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Lambda_B

Euk-Vir

Mahlapitsi_orthoreovirus

Lambda_B__YP_009246466__Mahlapitsi_orthoreovirus__2170064

Identity

Accession:: YP_009246466 ↗
Protein ID:: Lambda_B
Kingdom:: euk

Quality

74.9 mean pLDDT

Taxonomy

Orthornavirae› Duplornaviricota› Resentoviricetes› Reovirales› Spinareoviridae› Orthoreovirus› Mahlapitsi_orthoreovirus

TaxID: 2170064

Cluster

View cluster (29 members)

3D Structure

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Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 962-1046_1110-1174

PDB

Domain cluster: rep: VP2__YP_001837095__American_grass_carp_reovirus__465447__D966-1046_1125-1153

Pfam (2)

Accession	Name	Score	E-value	Q cov	HMM cov
PF07925.16 best	RdRP_5	53.9	8.70e-15	59.3%	6.9%
PF07925.16	RdRP_5	71.3	4.80e-20	48.0%	5.1%

D2 medium residues 14-63_156-216

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF07925.16 best	RdRP_5	24.6	5.90e-06	56.8%	4.1%

ECOD (2)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4905	4963.1.1.2 ↗	alpha complex topology › N-terminal additional helical subdomain in reovirus polymerase lambda3 › N-terminal additional helical subdomain in reovirus polymerase lambda3 › N-terminal additional helical subdomain in reovirus polymerase lambda3 › RdRP_5	0.93	90.0	5.90e-01	100.0%	54.1%
2392232	4963.1.1.2 ↗	alpha complex topology › N-terminal additional helical subdomain in reovirus polymerase lambda3 › N-terminal additional helical subdomain in reovirus polymerase lambda3 › N-terminal additional helical subdomain in reovirus polymerase lambda3 › RdRP_5	0.90	86.0	5.67e-01	100.0%	53.0%

D3 medium residues 64-155

PDB

Domain cluster: rep: core_RNA-dependent_RNA_polymerase__YP_009445963__Piscine_orthoreovirus__1157337__D63-154_212-236

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF07925.16 best	RdRP_5	76.2	1.60e-21	100.0%	7.1%

D4 medium residues 217-284_324-370_825-850

PDB

Domain cluster: representative

Pfam (3)

Accession	Name	Score	E-value	Q cov	HMM cov
PF07925.16 best	RdRP_5	57.2	8.90e-16	52.5%	5.0%
PF07925.16	RdRP_5	25.9	2.50e-06	36.9%	3.7%
PF07925.16	RdRP_5	20.8	8.40e-05	19.1%	2.1%

CATH (17)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4cbeA00	1.20.120.1640	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) ›	0.60	42.0	3.73e-01	72.3%	50.7%
1tj7A01	1.10.275.10	Mainly Alpha › Orthogonal Bundle › Fumarase C; Chain B, domain 1 › Fumarase/aspartase (N-terminal domain)	0.59	34.0	3.87e-01	81.6%	75.2%
3am6A00	1.20.1070.10	Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins	0.57	44.0	3.83e-01	81.6%	76.3%
4rocA01	1.10.472.10	Mainly Alpha › Orthogonal Bundle › Cyclin A; domain 1 › Cyclin-like	0.57	32.0	3.72e-01	81.6%	74.8%
2etdA00	1.20.1440.20	Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › LemA-like domain	0.57	33.0	3.33e-01	90.1%	55.3%
4fjvA02	1.20.1300.20	Mainly Alpha › Up-down Bundle › 3 helical TM bundles of succinate and fumarate reductases › Peptidase C65 Otubain, subdomain 2	0.57	34.0	3.42e-01	84.4%	56.9%
2qffA00	1.20.1270.10	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 ›	0.57	28.0	3.73e-01	82.3%	89.2%
3agtA00	1.20.120.50	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Hemerythrin-like	0.55	35.0	3.65e-01	87.2%	68.4%
7e4gA01	1.20.1070.10	Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins	0.55	42.0	3.81e-01	81.6%	81.7%
3jsbA01	1.20.1440.300	Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › RNA-directed RNA polymerase L, helical domain	0.53	28.0	3.46e-01	80.1%	84.0%
5xs2B02	1.10.472.10	Mainly Alpha › Orthogonal Bundle › Cyclin A; domain 1 › Cyclin-like	0.53	34.0	3.54e-01	93.6%	68.2%
8gr7A01	1.10.600.10	Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase	0.52	45.0	3.53e-01	95.7%	88.2%
6fakA02	1.10.246.10	Mainly Alpha › Orthogonal Bundle › Serum Albumin; Chain A, Domain 1 ›	0.52	30.0	3.81e-01	70.9%	100.0%
7wvzA02	3.40.366.10	Alpha Beta › 3-Layer(aba) Sandwich › Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 › Malonyl-Coenzyme A Acyl Carrier Protein, domain 2	0.52	44.0	3.37e-01	93.6%	87.2%
1yc9A01	1.20.1600.10	Mainly Alpha › Up-down Bundle › Outer membrane efflux proteins (OEP) › Outer membrane efflux proteins (OEP)	0.51	37.0	2.85e-01	75.9%	54.1%
2ot4A03	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.51	31.0	3.57e-01	85.1%	81.3%
6v0kA00	1.10.600.10	Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase	0.50	42.0	3.30e-01	90.1%	84.1%

ECOD (9)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4905	4963.1.1.2 ↗	alpha complex topology › N-terminal additional helical subdomain in reovirus polymerase lambda3 › N-terminal additional helical subdomain in reovirus polymerase lambda3 › N-terminal additional helical subdomain in reovirus polymerase lambda3 › RdRP_5	0.99	79.0	5.49e-01	81.6%	40.6%
2392232	4963.1.1.2 ↗	alpha complex topology › N-terminal additional helical subdomain in reovirus polymerase lambda3 › N-terminal additional helical subdomain in reovirus polymerase lambda3 › N-terminal additional helical subdomain in reovirus polymerase lambda3 › RdRP_5	0.96	76.0	5.30e-01	81.6%	41.0%
3728766	101.1.10.3 ↗	alpha arrays › HTH › HTH › Cyclin-like › TFIIB	0.55	36.0	3.56e-01	85.1%	61.3%
3378930	101.1.10.3 ↗	alpha arrays › HTH › HTH › Cyclin-like › TFIIB	0.54	35.0	3.68e-01	85.1%	72.0%
3742639	101.1.10.1 ↗	alpha arrays › HTH › HTH › Cyclin-like › Cyclin_N	0.53	35.0	3.50e-01	97.2%	63.3%
3626372	101.1.10.1 ↗	alpha arrays › HTH › HTH › Cyclin-like › Cyclin_N	0.52	34.0	3.63e-01	80.9%	75.2%
3754716	101.1.17.0 ↗	alpha arrays › HTH › HTH › FF domain	0.51	42.0	4.27e-01	92.2%	91.9%
3291654	206.1.1.11 ↗	a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › APH	0.51	37.0	3.17e-01	77.3%	58.3%
4030551	3871.1.1.1 ↗	alpha duplicates or obligate multimers › PHIST › PHIST › PHIST › PRESAN	0.50	35.0	3.22e-01	72.3%	76.3%

D5 medium residues 532-553_592-638_653-683

PDB

Domain cluster: representative

Pfam (2)

Accession	Name	Score	E-value	Q cov	HMM cov
PF07925.16 best	RdRP_5	63.4	1.20e-17	79.0%	7.2%
PF07925.16	RdRP_5	25.2	4.10e-06	26.0%	1.9%

CATH (2)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1mukA02	3.90.1850.10	Alpha Beta › Alpha-Beta Complex › RNA-directed RNA polymerase lambda-3 › RNA-directed RNA polymerase lambda-3	0.94	90.0	5.46e-01	100.0%	29.8%
3gqhA02	4.10.80.40	Few Secondary Structures › Irregular › Rhinovirus 14, subunit 4 › succinate dehydrogenase protein domain	0.52	20.0	2.86e-01	76.0%	80.0%

ECOD (1)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
5368	304.48.1.23 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_5	0.94	90.0	5.72e-01	100.0%	38.4%

D6 medium residues 865-950

PDB