRNA-intervening sequence | 0.54 | 46.0 | 4.69e-01 | 91.3% | 98.2% |
| 3kavA00 | 1.20.1270.360 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.54 | 44.0 | 4.62e-01 | 90.4% | 98.0% |
| 1a22A00 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.53 | 47.0 | 4.04e-01 | 95.7% | 91.1% |
| 4n4gA01 | 1.20.920.10 | Mainly Alpha › Up-down Bundle › Histone Acetyltransferase; Chain A › Bromodomain-like | 0.53 | 43.0 | 4.42e-01 | 96.5% | 92.8% |
| 1j6wA00 | 3.30.1360.80 | Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › S-ribosylhomocysteinase (LuxS) | 0.52 | 44.0 | 3.94e-01 | 92.2% | 69.6% |
| 1sgmA00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.51 | 39.0 | 3.35e-01 | 80.0% | 63.6% |
| 2clbA01 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.51 | 43.0 | 3.91e-01 | 93.9% | 69.2% |
| 2rgnB01 | 1.20.900.10 | Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain | 0.50 | 44.0 | 3.70e-01 | 98.3% | 70.1% |
ECOD (15)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3177607 | 109.4.1.163 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › SYMPK_PTA1_N | 0.61 | 42.0 | 3.05e-01 | 71.3% | 51.9% |
| 3650048 | 109.1.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › Glutathione S-transferase (GST)-C › Glutathione S-transferase (GST)-C | 0.60 | 39.0 | 3.04e-01 | 93.9% | 29.6% |
| 3692351 | 633.6.1.0 ↗ | alpha bundles › Bromodomain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA dehydrogenase C-terminal domain-like | 0.60 | 51.0 | 4.57e-01 | 93.0% | 88.7% |
| 3262164 | 4121.1.1.1 ↗ | a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like › CorA | 0.59 | 43.0 | 3.29e-01 | 75.7% | 64.6% |
| 3239549 | 5001.1.1.0 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like | 0.58 | 52.0 | 3.91e-01 | 100.0% | 79.6% |
| 4019886 | 633.10.1.0 ↗ | alpha bundles › Bromodomain-like › IVS-encoded protein-like › IVS-encoded protein-like | 0.55 | 47.0 | 4.46e-01 | 92.2% | 97.0% |
| 3495582 | 4163.1.2.1 ↗ | alpha bundles › GINS helical bundle-like › GINS helical bundle-like › PSF2 C-terminal domain-like › Sld5 | 0.55 | 33.0 | 3.39e-01 | 79.1% | 60.0% |
| 3214722 | 5001.1.1.63 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7TM_GPCR_Srab | 0.55 | 48.0 | 3.55e-01 | 100.0% | 78.8% |
| 3788423 | 604.1.1.132 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › KAR9 | 0.54 | 34.0 | 3.58e-01 | 95.7% | 69.5% |
| 3575903 | 174.1.1.0 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain | 0.52 | 45.0 | 3.86e-01 | 95.7% | 98.9% |
| 3992612 | 604.6.1.1 ↗ | alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain › GAT | 0.52 | 37.0 | 4.18e-01 | 76.5% | 95.6% |
| 3590280 | 141.1.1.1 ↗ | alpha bundles › Terpenoid synthases › Terpenoid synthases › Terpenoid synthases › polyprenyl_synt | 0.51 | 39.0 | 2.85e-01 | 82.6% | 46.0% |
| 3733626 | 310.2.1.0 ↗ | a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF | 0.51 | 37.0 | 3.46e-01 | 74.8% | 100.0% |
| 3634637 | 5050.1.1.1 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Sugar_tr | 0.50 | 43.0 | 3.33e-01 | 93.9% | 86.8% |
| 3488666 | 5054.1.1.2 ↗ | alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels › Ion_trans | 0.50 | 43.0 | 2.97e-01 | 93.0% | 27.9% |
D6
medium
residues 522-577_664-713
Domain cluster:
representative
CATH (19)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2iw3A02 | 1.20.1390.20 | Mainly Alpha › Up-down Bundle › PWI domain › | 0.68 | 47.0 | 4.99e-01 | 100.0% | 83.3% |
| 3tbiB02 | 6.10.140.1670 | Special › Helix non-globular › Helix Hairpins › | 0.68 | 41.0 | 4.24e-01 | 100.0% | 64.0% |
| 4unfA02 | 1.10.340.30 | Mainly Alpha › Orthogonal Bundle › Endonuclease III; domain 1 › Hypothetical protein; domain 2 | 0.67 | 46.0 | 4.46e-01 | 94.3% | 63.2% |
| 1qgtB00 | 1.10.4090.10 | Mainly Alpha › Orthogonal Bundle › Hepatitis B viral capsid (hbcag) fold › Viral capsid, core domain supefamily, Hepatitis B virus | 0.62 | 32.0 | 2.90e-01 | 98.1% | 36.4% |
| 1u61A00 | 1.10.1520.10 | Mainly Alpha › Orthogonal Bundle › Ribonuclease iii, N-terminal Endonuclease Domain; Chain A › Ribonuclease III domain | 0.61 | 40.0 | 3.76e-01 | 78.3% | 54.3% |
| 4bejB02 | 1.20.120.1240 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Dynamin, middle domain | 0.61 | 48.0 | 3.75e-01 | 83.0% | 79.4% |
| 3w0lD02 | 3.40.50.10490 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Glucose-6-phosphate isomerase like protein; domain 1 | 0.60 | 46.0 | 3.22e-01 | 100.0% | 25.4% |
| 1n5uA02 | 1.10.246.10 | Mainly Alpha › Orthogonal Bundle › Serum Albumin; Chain A, Domain 1 › | 0.59 | 36.0 | 3.86e-01 | 72.6% | 71.1% |
| 8gy0A01 | 1.10.600.10 | Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase | 0.58 | 48.0 | 3.57e-01 | 91.5% | 35.6% |
| 1u7gA00 | 1.10.3430.10 | Mainly Alpha › Orthogonal Bundle › Ammonium transporter fold › Ammonium transporter AmtB like domains | 0.56 | 45.0 | 3.13e-01 | 87.7% | 78.1% |
| 4ocqA01 | 3.90.1200.10 | Alpha Beta › Alpha-Beta Complex › Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2 › Aminoglycoside phosphotransferase (APH), C-terminal lobe | 0.56 | 49.0 | 3.84e-01 | 100.0% | 72.9% |
| 1n1bB02 | 1.10.600.10 | Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase | 0.55 | 47.0 | 3.43e-01 | 95.3% | 37.9% |
| 7zghA01 | 3.40.50.1240 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Phosphoglycerate mutase-like | 0.55 | 38.0 | 2.57e-01 | 70.8% | 34.7% |
| 2e9fB01 | 1.10.275.10 | Mainly Alpha › Orthogonal Bundle › Fumarase C; Chain B, domain 1 › Fumarase/aspartase (N-terminal domain) | 0.53 | 35.0 | 3.71e-01 | 82.1% | 75.0% |
| 2f5jB00 | 1.10.274.30 | Mainly Alpha › Orthogonal Bundle › Enzyme I; Chain A, domain 2 › MRG domain | 0.52 | 45.0 | 3.98e-01 | 98.1% | 77.4% |
| 3hbaA02 | 3.40.50.10490 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Glucose-6-phosphate isomerase like protein; domain 1 | 0.51 | 38.0 | 3.72e-01 | 76.4% | 100.0% |
| 2qzcA00 | 1.20.910.10 | Mainly Alpha › Up-down Bundle › Heme Oxygenase; Chain A › Heme oxygenase-like | 0.51 | 40.0 | 3.27e-01 | 84.9% | 69.4% |
| 4lqkA00 | 1.10.437.20 | Mainly Alpha › Orthogonal Bundle › Apoptosis Regulator Bcl-x › dsDNA poxvirus | 0.51 | 36.0 | 3.36e-01 | 100.0% | 57.6% |
| 4o1pA03 | 1.20.1440.180 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › KEN domain | 0.51 | 35.0 | 3.41e-01 | 100.0% | 61.8% |
ECOD (25)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4034503 | 101.26.1.1 ↗ | alpha arrays › HTH › Tex N-terminal domain › Tex N-terminal domain › Tex_N | 0.68 | 36.0 | 4.43e-01 | 100.0% | 83.1% |
| 3998879 | 101.1.1.0 ↗ | alpha arrays › HTH › HTH › Three-helical HTH | 0.62 | 47.0 | 4.60e-01 | 100.0% | 72.5% |
| 5066876 | 1079.1.1.12 ↗ | alpha complex topology › Transmembrane reductase CcdA › Transmembrane reductase CcdA › Transmembrane reductase CcdA › GDT1 | 0.61 | 50.0 | 4.30e-01 | 90.6% | 85.1% |
| 4028505 | 4207.1.2.47 ↗ | alpha duplicates or obligate multimers › Mediator hinge subcomplex-like › Mediator hinge subcomplex-like › MED7 hinge region › RIFIN | 0.60 | 46.0 | 4.10e-01 | 100.0% | 56.7% |
| 4587300 | 2003.1.5.25 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › GidB | 0.59 | 45.0 | 3.65e-01 | 82.1% | 94.8% |
| 3990268 | 5067.1.1.3 ↗ | alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Patched | 0.59 | 52.0 | 4.15e-01 | 99.1% | 60.0% |
| 3713349 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.58 | 48.0 | 3.84e-01 | 90.6% | 78.1% |
| 4426593 | 563.1.1.1 ↗ | alpha bundles › ATPD N-terminal domain-like › N-terminal domain of the delta subunit of the F1F0-ATP synthase › N-terminal domain of the delta subunit of the F1F0-ATP synthase › OSCP | 0.58 | 43.0 | 3.75e-01 | 97.2% | 50.0% |
| 3413892 | 632.19.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Choline binding protein A › Choline binding protein A | 0.55 | 38.0 | 3.70e-01 | 70.8% | 65.0% |
| 4451586 | 5050.1.1.18 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › PUCC | 0.55 | 45.0 | 3.69e-01 | 92.5% | 76.2% |
| 4970934 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.54 | 44.0 | 3.60e-01 | 88.7% | 74.6% |
| 4971391 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.54 | 39.0 | 3.28e-01 | 76.4% | 92.1% |
| 3501345 | 162.1.1.0 ↗ | alpha bundles › PTS-regulatory domain, PRD › PTS-regulatory domain, PRD › PTS-regulatory domain, PRD | 0.54 | 42.0 | 4.10e-01 | 83.0% | 96.5% |
| 5004498 | 310.2.1.0 ↗ | a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF | 0.53 | 42.0 | 4.38e-01 | 100.0% | 91.0% |
| 4608998 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.53 | 41.0 | 3.28e-01 | 86.8% | 78.3% |
| 4419364 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.52 | 40.0 | 3.11e-01 | 84.0% | 79.6% |
| 4978085 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.52 | 41.0 | 3.41e-01 | 85.8% | 79.5% |
| 3954386 | 101.1.1.248 ↗ | alpha arrays › HTH › HTH › Three-helical HTH › DUF772 | 0.52 | 44.0 | 4.29e-01 | 100.0% | 85.2% |
| 5026211 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.51 | 40.0 | 3.47e-01 | 85.8% | 85.1% |
| 3352332 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.51 | 43.0 | 3.34e-01 | 91.5% | 67.7% |
| 3589741 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.51 | 41.0 | 3.40e-01 | 88.7% | 79.5% |
| 4982548 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.51 | 40.0 | 3.37e-01 | 87.7% | 91.5% |
| 4962844 | 604.4.1.10 ↗ | alpha bundles › Spectrin repeat-like › Alpha-hemoglobin stabilizing protein AHSP › Alpha-hemoglobin stabilizing protein AHSP › PF26679 | 0.50 | 39.0 | 4.00e-01 | 84.9% | 87.0% |
| 3763473 | 148.1.3.0 ↗ | alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain | 0.50 | 40.0 | 3.76e-01 | 93.4% | 67.9% |
| 3632601 | 5050.1.1.11 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › UNC-93 | 0.50 | 39.0 | 3.09e-01 | 84.9% | 75.7% |