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M2-1_protein

Euk-Vir

Human_orthopneumovirus

M2-1_protein__NP_056864__Human_orthopneumovirus__11250

Identity

Accession:
NP_056864 ↗
Protein ID:
M2-1_protein
Kingdom:
euk

Quality

70.8 mean pLDDT

Taxonomy

Orthornavirae› Negarnaviricota› Monjiviricetes› Mononegavirales› Pneumoviridae› Orthopneumovirus› human_respiratory_syncytial_virus

TaxID: 11250

Cluster

View cluster (3 members)

3D Structure

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Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 70-174
PDB
Domain cluster: rep: matrix_protein_M2-1__YP_009094043__Pneumovirus_dog_Bari_100-12_ITA_2012__2482952__D75-174
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF06436.17 best Pneumovirus_M2 185.8 5.50e-55 100.0% 66.0%
CATH (29)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
4c3eM00 1.20.120.1350 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Pneumovirus matrix protein 2 (M2), zinc-binding domain 0.99 97.0 8.19e-01 100.0% 67.7%
5nohA00 1.20.120.1350 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Pneumovirus matrix protein 2 (M2), zinc-binding domain 0.98 93.0 9.41e-01 100.0% 99.0%
4cs9B02 1.20.120.1350 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Pneumovirus matrix protein 2 (M2), zinc-binding domain 0.92 85.0 8.43e-01 99.0% 94.4%
4cs9C00 1.20.120.1350 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Pneumovirus matrix protein 2 (M2), zinc-binding domain 0.90 84.0 7.07e-01 100.0% 62.4%
3ulqB00 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.58 32.0 4.09e-01 97.1% 96.6%
2l6hA00 1.20.120.330 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 0.58 51.0 4.46e-01 95.2% 70.1%
2f2gA00 1.20.910.10 Mainly Alpha › Up-down Bundle › Heme Oxygenase; Chain A › Heme oxygenase-like 0.58 43.0 3.43e-01 78.1% 97.2%
6zhiB02 1.20.1270.10 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.58 42.0 4.57e-01 81.9% 95.2%
3kavA00 1.20.1270.360 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.57 41.0 4.23e-01 76.2% 83.3%
3vkgA02 1.20.140.100 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Dynein motor heavy chain, linker domain, N-terminal subdomain 0.56 43.0 3.90e-01 81.9% 58.5%
2lmgA00 1.20.1270.10 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.56 38.0 4.29e-01 80.0% 98.6%
3fmsA02 1.20.120.530 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › GntR ligand-binding domain-like 0.55 40.0 3.71e-01 97.1% 57.4%
4xt1A00 1.20.1070.10 Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins 0.55 40.0 3.01e-01 77.1% 91.1%
3thxB03 1.10.1420.10 Mainly Alpha › Orthogonal Bundle › MutS, DNA mismatch repair protein; Chain A, domain 3 › 0.55 44.0 3.77e-01 95.2% 51.6%
2qkwA00 1.20.1270.140 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › AvrPto 0.54 40.0 4.13e-01 80.0% 93.1%
2rd3D00 1.20.910.10 Mainly Alpha › Up-down Bundle › Heme Oxygenase; Chain A › Heme oxygenase-like 0.54 41.0 3.26e-01 80.0% 96.8%
4hr1A00 1.20.1270.410 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.54 41.0 3.95e-01 80.0% 78.8%
2y44A00 1.20.1260.80 Mainly Alpha › Up-down Bundle › Ferritin › 0.54 41.0 3.40e-01 80.0% 90.8%
3caxA01 1.20.120.520 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › nmb1532 protein domain like 0.54 45.0 3.66e-01 95.2% 53.9%
3buxB01 1.20.930.20 Mainly Alpha › Up-down Bundle › Transcription Elongation Factor S-II; Chain A › Adaptor protein Cbl, N-terminal domain 0.52 40.0 3.80e-01 88.6% 67.4%
7tj9A01 1.20.120.350 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Voltage-gated potassium channels. Chain C 0.52 42.0 4.23e-01 88.6% 86.8%
4e40A00 1.20.1260.80 Mainly Alpha › Up-down Bundle › Ferritin › 0.52 39.0 3.07e-01 81.0% 80.4%
2uxwA01 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.52 39.0 3.37e-01 82.9% 65.6%
3lmfA00 1.20.1270.360 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.52 41.0 4.08e-01 99.0% 83.5%
4y9jA01 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.52 37.0 3.41e-01 76.2% 83.2%
1r2jA03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.51 38.0 3.49e-01 79.0% 72.2%
2qupA00 1.20.120.490 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Hypothetical protein TM1646-like domain 0.51 43.0 4.16e-01 95.2% 82.4%
2q12A00 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.51 41.0 3.19e-01 88.6% 74.4%
1zylA03 1.20.1270.170 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.50 33.0 3.41e-01 71.4% 68.0%
ECOD (42)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
2643566 3418.1.1.1 ↗ alpha arrays › Matrix protein 2-1 core domain › Matrix protein 2-1 core domain › Matrix protein 2-1 core domain › Pneumovirus_M2 0.97 94.0 9.46e-01 100.0% 99.1%
1293556 3418.1.1.1 ↗ alpha arrays › Matrix protein 2-1 core domain › Matrix protein 2-1 core domain › Matrix protein 2-1 core domain › Pneumovirus_M2 0.90 85.0 8.24e-01 100.0% 92.0%
3744144 632.6.1.5 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Plasmid maintenance system epsilon/zeta, antidote epsilon subunit › Plasmid maintenance system epsilon/zeta, antidote epsilon subunit › Med15_fungi 0.67 49.0 4.32e-01 81.0% 52.3%
4324384 632.15.1.7 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Staphylococcal complement inhibitor (SCIN) › Staphylococcal complement inhibitor (SCIN) › Med15_fungi 0.66 48.0 4.54e-01 81.0% 62.3%
3645353 632.1.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain 0.64 45.0 4.81e-01 81.0% 84.4%
2464258 3620.1.1.1 ↗ alpha bundles › Factor H-binding protein BbCRASP-1 › Factor H-binding protein BbCRASP-1 › Factor H-binding protein BbCRASP-1 › PFam54_60 0.61 47.0 3.74e-01 81.9% 71.3%
4993545 601.7.1.2 ↗ alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain › HEPN 0.60 52.0 4.46e-01 96.2% 77.1%
5012658 632.1.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain 0.59 45.0 4.77e-01 81.9% 93.3%
3267994 632.1.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain 0.59 44.0 4.47e-01 80.0% 86.7%
3356723 611.7.1.15 ↗ alpha bundles › N-cbl like › Mixed lineage kinase domain-like (MLKL) N-terminal domain › Mixed lineage kinase domain-like (MLKL) N-terminal domain › Rx_N 0.58 44.0 4.26e-01 80.0% 71.7%
5014074 632.1.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain 0.58 41.0 4.46e-01 74.3% 98.8%
3735143 3755.4.1.3 ↗ alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Helo_like_N 0.58 45.0 4.06e-01 81.0% 71.4%
5014264 632.11.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like 0.58 42.0 4.54e-01 81.0% 90.0%
3235535 192.29.1.0 ↗ alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) 0.58 50.0 4.94e-01 97.1% 100.0%
3676218 192.29.1.0 ↗ alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) 0.57 50.0 4.12e-01 95.2% 93.0%
3556701 174.1.1.0 ↗ few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain 0.56 39.0 3.51e-01 72.4% 81.9%
3934203 5001.1.1.5 ↗ alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_3 0.56 42.0 3.02e-01 78.1% 71.1%
4942062 632.11.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like 0.56 40.0 4.41e-01 81.9% 92.9%
4996688 601.37.1.0 ↗ alpha bundles › Four-helical up-and-down bundle › Photosystem II lipoprotein Psb27 › Photosystem II lipoprotein Psb27 0.56 42.0 4.34e-01 85.7% 85.0%
4017411 3755.4.1.0 ↗ alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain 0.56 44.0 3.86e-01 81.9% 75.3%
3889209 109.27.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › BACK domain › BACK domain 0.56 50.0 4.73e-01 100.0% 94.4%
5036629 632.11.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like 0.56 40.0 4.49e-01 84.8% 98.8%
3455444 207.1.1.0 ↗ beta duplicates or obligate multimers › Single-stranded right-handed beta-helix › Leucine-rich repeats › Leucine-rich repeats 0.56 43.0 2.89e-01 80.0% 29.7%
3672708 601.4.1.0 ↗ alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains 0.55 45.0 3.72e-01 85.7% 75.6%
3441615 3684.1.1.0 ↗ alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like 0.55 49.0 3.93e-01 98.1% 92.4%
3454208 632.15.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Staphylococcal complement inhibitor (SCIN) › Staphylococcal complement inhibitor (SCIN) 0.55 40.0 4.42e-01 79.0% 100.0%
3231443 3758.1.1.0 ↗ alpha bundles › Bacterial hemolysins-like › Bacterial hemolysins › Bacterial hemolysins 0.55 39.0 2.93e-01 71.4% 63.0%
3266960 611.8.1.1 ↗ alpha bundles › N-cbl like › C-terminal domain of E3 ubiquitin-protein ligase ARIH1 › C-terminal domain of E3 ubiquitin-protein ligase ARIH1 › Ariadne 0.55 42.0 3.66e-01 81.9% 78.2%
4431610 2004.1.1.492 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD_C, ADDB_N, PF27467 0.55 41.0 2.51e-01 80.0% 53.2%
3222373 605.4.1.18 ↗ alpha duplicates or obligate multimers › ROP-like › ROP protein › ROP protein › PF29357 0.55 40.0 4.40e-01 81.0% 96.5%
3920499 611.8.1.1 ↗ alpha bundles › N-cbl like › C-terminal domain of E3 ubiquitin-protein ligase ARIH1 › C-terminal domain of E3 ubiquitin-protein ligase ARIH1 › Ariadne 0.55 44.0 3.80e-01 87.6% 92.4%
3350129 5069.1.1.0 ↗ alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes 0.55 48.0 3.91e-01 100.0% 73.8%
3742811 604.6.1.1 ↗ alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain › GAT 0.54 42.0 4.12e-01 81.9% 88.7%
5013099 601.3.1.0 ↗ alpha bundles › Four-helical up-and-down bundle › Histidine-containing phosphotransfer domain, HPT domain › Histidine-containing phosphotransfer domain, HPT domain 0.54 46.0 4.30e-01 95.2% 74.1%
4060120 192.29.1.127 ↗ alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › ApoL 0.54 38.0 3.75e-01 98.1% 68.2%
3737139 4177.1.1.1 ↗ alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › FCH 0.53 44.0 3.23e-01 90.5% 75.4%
5042303 1203.1.2.19 ↗ alpha bundles › Shroom domain 2 › Shroom domain 2 › Human SD2 › LPG_synthase_TM 0.52 42.0 3.24e-01 89.5% 66.2%
3461715 632.1.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain 0.51 39.0 4.01e-01 81.0% 97.0%
4589405 2004.1.1.494 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ADDB_N, PF27467 0.51 40.0 2.47e-01 85.7% 55.2%
3486940 601.1.2.0 ↗ alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) 0.51 38.0 3.03e-01 80.0% 84.3%
3713433 2004.1.1.73 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › MMR_HSR1 0.51 41.0 3.02e-01 92.4% 56.9%
3931107 632.7.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Heat shock protein 70kD (HSP70), C-terminal subdomain › Heat shock protein 70kD (HSP70), C-terminal subdomain 0.50 37.0 3.49e-01 78.1% 81.5%