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IMGVR_UViG_3300033463_000002-3300033463-Ga0310690_10000036388

Arc-Vir

IMGVR_UViG_3300033463_000002-3300033463-Ga0310690_10000036388

Quality

94.2 mean pLDDT

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 17-45_98-168
PDB
Pfam (2)
AccessionNameScoreE-valueQ covHMM cov
PF00186.25 best DHFR_1 63.8 2.10e-17 69.0% 42.1%
PF00186.25 DHFR_1 34.5 2.20e-08 30.0% 18.2%
D2 medium residues 46-97
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00186.25 best DHFR_1 49.0 7.70e-13 100.0% 30.2%
CATH (43)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2w9hA00 3.40.430.10 Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A 0.92 78.0 5.35e-01 100.0% 29.9%
1cz3B00 3.40.430.10 Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A 0.88 80.0 5.44e-01 100.0% 32.1%
1dhiA00 3.40.430.10 Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A 0.86 74.0 5.16e-01 100.0% 30.8%
3vcoA00 3.40.430.10 Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A 0.86 79.0 5.25e-01 100.0% 32.2%
3k2hA01 3.40.430.10 Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A 0.85 78.0 5.17e-01 100.0% 29.4%
5eccA00 3.40.430.10 Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A 0.85 75.0 5.23e-01 100.0% 32.5%
3nzbX00 3.40.430.10 Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A 0.84 75.0 4.91e-01 100.0% 30.6%
1bozA00 3.40.430.10 Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A 0.83 74.0 5.00e-01 100.0% 32.3%
3ix9A00 3.40.430.10 Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A 0.83 74.0 5.11e-01 100.0% 31.9%
6pf8A01 3.40.430.10 Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A 0.81 73.0 4.99e-01 100.0% 32.4%
1ao8A00 3.40.430.10 Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A 0.81 71.0 5.00e-01 100.0% 32.7%
1j3jB00 3.40.430.10 Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A 0.79 70.0 4.59e-01 100.0% 26.4%
3ky8A01 3.40.430.10 Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A 0.75 65.0 4.54e-01 100.0% 35.1%
2yjgA01 3.90.226.30 Alpha Beta › Alpha-Beta Complex › 2-enoyl-CoA Hydratase; Chain A, domain 1 › LarA, C-terminal domain 0.75 66.0 4.51e-01 100.0% 69.7%
3jtwA00 3.40.430.10 Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A 0.74 64.0 4.48e-01 100.0% 34.1%
2xw7A00 3.40.430.10 Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A 0.73 65.0 4.46e-01 100.0% 33.7%
1aoeA00 3.40.430.10 Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A 0.72 63.0 4.28e-01 100.0% 28.6%
2pk3A01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.69 59.0 3.97e-01 100.0% 46.6%
3wg9A02 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.69 57.0 4.32e-01 100.0% 58.6%
5l4lA00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.67 58.0 3.68e-01 100.0% 29.9%
6jp6D01 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.67 56.0 3.76e-01 100.0% 30.8%
2nyuB00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.67 56.0 3.95e-01 100.0% 58.8%
4e4yA00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.66 55.0 3.65e-01 100.0% 44.2%
2fwmX00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.64 49.0 3.43e-01 94.2% 56.6%
5tshA02 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.63 52.0 3.40e-01 100.0% 33.0%
4ew6A01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.63 54.0 4.18e-01 100.0% 45.0%
2czrA01 3.40.1350.70 Alpha Beta › 3-Layer(aba) Sandwich › Trna Endonuclease; Chain: A, domain 1 › TBP-interacting protein, N-terminal domain 0.62 53.0 4.23e-01 98.1% 51.9%
3plnA03 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.62 50.0 3.70e-01 100.0% 32.5%
1uz5A01 3.40.980.10 Alpha Beta › 3-Layer(aba) Sandwich › Molybdenum Cofactor Biosythetic Enzyme; Chain A › MoaB/Mog-like domain 0.61 50.0 3.64e-01 98.1% 77.6%
1l1sA00 3.40.1260.10 Alpha Beta › 3-Layer(aba) Sandwich › Hypothetical Protein Ychn; Chain: A, › DsrEFH-like 0.61 49.0 4.03e-01 100.0% 62.2%
3tp9A02 3.40.250.10 Alpha Beta › 3-Layer(aba) Sandwich › Oxidized Rhodanese; domain 1 › Rhodanese-like domain 0.60 46.0 3.83e-01 92.3% 71.8%
2pd2A00 3.40.1260.10 Alpha Beta › 3-Layer(aba) Sandwich › Hypothetical Protein Ychn; Chain: A, › DsrEFH-like 0.60 48.0 4.04e-01 100.0% 64.8%
3aw9A01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.60 50.0 3.48e-01 100.0% 49.0%
5ucoA02 3.40.47.10 Alpha Beta › 3-Layer(aba) Sandwich › Peroxisomal Thiolase; Chain A, domain 1 › Thiolase/Chalcone synthase 0.60 47.0 3.53e-01 94.2% 73.9%
4a8jB00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.59 48.0 3.24e-01 94.2% 44.5%
1g8aA02 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.59 48.0 3.47e-01 100.0% 50.0%
3lq1A02 3.40.50.1220 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › TPP-binding domain 0.57 41.0 2.97e-01 80.8% 31.8%
1yz4B01 3.90.190.10 Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily 0.57 45.0 3.47e-01 100.0% 60.8%
2i5eA01 3.90.550.10 Alpha Beta › Alpha-Beta Complex › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A 0.57 46.0 3.41e-01 100.0% 73.7%
3r2uA02 3.40.250.10 Alpha Beta › 3-Layer(aba) Sandwich › Oxidized Rhodanese; domain 1 › Rhodanese-like domain 0.56 44.0 3.92e-01 92.3% 84.5%
2c20A01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.54 43.0 3.08e-01 100.0% 51.7%
3jvdA02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.53 45.0 3.42e-01 100.0% 60.3%
4zrmA01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.52 41.0 2.95e-01 100.0% 51.2%
ECOD (49)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4652224 7501.1.1.1 a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 0.92 82.0 5.56e-01 100.0% 30.5%
169540 7501.1.1.1 a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 0.91 82.0 5.54e-01 100.0% 30.1%
3963884 7501.1.1.1 a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 0.90 82.0 5.62e-01 100.0% 31.9%
2580403 7501.1.1.1 a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 0.90 79.0 5.27e-01 100.0% 28.0%
1841334 7501.1.1.1 a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 0.89 78.0 5.44e-01 100.0% 32.9%
4624802 7501.1.1.1 a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 0.86 78.0 5.35e-01 100.0% 32.5%
185430 7501.1.1.1 a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 0.85 77.0 5.17e-01 100.0% 29.6%
2831687 7501.1.1.1 a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 0.85 74.0 5.00e-01 100.0% 28.3%
4402042 7501.1.1.1 a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 0.84 76.0 5.11e-01 100.0% 32.4%
3913441 7501.1.1.1 a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 0.84 76.0 5.08e-01 100.0% 31.6%
4965070 7501.1.1.1 a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 0.83 74.0 5.06e-01 100.0% 34.3%
4563316 7501.1.1.1 a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 0.83 76.0 5.18e-01 100.0% 31.5%
137968 7501.1.1.1 a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 0.83 74.0 5.11e-01 100.0% 31.9%
3282327 7501.1.1.2 a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C 0.82 73.0 4.88e-01 100.0% 30.3%
4276639 7501.1.1.1 a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 0.82 74.0 5.09e-01 100.0% 30.6%
3232633 7501.1.1.1 a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 0.81 74.0 4.95e-01 100.0% 32.4%
3590464 7501.1.1.2 a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C 0.79 71.0 4.87e-01 100.0% 34.1%
4228699 7501.1.1.1 a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 0.76 69.0 4.56e-01 100.0% 27.0%
136641 7501.1.1.2 a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C 0.74 64.0 4.48e-01 100.0% 34.1%
4972896 7570.1.1.6 a/b three-layered sandwiches › MurD-like peptide ligases, peptide-binding domain › MurD-like peptide ligases, peptide-binding domain › MurD-like peptide ligases, peptide-binding domain › PF27274 0.70 61.0 4.71e-01 100.0% 54.2%
167405 2003.1.1.141 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › Polysacc_synt_2, GDP_Man_Dehyd 0.69 59.0 3.70e-01 100.0% 33.0%
5057875 7516.1.1.79 a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Glyco_trans_2_3 0.69 59.0 3.69e-01 100.0% 21.3%
5012331 7518.1.1.7 a/b three-layered sandwiches › PK C-terminal domain-like › PK C-terminal domain-like › PK C-terminal domain-like › DacZ_T 0.67 57.0 4.72e-01 100.0% 64.0%
5048571 2003.1.5.15 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › FtsJ 0.67 56.0 3.83e-01 100.0% 34.8%
4451549 2003.1.5.15 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › FtsJ 0.66 56.0 3.79e-01 100.0% 29.2%
4337397 2003.1.5.15 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › FtsJ 0.66 56.0 3.90e-01 100.0% 34.1%
3398751 7541.1.1.1 a/b three-layered sandwiches › Molybdenum cofactor biosynthesis proteins › Molybdenum cofactor biosynthesis proteins › Molybdenum cofactor biosynthesis proteins › MoCF_biosynth 0.65 54.0 3.86e-01 98.1% 76.0%
5031790 2003.1.1.52 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › RmlD_sub_bind 0.65 54.0 3.45e-01 100.0% 33.0%
4492591 298.1.1.0 a+b two layers › FwdE/GAPDH domain-like › Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain › Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain 0.64 55.0 3.55e-01 100.0% 20.9%
3967995 2004.1.1.42 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › T2SSE 0.64 53.0 3.22e-01 100.0% 22.2%
3272934 2003.1.5.15 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › FtsJ 0.64 53.0 3.35e-01 100.0% 19.4%
3255463 2003.1.1.67 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › NAD_binding_10 0.64 52.0 3.57e-01 100.0% 45.5%
4366164 2004.1.1.42 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › T2SSE 0.64 53.0 3.16e-01 100.0% 21.4%
5026098 2004.1.3.1 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › Pyruvate-ferredoxin oxidoreductase, PFOR, domain III › POR 0.63 51.0 3.56e-01 98.1% 39.0%
None 0.62 50.0 3.66e-01 96.2% 33.3%
3972492 2003.1.1.20 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › Epimerase 0.62 52.0 3.29e-01 100.0% 32.1%
3589928 2003.1.1.0 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains 0.62 53.0 3.88e-01 100.0% 52.0%
3972696 2003.1.1.0 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains 0.62 51.0 4.09e-01 100.0% 71.3%
None 0.61 50.0 3.05e-01 100.0% 21.9%
5058812 2004.1.1.42 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › T2SSE 0.60 49.0 3.27e-01 96.2% 32.8%
3388100 2004.1.1.42 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › T2SSE 0.60 48.0 2.99e-01 100.0% 23.1%
4962546 2003.1.5.33 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › UPF0146 0.59 50.0 3.80e-01 100.0% 58.6%
4015260 2003.1.1.53 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › NmrA 0.58 46.0 2.98e-01 100.0% 28.7%
4317903 2003.1.1.12 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › DapB_N 0.58 47.0 3.52e-01 100.0% 49.7%
4947609 2004.5.1.0 a/b three-layered sandwiches › P-loop domains-like › Differentially expressed in normal cells and neoplasia (DENN) domain › Differentially expressed in normal cells and neoplasia (DENN) domain 0.57 46.0 3.45e-01 94.2% 61.3%
5026145 7516.1.1.24 a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › NTP_transf_3 0.57 45.0 3.31e-01 100.0% 66.9%
5033653 2007.2.5.1 a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › Rhodanese/Cell cycle control phosphatase › Rhodanese 0.56 43.0 3.46e-01 92.3% 64.0%
4120615 2493.1.1.3 a/b three-layered sandwiches › MurF and HprK N-domain-like › MurF and HprK N-domain-like › MurF and HprK N-domain-like › LpxD 0.53 43.0 3.59e-01 100.0% 54.3%
3938470 109.4.1.544 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › ParcG 0.51 40.0 2.80e-01 98.1% 56.2%