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Lambda_C

Euk-Vir

Mahlapitsi_orthoreovirus

Lambda_C__YP_009246465__Mahlapitsi_orthoreovirus__2170064

Identity

Accession:
YP_009246465 ↗
Protein ID:
Lambda_C
Kingdom:
euk

Quality

80.3 mean pLDDT

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 394-427_700-794
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF21062.3 best Reovirus_L2_4th 43.1 4.70e-11 83.0% 84.5%
CATH (10)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1ej6A02 3.55.60.10 Alpha Beta › 3-Layer(bab) Sandwich › Reovirus components fold › Reovirus components 0.92 89.0 8.42e-01 100.0% 91.9%
3iylW02 3.55.60.10 Alpha Beta › 3-Layer(bab) Sandwich › Reovirus components fold › Reovirus components 0.90 86.0 8.18e-01 100.0% 92.6%
1vm0A00 3.30.110.20 Alpha Beta › 2-Layer Sandwich › Translation Initiation Factor IF3 › Alba-like domain 0.57 36.0 4.08e-01 70.5% 87.1%
8ediA01 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.55 36.0 3.99e-01 73.6% 81.7%
1mjfB02 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.54 39.0 3.27e-01 74.4% 93.5%
2oz4A01 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.53 32.0 3.63e-01 77.5% 78.4%
1iamA01 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.53 29.0 3.48e-01 71.3% 80.7%
1g84A00 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.53 34.0 3.74e-01 76.7% 81.0%
4qjvB00 3.30.1360.10 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › RNA polymerase, RBP11-like subunit 0.52 33.0 3.78e-01 72.9% 86.2%
6ef7A00 2.60.40.4140 Mainly Beta › Sandwich › Immunoglobulin-like › 0.51 33.0 3.41e-01 80.6% 67.7%
ECOD (10)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
2794455 3332.1.1.1 a+b two layers › ferredoxin-like domain in VP1 › ferredoxin-like domain in VP1 › ferredoxin-like domain in VP1 › Reovirus_L2_4th 0.88 65.0 6.88e-01 77.5% 85.1%
4948152 256.1.1.0 a+b two layers › MTH1598-like › MTH1598-like › MTH1598-like 0.58 31.0 4.08e-01 79.1% 97.1%
4153241 242.1.1.7 a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases › LAGLIDADG_3 0.57 41.0 4.47e-01 75.2% 91.4%
4959915 256.1.1.1 a+b two layers › MTH1598-like › MTH1598-like › MTH1598-like › Archease 0.56 31.0 4.08e-01 79.8% 100.0%
5022358 242.1.1.7 a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases › LAGLIDADG_3 0.56 40.0 4.24e-01 74.4% 84.3%
5027887 256.1.1.1 a+b two layers › MTH1598-like › MTH1598-like › MTH1598-like › Archease 0.56 31.0 4.01e-01 79.1% 100.0%
5060591 873.1.1.0 a+b complex topology › H-NOX domain › H-NOX domain › H-NOX domain 0.53 38.0 3.68e-01 72.9% 75.7%
3645120 304.8.1.55 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › ACT_ACR9_C 0.53 32.0 3.57e-01 77.5% 74.3%
3948220 312.1.1.4 a+b three layers › HIT-like › HIT-related › HIT-related › CDH 0.51 33.0 3.51e-01 83.7% 74.5%
5037021 305.1.1.1 a+b two layers › DCoH-like › RBP11-like subunits of RNA polymerase › RBP11-like subunits of RNA polymerase › RNA_pol_L 0.51 32.0 3.59e-01 72.9% 81.0%
D2 high residues 883-1024
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF21066.4 best Reovirus_L2_MT2 89.6 3.20e-25 100.0% 60.6%
CATH (18)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3iylW04 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.93 89.0 7.27e-01 100.0% 60.5%
1ej6A04 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.92 88.0 7.28e-01 100.0% 61.3%
3htxD03 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.70 52.0 4.44e-01 100.0% 49.3%
2bkyX00 3.30.110.20 Alpha Beta › 2-Layer Sandwich › Translation Initiation Factor IF3 › Alba-like domain 0.67 39.0 4.94e-01 98.6% 96.5%
3me5A02 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.64 44.0 3.65e-01 100.0% 40.3%
4atnA03 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.63 39.0 3.64e-01 100.0% 47.8%
3fbuA00 3.40.630.30 Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) 0.62 38.0 3.60e-01 99.3% 51.2%
1q2yA00 3.40.630.30 Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) 0.60 35.0 3.58e-01 100.0% 57.9%
5hc8A00 3.40.1180.10 Alpha Beta › 3-Layer(aba) Sandwich › Undecaprenyl pyrophosphate synthetase › Decaprenyl diphosphate synthase-like 0.57 45.0 3.76e-01 81.7% 66.9%
3vc1J00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.56 51.0 4.11e-01 100.0% 69.2%
3cc8A00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.56 49.0 4.28e-01 100.0% 63.5%
3bkxA00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.55 50.0 4.02e-01 100.0% 56.4%
4ua3A00 3.40.630.30 Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) 0.54 35.0 3.25e-01 100.0% 50.5%
2g3aA02 3.40.630.30 Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) 0.53 38.0 4.32e-01 100.0% 99.0%
3pp9B00 3.40.630.30 Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) 0.52 39.0 3.65e-01 100.0% 63.8%
1ro5A01 3.40.630.30 Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) 0.52 38.0 3.44e-01 100.0% 57.2%
1vybA00 3.60.10.10 Alpha Beta › 4-Layer Sandwich › Deoxyribonuclease I; Chain A › Endonuclease/exonuclease/phosphatase 0.51 41.0 3.49e-01 100.0% 52.1%
7paxA01 3.40.1180.10 Alpha Beta › 3-Layer(aba) Sandwich › Undecaprenyl pyrophosphate synthetase › Decaprenyl diphosphate synthase-like 0.50 45.0 3.65e-01 97.2% 72.5%
ECOD (24)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
1162279 2003.1.5.91 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Reovirus_L2_MT2 0.91 81.0 6.70e-01 92.3% 57.3%
3039309 2003.1.5.91 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Reovirus_L2_MT2 0.91 87.0 7.24e-01 100.0% 62.1%
4989805 328.5.1.0 a+b two layers › IF3-like › SirA-like › SirA-like 0.73 36.0 4.92e-01 97.9% 94.3%
5057825 328.1.1.0 a+b two layers › IF3-like › AlbA-like › AlbA-like 0.72 37.0 4.84e-01 98.6% 90.7%
2773459 7581.1.1.0 a/b three-layered sandwiches › Thiolase-like › Thiolase-like › Thiolase-like 0.70 30.0 3.24e-01 98.6% 46.0%
3223591 207.1.1.247 beta duplicates or obligate multimers › Single-stranded right-handed beta-helix › Leucine-rich repeats › Leucine-rich repeats › PF28313 0.68 45.0 3.28e-01 100.0% 25.5%
4950383 2003.1.5.66 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 0.65 50.0 4.27e-01 100.0% 51.8%
4977512 2003.1.5.81 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_25 0.65 50.0 4.52e-01 100.0% 58.8%
3506224 246.3.1.10 a+b four layers › Carbon-nitrogen hydrolase-like › DNase I-like › DNase I-like › Exo_endo_phos_PGAP2IP 0.64 37.0 3.15e-01 99.3% 32.9%
4441830 2003.1.5.1 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › DNA_methylase 0.63 46.0 3.44e-01 100.0% 31.0%
3998228 246.3.1.0 a+b four layers › Carbon-nitrogen hydrolase-like › DNase I-like › DNase I-like 0.60 35.0 3.24e-01 99.3% 43.8%
None 0.60 38.0 3.45e-01 100.0% 48.1%
1688236 2003.1.5.79 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_23 0.59 51.0 4.20e-01 100.0% 52.1%
4979611 213.1.1.1 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › Acetyltransf_1 0.59 37.0 3.61e-01 100.0% 56.8%
4947752 2003.1.5.0 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases 0.58 49.0 4.36e-01 98.6% 65.1%
5024857 213.1.1.0 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) 0.56 38.0 3.41e-01 99.3% 47.8%
4957729 213.1.1.0 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) 0.55 37.0 3.37e-01 99.3% 51.1%
3590046 213.1.1.1 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › Acetyltransf_1 0.54 37.0 3.53e-01 99.3% 58.2%
3433204 246.3.1.1 a+b four layers › Carbon-nitrogen hydrolase-like › DNase I-like › DNase I-like › Exo_endo_phos 0.51 43.0 3.61e-01 100.0% 53.3%
4016812 5104.1.1.3 a+b three layers › C-terminal domain in DHH phosphoesterases › C-terminal domain in DHH phosphoesterases › C-terminal domain in DHH phosphoesterases › DHHA2 0.51 34.0 3.39e-01 100.0% 63.6%
4965603 213.1.1.1 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › Acetyltransf_1 0.51 33.0 3.24e-01 100.0% 59.4%
5029812 7534.1.1.1 a/b three-layered sandwiches › Undecaprenyl diphosphate synthase › Undecaprenyl diphosphate synthase › Undecaprenyl diphosphate synthase › Prenyltransf 0.51 46.0 3.89e-01 97.2% 82.1%
3506123 7567.1.1.1 a/b three-layered sandwiches › LmbE-like › LmbE-like › LmbE-like › PIG-L 0.50 44.0 3.82e-01 97.2% 96.9%
3938655 327.11.2.0 a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Eukaryotic type KH-domain (KH-domain type I) 0.50 26.0 3.16e-01 96.5% 76.7%
D3 medium residues 26-146
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF21064.3 best Reovirus_L2_N 53.0 5.50e-14 92.6% 57.8%
CATH (4)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1ej6A01 3.90.1810.10 Alpha Beta › Alpha-Beta Complex › Reovirus components fold › Reovirus components 0.96 94.0 6.23e-01 100.0% 31.5%
3iylW01 3.90.1810.10 Alpha Beta › Alpha-Beta Complex › Reovirus components fold › Reovirus components 0.88 84.0 5.64e-01 100.0% 32.2%
2a7oA00 1.10.1740.100 Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › Set2, Rpb1 interacting domain 0.63 42.0 4.62e-01 83.5% 82.0%
3smvA02 1.10.150.750 Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › 0.60 33.0 4.02e-01 74.4% 83.1%
ECOD (4)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
1137618 839.1.1.0 a+b complex topology › Rotavirus NSP2 fragment, N-terminal domain › Rotavirus NSP2 fragment, N-terminal domain › Rotavirus NSP2 fragment, N-terminal domain 0.96 90.0 8.42e-01 95.9% 82.9%
3039259 839.1.1.1 a+b complex topology › Rotavirus NSP2 fragment, N-terminal domain › Rotavirus NSP2 fragment, N-terminal domain › Rotavirus NSP2 fragment, N-terminal domain › Reovirus_L2_N 0.96 89.0 8.41e-01 95.9% 82.9%
2992505 839.1.1.1 a+b complex topology › Rotavirus NSP2 fragment, N-terminal domain › Rotavirus NSP2 fragment, N-terminal domain › Rotavirus NSP2 fragment, N-terminal domain › Reovirus_L2_N 0.86 79.0 7.38e-01 95.9% 83.1%
1162283 839.1.1.0 a+b complex topology › Rotavirus NSP2 fragment, N-terminal domain › Rotavirus NSP2 fragment, N-terminal domain › Rotavirus NSP2 fragment, N-terminal domain 0.85 78.0 7.34e-01 96.7% 82.5%
D4 medium residues 147-339
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF21063.2 best Reovirus_L2_GTase 141.0 5.80e-41 93.8% 69.2%
CATH (4)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1ej6A01 3.90.1810.10 Alpha Beta › Alpha-Beta Complex › Reovirus components fold › Reovirus components 0.91 88.0 6.72e-01 100.0% 50.8%
3iylW01 3.90.1810.10 Alpha Beta › Alpha-Beta Complex › Reovirus components fold › Reovirus components 0.89 85.0 6.54e-01 100.0% 50.0%
2w7vA00 3.30.1360.100 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › General secretion pathway protein M, EpsM 0.53 22.0 3.21e-01 73.6% 85.4%
7r3eB02 3.30.450.80 Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › Transcription factor LuxR-like, autoinducer-binding domain 0.50 29.0 3.16e-01 96.4% 65.6%
ECOD (7)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
2794451 312.1.1.13 a+b three layers › HIT-like › HIT-related › HIT-related › Reovirus_L2_GTase 0.90 87.0 7.84e-01 100.0% 78.0%
185350 312.1.1.13 a+b three layers › HIT-like › HIT-related › HIT-related › Reovirus_L2_GTase 0.89 85.0 7.71e-01 100.0% 78.5%
3900183 390.1.1.0 few secondary structure elements › Hairpin loop containing domain-like › Hairpin loop containing domain-like › Hairpin loop containing domain-like 0.60 25.0 3.49e-01 72.0% 78.9%
3838009 1118.1.1.2 a+b complex topology › Anchorless fibronectin/fibrinogen binding protein C-terminal domain › Anchorless fibronectin/fibrinogen binding protein C-terminal domain › Anchorless fibronectin/fibrinogen binding protein C-terminal domain › NFACT-R_2 0.53 27.0 3.55e-01 75.1% 92.6%
3170399 1118.1.1.1 a+b complex topology › Anchorless fibronectin/fibrinogen binding protein C-terminal domain › Anchorless fibronectin/fibrinogen binding protein C-terminal domain › Anchorless fibronectin/fibrinogen binding protein C-terminal domain › NFACT-R_1 0.51 33.0 3.40e-01 76.7% 65.8%
2990398 1118.1.1.1 a+b complex topology › Anchorless fibronectin/fibrinogen binding protein C-terminal domain › Anchorless fibronectin/fibrinogen binding protein C-terminal domain › Anchorless fibronectin/fibrinogen binding protein C-terminal domain › NFACT-R_1 0.51 32.0 3.38e-01 76.7% 66.9%
3596168 1118.1.1.0 a+b complex topology › Anchorless fibronectin/fibrinogen binding protein C-terminal domain › Anchorless fibronectin/fibrinogen binding protein C-terminal domain › Anchorless fibronectin/fibrinogen binding protein C-terminal domain 0.51 32.0 3.78e-01 76.7% 91.5%
D5 medium residues 428-455_503-580_599-621_634-668
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF21065.4 best Reovirus_L2_MT1 82.9 3.40e-23 90.2% 53.9%
CATH (58)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1ej6A03 3.40.50.10760 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Reovirus core 0.91 88.0 7.27e-01 100.0% 90.9%
3iylW03 3.40.50.10760 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Reovirus core 0.85 81.0 6.87e-01 100.0% 90.4%
3trkA02 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.69 57.0 5.51e-01 86.6% 94.0%
5ezqA02 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.68 56.0 5.42e-01 86.6% 92.4%
1yzhB00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.65 47.0 4.32e-01 73.8% 84.5%
3tkaA01 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.63 55.0 5.33e-01 92.1% 100.0%
2plwA00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.63 56.0 5.42e-01 92.7% 96.7%
2f8lA02 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.63 57.0 4.97e-01 97.0% 84.6%
3axsA01 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.62 58.0 4.59e-01 100.0% 82.0%
4krgA02 3.40.50.12180 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.62 53.0 4.90e-01 90.2% 90.7%
1m6yA01 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.62 53.0 5.17e-01 90.9% 98.9%
1g38A01 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.62 56.0 5.03e-01 97.6% 98.7%
4krgA01 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.62 56.0 4.79e-01 96.3% 83.5%
1o54A02 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.61 54.0 5.10e-01 93.9% 92.2%
3ajdA02 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.61 52.0 4.95e-01 91.5% 100.0%
3e4cB00 3.40.50.1460 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.60 44.0 3.77e-01 75.6% 87.7%
1k7cA00 3.40.50.1110 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › SGNH hydrolase 0.60 43.0 3.80e-01 72.0% 94.0%
3e05B00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.60 52.0 4.91e-01 91.5% 89.1%
1p91B00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.60 52.0 4.47e-01 92.7% 79.1%
1e5tA01 3.40.50.1820 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain 0.60 50.0 3.93e-01 90.9% 88.0%
4u1qA02 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.58 50.0 4.82e-01 92.1% 90.9%
3mczA02 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.58 51.0 4.46e-01 94.5% 98.0%
3hm2A00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.58 51.0 5.03e-01 93.3% 100.0%
3d2lC01 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.58 50.0 4.91e-01 92.1% 92.1%
1dusA00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.58 50.0 4.71e-01 91.5% 91.8%
1x19A02 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.57 50.0 5.06e-01 91.5% 99.4%
3gbvA01 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.57 40.0 4.35e-01 72.6% 90.0%
3lzdA03 3.40.50.11860 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Diphthamide synthesis DPH1/DPH2 domain 3 0.56 33.0 4.08e-01 83.5% 92.2%
4wzzA01 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.55 40.0 4.06e-01 73.8% 98.8%
3nuqA02 3.40.50.1000 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HAD superfamily/HAD-like 0.55 39.0 3.87e-01 71.3% 87.6%
4uuwA01 3.40.980.10 Alpha Beta › 3-Layer(aba) Sandwich › Molybdenum Cofactor Biosythetic Enzyme; Chain A › MoaB/Mog-like domain 0.55 40.0 3.98e-01 75.0% 83.7%
3ty4B00 3.40.718.10 Alpha Beta › 3-Layer(aba) Sandwich › Isopropylmalate Dehydrogenase › Isopropylmalate Dehydrogenase 0.54 40.0 3.11e-01 75.0% 77.9%
1jx6A02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.54 43.0 4.53e-01 97.6% 92.7%
4n03A02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.54 45.0 4.46e-01 89.6% 83.0%
5bq3A02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.54 46.0 4.71e-01 98.8% 96.8%
3q41A01 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.54 41.0 3.97e-01 80.5% 96.9%
3bmxA02 3.40.50.1700 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Glycoside hydrolase family 3 C-terminal domain 0.54 49.0 4.44e-01 100.0% 93.7%
1tjyA02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.53 45.0 4.66e-01 98.8% 96.7%
3g1wA02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.53 43.0 4.54e-01 97.0% 95.9%
4wzzA02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.53 44.0 4.53e-01 89.6% 93.1%
3d02A02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.53 45.0 4.64e-01 98.2% 96.7%
2h3hB02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.53 43.0 4.43e-01 98.8% 90.4%
3kjxA03 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.53 42.0 4.50e-01 90.2% 98.6%
2wteA01 3.40.50.11700 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.53 40.0 4.29e-01 93.9% 93.5%
3flkA00 3.40.718.10 Alpha Beta › 3-Layer(aba) Sandwich › Isopropylmalate Dehydrogenase › Isopropylmalate Dehydrogenase 0.53 38.0 3.01e-01 74.4% 75.8%
3n0xA02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.53 43.0 4.35e-01 97.6% 87.2%
2pueA03 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.52 42.0 4.37e-01 90.2% 94.6%
3e3mA02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.52 42.0 4.44e-01 95.7% 97.9%
2amfA01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.52 36.0 3.82e-01 71.3% 86.6%
4p1zA00 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.51 37.0 4.14e-01 75.6% 96.1%
2vdwG00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.51 44.0 3.76e-01 94.5% 96.0%
3kp1A04 3.40.50.280 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Cobalamin-binding domain 0.51 38.0 3.98e-01 77.4% 96.0%
3ksmA02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.51 43.0 4.48e-01 89.6% 98.7%
1sbpA01 3.40.190.10 Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II 0.51 34.0 3.53e-01 74.4% 70.9%
4irxA02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.51 43.0 4.39e-01 90.9% 93.2%
5hsgA02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.51 43.0 4.36e-01 91.5% 93.8%
4kvfA01 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.50 43.0 4.40e-01 92.1% 96.9%
1jx6A01 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.50 41.0 4.00e-01 87.2% 87.9%
ECOD (68)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
1137615 2003.1.5.90 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Reovirus_L2_MT1 0.91 88.0 6.92e-01 100.0% 79.4%
185352 2003.1.5.90 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Reovirus_L2_MT1 0.84 80.0 6.79e-01 98.2% 90.6%
3679579 2003.1.5.23 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_4 0.66 48.0 4.48e-01 73.8% 89.9%
None 0.64 58.0 5.32e-01 95.7% 91.4%
4204474 2003.1.5.17 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_5 0.63 55.0 4.58e-01 90.9% 88.8%
4584257 2003.1.5.17 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_5 0.63 54.0 5.08e-01 90.9% 96.4%
4434568 102.1.1.6 alpha arrays › HhH/H2TH › SAM/DNA-glycosylase › SAM domain-like › Methyltransf_5 0.62 54.0 5.10e-01 92.7% 92.4%
3292868 2003.1.5.17 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_5 0.62 54.0 4.46e-01 92.1% 90.1%
4056269 2003.1.5.17 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_5 0.62 55.0 5.10e-01 95.1% 95.2%
4063958 2003.1.5.17 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_5 0.62 54.0 5.03e-01 91.5% 93.5%
4337038 2003.1.5.17 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_5 0.62 54.0 4.89e-01 92.7% 98.2%
None 0.62 54.0 4.95e-01 92.1% 96.7%
4515089 2003.1.5.17 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_5 0.62 56.0 4.97e-01 97.6% 93.6%
3826560 2003.1.5.17 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_5 0.62 54.0 4.41e-01 91.5% 87.0%
4051182 2003.1.5.17 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_5 0.62 55.0 4.70e-01 94.5% 88.2%
4281922 2003.1.5.17 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_5 0.62 54.0 4.96e-01 92.7% 94.8%
4237810 2003.1.5.17 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_5 0.62 54.0 4.76e-01 93.9% 84.1%
None 0.62 53.0 4.89e-01 91.5% 99.0%
5059031 2003.1.5.5 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › UPF0020 0.62 54.0 5.09e-01 91.5% 86.3%
4488756 102.1.1.6 alpha arrays › HhH/H2TH › SAM/DNA-glycosylase › SAM domain-like › Methyltransf_5 0.61 53.0 4.81e-01 90.9% 95.3%
4198622 2003.1.5.17 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_5 0.61 55.0 5.01e-01 95.1% 92.9%
3944327 2003.1.5.179 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › PF30636 0.61 53.0 5.08e-01 90.9% 91.4%
3970631 2003.1.5.0 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases 0.61 55.0 4.65e-01 95.1% 91.2%
4594023 2003.1.5.17 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_5 0.61 53.0 5.06e-01 90.9% 98.4%
3967659 2003.1.5.179 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › PF30636 0.61 54.0 5.04e-01 92.7% 87.7%
3675198 2007.5.1.1 a/b three-layered sandwiches › Flavodoxin-like › SGNH hydrolase › SGNH hydrolase › Lipase_GDSL 0.61 45.0 3.88e-01 75.6% 89.8%
3671086 2007.5.1.8 a/b three-layered sandwiches › Flavodoxin-like › SGNH hydrolase › SGNH hydrolase › Lipase_GDSL_2 0.61 44.0 4.04e-01 73.2% 99.0%
4026458 2003.1.5.17 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_5 0.61 53.0 4.76e-01 91.5% 91.7%
4339753 2003.1.5.17 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_5 0.61 54.0 4.86e-01 93.9% 100.0%
5064244 2003.1.5.5 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › UPF0020 0.60 52.0 5.01e-01 90.9% 90.8%
3696346 7579.1.1.16 a/b three-layered sandwiches › alpha/beta-Hydrolases › alpha/beta-Hydrolases › alpha/beta-Hydrolases › Palm_thioest 0.60 46.0 3.68e-01 81.1% 74.6%
3692743 2003.1.5.0 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases 0.60 52.0 4.27e-01 92.7% 90.7%
4928510 2003.1.5.22 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › N6_Mtase 0.60 54.0 4.57e-01 97.0% 90.5%
3359440 7512.1.1.0 a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase 0.59 45.0 3.79e-01 80.5% 83.2%
3321302 2003.1.5.23 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_4 0.57 51.0 4.40e-01 94.5% 100.0%
4023510 7575.1.1.0 a/b three-layered sandwiches › Caspase-like › Caspase-like › Caspase-like 0.57 44.0 3.95e-01 81.7% 94.9%
4982457 7541.1.1.1 a/b three-layered sandwiches › Molybdenum cofactor biosynthesis proteins › Molybdenum cofactor biosynthesis proteins › Molybdenum cofactor biosynthesis proteins › MoCF_biosynth 0.57 42.0 4.06e-01 75.0% 83.9%
4976372 2007.1.1.0 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Class I glutamine amidotransferase-like 0.57 41.0 3.81e-01 73.8% 81.0%
5070977 7590.1.1.0 a/b three-layered sandwiches › Middle domain in Argonaute homologs › Middle domain in Argonaute homologs › Middle domain in Argonaute homologs 0.56 38.0 4.44e-01 84.1% 97.4%
1253201 2007.1.2.13 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › Peripla_BP_6 0.55 45.0 4.81e-01 87.2% 100.0%
3970692 7541.1.1.0 a/b three-layered sandwiches › Molybdenum cofactor biosynthesis proteins › Molybdenum cofactor biosynthesis proteins › Molybdenum cofactor biosynthesis proteins 0.55 40.0 3.96e-01 75.6% 71.2%
5016873 2007.1.14.33 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Chelatase-like › CGGC 0.55 38.0 4.18e-01 70.7% 100.0%
3372780 7512.1.1.0 a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase 0.54 39.0 3.56e-01 73.8% 88.4%
4053805 7541.1.1.1 a/b three-layered sandwiches › Molybdenum cofactor biosynthesis proteins › Molybdenum cofactor biosynthesis proteins › Molybdenum cofactor biosynthesis proteins › MoCF_biosynth 0.54 40.0 3.88e-01 75.6% 80.0%
3722977 2003.1.5.153 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › PCMT, Methyltransf_25 0.54 50.0 4.50e-01 100.0% 96.0%
3588299 2007.1.2.11 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › Peripla_BP_4 0.54 40.0 4.46e-01 88.4% 97.7%
2049260 7523.1.1.30 a/b three-layered sandwiches › Periplasmic binding protein-like II › Periplasmic binding protein-like II › Periplasmic binding protein-like II › SBP_bac_11 0.54 31.0 3.96e-01 70.1% 96.9%
4085642 7541.1.1.1 a/b three-layered sandwiches › Molybdenum cofactor biosynthesis proteins › Molybdenum cofactor biosynthesis proteins › Molybdenum cofactor biosynthesis proteins › MoCF_biosynth 0.54 41.0 3.93e-01 77.4% 83.8%
3951092 7541.1.1.1 a/b three-layered sandwiches › Molybdenum cofactor biosynthesis proteins › Molybdenum cofactor biosynthesis proteins › Molybdenum cofactor biosynthesis proteins › MoCF_biosynth 0.54 39.0 3.90e-01 76.2% 71.8%
4200435 7541.1.1.1 a/b three-layered sandwiches › Molybdenum cofactor biosynthesis proteins › Molybdenum cofactor biosynthesis proteins › Molybdenum cofactor biosynthesis proteins › MoCF_biosynth 0.54 39.0 3.85e-01 75.0% 78.3%
1005403 2007.1.2.11 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › Peripla_BP_4 0.54 42.0 4.58e-01 86.6% 100.0%
4092467 7541.1.1.1 a/b three-layered sandwiches › Molybdenum cofactor biosynthesis proteins › Molybdenum cofactor biosynthesis proteins › Molybdenum cofactor biosynthesis proteins › MoCF_biosynth 0.54 40.0 4.09e-01 76.8% 78.8%
3399393 7524.1.1.4 a/b three-layered sandwiches › ALDH-like › ALDH-like › ALDH-like › DUF1487 0.54 40.0 3.57e-01 77.4% 89.8%
3699707 2007.1.3.0 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › CheY-like 0.53 37.0 4.22e-01 73.8% 94.4%
None 0.53 49.0 4.21e-01 99.4% 81.8%
3998087 2004.1.1.598 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › PF29907 0.53 38.0 3.59e-01 73.8% 89.5%
3109967 7575.1.1.1 a/b three-layered sandwiches › Caspase-like › Caspase-like › Caspase-like › Peptidase_C14 0.52 36.0 3.65e-01 70.7% 82.7%
3743682 2007.1.4.2 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Phosphofructokinase N-terminal domain › DAGK_cat 0.52 39.0 4.26e-01 76.2% 100.0%
3907772 2007.1.2.0 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I 0.52 48.0 4.00e-01 100.0% 88.6%
4935149 2007.1.16.1 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Iron-sulphur enzyme Dph2 › Diphthamide_syn 0.52 35.0 4.12e-01 80.5% 97.4%
3260120 7590.1.1.2 a/b three-layered sandwiches › Middle domain in Argonaute homologs › Middle domain in Argonaute homologs › Middle domain in Argonaute homologs › Piwi 0.52 38.0 4.17e-01 76.2% 94.1%
4947056 7540.1.1.1 a/b three-layered sandwiches › Bacterial fluorinating enzyme, N-terminal domain › Bacterial fluorinating enzyme, N-terminal domain › Bacterial fluorinating enzyme, N-terminal domain › SAM_HAT_N 0.52 40.0 4.12e-01 80.5% 97.5%
3938516 2007.1.2.4 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › ANF_receptor 0.52 46.0 3.58e-01 95.1% 86.0%
4947483 2007.1.3.0 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › CheY-like 0.51 36.0 4.07e-01 72.6% 94.4%
3611378 2007.1.2.27 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › Peripla_BP_A-cyclase 0.51 39.0 3.43e-01 81.1% 92.8%
4016942 2003.1.1.120 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › NAD-bd_HRPKS_sdrA 0.50 39.0 3.85e-01 81.1% 100.0%
5056395 2007.1.16.1 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Iron-sulphur enzyme Dph2 › Diphthamide_syn 0.50 31.0 3.78e-01 79.3% 100.0%
3711166 2007.1.2.0 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I 0.50 42.0 4.07e-01 92.1% 97.4%
D6 medium residues 795-846
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF21066.4 best Reovirus_L2_MT2 28.4 1.70e-06 88.5% 11.7%
CATH (2)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
4nzpA01 3.40.50.620 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HUPs 0.64 45.0 3.45e-01 78.8% 34.8%
1reqA02 3.40.50.280 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Cobalamin-binding domain 0.51 41.0 3.05e-01 100.0% 67.7%
ECOD (2)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4008301 101.1.2.6 alpha arrays › HTH › HTH › winged helix domain › GntR 0.58 43.0 3.75e-01 86.5% 80.0%
4205896 7588.1.1.1 a/b three-layered sandwiches › NadA-like/4-hydroxy-3-methylbut-2-enyl diphosphate reductase › NadA-like/4-hydroxy-3-methylbut-2-enyl diphosphate reductase › NadA-like/4-hydroxy-3-methylbut-2-enyl diphosphate reductase › LYTB 0.51 42.0 3.52e-01 100.0% 54.0%