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IMGVR_UViG_3300037454_000906-3300037454-Ga0394156_0000018_2022_2672
Arc-VirIMGVR_UViG_3300037454_000906-3300037454-Ga0394156_0000018_2022_2672
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 2-203
Domain cluster:
rep: dihydrofolate_reductase__YP_009119754__Pandoravirus_inopinatum__1605721__D21-210
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00186.25 best | DHFR_1 | 150.9 | 3.30e-44 | 75.7% | 87.4% |
CATH (52)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2w9hA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.95 | 72.0 | 8.27e-01 | 85.1% | 100.0% |
| 3ix9A00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.94 | 75.0 | 8.32e-01 | 85.6% | 98.8% |
| 5eccA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.93 | 71.0 | 8.10e-01 | 85.1% | 99.4% |
| 1dhiA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.93 | 72.0 | 8.12e-01 | 85.1% | 100.0% |
| 1ao8A00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.92 | 72.0 | 8.13e-01 | 85.1% | 100.0% |
| 1vdrA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.90 | 69.0 | 7.87e-01 | 85.1% | 100.0% |
| 3nzbX00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.90 | 75.0 | 7.49e-01 | 85.6% | 97.6% |
| 1bozA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.89 | 74.0 | 7.80e-01 | 85.6% | 98.9% |
| 6pf8A01 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.86 | 72.0 | 7.71e-01 | 85.1% | 98.9% |
| 1cz3B00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.86 | 69.0 | 7.61e-01 | 87.1% | 99.4% |
| 1j3jB00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.85 | 72.0 | 7.06e-01 | 86.6% | 95.8% |
| 1aoeA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.85 | 71.0 | 7.28e-01 | 85.1% | 97.9% |
| 4eckA01 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.85 | 71.0 | 7.52e-01 | 85.1% | 99.4% |
| 3k2hA01 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.83 | 73.0 | 7.58e-01 | 90.1% | 96.8% |
| 3vcoA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.83 | 68.0 | 7.20e-01 | 85.1% | 98.4% |
| 1juvA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.82 | 67.0 | 6.93e-01 | 84.2% | 100.0% |
| 2p4gA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.80 | 67.0 | 6.21e-01 | 86.1% | 92.3% |
| 2hxvA02 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.80 | 66.0 | 6.74e-01 | 85.1% | 99.5% |
| 2aznA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.80 | 67.0 | 6.47e-01 | 85.6% | 98.2% |
| 2b3zA02 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.79 | 66.0 | 6.31e-01 | 85.1% | 94.7% |
| 3zpgA02 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.79 | 66.0 | 6.42e-01 | 85.1% | 94.4% |
| 3kgyA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.79 | 65.0 | 6.38e-01 | 85.1% | 96.3% |
| 2xw7A00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.79 | 65.0 | 6.94e-01 | 85.6% | 97.7% |
| 3ky8A01 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.78 | 64.0 | 6.94e-01 | 84.7% | 100.0% |
| 4xt6A00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.77 | 64.0 | 6.01e-01 | 85.1% | 89.0% |
| 2g6vA02 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.77 | 64.0 | 6.16e-01 | 85.1% | 94.6% |
| 3jtwA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.77 | 64.0 | 6.82e-01 | 85.1% | 98.9% |
| 2h2qB01 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.74 | 65.0 | 6.41e-01 | 90.1% | 90.1% |
| 1ej6A04 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.58 | 45.0 | 4.37e-01 | 80.7% | 97.8% |
| 2gs9A01 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.58 | 45.0 | 4.54e-01 | 80.7% | 100.0% |
| 3ephA01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.58 | 53.0 | 4.74e-01 | 97.5% | 97.5% |
| 5b7hB01 | 3.40.190.10 | Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II | 0.58 | 27.0 | 3.59e-01 | 90.6% | 80.6% |
| 2ql3A01 | 3.40.190.10 | Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II | 0.58 | 28.0 | 3.84e-01 | 90.6% | 91.9% |
| 3cvoA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.56 | 43.0 | 4.40e-01 | 78.2% | 90.2% |
| 1u7nA00 | 3.40.718.10 | Alpha Beta › 3-Layer(aba) Sandwich › Isopropylmalate Dehydrogenase › Isopropylmalate Dehydrogenase | 0.56 | 40.0 | 3.48e-01 | 72.3% | 99.7% |
| 2iyeA01 | 3.40.50.1000 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HAD superfamily/HAD-like | 0.55 | 36.0 | 3.95e-01 | 83.7% | 81.5% |
| 4d3pA00 | 3.90.190.10 | Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily | 0.54 | 32.0 | 3.73e-01 | 95.0% | 78.9% |
| 7jt8I02 | 3.90.190.20 | Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Mur ligase, C-terminal domain | 0.54 | 37.0 | 4.27e-01 | 87.6% | 95.8% |
| 3douA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.54 | 43.0 | 4.55e-01 | 82.7% | 98.3% |
| 1e0tA01 | 3.40.1380.20 | Alpha Beta › 3-Layer(aba) Sandwich › Pyruvate Kinase; Chain: A, domain 1 › Pyruvate kinase, C-terminal domain | 0.54 | 31.0 | 3.90e-01 | 76.2% | 92.7% |
| 2g6zA00 | 3.90.190.10 | Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily | 0.54 | 32.0 | 3.72e-01 | 95.0% | 79.6% |
| 2esbA00 | 3.90.190.10 | Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily | 0.53 | 31.0 | 3.49e-01 | 82.7% | 71.0% |
| 6jp6D01 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.53 | 46.0 | 4.48e-01 | 92.6% | 94.6% |
| 5cm2Z00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.53 | 39.0 | 4.10e-01 | 76.2% | 98.4% |
| 1d5rA01 | 3.90.190.10 | Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily | 0.53 | 35.0 | 3.74e-01 | 95.5% | 76.4% |
| 2r0bA00 | 3.90.190.10 | Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily | 0.53 | 33.0 | 3.72e-01 | 95.5% | 81.5% |
| 4bubA02 | 3.40.1190.10 | Alpha Beta › 3-Layer(aba) Sandwich › UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase › Mur-like, catalytic domain | 0.53 | 44.0 | 4.25e-01 | 89.1% | 89.6% |
| 2r2aA00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.52 | 43.0 | 4.43e-01 | 100.0% | 92.1% |
| 4zemA02 | 3.40.50.10470 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Translation initiation factor eif-2b; domain 2 | 0.51 | 39.0 | 4.21e-01 | 100.0% | 94.0% |
| 4nl4H03 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.51 | 38.0 | 3.89e-01 | 97.5% | 80.1% |
| 4kavA00 | 3.40.720.10 | Alpha Beta › 3-Layer(aba) Sandwich › Alkaline Phosphatase, subunit A › Alkaline Phosphatase, subunit A | 0.50 | 46.0 | 3.91e-01 | 100.0% | 90.4% |
| 2dr3A00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.50 | 46.0 | 4.44e-01 | 100.0% | 91.4% |
ECOD (71)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 169540 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.96 | 75.0 | 8.34e-01 | 85.6% | 97.0% |
| 3963884 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.95 | 73.0 | 8.29e-01 | 84.2% | 98.8% |
| 137968 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.94 | 75.0 | 8.32e-01 | 85.6% | 98.8% |
| 4624802 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.94 | 74.0 | 8.32e-01 | 85.6% | 100.0% |
| 4279950 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.92 | 74.0 | 8.19e-01 | 87.1% | 100.0% |
| 2831687 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.91 | 71.0 | 7.69e-01 | 85.6% | 91.9% |
| 4652224 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.91 | 72.0 | 8.07e-01 | 85.6% | 99.4% |
| 4563316 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.91 | 71.0 | 7.89e-01 | 87.6% | 97.0% |
| 4276639 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.91 | 73.0 | 7.97e-01 | 88.1% | 97.1% |
| 2847460 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.90 | 68.0 | 7.77e-01 | 90.6% | 99.4% |
| 4667474 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.90 | 75.0 | 7.98e-01 | 84.7% | 100.0% |
| 3738384 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.90 | 75.0 | 7.02e-01 | 85.6% | 90.4% |
| 4402042 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.89 | 74.0 | 7.80e-01 | 85.1% | 98.9% |
| 10268 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.89 | 75.0 | 7.44e-01 | 85.6% | 97.6% |
| 4392683 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.89 | 70.0 | 7.84e-01 | 85.1% | 98.8% |
| 4295510 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.88 | 69.0 | 7.72e-01 | 87.1% | 100.0% |
| 136031 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.88 | 73.0 | 7.18e-01 | 85.1% | 99.1% |
| 4965070 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.88 | 70.0 | 7.51e-01 | 85.1% | 93.1% |
| 3900511 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.88 | 75.0 | 7.82e-01 | 87.1% | 99.5% |
| 3913441 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.87 | 74.0 | 7.69e-01 | 87.1% | 98.4% |
| 3697700 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.87 | 72.0 | 6.16e-01 | 85.1% | 98.0% |
| 4123104 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.87 | 69.0 | 7.63e-01 | 85.1% | 98.8% |
| 3232633 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.87 | 72.0 | 7.55e-01 | 84.7% | 98.9% |
| 2580403 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.87 | 63.0 | 6.85e-01 | 85.6% | 85.7% |
| 3263045 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.87 | 76.0 | 7.65e-01 | 89.6% | 99.0% |
| 4315799 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.86 | 71.0 | 7.70e-01 | 85.1% | 99.4% |
| 4183099 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.86 | 72.0 | 7.64e-01 | 86.1% | 95.6% |
| 185430 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.86 | 72.0 | 7.54e-01 | 85.6% | 96.2% |
| 4115051 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.85 | 73.0 | 6.76e-01 | 87.1% | 96.7% |
| 4228699 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.85 | 70.0 | 7.06e-01 | 84.2% | 100.0% |
| 5030442 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.85 | 69.0 | 7.59e-01 | 84.7% | 99.4% |
| 4209889 | 7501.1.1.0 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases | 0.85 | 60.0 | 7.05e-01 | 86.6% | 100.0% |
| 2503171 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.84 | 72.0 | 7.69e-01 | 90.1% | 98.9% |
| 4392834 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.82 | 72.0 | 6.87e-01 | 90.1% | 98.7% |
| 10266 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.82 | 67.0 | 6.93e-01 | 84.2% | 100.0% |
| 3974710 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.82 | 68.0 | 7.34e-01 | 85.6% | 98.3% |
| 5009586 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.81 | 67.0 | 6.60e-01 | 84.2% | 97.6% |
| 4992215 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.81 | 68.0 | 6.62e-01 | 85.6% | 98.6% |
| 3581890 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.81 | 67.0 | 6.88e-01 | 85.1% | 97.4% |
| 10273 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.80 | 66.0 | 6.74e-01 | 85.1% | 99.5% |
| 3284365 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.80 | 66.0 | 6.82e-01 | 85.6% | 99.0% |
| 3590464 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.80 | 66.0 | 7.09e-01 | 85.1% | 98.8% |
| 4262258 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.79 | 66.0 | 6.35e-01 | 85.6% | 95.1% |
| 3282327 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.79 | 66.0 | 6.73e-01 | 85.1% | 99.0% |
| 4946280 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.79 | 65.0 | 6.36e-01 | 85.1% | 98.6% |
| 1764169 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.79 | 66.0 | 6.07e-01 | 85.1% | 87.8% |
| 3289701 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.79 | 66.0 | 6.45e-01 | 85.6% | 99.1% |
| 5063695 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.79 | 65.0 | 6.74e-01 | 84.7% | 97.4% |
| 3953555 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.78 | 65.0 | 6.75e-01 | 85.1% | 97.9% |
| 137569 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.78 | 65.0 | 6.96e-01 | 85.6% | 99.4% |
| 3282759 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.78 | 64.0 | 6.78e-01 | 85.1% | 98.9% |
| 3279668 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.77 | 63.0 | 6.63e-01 | 84.7% | 98.9% |
| 163314 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.77 | 64.0 | 6.20e-01 | 85.1% | 95.9% |
| 1841334 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.77 | 56.0 | 6.56e-01 | 87.1% | 100.0% |
| 136641 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.77 | 64.0 | 6.82e-01 | 85.1% | 98.9% |
| 3385448 | 7501.1.1.0 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases | 0.77 | 58.0 | 6.52e-01 | 84.2% | 97.5% |
| 3277763 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.76 | 63.0 | 6.59e-01 | 85.1% | 98.9% |
| 3839944 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.75 | 61.0 | 6.49e-01 | 85.1% | 93.9% |
| 3740375 | 7501.1.1.0 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases | 0.67 | 58.0 | 5.92e-01 | 90.1% | 100.0% |
| 4936542 | 2003.1.5.33 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › UPF0146 | 0.64 | 42.0 | 4.98e-01 | 77.2% | 99.2% |
| 3334856 | 7523.1.1.0 ↗ | a/b three-layered sandwiches › Periplasmic binding protein-like II › Periplasmic binding protein-like II › Periplasmic binding protein-like II | 0.58 | 34.0 | 3.97e-01 | 92.6% | 81.4% |
| 5012331 | 7518.1.1.7 ↗ | a/b three-layered sandwiches › PK C-terminal domain-like › PK C-terminal domain-like › PK C-terminal domain-like › DacZ_T | 0.58 | 30.0 | 4.13e-01 | 79.2% | 100.0% |
| 3958608 | 2003.1.5.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases | 0.57 | 43.0 | 4.22e-01 | 77.2% | 96.3% |
| 5057405 | 2004.1.1.1200 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DUF835 | 0.57 | 40.0 | 4.56e-01 | 83.7% | 96.7% |
| 4977716 | 2003.1.5.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases | 0.56 | 39.0 | 4.52e-01 | 72.8% | 100.0% |
| 4434842 | 2003.1.5.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases | 0.54 | 42.0 | 3.77e-01 | 81.2% | 74.0% |
| 4000139 | 2007.2.3.2 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › DSPc | 0.53 | 33.0 | 4.01e-01 | 96.5% | 94.6% |
| 3307924 | 2003.1.5.165 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11, Methyltransf_23 | 0.53 | 41.0 | 3.94e-01 | 81.7% | 94.2% |
| 4989786 | 2004.1.1.146 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ATPase | 0.52 | 42.0 | 4.34e-01 | 99.5% | 88.2% |
| 3241142 | 2006.1.1.0 ↗ | a/b three-layered sandwiches › HAD domain-like › HAD domain-related › HAD-like | 0.52 | 25.0 | 3.29e-01 | 96.5% | 82.9% |
| 4959153 | 7518.1.1.6 ↗ | a/b three-layered sandwiches › PK C-terminal domain-like › PK C-terminal domain-like › PK C-terminal domain-like › DacZ_A | 0.51 | 31.0 | 3.90e-01 | 78.7% | 97.6% |