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KM359505.1AIR93562.1X__00225

Bact-Vir

KM359505.1__AIR93562.1__X__00225

Identity

Accession:: KM359505 ↗
Kingdom:: phage

Quality

90.4 mean pLDDT

Taxonomy

Heunggongvirae› Uroviricota› Caudoviricetes› Pantevenvirales› Kyanoviridae› Haifavirus› Prochlorococcus_phage_P-TIM68

TaxID: 1542477

Cluster

Singleton — not in a non-trivial cluster

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 42-163

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00223.25 best	PsaA_PsaB	163.8	8.10e-48	100.0%	17.2%

CATH (48)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1jb0A00	1.20.1130.10	Mainly Alpha › Up-down Bundle › Photosystem I p700 chlorophyll A apoprotein A1 › Photosystem I PsaA/PsaB	0.92	87.0	5.16e-01	100.0%	16.1%
1x8zB00	1.20.140.40	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Invertase/pectin methylesterase inhibitor family protein	0.82	46.0	4.32e-01	100.0%	46.3%
1uurA01	1.20.58.240	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › STAT; domain 1	0.80	45.0	4.73e-01	98.4%	60.9%
1xwmA00	1.20.58.220	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2	0.80	44.0	3.57e-01	100.0%	31.1%
1yo7A00	1.20.120.230	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like	0.79	40.0	4.13e-01	100.0%	51.7%
1sumB02	1.20.58.220	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2	0.78	40.0	4.12e-01	100.0%	51.7%
2i0mA01	1.20.58.220	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2	0.77	42.0	4.56e-01	100.0%	62.3%
3zbhA00	1.10.287.1060	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like	0.76	47.0	5.50e-01	100.0%	85.6%
2i0mA02	1.20.58.220	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2	0.74	41.0	4.52e-01	99.2%	65.3%
4iggA01	1.10.287.160	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat	0.74	42.0	5.42e-01	99.2%	100.0%
3edvB01	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.72	42.0	4.05e-01	100.0%	51.5%
1wcrA00	1.20.58.80	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit	0.72	39.0	4.30e-01	96.7%	64.1%
1t72A01	1.20.58.220	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2	0.72	44.0	4.57e-01	98.4%	64.1%
2ot4A03	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.71	41.0	4.36e-01	96.7%	64.5%
1sumB01	1.20.58.220	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2	0.70	41.0	4.36e-01	100.0%	65.4%
2oduA02	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.68	42.0	4.48e-01	99.2%	71.4%
1t72A02	1.20.58.220	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2	0.67	40.0	4.43e-01	93.4%	73.5%
3pe0A02	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.67	40.0	4.27e-01	98.4%	67.9%
2qkwA00	1.20.1270.140	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › AvrPto	0.67	40.0	4.30e-01	96.7%	70.3%
4ioeA00	1.10.287.850	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HP0062-like domain	0.66	44.0	5.24e-01	95.9%	95.4%
2vs0A00	1.10.287.1060	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like	0.66	42.0	5.01e-01	98.4%	96.3%
1o3uA00	1.20.120.330	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2	0.65	33.0	3.41e-01	98.4%	49.2%
1vctA01	1.20.58.220	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2	0.65	39.0	4.16e-01	100.0%	67.0%
3v5uA01	6.10.280.80	Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › NCX, peripheral helical region	0.64	39.0	4.89e-01	92.6%	98.7%
4yonA01	1.20.900.10	Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain	0.64	42.0	3.47e-01	100.0%	38.0%
2c0uA03	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.63	43.0	3.81e-01	100.0%	50.3%
6iknD01	1.20.1270.60	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain	0.61	43.0	3.25e-01	99.2%	32.6%
3anwB00	1.20.58.2050	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.61	31.0	2.85e-01	76.2%	37.0%
1bf5A01	1.20.1050.20	Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › STAT transcription factor, all-alpha domain	0.61	41.0	3.66e-01	100.0%	49.4%
1qdbA02	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.60	37.0	3.55e-01	95.9%	51.7%
2ewfA02	1.20.1270.310	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 ›	0.60	28.0	3.41e-01	88.5%	65.4%
3ck6C02	1.20.58.340	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Magnesium transport protein CorA, transmembrane region	0.59	36.0	3.68e-01	99.2%	61.3%
4gyvE00	1.20.900.10	Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain	0.59	41.0	3.35e-01	100.0%	40.0%
1fioA00	1.20.58.70	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.58	47.0	4.01e-01	100.0%	54.2%
1io1A01	1.20.1330.10	Mainly Alpha › Up-down Bundle › f41 fragment of flagellin, N-terminal domain › f41 fragment of flagellin, N-terminal domain	0.58	55.0	4.84e-01	100.0%	97.0%
2xubA05	6.10.140.1450	Special › Helix non-globular › Helix Hairpins ›	0.58	42.0	4.76e-01	98.4%	96.9%
1fntc01	1.20.120.180	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Proteasome activator pa28, C-terminal domain	0.55	42.0	3.61e-01	100.0%	51.6%
3i01A01	1.20.1270.30	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 ›	0.55	52.0	4.51e-01	100.0%	75.1%
4h3tA02	1.10.132.100	Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 ›	0.55	37.0	3.53e-01	100.0%	58.9%
7b7tA01	1.20.1270.30	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 ›	0.55	51.0	4.62e-01	100.0%	82.6%
6xkyA01	1.20.1330.10	Mainly Alpha › Up-down Bundle › f41 fragment of flagellin, N-terminal domain › f41 fragment of flagellin, N-terminal domain	0.54	49.0	4.28e-01	100.0%	94.7%
1f1mA00	1.20.120.240	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Lipoprotein, type 6	0.54	48.0	4.40e-01	99.2%	99.4%
2d4uB00	1.20.120.30	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Aspartate receptor, ligand-binding domain	0.53	48.0	4.44e-01	99.2%	92.9%
4oydB00	1.10.132.20	Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor	0.53	35.0	3.65e-01	95.9%	70.9%
1i6zA00	1.20.58.120	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain	0.52	35.0	3.46e-01	100.0%	63.0%
7utzR02	1.20.1070.10	Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins	0.51	45.0	3.49e-01	98.4%	85.0%
4yjwA00	1.20.120.930	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Uncharacterised protein PF12889, N-terminal DUF3829	0.51	45.0	4.17e-01	97.5%	100.0%
3ajwA00	1.10.287.1700	Mainly Alpha › Orthogonal Bundle › Helix Hairpins ›	0.50	44.0	4.31e-01	99.2%	84.3%

ECOD (59)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4874228	5037.1.1.2 ↗	alpha bundles › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › PsaA_PsaB	0.95	92.0	6.10e-01	100.0%	30.0%
2732163	5075.1.1.1 ↗	alpha bundles › Photosystem II antenna protein-like › Photosystem II antenna protein-like › Photosystem II antenna protein-like › PsaA_PsaB	0.95	92.0	6.64e-01	100.0%	42.1%
4335432	5037.1.1.2 ↗	alpha bundles › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › PsaA_PsaB	0.95	92.0	5.44e-01	100.0%	16.6%
4345719	5075.1.1.1 ↗	alpha bundles › Photosystem II antenna protein-like › Photosystem II antenna protein-like › Photosystem II antenna protein-like › PsaA_PsaB	0.95	92.0	5.96e-01	100.0%	38.9%
4206112	5075.1.1.1 ↗	alpha bundles › Photosystem II antenna protein-like › Photosystem II antenna protein-like › Photosystem II antenna protein-like › PsaA_PsaB	0.94	83.0	5.69e-01	100.0%	31.9%
4832360	5037.1.1.2 ↗	alpha bundles › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › PsaA_PsaB	0.94	72.0	6.35e-01	100.0%	57.5%
4130349	5075.1.1.1 ↗	alpha bundles › Photosystem II antenna protein-like › Photosystem II antenna protein-like › Photosystem II antenna protein-like › PsaA_PsaB	0.93	87.0	5.16e-01	100.0%	16.0%
4063980	5037.1.1.2 ↗	alpha bundles › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › PsaA_PsaB	0.92	87.0	5.16e-01	100.0%	16.0%
2578612	5075.1.1.1 ↗	alpha bundles › Photosystem II antenna protein-like › Photosystem II antenna protein-like › Photosystem II antenna protein-like › PsaA_PsaB	0.92	87.0	5.71e-01	100.0%	28.1%
4874226	5075.1.1.1 ↗	alpha bundles › Photosystem II antenna protein-like › Photosystem II antenna protein-like › Photosystem II antenna protein-like › PsaA_PsaB	0.92	87.0	5.69e-01	100.0%	28.1%
4857024	5075.1.1.1 ↗	alpha bundles › Photosystem II antenna protein-like › Photosystem II antenna protein-like › Photosystem II antenna protein-like › PsaA_PsaB	0.91	82.0	5.87e-01	100.0%	36.9%
4856390	5037.1.1.2 ↗	alpha bundles › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › PsaA_PsaB	0.91	85.0	5.84e-01	100.0%	33.1%
4857224	5075.1.1.1 ↗	alpha bundles › Photosystem II antenna protein-like › Photosystem II antenna protein-like › Photosystem II antenna protein-like › PsaA_PsaB	0.91	85.0	5.81e-01	100.0%	32.7%
4857228	5075.1.1.1 ↗	alpha bundles › Photosystem II antenna protein-like › Photosystem II antenna protein-like › Photosystem II antenna protein-like › PsaA_PsaB	0.90	87.0	5.87e-01	100.0%	32.2%
4467439	5075.1.1.1 ↗	alpha bundles › Photosystem II antenna protein-like › Photosystem II antenna protein-like › Photosystem II antenna protein-like › PsaA_PsaB	0.89	86.0	5.80e-01	100.0%	32.3%
3956792	150.5.1.0 ↗	alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › ESAT-6 like › ESAT-6 like	0.78	43.0	4.82e-01	100.0%	68.4%
3961790	150.8.1.1 ↗	alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › PPE › PPE › PPE	0.78	48.0	4.75e-01	100.0%	59.2%
5068709	633.12.1.0 ↗	alpha bundles › Bromodomain-like › Ta0600-like › Ta0600-like	0.75	32.0	3.76e-01	84.4%	55.1%
3629105	174.1.1.0 ↗	few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain	0.75	42.0	3.81e-01	100.0%	41.2%
3962961	150.5.1.53 ↗	alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › ESAT-6 like › ESAT-6 like › PPE	0.74	47.0	5.77e-01	100.0%	97.5%
3995514	150.1.1.0 ↗	alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin	0.74	46.0	4.30e-01	100.0%	52.4%
4015520	174.1.1.0 ↗	few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain	0.71	42.0	3.78e-01	100.0%	43.6%
3882493	633.23.1.34 ↗	alpha bundles › Bromodomain-like › Claudin › Claudin › CD20	0.71	41.0	3.77e-01	98.4%	44.5%
3874696	174.1.1.43 ↗	few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › CD20	0.71	44.0	3.94e-01	100.0%	47.5%
3734418	4121.1.1.0 ↗	a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like	0.69	38.0	2.78e-01	99.2%	20.0%
3600017	3291.1.1.0 ↗	alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related	0.68	46.0	4.73e-01	100.0%	73.0%
4011777	4121.1.1.0 ↗	a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like	0.67	48.0	3.28e-01	100.0%	23.4%
3746251	633.21.1.23 ↗	alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 › CD20	0.67	45.0	4.05e-01	99.2%	51.9%
3911582	633.21.1.23 ↗	alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 › CD20	0.67	45.0	4.20e-01	100.0%	56.0%
3691694	192.2.1.1 ↗	alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin › Prefoldin_2	0.66	47.0	4.74e-01	99.2%	72.0%
3696407	4121.1.1.7 ↗	a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like › PF26616	0.66	44.0	3.47e-01	100.0%	34.5%
5005708	3755.3.1.127 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › NFACT_N	0.66	53.0	4.57e-01	100.0%	57.2%
3924137	601.54.1.5 ↗	alpha bundles › Four-helical up-and-down bundle › low CO2-inducible protein LCI1 › low CO2-inducible protein LCI1 › PF29123	0.64	45.0	4.17e-01	100.0%	58.0%
3623993	603.1.1.17 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins › SNARE	0.64	40.0	3.26e-01	100.0%	33.0%
4030279	633.21.1.0 ↗	alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107	0.64	51.0	3.64e-01	100.0%	30.6%
4946897	150.1.1.0 ↗	alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin	0.64	46.0	4.02e-01	100.0%	52.4%
3875388	174.1.1.46 ↗	few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › L6_membrane	0.63	45.0	3.94e-01	100.0%	50.9%
3273910	622.4.1.0 ↗	alpha bundles › YvfG-like › Mite allergen Der p 5-related › Mite allergen Der p 5-related	0.62	47.0	4.89e-01	100.0%	84.3%
3215867	633.23.1.0 ↗	alpha bundles › Bromodomain-like › Claudin › Claudin	0.61	48.0	4.11e-01	100.0%	53.5%
3288436	150.5.1.11 ↗	alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › ESAT-6 like › ESAT-6 like › T7SS_ESX_EspC	0.61	44.0	4.78e-01	96.7%	85.7%
5070218	192.2.1.2 ↗	alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin › Prefoldin	0.61	51.0	5.13e-01	99.2%	89.2%
3339051	7015.1.1.0 ↗	alpha bundles › Palmitoyltransferase DHHC transmembrane domain › Palmitoyltransferase DHHC transmembrane domain › Palmitoyltransferase DHHC transmembrane domain	0.61	39.0	3.70e-01	95.9%	55.7%
3773794	6170.1.1.25 ↗	alpha bundles › Kv7 proximal C-terminal Domain › Kv7 proximal C-terminal Domain › Kv7 proximal C-terminal Domain › PF30874	0.60	37.0	4.26e-01	95.1%	85.9%
3251611	603.1.1.0 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins	0.59	38.0	3.12e-01	100.0%	35.0%
3394225	192.2.1.1 ↗	alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin › Prefoldin_2	0.59	48.0	5.00e-01	100.0%	91.3%
3603899	192.2.1.2 ↗	alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin › Prefoldin	0.58	52.0	5.00e-01	100.0%	84.4%
3896368	192.2.1.2 ↗	alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin › Prefoldin	0.58	51.0	4.77e-01	99.2%	76.4%
4029228	192.2.1.2 ↗	alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin › Prefoldin	0.56	51.0	4.37e-01	100.0%	63.2%
3756888	601.1.1.0 ↗	alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin	0.56	41.0	3.72e-01	100.0%	58.1%
3380500	192.29.1.34 ↗	alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › DUF677	0.55	51.0	4.20e-01	100.0%	96.7%
4951888	5082.1.1.1 ↗	alpha bundles › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation_efflux	0.55	52.0	4.26e-01	100.0%	65.4%
3212939	174.1.1.0 ↗	few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain	0.55	43.0	3.93e-01	97.5%	63.9%
4133710	3747.1.1.2 ↗	a+b two layers › Flagellar hook protein FlgE D0 domain › Flagellar hook protein FlgE D0 domain › Flagellar hook protein FlgE D0 domain › Flg_bb_rod,Flg_bbr_C	0.55	50.0	4.95e-01	98.4%	96.2%
4609538	192.29.1.0 ↗	alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding)	0.54	47.0	4.87e-01	93.4%	99.1%
3775826	4016.1.1.0 ↗	alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase	0.54	39.0	3.73e-01	95.9%	64.1%
3538512	3892.1.1.0 ↗	alpha bundles › Transhydrogeanse domain II › Transhydrogeanse domain II › Transhydrogeanse domain II	0.53	39.0	3.57e-01	95.9%	58.1%
4359979	3882.1.1.1 ↗	alpha bundles › Atg17 › Atg17 › Atg17 › ATG17_like	0.53	49.0	3.23e-01	99.2%	26.7%
3413217	192.2.1.1 ↗	alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin › Prefoldin_2	0.53	44.0	4.53e-01	97.5%	93.0%
3473150	601.2.1.5 ↗	alpha bundles › Four-helical up-and-down bundle › Cytochromes › Cytochromes › Ctr	0.53	44.0	3.98e-01	100.0%	66.1%

D2 medium residues 164-293

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00223.25 best	PsaA_PsaB	192.7	1.40e-56	100.0%	16.6%

CATH (16)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1jb0A00	1.20.1130.10	Mainly Alpha › Up-down Bundle › Photosystem I p700 chlorophyll A apoprotein A1 › Photosystem I PsaA/PsaB	0.79	76.0	4.53e-01	100.0%	17.4%
1sumB01	1.20.58.220	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2	0.75	38.0	4.17e-01	94.6%	58.9%
1t72A01	1.20.58.220	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2	0.72	41.0	4.31e-01	96.9%	62.4%
1uurA01	1.20.58.240	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › STAT; domain 1	0.67	37.0	4.04e-01	94.6%	63.6%
2ot4A03	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.67	38.0	4.13e-01	96.9%	66.4%
4o8sA02	1.20.58.1790	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › JHP933, helical tail domain	0.64	31.0	3.46e-01	87.7%	56.1%
3pe0A01	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.64	34.0	3.77e-01	94.6%	63.4%
1wcrA00	1.20.58.80	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit	0.62	33.0	3.64e-01	88.5%	63.1%
4wk5A00	1.10.600.10	Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase	0.61	36.0	2.85e-01	100.0%	29.3%
1l8dA00	1.10.287.510	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin	0.61	40.0	4.45e-01	94.6%	84.5%
3pe0A02	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.60	35.0	3.86e-01	94.6%	70.8%
2imiB02	1.20.1050.10	Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 ›	0.59	33.0	3.23e-01	96.2%	49.3%
1g12A00	3.40.390.10	Alpha Beta › 3-Layer(aba) Sandwich › Collagenase (Catalytic Domain) › Collagenase (Catalytic Domain)	0.55	32.0	2.93e-01	93.1%	42.5%
6zzx601	1.10.3460.10	Mainly Alpha › Orthogonal Bundle › Chlorophyll a-b binding protein › Chlorophyll a/b binding protein domain	0.55	36.0	3.03e-01	100.0%	37.8%
2o01L01	1.20.1240.10	Mainly Alpha › Up-down Bundle › Photosystem 1 Reaction Centre Subunit Xi; Chain: L; › Photosystem I PsaL, reaction centre subunit XI	0.53	34.0	3.67e-01	96.2%	75.7%
1hciA03	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.52	34.0	3.59e-01	93.1%	72.5%

ECOD (23)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4335432	5037.1.1.2 ↗	alpha bundles › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › PsaA_PsaB	1.00	98.0	5.82e-01	100.0%	17.7%
4874228	5037.1.1.2 ↗	alpha bundles › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › PsaA_PsaB	0.99	98.0	6.50e-01	100.0%	31.9%
2732163	5075.1.1.1 ↗	alpha bundles › Photosystem II antenna protein-like › Photosystem II antenna protein-like › Photosystem II antenna protein-like › PsaA_PsaB	0.98	96.0	7.01e-01	100.0%	44.8%
4345719	5075.1.1.1 ↗	alpha bundles › Photosystem II antenna protein-like › Photosystem II antenna protein-like › Photosystem II antenna protein-like › PsaA_PsaB	0.93	90.0	5.96e-01	100.0%	41.1%
4130349	5075.1.1.1 ↗	alpha bundles › Photosystem II antenna protein-like › Photosystem II antenna protein-like › Photosystem II antenna protein-like › PsaA_PsaB	0.80	77.0	4.61e-01	100.0%	17.7%
4063980	5037.1.1.2 ↗	alpha bundles › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › PsaA_PsaB	0.80	77.0	4.60e-01	100.0%	18.8%
4874226	5075.1.1.1 ↗	alpha bundles › Photosystem II antenna protein-like › Photosystem II antenna protein-like › Photosystem II antenna protein-like › PsaA_PsaB	0.79	75.0	5.05e-01	100.0%	31.2%
4857224	5075.1.1.1 ↗	alpha bundles › Photosystem II antenna protein-like › Photosystem II antenna protein-like › Photosystem II antenna protein-like › PsaA_PsaB	0.73	60.0	4.24e-01	100.0%	30.8%
4939717	3758.2.1.1 ↗	alpha bundles › Bacterial hemolysins-like › Biopolymer transport protein ExbB › Biopolymer transport protein ExbB › MotA_ExbB	0.72	41.0	3.53e-01	97.7%	37.3%
3725481	5069.1.1.0 ↗	alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes	0.67	39.0	3.62e-01	95.4%	46.9%
5014330	148.1.3.402 ↗	alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain › Rad50_zn_hook	0.67	39.0	4.24e-01	96.9%	68.2%
4206112	5075.1.1.1 ↗	alpha bundles › Photosystem II antenna protein-like › Photosystem II antenna protein-like › Photosystem II antenna protein-like › PsaA_PsaB	0.66	52.0	3.81e-01	100.0%	31.6%
3814455	109.4.1.1587 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › MOR2-PAG1_N, MOR2-PAG1_mid	0.58	40.0	2.25e-01	70.8%	14.2%
3939383	603.1.1.19 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins › Syntaxin-18_N	0.57	38.0	3.21e-01	97.7%	41.0%
4027885	3291.1.1.220 ↗	alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Stevor	0.57	46.0	4.54e-01	96.9%	80.4%
3517183	5086.1.1.172 ↗	alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › UCH_C	0.56	38.0	3.78e-01	93.8%	65.9%
3396038	5050.1.1.1 ↗	alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Sugar_tr	0.56	47.0	3.82e-01	90.0%	87.8%
3705975	5050.1.1.9 ↗	alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1	0.54	49.0	3.84e-01	100.0%	68.4%
3205986	5050.1.1.9 ↗	alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1	0.52	46.0	3.77e-01	97.7%	89.4%
5019788	5050.1.1.86 ↗	alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › LysE	0.52	40.0	3.43e-01	81.5%	100.0%
3489991	5050.1.1.9 ↗	alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1	0.52	42.0	3.46e-01	87.7%	89.4%
3163982	5059.1.1.1 ↗	alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › EamA	0.52	43.0	3.38e-01	90.8%	82.1%
4049075	3755.3.1.0 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin	0.51	40.0	4.06e-01	96.9%	83.1%

D3 medium residues 326-411

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00223.25 best	PsaA_PsaB	132.1	3.20e-38	100.0%	12.1%

CATH (64)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1jb0A00	1.20.1130.10	Mainly Alpha › Up-down Bundle › Photosystem I p700 chlorophyll A apoprotein A1 › Photosystem I PsaA/PsaB	0.99	97.0	5.45e-01	100.0%	11.6%
2vs0A00	1.10.287.1060	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like	0.81	65.0	6.73e-01	83.7%	96.3%
3zbhA00	1.10.287.1060	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like	0.81	66.0	6.54e-01	86.0%	91.1%
1qv9A02	6.10.140.120	Special › Helix non-globular › Helix Hairpins ›	0.78	57.0	5.32e-01	75.6%	63.1%
2qffA00	1.20.1270.10	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 ›	0.78	46.0	4.97e-01	73.3%	68.9%
1jkvA01	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.78	55.0	4.21e-01	82.6%	32.5%
1sumB01	1.20.58.220	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2	0.78	59.0	5.48e-01	80.2%	65.4%
1lkoA01	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.77	57.0	4.72e-01	79.1%	45.5%
2lw1A00	1.10.287.380	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Valyl-tRNA synthetase, C-terminal domain	0.76	55.0	5.53e-01	86.0%	75.3%
2qqyA00	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.75	55.0	4.68e-01	82.6%	47.8%
1vctA01	1.20.58.220	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2	0.75	55.0	5.07e-01	80.2%	60.6%
1t72A01	1.20.58.220	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2	0.75	62.0	5.62e-01	100.0%	66.7%
3m9vA03	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.74	59.0	4.80e-01	84.9%	49.0%
2rkhA02	1.20.1280.20	Mainly Alpha › Up-down Bundle › Monooxygenase › HscB, C-terminal domain	0.74	52.0	5.48e-01	72.1%	81.6%
4l0rB00	1.20.58.90	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.74	59.0	6.29e-01	89.5%	100.0%
4cybD00	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.73	51.0	4.08e-01	80.2%	36.8%
1hs7A00	1.20.58.70	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.73	55.0	5.28e-01	95.3%	70.1%
2qywA00	1.20.58.400	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › t-snare proteins	0.73	57.0	5.56e-01	97.7%	75.8%
1ydxA02	1.10.287.1120	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Bipartite methylase S protein	0.73	60.0	5.96e-01	88.4%	86.7%
2fji101	1.10.357.50	Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 ›	0.72	57.0	4.27e-01	84.9%	75.6%
4ioeA00	1.10.287.850	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HP0062-like domain	0.72	58.0	5.79e-01	90.7%	85.1%
3pivA00	1.20.1250.10	Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; ›	0.72	50.0	4.06e-01	88.4%	39.7%
1i6zA00	1.20.58.120	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain	0.72	59.0	5.05e-01	90.7%	56.3%
2d1lA00	1.20.1270.60	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain	0.72	57.0	4.09e-01	86.0%	30.5%
5nl6A02	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.71	56.0	5.22e-01	98.8%	67.6%
2gs4A00	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.71	54.0	4.45e-01	82.6%	44.3%
4w4kA00	1.10.287.850	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HP0062-like domain	0.71	57.0	5.88e-01	88.4%	90.2%
3txsC01	1.10.287.1060	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like	0.70	54.0	5.76e-01	87.2%	94.7%
3favD00	1.10.287.1060	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like	0.70	57.0	5.92e-01	90.7%	96.2%
2rd0B00	1.10.287.1490	Mainly Alpha › Orthogonal Bundle › Helix Hairpins ›	0.70	57.0	4.82e-01	87.2%	54.7%
1tjoB00	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.70	51.0	3.99e-01	80.2%	37.1%
4i0xG00	1.10.287.1060	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like	0.70	52.0	5.68e-01	80.2%	100.0%
4od4A02	1.20.120.1780	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › UbiA prenyltransferase	0.69	62.0	5.50e-01	95.3%	98.3%
4e4eA01	1.10.287.990	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Fe,Mn superoxide dismutase (SOD) domain	0.69	53.0	5.74e-01	86.0%	98.6%
1j30A00	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.69	56.0	4.70e-01	97.7%	52.5%
1rv2D04	1.10.287.690	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › B family DNA polymerase, finger domain	0.69	51.0	5.58e-01	79.1%	100.0%
1wa8A00	1.10.287.1060	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like	0.68	58.0	5.54e-01	95.3%	81.8%
4hwdD00	1.20.58.120	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain	0.68	48.0	4.80e-01	98.8%	72.2%
1txdA01	1.20.900.10	Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain	0.67	55.0	3.98e-01	87.2%	72.7%
2g38B00	1.20.1260.20	Mainly Alpha › Up-down Bundle › Ferritin › PPE superfamily	0.67	54.0	4.34e-01	88.4%	43.9%
3r84B00	6.10.280.160	Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Mediator of RNA polymerase II transcription subunit 22	0.67	54.0	5.60e-01	86.0%	97.5%
8fbnB01	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.67	55.0	4.07e-01	89.5%	51.4%
5kbwB00	1.10.1760.20	Mainly Alpha › Orthogonal Bundle › Arp2/3 complex 21 kDa subunit ARPC3 ›	0.67	53.0	4.28e-01	87.2%	99.4%
1dd5A01	1.10.132.20	Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor	0.67	54.0	5.00e-01	87.2%	78.9%
4aflA00	6.10.140.1740	Special › Helix non-globular › Helix Hairpins ›	0.66	55.0	5.20e-01	89.5%	77.5%
4p9fA02	1.20.120.530	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › GntR ligand-binding domain-like	0.66	38.0	3.21e-01	74.4%	34.0%
4gzrB00	1.10.287.1060	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like	0.66	51.0	5.36e-01	83.7%	93.5%
2xokP00	1.20.20.10	Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C	0.66	49.0	5.24e-01	82.6%	91.9%
3fseB02	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.66	51.0	4.29e-01	82.6%	78.5%
2x2vA00	1.20.20.10	Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C	0.66	48.0	5.22e-01	82.6%	98.5%
3caxA01	1.20.120.520	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › nmb1532 protein domain like	0.65	56.0	4.23e-01	96.5%	97.7%
2hujA00	1.20.120.440	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › YppE-like	0.65	52.0	4.65e-01	88.4%	99.2%
3nymA00	6.10.290.10	Special › Helix non-globular › Four Helix Bundle (Hemerythrin (Met), subunit A) ›	0.64	52.0	4.61e-01	88.4%	83.1%
2e9xA01	1.20.58.1030	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.64	56.0	4.88e-01	96.5%	71.1%
1cnt200	1.20.1250.10	Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; ›	0.64	57.0	4.95e-01	97.7%	100.0%
4v1gA00	1.20.20.10	Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C	0.64	51.0	5.15e-01	88.4%	88.2%
2kg7B00	1.10.287.1060	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like	0.63	45.0	4.39e-01	83.7%	67.0%
6ynwH01	1.20.20.10	Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C	0.63	46.0	4.91e-01	82.6%	91.9%
3iqtA01	1.20.120.160	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain	0.60	44.0	4.04e-01	79.1%	84.2%
1s35A01	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.59	47.0	4.58e-01	98.8%	78.2%
1f6fA00	1.20.1250.10	Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; ›	0.58	51.0	4.04e-01	98.8%	97.3%
1v4aA01	1.10.4050.10	Mainly Alpha › Orthogonal Bundle › Nucleotidyltransferase substrate binding subunit/domain fold › Glutamine synthase adenylyltransferase GlnE	0.58	40.0	3.75e-01	72.1%	73.4%
1bgfA00	1.10.532.10	Mainly Alpha › Orthogonal Bundle › Transcription Factor, Stat-4 › STAT transcription factor, N-terminal domain	0.56	39.0	3.45e-01	72.1%	89.5%
1tf5A04	1.10.3060.10	Mainly Alpha › Orthogonal Bundle › Helical scaffold and wing domains of SecA › Helical scaffold and wing domains of SecA	0.56	48.0	3.71e-01	93.0%	65.4%

ECOD (58)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4063980	5037.1.1.2 ↗	alpha bundles › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › PsaA_PsaB	1.00	92.0	5.15e-01	100.0%	10.9%
4130349	5075.1.1.1 ↗	alpha bundles › Photosystem II antenna protein-like › Photosystem II antenna protein-like › Photosystem II antenna protein-like › PsaA_PsaB	1.00	97.0	5.45e-01	100.0%	11.5%
4874228	5037.1.1.2 ↗	alpha bundles › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › PsaA_PsaB	1.00	91.0	5.59e-01	94.2%	19.9%
4874226	5075.1.1.1 ↗	alpha bundles › Photosystem II antenna protein-like › Photosystem II antenna protein-like › Photosystem II antenna protein-like › PsaA_PsaB	0.99	97.0	5.87e-01	100.0%	20.3%
4467439	5075.1.1.1 ↗	alpha bundles › Photosystem II antenna protein-like › Photosystem II antenna protein-like › Photosystem II antenna protein-like › PsaA_PsaB	0.99	84.0	5.24e-01	87.2%	20.0%
2578612	5075.1.1.1 ↗	alpha bundles › Photosystem II antenna protein-like › Photosystem II antenna protein-like › Photosystem II antenna protein-like › PsaA_PsaB	0.99	91.0	5.52e-01	94.2%	19.1%
4345719	5075.1.1.1 ↗	alpha bundles › Photosystem II antenna protein-like › Photosystem II antenna protein-like › Photosystem II antenna protein-like › PsaA_PsaB	0.98	83.0	5.04e-01	87.2%	17.2%
4206112	5075.1.1.1 ↗	alpha bundles › Photosystem II antenna protein-like › Photosystem II antenna protein-like › Photosystem II antenna protein-like › PsaA_PsaB	0.97	82.0	5.21e-01	87.2%	22.0%
4857224	5075.1.1.1 ↗	alpha bundles › Photosystem II antenna protein-like › Photosystem II antenna protein-like › Photosystem II antenna protein-like › PsaA_PsaB	0.96	83.0	5.22e-01	100.0%	21.2%
4857024	5075.1.1.1 ↗	alpha bundles › Photosystem II antenna protein-like › Photosystem II antenna protein-like › Photosystem II antenna protein-like › PsaA_PsaB	0.96	84.0	5.46e-01	95.3%	25.2%
4857228	5075.1.1.1 ↗	alpha bundles › Photosystem II antenna protein-like › Photosystem II antenna protein-like › Photosystem II antenna protein-like › PsaA_PsaB	0.92	89.0	5.54e-01	100.0%	22.8%
3285714	150.5.1.0 ↗	alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › ESAT-6 like › ESAT-6 like	0.84	67.0	6.22e-01	84.9%	68.6%
3954313	150.5.1.52 ↗	alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › ESAT-6 like › ESAT-6 like › PE	0.80	65.0	6.27e-01	84.9%	89.5%
399541	150.5.1.1 ↗	alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › ESAT-6 like › ESAT-6 like › WXG100	0.80	65.0	6.24e-01	86.0%	82.7%
3258488	192.29.1.0 ↗	alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding)	0.80	61.0	5.78e-01	90.7%	69.0%
4873188	3291.1.1.1 ↗	alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Snf7	0.79	68.0	5.23e-01	90.7%	48.9%
3732045	4121.1.1.0 ↗	a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like	0.78	63.0	4.37e-01	84.9%	29.0%
4041347	192.7.1.2 ↗	alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm › Seryl_tRNA_N	0.78	67.0	6.17e-01	93.0%	91.8%
3734442	192.8.1.35 ↗	alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain › DUF6594	0.77	61.0	5.23e-01	87.2%	54.6%
4962781	605.1.1.0 ↗	alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase	0.77	61.0	6.47e-01	89.5%	94.7%
55139	604.3.1.1 ↗	alpha bundles › Spectrin repeat-like › BAG domain › BAG domain › BAG	0.77	56.0	4.93e-01	75.6%	54.9%
5064482	3755.3.1.0 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin	0.77	66.0	5.23e-01	91.9%	61.8%
5078878	3291.1.1.1 ↗	alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Snf7	0.77	63.0	5.00e-01	87.2%	46.7%
3594138	604.32.1.0 ↗	alpha bundles › Spectrin repeat-like › Recombination protein uvsY › Recombination protein uvsY	0.77	62.0	5.44e-01	88.4%	60.8%
4015178	3755.4.1.0 ↗	alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain	0.76	62.0	5.08e-01	87.2%	50.3%
4174467	3291.1.1.0 ↗	alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related	0.76	60.0	5.90e-01	89.5%	78.9%
4034237	5055.1.1.0 ↗	extended segments › Small-conductance potassium channel › Small-conductance potassium channel › Small-conductance potassium channel	0.76	57.0	5.15e-01	81.4%	59.1%
3696407	4121.1.1.7 ↗	a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like › PF26616	0.75	61.0	4.41e-01	87.2%	35.7%
3902100	3291.1.1.0 ↗	alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related	0.75	61.0	6.16e-01	89.5%	87.1%
3507551	192.5.1.0 ↗	alpha bundles › Long alpha-hairpin › HR1 repeat › HR1 repeat	0.75	65.0	6.33e-01	93.0%	90.5%
3556027	5086.1.1.0 ↗	alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins	0.75	60.0	6.12e-01	89.5%	87.1%
3855461	3922.1.1.0 ↗	alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3	0.75	60.0	6.09e-01	89.5%	87.1%
4971634	159.1.1.1 ↗	alpha bundles › all-alpha NTP pyrophosphatases › all-alpha NTP pyrophosphatases › Hypothetical protein AF_0060 › MazG	0.75	55.0	5.11e-01	86.0%	62.9%
3949790	150.5.1.1 ↗	alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › ESAT-6 like › ESAT-6 like › WXG100	0.74	59.0	5.62e-01	87.2%	73.0%
3247549	174.1.1.0 ↗	few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain	0.74	60.0	5.03e-01	86.0%	56.4%
3953227	150.5.1.0 ↗	alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › ESAT-6 like › ESAT-6 like	0.74	61.0	5.77e-01	87.2%	99.0%
3776400	192.5.1.1 ↗	alpha bundles › Long alpha-hairpin › HR1 repeat › HR1 repeat › HR1	0.73	58.0	6.06e-01	84.9%	95.0%
3590712	7516.1.1.2 ↗	a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Glycos_transf_2	0.73	63.0	4.17e-01	90.7%	38.1%
3248284	622.4.1.0 ↗	alpha bundles › YvfG-like › Mite allergen Der p 5-related › Mite allergen Der p 5-related	0.72	58.0	5.40e-01	86.0%	69.5%
3971109	5086.1.1.85 ↗	alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › HH_AAEA_pHBA	0.72	55.0	5.80e-01	83.7%	93.3%
5024278	3758.2.1.1 ↗	alpha bundles › Bacterial hemolysins-like › Biopolymer transport protein ExbB › Biopolymer transport protein ExbB › MotA_ExbB	0.72	61.0	4.71e-01	90.7%	43.3%
3969942	604.5.1.2 ↗	alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › PhoU	0.72	56.0	5.11e-01	84.9%	62.6%
3980428	605.1.1.1 ↗	alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › HisKA	0.71	55.0	5.84e-01	86.0%	93.3%
3602521	4323.1.1.0 ↗	alpha bundles › helical bundle domain in vacuolar ATP synthase subunit C › helical bundle domain in vacuolar ATP synthase subunit C › helical bundle domain in vacuolar ATP synthase subunit C	0.71	63.0	5.12e-01	97.7%	57.5%
4939077	1079.1.1.0 ↗	alpha complex topology › Transmembrane reductase CcdA › Transmembrane reductase CcdA › Transmembrane reductase CcdA	0.71	53.0	3.85e-01	76.7%	68.4%
3629105	174.1.1.0 ↗	few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain	0.71	59.0	4.79e-01	93.0%	48.8%
3961347	150.5.1.53 ↗	alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › ESAT-6 like › ESAT-6 like › PPE	0.71	54.0	5.50e-01	82.6%	84.7%
3261777	4177.1.1.8 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › BAR_3	0.71	59.0	4.31e-01	90.7%	70.2%
5069958	604.12.1.0 ↗	alpha bundles › Spectrin repeat-like › MIT domain › MIT domain	0.70	53.0	5.06e-01	84.9%	69.0%
3444418	3755.4.1.17 ↗	alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Rx_N	0.70	62.0	5.10e-01	97.7%	59.4%
3615597	5050.1.1.0 ↗	alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter	0.68	60.0	4.39e-01	97.7%	89.8%
3387995	3758.2.1.1 ↗	alpha bundles › Bacterial hemolysins-like › Biopolymer transport protein ExbB › Biopolymer transport protein ExbB › MotA_ExbB	0.68	59.0	4.51e-01	95.3%	52.5%
4397666	5086.1.1.0 ↗	alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins	0.68	54.0	4.33e-01	86.0%	47.1%
3236866	1135.1.1.3 ↗	a+b complex topology › Immune Mapped Protein 2 (IMP2) › Immune Mapped Protein 2 (IMP2) › Immune Mapped Protein 2 (IMP2) › CytochromB561_N	0.67	54.0	5.22e-01	84.9%	78.9%
3462100	604.1.1.102 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › DUF8324	0.67	53.0	4.80e-01	89.5%	61.7%
3923182	174.1.1.43 ↗	few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › CD20	0.67	58.0	4.83e-01	100.0%	54.7%
3542652	633.23.1.34 ↗	alpha bundles › Bromodomain-like › Claudin › Claudin › CD20	0.65	58.0	4.65e-01	100.0%	51.8%
3283672	4121.1.1.1 ↗	a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like › CorA	0.61	53.0	3.82e-01	100.0%	34.4%

D4 medium residues 412-450_516-629

PDB

Domain cluster: representative

Pfam (2)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00223.25 best	PsaA_PsaB	208.9	1.80e-61	75.2%	16.0%
PF00223.25	PsaA_PsaB	62.5	3.40e-17	26.1%	5.5%

CATH (40)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1jb0A00	1.20.1130.10	Mainly Alpha › Up-down Bundle › Photosystem I p700 chlorophyll A apoprotein A1 › Photosystem I PsaA/PsaB	0.95	93.0	5.68e-01	100.0%	30.4%
8hk0B03	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.72	48.0	5.03e-01	88.2%	74.6%
1egdA03	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.71	47.0	4.92e-01	88.2%	72.3%
1sziA02	1.20.120.340	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Flagellar protein FliS	0.71	49.0	5.14e-01	96.7%	78.1%
1w9rA00	1.20.58.440	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › choline binding protein A	0.71	49.0	5.42e-01	86.9%	89.9%
2yevA03	1.20.120.80	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c oxidase, subunit III, four-helix bundle	0.67	49.0	4.58e-01	97.4%	62.0%
1jogA00	1.20.120.330	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2	0.67	47.0	5.02e-01	75.8%	81.5%
5zw7A03	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.66	47.0	4.73e-01	85.6%	73.0%
7d3uC01	1.10.287.3510	Mainly Alpha › Orthogonal Bundle › Helix Hairpins ›	0.65	44.0	5.10e-01	90.8%	97.2%
2wdqD00	1.20.1300.10	Mainly Alpha › Up-down Bundle › 3 helical TM bundles of succinate and fumarate reductases › Fumarate reductase/succinate dehydrogenase, transmembrane subunit	0.65	44.0	5.14e-01	79.7%	100.0%
2b0hA01	1.20.120.230	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like	0.65	44.0	4.74e-01	95.4%	81.2%
4xvxA03	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.65	45.0	4.58e-01	88.9%	72.8%
1w99A01	1.20.190.10	Mainly Alpha › Up-down Bundle › Delta-Endotoxin; domain 1 › Pesticidal crystal protein, N-terminal domain	0.64	46.0	4.43e-01	86.9%	64.7%
3rx6A00	1.20.58.1090	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phage polarity suppression protein monomer	0.62	47.0	4.40e-01	79.1%	90.9%
1t72A01	1.20.58.220	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2	0.61	42.0	4.74e-01	97.4%	90.6%
1x04A00	1.20.1270.60	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain	0.61	44.0	3.99e-01	73.2%	75.5%
1qoyA00	1.20.1170.10	Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; ›	0.61	52.0	4.18e-01	93.5%	77.6%
4hwhE00	1.20.58.120	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain	0.60	35.0	4.49e-01	94.8%	98.9%
1xzpA02	1.20.120.430	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › tRNA modification GTPase MnmE domain 2	0.60	44.0	4.29e-01	96.1%	68.7%
2i0mA01	1.20.58.220	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2	0.60	40.0	4.68e-01	97.4%	96.2%
1lvfB00	1.20.58.90	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.59	40.0	4.71e-01	94.8%	100.0%
1sumB01	1.20.58.220	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2	0.59	40.0	4.67e-01	97.4%	99.1%
7ae2A01	1.20.120.580	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › bsu32300-like	0.59	42.0	4.45e-01	91.5%	82.5%
3jrtA00	1.20.120.1060	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) ›	0.58	47.0	4.61e-01	96.7%	78.3%
5mlc900	1.10.132.20	Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor	0.58	38.0	4.40e-01	91.5%	93.5%
4e40A00	1.20.1260.80	Mainly Alpha › Up-down Bundle › Ferritin ›	0.57	43.0	3.64e-01	77.1%	73.1%
4oydB00	1.10.132.20	Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor	0.57	40.0	4.42e-01	93.5%	92.3%
4egwA02	1.20.58.340	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Magnesium transport protein CorA, transmembrane region	0.57	42.0	4.66e-01	98.0%	97.5%
2wzkA03	1.20.1310.10	Mainly Alpha › Up-down Bundle › 5 helical Cullin repeat like › Cullin Repeats	0.56	32.0	3.72e-01	87.6%	77.3%
1hx8A02	1.20.58.150	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › ANTH domain	0.55	37.0	4.18e-01	81.7%	88.9%
4kb2A01	1.10.132.20	Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor	0.55	37.0	4.30e-01	94.1%	96.3%
4nwpD00	1.20.1200.10	Mainly Alpha › Up-down Bundle › Hypothetical Protein Ta1238; Chain: A; › Cobalamin adenosyltransferase-like	0.54	42.0	4.31e-01	81.0%	98.0%
6h2dS01	1.20.1170.10	Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; ›	0.53	47.0	4.18e-01	98.7%	89.2%
2pfdA03	1.20.120.680	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Formiminotetrahydrofolate cyclodeaminase monomer, up-and-down helical bundle	0.53	40.0	3.61e-01	98.0%	58.6%
2fupA00	1.20.58.300	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › FlgN-like	0.52	38.0	4.22e-01	96.1%	91.3%
4nqfA00	1.20.120.330	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2	0.52	39.0	4.08e-01	96.7%	84.1%
4fz4A00	1.20.140.130	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 ›	0.51	36.0	3.68e-01	74.5%	72.7%
2cz2A02	1.20.1050.10	Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 ›	0.51	30.0	3.33e-01	75.8%	70.6%
3v0aB02	1.20.1120.10	Mainly Alpha › Up-down Bundle › "Clostridium botulinum neurotoxin B, ""coiled-coil"" domain" › "Clostridium botulinum neurotoxin b, ""coiled-coil"" domain"	0.51	46.0	3.57e-01	98.7%	92.7%
8a1gC01	1.20.1270.60	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain	0.50	41.0	3.95e-01	88.2%	95.6%

ECOD (35)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4266999	5037.1.1.2 ↗	alpha bundles › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › PsaA_PsaB	0.98	96.0	7.03e-01	100.0%	64.7%
4335432	5037.1.1.2 ↗	alpha bundles › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › PsaA_PsaB	0.98	96.0	5.86e-01	100.0%	29.6%
4664596	5037.1.1.2 ↗	alpha bundles › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › PsaA_PsaB	0.96	94.0	6.75e-01	100.0%	69.4%
4147275	5075.1.1.1 ↗	alpha bundles › Photosystem II antenna protein-like › Photosystem II antenna protein-like › Photosystem II antenna protein-like › PsaA_PsaB	0.96	94.0	6.78e-01	100.0%	63.1%
4421535	5037.1.1.2 ↗	alpha bundles › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › PsaA_PsaB	0.96	94.0	6.84e-01	100.0%	58.3%
4063980	5037.1.1.2 ↗	alpha bundles › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › PsaA_PsaB	0.96	93.0	5.71e-01	100.0%	30.3%
4130349	5075.1.1.1 ↗	alpha bundles › Photosystem II antenna protein-like › Photosystem II antenna protein-like › Photosystem II antenna protein-like › PsaA_PsaB	0.96	93.0	5.70e-01	100.0%	30.2%
4000352	109.4.1.152 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › RPN7	0.79	46.0	4.31e-01	74.5%	48.9%
3464696	192.29.1.0 ↗	alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding)	0.73	51.0	5.56e-01	94.1%	83.8%
3901991	633.23.1.22 ↗	alpha bundles › Bromodomain-like › Claudin › Claudin › MARVEL	0.72	55.0	5.63e-01	83.0%	81.8%
5059491	633.23.1.0 ↗	alpha bundles › Bromodomain-like › Claudin › Claudin	0.71	50.0	4.54e-01	86.3%	54.5%
3963743	192.29.1.0 ↗	alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding)	0.68	44.0	5.20e-01	77.1%	95.2%
3969620	5069.1.2.2 ↗	alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Respiratory nitrate reductase 1 gamma chain › DUF3483	0.67	42.0	3.91e-01	78.4%	49.2%
3619724	604.12.1.0 ↗	alpha bundles › Spectrin repeat-like › MIT domain › MIT domain	0.67	43.0	5.16e-01	98.0%	100.0%
3801950	3755.4.1.0 ↗	alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain	0.67	39.0	3.56e-01	96.1%	43.4%
4929673	192.29.1.0 ↗	alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding)	0.65	52.0	5.34e-01	96.1%	87.3%
4001947	5001.1.1.1 ↗	alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1	0.64	51.0	5.19e-01	100.0%	84.7%
3697705	3684.1.1.0 ↗	alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like	0.63	57.0	5.26e-01	96.1%	77.9%
3701568	601.1.1.99 ↗	alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › Got1	0.61	41.0	4.31e-01	96.1%	76.3%
5066116	633.6.1.1 ↗	alpha bundles › Bromodomain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA_dh_1	0.60	44.0	4.35e-01	74.5%	94.4%
3730963	4121.1.1.0 ↗	a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like	0.60	50.0	3.54e-01	86.9%	78.0%
3291574	192.29.1.248 ↗	alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › PF27150	0.59	40.0	4.32e-01	98.7%	82.4%
3601528	5069.1.1.0 ↗	alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes	0.59	52.0	4.10e-01	96.1%	73.4%
3915925	5069.1.3.98 ↗	alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Fumarate reductase respiratory complex transmembrane subunits › ARL6IP6	0.58	36.0	4.33e-01	72.5%	93.9%
4625331	3684.1.1.0 ↗	alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like	0.58	51.0	4.58e-01	94.8%	75.7%
5043292	3755.3.1.0 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin	0.57	47.0	4.30e-01	85.6%	74.9%
4407957	601.1.1.0 ↗	alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin	0.56	50.0	4.53e-01	96.1%	74.6%
3917171	192.29.1.0 ↗	alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding)	0.55	49.0	4.72e-01	97.4%	84.6%
3275771	192.29.1.0 ↗	alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding)	0.55	47.0	4.36e-01	90.8%	83.7%
3688219	4121.1.1.1 ↗	a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like › CorA	0.54	45.0	3.63e-01	86.9%	71.0%
3837311	3684.1.1.0 ↗	alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like	0.53	46.0	3.99e-01	95.4%	87.8%
3404486	192.29.1.0 ↗	alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding)	0.52	45.0	4.28e-01	96.7%	78.4%
3463576	3684.1.1.2 ↗	alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › BPS1	0.52	42.0	3.75e-01	99.3%	60.0%
3273401	603.1.1.0 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins	0.52	45.0	4.06e-01	92.2%	92.7%
3420000	601.19.1.27 ↗	alpha bundles › Four-helical up-and-down bundle › Apolipoprotein › Apolipoprotein › DUF7795	0.51	45.0	4.24e-01	96.1%	88.1%

D5 medium residues 451-515

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00223.25 best	PsaA_PsaB	40.2	2.00e-10	100.0%	9.4%

ECOD (2)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4335432	5037.1.1.2 ↗	alpha bundles › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › PsaA_PsaB	0.85	77.0	4.29e-01	100.0%	8.7%
4266999	5037.1.1.2 ↗	alpha bundles › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › PsaA_PsaB	0.81	74.0	4.58e-01	100.0%	19.7%

D6 medium residues 630-737

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00223.25 best	PsaA_PsaB	174.4	4.90e-51	93.5%	14.2%

CATH (62)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1jb0A00	1.20.1130.10	Mainly Alpha › Up-down Bundle › Photosystem I p700 chlorophyll A apoprotein A1 › Photosystem I PsaA/PsaB	0.85	74.0	4.35e-01	99.1%	13.4%
3mq1A01	1.20.58.970	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.82	48.0	5.20e-01	88.0%	68.5%
2lm9A00	1.20.58.970	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.80	47.0	4.99e-01	88.0%	65.6%
2c41C01	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.79	43.0	3.82e-01	82.4%	38.9%
1uurA01	1.20.58.240	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › STAT; domain 1	0.77	46.0	4.57e-01	88.0%	57.3%
1vctA01	1.20.58.220	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2	0.77	43.0	4.37e-01	84.3%	55.0%
1yo7A00	1.20.120.230	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like	0.77	44.0	4.22e-01	87.0%	50.0%
1e2aA00	1.20.58.80	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit	0.76	42.0	4.40e-01	88.9%	57.8%
4hwhE00	1.20.58.120	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain	0.76	40.0	4.43e-01	84.3%	62.5%
2i0mA02	1.20.58.220	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2	0.75	45.0	4.72e-01	87.0%	64.4%
3nvoB02	1.20.58.340	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Magnesium transport protein CorA, transmembrane region	0.74	49.0	4.79e-01	88.0%	62.1%
1i6zA00	1.20.58.120	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain	0.73	46.0	4.25e-01	87.0%	51.1%
3fppA03	6.10.140.1990	Special › Helix non-globular › Helix Hairpins ›	0.72	46.0	5.04e-01	88.0%	79.5%
2gtaA00	1.10.287.1080	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › MazG-like	0.72	40.0	4.24e-01	86.1%	60.8%
3v5uA01	6.10.280.80	Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › NCX, peripheral helical region	0.71	48.0	5.68e-01	85.2%	98.7%
1t98A02	1.20.58.590	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Chromosome partition protein MukF, middle domain	0.70	40.0	3.46e-01	87.0%	36.8%
4iggA01	1.10.287.160	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat	0.70	43.0	5.23e-01	97.2%	100.0%
5nl6A02	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.69	42.0	4.20e-01	88.9%	58.3%
2ot4A03	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.69	46.0	4.69e-01	100.0%	69.2%
3l1nA02	1.20.1280.140	Mainly Alpha › Up-down Bundle › Monooxygenase ›	0.68	36.0	3.97e-01	80.6%	62.1%
2qkwA00	1.20.1270.140	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › AvrPto	0.67	47.0	4.84e-01	100.0%	77.2%
2yksA02	1.20.58.390	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Neurotransmitter-gated ion-channel transmembrane domain	0.67	36.0	3.49e-01	88.0%	47.9%
3aeiA00	1.10.287.370	Mainly Alpha › Orthogonal Bundle › Helix Hairpins ›	0.67	52.0	5.55e-01	88.0%	94.7%
2zdiB00	1.10.287.370	Mainly Alpha › Orthogonal Bundle › Helix Hairpins ›	0.66	52.0	5.28e-01	88.0%	84.0%
1j1jA02	1.20.58.200	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 2	0.66	36.0	3.98e-01	87.0%	65.9%
2vs0A00	1.10.287.1060	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like	0.66	47.0	5.29e-01	84.3%	96.3%
1lvfB00	1.20.58.90	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.65	43.0	4.43e-01	88.0%	70.2%
1w0bA01	1.20.58.420	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › AHSP	0.65	37.0	4.00e-01	98.1%	65.2%
6xkyA01	1.20.1330.10	Mainly Alpha › Up-down Bundle › f41 fragment of flagellin, N-terminal domain › f41 fragment of flagellin, N-terminal domain	0.65	54.0	4.41e-01	88.0%	85.6%
1kxpD02	1.10.246.10	Mainly Alpha › Orthogonal Bundle › Serum Albumin; Chain A, Domain 1 ›	0.64	38.0	4.19e-01	100.0%	71.6%
3rkgA02	1.20.58.340	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Magnesium transport protein CorA, transmembrane region	0.63	47.0	4.09e-01	87.0%	51.8%
3p8cF01	6.10.140.1620	Special › Helix non-globular › Helix Hairpins ›	0.63	46.0	4.70e-01	88.0%	78.1%
5wp3B00	1.10.132.20	Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor	0.62	41.0	4.20e-01	99.1%	68.6%
3ihvA01	1.25.40.890	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat ›	0.61	47.0	4.07e-01	80.6%	75.6%
3a06B03	1.10.1740.10	Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › RNA polymerase sigma factor, region 2, helix turn helix motif	0.61	30.0	3.27e-01	96.3%	56.8%
1hciA03	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.60	42.0	4.07e-01	86.1%	64.2%
3x29A00	1.20.140.150	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 ›	0.60	53.0	4.54e-01	100.0%	62.0%
3pe0A01	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.59	36.0	3.71e-01	81.5%	63.4%
3rrkA02	1.20.1460.20	Mainly Alpha › Up-down Bundle › subunit c (vma5p) of the yeast v-atpase, domain 2 ›	0.58	52.0	4.57e-01	96.3%	77.4%
2ch7A00	1.10.287.950	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Methyl-accepting chemotaxis protein	0.58	48.0	3.39e-01	88.0%	30.4%
1yjgA00	1.20.120.240	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Lipoprotein, type 6	0.58	47.0	4.16e-01	88.0%	100.0%
7zxkC01	1.20.1250.10	Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; ›	0.57	46.0	4.05e-01	84.3%	100.0%
2b0hA01	1.20.120.230	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like	0.56	41.0	3.93e-01	76.9%	100.0%
3kdqA00	6.10.320.10	Special › Helix non-globular › Ferritin ›	0.56	51.0	4.51e-01	98.1%	96.7%
4jioA01	1.20.120.560	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › alix/aip1 in complex with the ypdl late domain	0.56	51.0	4.47e-01	100.0%	75.2%
1hciA01	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.56	42.0	4.04e-01	87.0%	68.3%
2d4uB00	1.20.120.30	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Aspartate receptor, ligand-binding domain	0.56	44.0	3.99e-01	87.0%	94.2%
4wk5A00	1.10.600.10	Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase	0.55	47.0	3.51e-01	91.7%	53.9%
4yonA01	1.20.900.10	Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain	0.55	44.0	3.52e-01	87.0%	81.0%
5nl6B01	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.55	40.0	3.91e-01	88.0%	69.4%
3pltA00	1.20.1270.60	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain	0.54	48.0	3.82e-01	96.3%	69.2%
1xwjA01	1.20.120.230	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like	0.54	51.0	4.77e-01	100.0%	90.8%
4p79A00	1.20.140.150	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 ›	0.53	49.0	4.04e-01	99.1%	63.5%
3i2wA01	1.20.1270.60	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain	0.53	47.0	3.58e-01	99.1%	75.6%
3ic9A02	1.10.287.990	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Fe,Mn superoxide dismutase (SOD) domain	0.53	33.0	3.90e-01	74.1%	95.7%
3ipiA00	1.10.600.10	Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase	0.53	47.0	3.52e-01	98.1%	77.2%
3qweA00	1.20.1270.60	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain	0.52	47.0	3.54e-01	100.0%	76.2%
4mhlA00	1.20.1250.10	Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; ›	0.52	47.0	4.08e-01	98.1%	98.8%
2jx0A00	1.20.120.330	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2	0.51	47.0	4.42e-01	100.0%	91.6%
8sbeA01	1.20.1250.20	Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains	0.51	43.0	3.56e-01	92.6%	66.3%
1qdbA02	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.51	40.0	3.69e-01	100.0%	64.3%
3qa8A04	1.20.1270.250	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 ›	0.50	46.0	3.54e-01	99.1%	70.8%

ECOD (72)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4335432	5037.1.1.2 ↗	alpha bundles › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › PsaA_PsaB	0.86	81.0	4.78e-01	100.0%	14.7%
4664596	5037.1.1.2 ↗	alpha bundles › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › PsaA_PsaB	0.86	75.0	5.02e-01	99.1%	27.3%
4130349	5075.1.1.1 ↗	alpha bundles › Photosystem II antenna protein-like › Photosystem II antenna protein-like › Photosystem II antenna protein-like › PsaA_PsaB	0.86	75.0	4.40e-01	99.1%	13.3%
4266999	5037.1.1.2 ↗	alpha bundles › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › PsaA_PsaB	0.86	80.0	5.47e-01	99.1%	31.5%
4421535	5037.1.1.2 ↗	alpha bundles › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › Bacterial photosystem II reaction centre L and M subunits-like › PsaA_PsaB	0.85	73.0	4.97e-01	97.2%	28.1%
3620978	2003.1.2.18 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › FAD/NAD(P)-binding domain	0.82	48.0	3.35e-01	88.0%	19.7%
3624615	633.23.1.0 ↗	alpha bundles › Bromodomain-like › Claudin › Claudin	0.80	48.0	4.40e-01	87.0%	48.1%
3709562	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.77	48.0	4.26e-01	88.9%	44.7%
4432932	3615.1.1.10 ↗	alpha bundles › Bacterial dynamin-like protein helical domain › Bacterial dynamin-like protein helical domain › Bacterial dynamin-like protein helical domain › TMEM125	0.76	50.0	4.63e-01	89.8%	53.3%
3702706	192.15.1.0 ↗	alpha bundles › Long alpha-hairpin › Endosomal sorting complex assembly domains › Endosomal sorting complex assembly domains	0.75	49.0	5.68e-01	87.0%	90.0%
3957336	604.5.1.2 ↗	alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › PhoU	0.75	45.0	4.65e-01	87.0%	64.0%
3273377	4177.1.1.0 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like	0.74	50.0	3.91e-01	88.0%	34.4%
4016292	192.2.1.18 ↗	alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin › ING	0.74	50.0	4.61e-01	88.0%	54.8%
4979114	150.1.1.0 ↗	alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin	0.73	45.0	4.28e-01	88.0%	52.8%
3507833	604.5.1.10 ↗	alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › HRG	0.73	50.0	4.61e-01	85.2%	56.3%
4596325	3755.4.1.0 ↗	alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain	0.72	59.0	5.29e-01	88.0%	66.7%
3961148	3755.3.1.0 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin	0.71	48.0	4.64e-01	88.0%	61.7%
3795092	622.4.1.0 ↗	alpha bundles › YvfG-like › Mite allergen Der p 5-related › Mite allergen Der p 5-related	0.71	52.0	4.78e-01	88.0%	60.7%
3947717	3755.3.1.0 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin	0.70	46.0	4.02e-01	88.0%	45.8%
3182561	3755.3.1.0 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin	0.69	50.0	4.31e-01	88.9%	49.7%
5065759	5057.1.1.0 ↗	alpha bundles › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore	0.69	43.0	4.10e-01	87.0%	54.4%
5028061	192.2.1.1 ↗	alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin › Prefoldin_2	0.68	52.0	5.62e-01	88.0%	96.7%
3938687	5057.1.1.0 ↗	alpha bundles › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore	0.67	37.0	3.30e-01	89.8%	36.8%
4836886	5057.1.1.1 ↗	alpha bundles › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore › Neur_chan_memb	0.66	40.0	4.41e-01	84.3%	74.7%
3924462	632.1.1.11 ↗	alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain › HYOU1_C	0.66	39.0	3.81e-01	83.3%	51.7%
3283355	150.5.1.51 ↗	alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › ESAT-6 like › ESAT-6 like › WXG100_2	0.66	47.0	5.19e-01	87.0%	92.9%
3936858	11.12.1.2 ↗	beta sandwiches › Immunoglobulin-like beta-sandwich › Nicotinic receptor ligand binding domain-like › Nicotinic receptor ligand binding domain-like › Neur_chan_LBD,Neur_chan_memb	0.66	41.0	2.70e-01	87.0%	15.1%
3739377	4177.1.1.1 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › FCH	0.66	47.0	3.44e-01	88.0%	27.5%
3504301	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.65	44.0	4.40e-01	87.0%	67.3%
3577736	5057.1.1.1 ↗	alpha bundles › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore › Neur_chan_memb	0.65	41.0	3.99e-01	87.0%	56.7%
4557139	2492.1.1.56 ↗	a+b three layers › Cytidine deaminase-like › Cytidine deaminase-like › Cytidine deaminase-like › eIF3h_C	0.63	45.0	3.08e-01	73.1%	70.3%
4090475	632.22.1.1 ↗	alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats › EzrA	0.63	46.0	4.72e-01	98.1%	79.0%
3927319	192.2.1.2 ↗	alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin › Prefoldin	0.63	52.0	5.38e-01	87.0%	98.0%
4881130	5057.1.1.1 ↗	alpha bundles › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore › Neur_chan_memb	0.63	38.0	4.13e-01	84.3%	72.2%
3226726	632.7.1.0 ↗	alpha bundles › immunoglobulin/albumin-binding domain-like › Heat shock protein 70kD (HSP70), C-terminal subdomain › Heat shock protein 70kD (HSP70), C-terminal subdomain	0.63	38.0	3.75e-01	78.7%	55.7%
3928106	632.7.1.25 ↗	alpha bundles › immunoglobulin/albumin-binding domain-like › Heat shock protein 70kD (HSP70), C-terminal subdomain › Heat shock protein 70kD (HSP70), C-terminal subdomain › PF27508	0.62	44.0	4.26e-01	100.0%	65.8%
3873955	7016.1.1.0 ↗	extended segments › Palmitoyltransferase DHHC C-terminal domain › Palmitoyltransferase DHHC C-terminal domain › Palmitoyltransferase DHHC C-terminal domain	0.61	52.0	4.62e-01	92.6%	70.3%
1877523	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.60	43.0	4.31e-01	87.0%	72.3%
3829344	3922.1.1.295 ↗	alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › DUF7653	0.59	45.0	3.56e-01	88.0%	40.5%
4986986	3633.1.1.0 ↗	alpha duplicates or obligate multimers › Haptoglobin-hemoglobin receptor › Haptoglobin-hemoglobin receptor › Haptoglobin-hemoglobin receptor	0.59	49.0	3.88e-01	88.0%	45.9%
3994910	7015.1.1.0 ↗	alpha bundles › Palmitoyltransferase DHHC transmembrane domain › Palmitoyltransferase DHHC transmembrane domain › Palmitoyltransferase DHHC transmembrane domain	0.59	40.0	3.66e-01	87.0%	50.7%
5041715	192.2.1.0 ↗	alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin	0.58	48.0	4.77e-01	86.1%	100.0%
4031920	1075.1.2.1 ↗	alpha bundles › Type II ABC exporter transmembrane domain fold › Type II ABC exporter transmembrane domain-related › MacB transmembrane domain › FtsX	0.58	41.0	3.54e-01	98.1%	43.2%
3396400	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.58	47.0	4.44e-01	87.0%	73.6%
3680007	3755.3.1.549 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › PF28649	0.58	48.0	4.49e-01	88.0%	73.1%
3699463	3755.3.1.0 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin	0.57	48.0	3.74e-01	88.0%	51.2%
3171466	3755.3.1.459 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › AIM11_N	0.57	46.0	4.58e-01	88.9%	82.7%
4964044	5058.1.1.16 ↗	alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › MS_channel_1st_1	0.57	34.0	3.53e-01	72.2%	63.0%
3539308	3755.3.1.0 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin	0.57	47.0	3.52e-01	88.0%	37.6%
4549103	3755.4.1.54 ↗	alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › PF30340	0.57	47.0	3.16e-01	88.0%	48.9%
4206235	3755.4.1.0 ↗	alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain	0.57	46.0	3.47e-01	87.0%	100.0%
3588738	150.5.1.83 ↗	alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › ESAT-6 like › ESAT-6 like › DUF3899	0.57	44.0	4.46e-01	87.0%	80.9%
4149566	3922.1.1.0 ↗	alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3	0.56	46.0	3.43e-01	86.1%	63.6%
3279024	150.5.1.51 ↗	alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › ESAT-6 like › ESAT-6 like › WXG100_2	0.56	49.0	4.61e-01	94.4%	85.4%
3638634	3755.3.1.0 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin	0.56	43.0	4.28e-01	84.3%	78.3%
4642325	5086.1.1.84 ↗	alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › HH_MFP_RND	0.55	45.0	4.28e-01	88.0%	96.9%
5078892	604.5.1.1 ↗	alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › PhoU_div	0.55	50.0	3.94e-01	98.1%	94.4%
3797042	174.1.1.0 ↗	few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain	0.54	44.0	3.96e-01	88.0%	94.7%
3264568	3748.1.1.3 ↗	extended segments › 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain › 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain › 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain › eIF3h_C	0.54	44.0	4.50e-01	87.0%	98.1%
4276914	3782.1.1.1 ↗	a+b duplicates or obligate multimers › Envelope glycoprotein GP2-related › Envelope glycoprotein GP2-related › Envelope glycoprotein GP2-related › TLV_coat	0.54	44.0	4.30e-01	88.0%	79.2%
3513364	174.1.1.1 ↗	few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin	0.54	44.0	3.91e-01	87.0%	87.3%
3421989	3291.1.1.0 ↗	alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related	0.54	43.0	4.11e-01	87.0%	73.6%
4410114	3755.3.1.0 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin	0.54	41.0	3.15e-01	88.0%	34.9%
5077822	604.5.1.1 ↗	alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › PhoU_div	0.53	48.0	3.84e-01	98.1%	97.1%
3815650	604.1.1.134 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › PF28715	0.53	46.0	3.74e-01	95.4%	55.6%
3438770	3567.1.1.0 ↗	a+b duplicates or obligate multimers › MPER trimer › MPER trimer › MPER trimer	0.53	40.0	3.54e-01	95.4%	52.7%
3362557	4177.1.1.8 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › BAR_3	0.53	47.0	3.83e-01	100.0%	78.1%
3205695	3755.3.1.0 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin	0.52	43.0	3.23e-01	88.0%	37.6%
4060749	2492.1.1.4 ↗	a+b three layers › Cytidine deaminase-like › Cytidine deaminase-like › Cytidine deaminase-like	0.52	43.0	2.99e-01	88.0%	32.8%
3914720	3745.1.1.1 ↗	alpha bundles › Sodium/Calcium exchanger › Sodium/Calcium exchanger › Sodium/Calcium exchanger › Na_Ca_ex	0.50	44.0	3.08e-01	100.0%	90.5%
3958112	1075.1.2.0 ↗	alpha bundles › Type II ABC exporter transmembrane domain fold › Type II ABC exporter transmembrane domain-related › MacB transmembrane domain	0.50	41.0	3.17e-01	88.9%	63.7%
3638504	2492.1.1.4 ↗	a+b three layers › Cytidine deaminase-like › Cytidine deaminase-like › Cytidine deaminase-like	0.50	41.0	2.81e-01	88.9%	26.0%