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MW302330.1QTJ63005.1X__00027

Bact-Vir

MW302330.1__QTJ63005.1__X__00027

Identity

Accession:: MW302330 ↗
Kingdom:: phage

Quality

91.5 mean pLDDT

Taxonomy

Heunggongvirae› Uroviricota› Caudoviricetes› Stenotrophomonas_phage_TS-12

TaxID: 2796496

Cluster

Singleton — not in a non-trivial cluster

3D Structure

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Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 4-114

PDB

Domain cluster: rep: CAKLQF020000025.1__CAH1092096.1__SAMEA5780031_03475__00013__D4-110

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00590.26 best	TP_methylase	88.6	7.90e-25	100.0%	53.3%

CATH (67)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1pjqA04	3.40.1010.10	Alpha Beta › 3-Layer(aba) Sandwich › Cobalt-precorrin-4 Transmethylase; domain 1 › Tetrapyrrole methylase, N-terminal domain	0.95	89.0	8.81e-01	100.0%	93.9%
3ndcA01	3.40.1010.10	Alpha Beta › 3-Layer(aba) Sandwich › Cobalt-precorrin-4 Transmethylase; domain 1 › Tetrapyrrole methylase, N-terminal domain	0.94	86.0	8.61e-01	100.0%	93.8%
6mjgA01	3.40.1010.10	Alpha Beta › 3-Layer(aba) Sandwich › Cobalt-precorrin-4 Transmethylase; domain 1 › Tetrapyrrole methylase, N-terminal domain	0.89	84.0	8.16e-01	100.0%	95.0%
2qbuA01	3.40.1010.10	Alpha Beta › 3-Layer(aba) Sandwich › Cobalt-precorrin-4 Transmethylase; domain 1 › Tetrapyrrole methylase, N-terminal domain	0.87	82.0	7.70e-01	100.0%	94.7%
3nutC01	3.40.1010.10	Alpha Beta › 3-Layer(aba) Sandwich › Cobalt-precorrin-4 Transmethylase; domain 1 › Tetrapyrrole methylase, N-terminal domain	0.87	80.0	7.93e-01	100.0%	93.9%
2e0nA01	3.40.1010.10	Alpha Beta › 3-Layer(aba) Sandwich › Cobalt-precorrin-4 Transmethylase; domain 1 › Tetrapyrrole methylase, N-terminal domain	0.84	80.0	7.77e-01	100.0%	96.7%
1wdeA01	3.40.1010.10	Alpha Beta › 3-Layer(aba) Sandwich › Cobalt-precorrin-4 Transmethylase; domain 1 › Tetrapyrrole methylase, N-terminal domain	0.84	79.0	7.78e-01	100.0%	94.8%
2dsgA01	3.40.1010.10	Alpha Beta › 3-Layer(aba) Sandwich › Cobalt-precorrin-4 Transmethylase; domain 1 › Tetrapyrrole methylase, N-terminal domain	0.82	77.0	7.67e-01	100.0%	96.5%
2zvbA01	3.40.1010.10	Alpha Beta › 3-Layer(aba) Sandwich › Cobalt-precorrin-4 Transmethylase; domain 1 › Tetrapyrrole methylase, N-terminal domain	0.82	78.0	7.29e-01	100.0%	96.2%
2npnA01	3.40.1010.10	Alpha Beta › 3-Layer(aba) Sandwich › Cobalt-precorrin-4 Transmethylase; domain 1 › Tetrapyrrole methylase, N-terminal domain	0.78	73.0	6.93e-01	100.0%	95.3%
3hh1A00	3.40.1010.10	Alpha Beta › 3-Layer(aba) Sandwich › Cobalt-precorrin-4 Transmethylase; domain 1 › Tetrapyrrole methylase, N-terminal domain	0.76	68.0	6.82e-01	100.0%	95.6%
3qyfA01	3.40.50.10770	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Hypothetical protein VC1899 like domain (Restriction endonuclease-like)	0.67	60.0	5.32e-01	100.0%	86.1%
1zu4A02	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.67	60.0	4.84e-01	100.0%	58.3%
2bdtA00	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.67	58.0	4.99e-01	100.0%	60.8%
1d5rA01	3.90.190.10	Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily	0.66	60.0	5.14e-01	100.0%	74.7%
7aj0A01	3.40.720.10	Alpha Beta › 3-Layer(aba) Sandwich › Alkaline Phosphatase, subunit A › Alkaline Phosphatase, subunit A	0.66	59.0	4.06e-01	100.0%	68.3%
1fpzC00	3.90.190.10	Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily	0.66	60.0	5.11e-01	100.0%	75.3%
3a4lB01	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.66	55.0	4.70e-01	100.0%	56.2%
1pvdA03	3.40.50.970	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains	0.66	56.0	4.57e-01	92.8%	84.3%
2l82A00	3.40.50.11230	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold ›	0.65	57.0	5.02e-01	100.0%	66.0%
3bosB01	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.65	54.0	4.81e-01	91.0%	86.4%
5tcdA01	3.40.720.10	Alpha Beta › 3-Layer(aba) Sandwich › Alkaline Phosphatase, subunit A › Alkaline Phosphatase, subunit A	0.65	58.0	4.35e-01	100.0%	74.6%
3h6gA02	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.65	54.0	4.75e-01	91.9%	75.6%
2esbA00	3.90.190.10	Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily	0.64	59.0	5.18e-01	100.0%	69.8%
6gt9A02	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.64	54.0	4.72e-01	93.7%	74.7%
1iayA02	3.40.640.10	Alpha Beta › 3-Layer(aba) Sandwich › Aspartate Aminotransferase; domain 2 › Type I PLP-dependent aspartate aminotransferase-like (Major domain)	0.64	52.0	4.06e-01	89.2%	59.6%
2hcmA01	3.90.190.10	Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily	0.64	58.0	5.25e-01	100.0%	75.8%
3lupA01	3.40.50.10170	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold ›	0.64	47.0	4.25e-01	78.4%	74.2%
4nqrA02	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.63	53.0	4.75e-01	91.0%	81.9%
4ydsA00	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.63	56.0	4.49e-01	100.0%	70.4%
2g6zA00	3.90.190.10	Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily	0.63	58.0	5.24e-01	100.0%	76.9%
5l3sB02	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.63	56.0	4.58e-01	100.0%	55.7%
2p4dA00	3.90.190.10	Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily	0.63	58.0	5.04e-01	100.0%	71.8%
2j16A00	3.90.190.10	Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily	0.63	54.0	5.05e-01	100.0%	76.7%
7yiyA01	3.40.640.10	Alpha Beta › 3-Layer(aba) Sandwich › Aspartate Aminotransferase; domain 2 › Type I PLP-dependent aspartate aminotransferase-like (Major domain)	0.63	52.0	4.08e-01	91.0%	55.7%
6ecpB01	3.40.50.10860	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Leucine Dehydrogenase, chain A, domain 1	0.62	48.0	4.43e-01	82.0%	77.2%
1qhxA00	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.62	57.0	4.86e-01	100.0%	64.0%
3imkA00	3.40.50.450	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold ›	0.62	52.0	4.68e-01	92.8%	95.6%
5eghB01	3.40.720.10	Alpha Beta › 3-Layer(aba) Sandwich › Alkaline Phosphatase, subunit A › Alkaline Phosphatase, subunit A	0.62	55.0	4.17e-01	100.0%	75.5%
1yz4B01	3.90.190.10	Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily	0.62	57.0	5.08e-01	100.0%	73.2%
4d3pA00	3.90.190.10	Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily	0.62	56.0	5.12e-01	100.0%	78.2%
1bifA01	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.62	57.0	4.59e-01	100.0%	56.3%
3ksmA01	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.62	46.0	4.48e-01	79.3%	80.2%
4n82B00	3.40.50.360	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Flavodoxin domain	0.62	45.0	4.10e-01	77.5%	83.0%
7q1bA01	3.40.800.20	Alpha Beta › 3-Layer(aba) Sandwich › Arginase; Chain A › Histone deacetylase domain	0.62	53.0	3.77e-01	98.2%	47.3%
1r6hA00	3.90.190.10	Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily	0.61	54.0	4.71e-01	99.1%	69.8%
4a8jA00	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.61	55.0	4.13e-01	100.0%	63.2%
2lndA00	3.40.50.11230	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold ›	0.61	42.0	4.26e-01	71.2%	95.5%
8gj8A01	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.61	54.0	4.19e-01	100.0%	66.0%
8alzB05	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.61	53.0	4.42e-01	99.1%	71.2%
1vpyA00	3.20.20.410	Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Protein of unknown function UPF0759	0.60	54.0	4.12e-01	97.3%	98.4%
2pt5B00	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.60	49.0	4.27e-01	100.0%	58.1%
3thxB05	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.60	50.0	3.81e-01	90.1%	62.3%
3kkeB01	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.59	44.0	4.06e-01	78.4%	66.0%
3h8lA02	3.50.50.60	Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain	0.59	43.0	3.89e-01	75.7%	94.7%
2qbyA02	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.59	48.0	4.25e-01	91.9%	97.1%
3cm0A00	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.59	51.0	4.31e-01	100.0%	57.6%
2p6rA01	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.58	52.0	4.37e-01	100.0%	71.6%
2orwB01	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.57	51.0	4.93e-01	100.0%	97.6%
4pqgA03	3.40.50.2000	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Glycogen Phosphorylase B;	0.57	47.0	4.09e-01	100.0%	58.6%
3pdiA02	3.40.50.12380	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Nitrogenase MoFe cofactor biosynthesis protein NifE, C-terminal	0.56	49.0	3.65e-01	94.6%	61.9%
7t85A01	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.56	50.0	4.43e-01	100.0%	68.9%
3eccA01	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.56	50.0	4.42e-01	100.0%	83.3%
4lvnA00	3.40.50.200	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Peptidase S8/S53 domain	0.55	45.0	3.25e-01	91.0%	63.4%
3nt7A00	3.40.470.10	Alpha Beta › 3-Layer(aba) Sandwich › Uracil-DNA Glycosylase, subunit E › Uracil-DNA glycosylase-like domain	0.54	46.0	3.72e-01	92.8%	70.0%
7ahdC01	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.54	45.0	3.60e-01	93.7%	93.8%
3geeA03	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.53	39.0	3.74e-01	79.3%	85.0%

ECOD (97)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4991445	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.94	86.0	8.65e-01	100.0%	95.5%
3727490	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.94	91.0	8.95e-01	100.0%	96.5%
3344081	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.94	91.0	8.24e-01	100.0%	79.3%
1937215	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.93	86.0	8.68e-01	100.0%	96.4%
1933252	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.92	84.0	8.22e-01	100.0%	89.8%
5025545	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.91	86.0	8.51e-01	100.0%	95.7%
4949363	7550.1.1.0 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain	0.90	66.0	7.57e-01	99.1%	98.8%
3003338	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.90	85.0	8.17e-01	100.0%	92.8%
3960537	7550.1.1.0 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain	0.90	80.0	8.24e-01	99.1%	98.1%
4824477	1137.1.1.1 ↗	a+b two layers › Tetrapyrrole methylase C-terminal domain-like › Tetrapyrrole methylase C-terminal domain › Tetrapyrrole methylase C-terminal domain › TP_methylase	0.90	85.0	7.92e-01	100.0%	86.6%
4880839	1137.1.1.1 ↗	a+b two layers › Tetrapyrrole methylase C-terminal domain-like › Tetrapyrrole methylase C-terminal domain › Tetrapyrrole methylase C-terminal domain › TP_methylase	0.89	85.0	8.16e-01	100.0%	89.5%
3278863	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.89	84.0	7.81e-01	100.0%	94.8%
2790699	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.89	85.0	8.16e-01	100.0%	96.7%
5004028	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.89	80.0	7.94e-01	100.0%	91.3%
4953998	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.89	80.0	8.10e-01	100.0%	95.5%
3946614	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.88	74.0	7.81e-01	100.0%	97.0%
5025533	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.88	77.0	7.97e-01	100.0%	97.1%
3960524	7550.1.1.0 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain	0.88	83.0	7.84e-01	100.0%	98.5%
4989175	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.88	73.0	7.67e-01	100.0%	96.0%
3945798	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.87	83.0	7.93e-01	100.0%	96.8%
5025537	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.87	82.0	7.75e-01	100.0%	96.9%
4930296	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.87	70.0	7.42e-01	100.0%	94.0%
4876648	1137.1.1.1 ↗	a+b two layers › Tetrapyrrole methylase C-terminal domain-like › Tetrapyrrole methylase C-terminal domain › Tetrapyrrole methylase C-terminal domain › TP_methylase	0.87	82.0	7.56e-01	100.0%	89.9%
4180794	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.87	73.0	7.36e-01	100.0%	89.1%
1937225	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.87	80.0	7.96e-01	100.0%	94.7%
3954343	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.86	82.0	7.34e-01	100.0%	98.6%
1936910	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.85	81.0	7.61e-01	100.0%	93.8%
4117003	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.85	81.0	8.02e-01	100.0%	96.5%
4989709	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.84	72.0	7.57e-01	100.0%	99.0%
4961340	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.84	73.0	7.34e-01	100.0%	90.3%
4936095	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.84	79.0	7.80e-01	100.0%	95.7%
1933267	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.84	79.0	7.78e-01	100.0%	94.8%
4961355	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.84	79.0	7.72e-01	100.0%	95.8%
4034004	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.83	78.0	7.63e-01	100.0%	95.0%
4927305	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.83	77.0	7.76e-01	100.0%	98.2%
4929526	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.83	75.0	7.57e-01	100.0%	96.4%
5023021	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.83	78.0	7.46e-01	100.0%	95.2%
3507985	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.83	78.0	7.27e-01	100.0%	94.1%
4982736	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.83	76.0	7.70e-01	100.0%	98.2%
4578029	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.83	77.0	7.78e-01	100.0%	99.1%
5003548	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.82	77.0	7.66e-01	100.0%	98.3%
4986412	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.82	76.0	7.08e-01	100.0%	96.3%
4967831	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.81	75.0	7.44e-01	100.0%	94.8%
3956466	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.80	73.0	7.36e-01	99.1%	98.2%
5023439	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.80	75.0	7.43e-01	100.0%	96.5%
4989719	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.79	72.0	7.31e-01	99.1%	99.1%
1937223	7550.1.1.1 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase	0.78	73.0	6.93e-01	100.0%	95.3%
5003310	7550.1.1.4 ↗	a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › DUF488	0.71	64.0	5.99e-01	100.0%	98.5%
5016446	2004.1.1.88 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › cobW	0.70	63.0	5.09e-01	100.0%	54.9%
4030756	2004.1.1.88 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › cobW	0.69	62.0	5.05e-01	100.0%	56.2%
3598792	2007.2.3.0 ↗	a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II	0.69	63.0	4.98e-01	100.0%	78.6%
None	—		0.67	62.0	4.51e-01	100.0%	46.2%
4031134	2004.1.1.88 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › cobW	0.67	60.0	4.92e-01	100.0%	56.2%
3255366	2004.1.1.71 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › IPPT	0.67	61.0	4.42e-01	100.0%	41.6%
3483244	2007.2.3.0 ↗	a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II	0.67	61.0	5.05e-01	100.0%	66.7%
5002019	2004.1.1.88 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › cobW	0.67	60.0	4.73e-01	100.0%	50.6%
3936292	7590.1.1.2 ↗	a/b three-layered sandwiches › Middle domain in Argonaute homologs › Middle domain in Argonaute homologs › Middle domain in Argonaute homologs › Piwi	0.67	50.0	4.37e-01	78.4%	61.2%
3491590	2007.2.3.11 ↗	a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › PTP-SAK	0.66	60.0	5.50e-01	99.1%	80.0%
3421514	2007.2.3.2 ↗	a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › DSPc	0.66	57.0	4.86e-01	92.8%	76.6%
3190462	2007.2.3.2 ↗	a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › DSPc	0.66	58.0	4.75e-01	100.0%	70.2%
3226005	2004.1.1.163 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › KTI12	0.65	54.0	4.71e-01	100.0%	58.8%
4995711	2004.1.1.208 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_33	0.65	56.0	4.87e-01	100.0%	62.8%
3900909	7515.1.1.6 ↗	a/b three-layered sandwiches › Alkaline phosphatase-like › Alkaline phosphatase-like › Alkaline phosphatase-like › Phosphodiest	0.65	58.0	4.28e-01	100.0%	70.7%
None	—		0.65	58.0	4.67e-01	99.1%	63.3%
4182480	2004.1.1.71 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › IPPT	0.65	58.0	4.59e-01	100.0%	53.9%
3964303	2004.1.1.88 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › cobW	0.64	58.0	4.69e-01	100.0%	54.9%
3514292	2007.2.3.2 ↗	a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › DSPc	0.64	59.0	5.53e-01	100.0%	85.2%
4135668	3949.1.1.1 ↗	alpha arrays › tRNA delta(2)-isopentenylpyrophosphate transferase helical insertion domain › tRNA delta(2)-isopentenylpyrophosphate transferase helical insertion domain › tRNA delta(2)-isopentenylpyrophosphate transferase helical insertion domain › IPPT	0.64	58.0	4.58e-01	100.0%	52.6%
3850992	2007.2.3.2 ↗	a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › DSPc	0.64	58.0	5.13e-01	100.0%	71.2%
2099531	2007.2.3.2 ↗	a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › DSPc	0.64	59.0	5.02e-01	100.0%	71.8%
4928739	2007.2.3.11 ↗	a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › PTP-SAK	0.64	57.0	5.02e-01	99.1%	69.7%
3885759	2007.2.3.11 ↗	a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › PTP-SAK	0.63	58.0	5.28e-01	100.0%	80.0%
3886901	2007.2.3.11 ↗	a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › PTP-SAK	0.63	58.0	5.28e-01	100.0%	80.0%
4949237	7515.1.1.8 ↗	a/b three-layered sandwiches › Alkaline phosphatase-like › Alkaline phosphatase-like › Alkaline phosphatase-like › Metalloenzyme	0.63	58.0	4.87e-01	100.0%	72.4%
158603	2007.2.3.2 ↗	a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › DSPc	0.63	56.0	4.70e-01	100.0%	68.6%
5049258	2007.2.3.12 ↗	a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › Tc-R-P	0.63	57.0	5.30e-01	100.0%	82.9%
3660088	2007.2.3.2 ↗	a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › DSPc	0.63	57.0	4.80e-01	100.0%	62.2%
2050785	2007.2.3.2 ↗	a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › DSPc	0.63	58.0	4.87e-01	100.0%	64.6%
3712369	2007.2.3.2 ↗	a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › DSPc	0.63	57.0	4.81e-01	100.0%	62.2%
3262635	2007.2.3.2 ↗	a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › DSPc	0.63	55.0	5.01e-01	100.0%	78.1%
3478439	2007.2.3.2 ↗	a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › DSPc	0.62	57.0	4.60e-01	100.0%	55.5%
3494094	2007.2.3.2 ↗	a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › DSPc	0.62	55.0	4.64e-01	97.3%	91.5%
4367798	2004.1.1.65 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › 6PF2K	0.62	57.0	4.53e-01	100.0%	52.7%
3754962	2004.1.1.65 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › 6PF2K	0.62	57.0	4.29e-01	100.0%	44.6%
4296910	4230.1.1.1 ↗	alpha arrays › DnaD domain › DnaD domain › DnaD domain › DSPc	0.62	56.0	4.74e-01	100.0%	61.1%
4977588	2007.2.3.11 ↗	a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › PTP-SAK	0.62	56.0	5.15e-01	100.0%	79.3%
3993211	2007.2.3.2 ↗	a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › DSPc	0.62	56.0	4.97e-01	100.0%	70.6%
5069140	2004.1.1.0 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases	0.62	54.0	4.69e-01	100.0%	93.9%
4948530	2007.2.3.12 ↗	a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › Tc-R-P	0.62	55.0	5.03e-01	100.0%	76.0%
4033361	2004.1.1.103 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Sua5_C	0.62	51.0	5.17e-01	100.0%	90.9%
3688753	2004.1.1.65 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › 6PF2K	0.61	56.0	4.38e-01	100.0%	56.2%
4334141	2007.2.3.2 ↗	a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › DSPc	0.61	55.0	4.63e-01	100.0%	59.5%
3490099	2007.2.3.2 ↗	a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › DSPc	0.61	55.0	5.02e-01	100.0%	77.2%
3485534	7515.1.1.6 ↗	a/b three-layered sandwiches › Alkaline phosphatase-like › Alkaline phosphatase-like › Alkaline phosphatase-like › Phosphodiest	0.60	53.0	3.86e-01	100.0%	62.5%
3689748	2004.1.1.148 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ORC3_N	0.59	50.0	3.93e-01	91.9%	79.6%
3172678	2004.1.1.163 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › KTI12	0.59	53.0	4.47e-01	100.0%	59.5%
3928585	207.1.1.156 ↗	beta duplicates or obligate multimers › Single-stranded right-handed beta-helix › Leucine-rich repeats › Leucine-rich repeats › PF27094	0.57	45.0	3.54e-01	82.0%	75.6%

D2 high residues 119-246

PDB

Domain cluster: rep: CAKLQF020000025.1__CAH1092096.1__SAMEA5780031_03475__00013__D115-223

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00590.26 best	TP_methylase	52.5	8.90e-14	75.8%	42.9%

D3 high residues 253-282_391-467

PDB

Domain cluster: representative

CATH (72)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1jr2A01	3.40.50.10090	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold ›	0.73	67.0	6.50e-01	100.0%	95.0%
3mw8A01	3.40.50.10090	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold ›	0.73	67.0	6.49e-01	100.0%	96.6%
1wcwA01	3.40.50.10090	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold ›	0.71	64.0	6.08e-01	99.1%	92.0%
7ntgA01	3.40.50.10490	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Glucose-6-phosphate isomerase like protein; domain 1	0.67	60.0	5.10e-01	100.0%	79.7%
1sulB00	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.67	59.0	4.88e-01	99.1%	83.1%
3kloA01	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.64	57.0	5.22e-01	99.1%	80.6%
1bmtA02	3.40.50.280	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Cobalamin-binding domain	0.64	56.0	4.99e-01	99.1%	73.4%
1reqA02	3.40.50.280	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Cobalamin-binding domain	0.64	57.0	4.98e-01	100.0%	70.7%
3huuC02	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.64	56.0	5.22e-01	97.2%	79.7%
3egcD02	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.63	56.0	5.27e-01	97.2%	84.5%
3c48A01	3.40.50.2000	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Glycogen Phosphorylase B;	0.63	56.0	4.50e-01	100.0%	89.0%
3fniA00	3.40.50.360	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Flavodoxin domain	0.63	57.0	5.05e-01	100.0%	89.0%
1oxkB00	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.63	57.0	5.36e-01	100.0%	91.4%
2i2xB02	3.40.50.280	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Cobalamin-binding domain	0.63	55.0	5.14e-01	99.1%	80.3%
3om0A02	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.63	54.0	4.80e-01	97.2%	86.3%
3gybA02	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.63	53.0	4.88e-01	92.5%	85.5%
5uzxA00	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.63	56.0	4.39e-01	100.0%	95.7%
2x7xA02	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.62	54.0	4.98e-01	96.3%	82.6%
3k4hA02	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.62	53.0	4.84e-01	93.5%	85.9%
3oesA00	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.62	54.0	4.88e-01	100.0%	89.2%
3kkeA02	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.62	54.0	4.85e-01	97.2%	81.2%
4o5aA02	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.62	52.0	4.80e-01	92.5%	84.9%
4s1wB01	3.40.50.10490	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Glucose-6-phosphate isomerase like protein; domain 1	0.62	55.0	4.55e-01	100.0%	62.9%
5e7qA01	3.40.50.12780	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › ANL, N-terminal domain	0.62	51.0	3.46e-01	100.0%	23.9%
1mdbA01	3.40.50.980	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold ›	0.62	50.0	4.43e-01	98.1%	60.1%
3mbhA00	3.40.1190.20	Alpha Beta › 3-Layer(aba) Sandwich › UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase › Ribokinase	0.61	54.0	3.99e-01	100.0%	90.3%
2qzjA00	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.61	54.0	5.23e-01	100.0%	87.6%
3gv0A02	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.61	53.0	4.95e-01	97.2%	85.7%
3jy6D02	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.61	54.0	5.02e-01	100.0%	83.7%
1efaA03	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.60	52.0	4.80e-01	97.2%	82.5%
3jvdA02	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.60	52.0	4.89e-01	97.2%	81.6%
2rjoA02	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.60	52.0	4.46e-01	96.3%	69.4%
2qxyA00	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.60	54.0	5.23e-01	100.0%	91.6%
3ksmA02	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.60	52.0	4.67e-01	97.2%	81.3%
2n3zA00	3.40.50.11230	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold ›	0.60	48.0	4.95e-01	100.0%	93.9%
3e1sA03	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.60	43.0	3.99e-01	88.8%	58.2%
3wnvA01	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.59	52.0	4.74e-01	97.2%	92.3%
2vk2A02	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.59	51.0	4.55e-01	100.0%	75.2%
3l9wA01	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.59	53.0	4.62e-01	100.0%	73.6%
4gx0B04	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.59	52.0	4.93e-01	100.0%	89.3%
2vk1A01	3.40.50.970	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains	0.59	51.0	4.37e-01	100.0%	86.1%
2j5vB01	3.40.1160.10	Alpha Beta › 3-Layer(aba) Sandwich › Carbamate kinase › Acetylglutamate kinase-like	0.59	49.0	3.86e-01	91.6%	91.8%
1dpmA00	3.20.20.140	Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Metal-dependent hydrolases	0.59	52.0	3.73e-01	100.0%	87.5%
3op2A02	3.20.20.120	Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Enolase-like C-terminal domain	0.59	46.0	3.58e-01	85.0%	69.1%
2qu7A02	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.58	50.0	4.68e-01	97.2%	86.2%
2aefA01	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.58	51.0	5.07e-01	100.0%	99.1%
4yo7A02	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.58	51.0	4.58e-01	100.0%	76.9%
3ujpA02	3.40.50.1980	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Nitrogenase molybdenum iron protein domain	0.58	51.0	5.00e-01	96.3%	91.3%
3m9wA02	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.58	51.0	4.48e-01	100.0%	75.3%
3d8uB01	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.58	50.0	4.89e-01	98.1%	91.7%
4ry8C02	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.58	51.0	4.47e-01	100.0%	72.3%
3fwzA00	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.57	51.0	4.71e-01	100.0%	87.9%
3tr9B00	3.20.20.20	Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Dihydropteroate synthase-like	0.57	51.0	3.84e-01	100.0%	42.6%
2w2kA01	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.57	51.0	4.62e-01	100.0%	90.6%
2fqxA01	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.57	51.0	4.77e-01	100.0%	97.7%
2x7jA01	3.40.50.970	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains	0.57	49.0	4.15e-01	100.0%	81.0%
3hwwA01	3.40.50.970	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains	0.57	49.0	4.08e-01	100.0%	73.0%
4yleA02	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.56	49.0	4.51e-01	100.0%	82.9%
4iilA01	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.56	49.0	4.55e-01	99.1%	87.6%
1xa3A01	3.40.50.10540	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Crotonobetainyl-coa:carnitine coa-transferase; domain 1	0.56	48.0	3.56e-01	96.3%	54.2%
1u3dA01	3.40.50.620	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HUPs	0.56	41.0	3.69e-01	78.5%	78.3%
7e5wA01	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.56	49.0	4.65e-01	100.0%	85.9%
4ycsA00	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.55	48.0	4.64e-01	100.0%	87.0%
3hnoA01	3.40.50.450	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold ›	0.55	44.0	3.54e-01	87.9%	81.9%
3cq4A02	3.40.640.10	Alpha Beta › 3-Layer(aba) Sandwich › Aspartate Aminotransferase; domain 2 › Type I PLP-dependent aspartate aminotransferase-like (Major domain)	0.55	48.0	3.82e-01	100.0%	62.9%
8bj4A01	3.40.640.10	Alpha Beta › 3-Layer(aba) Sandwich › Aspartate Aminotransferase; domain 2 › Type I PLP-dependent aspartate aminotransferase-like (Major domain)	0.55	48.0	3.87e-01	100.0%	64.8%
3dmyA02	3.40.50.261	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Succinyl-CoA synthetase domains	0.55	47.0	4.36e-01	98.1%	83.6%
3lucA01	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.54	44.0	4.21e-01	90.7%	93.8%
2omkA00	3.40.50.10240	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Thiamin pyrophosphokinase, catalytic domain	0.54	47.0	3.64e-01	93.5%	48.2%
2ps2A02	3.20.20.120	Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Enolase-like C-terminal domain	0.52	46.0	3.60e-01	99.1%	66.4%
2pmqA02	3.20.20.120	Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Enolase-like C-terminal domain	0.52	45.0	3.56e-01	99.1%	57.7%
2g9zA02	3.40.50.10240	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Thiamin pyrophosphokinase, catalytic domain	0.51	45.0	3.86e-01	98.1%	65.7%

ECOD (72)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3965557	2007.1.8.1 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Uroporphyrinogen III synthase (U3S, HemD) › HEM4	0.74	68.0	6.59e-01	100.0%	90.8%
5017064	2007.1.8.1 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Uroporphyrinogen III synthase (U3S, HemD) › HEM4	0.74	67.0	6.31e-01	100.0%	99.2%
3550648	2007.1.8.1 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Uroporphyrinogen III synthase (U3S, HemD) › HEM4	0.73	67.0	6.28e-01	100.0%	95.4%
4987655	2007.1.8.1 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Uroporphyrinogen III synthase (U3S, HemD) › HEM4	0.73	66.0	6.30e-01	99.1%	97.6%
3490476	2007.1.8.1 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Uroporphyrinogen III synthase (U3S, HemD) › HEM4	0.72	66.0	6.21e-01	100.0%	96.2%
5008423	2007.1.8.1 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Uroporphyrinogen III synthase (U3S, HemD) › HEM4	0.71	64.0	6.13e-01	100.0%	96.0%
4480518	2007.1.2.10 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › Peripla_BP_3	0.68	57.0	5.34e-01	93.5%	85.9%
4991427	2007.1.8.1 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Uroporphyrinogen III synthase (U3S, HemD) › HEM4	0.67	62.0	5.81e-01	100.0%	89.1%
4976539	2007.1.3.4 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › CheY-like › B12-binding	0.67	60.0	4.88e-01	100.0%	84.9%
4084031	2007.1.3.4 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › CheY-like › B12-binding	0.67	59.0	4.76e-01	100.0%	75.5%
4974821	2007.1.3.4 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › CheY-like › B12-binding	0.67	60.0	4.94e-01	100.0%	83.6%
4967351	2007.1.3.4 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › CheY-like › B12-binding	0.67	59.0	4.99e-01	100.0%	88.1%
5056466	2007.1.3.4 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › CheY-like › B12-binding	0.67	59.0	4.95e-01	100.0%	83.7%
5077011	2007.1.3.4 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › CheY-like › B12-binding	0.67	59.0	5.00e-01	100.0%	87.0%
4998917	2007.1.3.4 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › CheY-like › B12-binding	0.67	59.0	4.82e-01	100.0%	80.5%
4976255	2007.1.3.4 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › CheY-like › B12-binding	0.66	59.0	5.51e-01	100.0%	84.4%
5055474	2007.1.3.4 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › CheY-like › B12-binding	0.66	59.0	4.92e-01	100.0%	88.4%
3403478	2007.15.1.4 ↗	a/b three-layered sandwiches › Flavodoxin-like › N-deoxyribosyltransferase › N-deoxyribosyltransferase › Nuc_deoxyri_tr2	0.66	59.0	5.35e-01	99.1%	92.4%
5051289	2007.1.3.4 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › CheY-like › B12-binding	0.65	58.0	4.81e-01	100.0%	84.6%
4996850	2007.1.3.1 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › CheY-like › Response_reg	0.65	58.0	5.52e-01	100.0%	92.8%
3253433	2007.1.3.0 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › CheY-like	0.64	58.0	5.36e-01	100.0%	81.5%
3280738	2007.1.4.0 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Phosphofructokinase N-terminal domain	0.64	51.0	5.35e-01	86.9%	94.7%
3892378	323.1.1.3 ↗	a+b complex topology › CoA-dependent acyltransferases › CoA-dependent acyltransferases › CoA-dependent acyltransferases › AMP-binding	0.64	57.0	4.80e-01	100.0%	58.4%
3166357	323.1.1.3 ↗	a+b complex topology › CoA-dependent acyltransferases › CoA-dependent acyltransferases › CoA-dependent acyltransferases › AMP-binding	0.64	53.0	4.46e-01	98.1%	53.9%
4927072	2007.1.3.1 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › CheY-like › Response_reg	0.63	55.0	5.25e-01	99.1%	91.5%
3401875	2007.1.3.34 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › CheY-like › PDE8A_N	0.63	55.0	4.98e-01	99.1%	82.7%
3784364	2007.1.3.1 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › CheY-like › Response_reg	0.63	56.0	4.60e-01	100.0%	58.5%
3475302	2007.1.2.0 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I	0.62	55.0	4.90e-01	100.0%	87.1%
4927745	2007.1.3.1 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › CheY-like › Response_reg	0.62	55.0	5.30e-01	100.0%	94.4%
1253036	2007.1.2.10 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › Peripla_BP_3	0.62	56.0	5.30e-01	100.0%	84.9%
2032483	323.1.1.3 ↗	a+b complex topology › CoA-dependent acyltransferases › CoA-dependent acyltransferases › CoA-dependent acyltransferases › AMP-binding	0.62	51.0	4.51e-01	100.0%	60.8%
5016073	7512.1.1.30 ↗	a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › Glyco_transf_4	0.62	55.0	4.56e-01	99.1%	94.7%
3745227	2007.1.2.4 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › ANF_receptor	0.62	54.0	4.64e-01	100.0%	73.3%
4355338	323.1.1.3 ↗	a+b complex topology › CoA-dependent acyltransferases › CoA-dependent acyltransferases › CoA-dependent acyltransferases › AMP-binding	0.62	52.0	4.31e-01	100.0%	51.3%
3971737	2007.1.3.0 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › CheY-like	0.61	54.0	4.03e-01	100.0%	42.4%
3736398	323.1.1.3 ↗	a+b complex topology › CoA-dependent acyltransferases › CoA-dependent acyltransferases › CoA-dependent acyltransferases › AMP-binding	0.61	52.0	4.24e-01	100.0%	50.0%
3390077	2007.1.2.4 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › ANF_receptor	0.61	53.0	4.70e-01	98.1%	78.8%
3301278	2007.1.3.1 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › CheY-like › Response_reg	0.61	54.0	4.88e-01	99.1%	73.3%
4999395	7512.1.1.30 ↗	a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › Glyco_transf_4	0.61	54.0	4.43e-01	100.0%	99.0%
4534691	2007.1.3.0 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › CheY-like	0.59	52.0	4.89e-01	100.0%	83.7%
3199603	2003.1.11.1 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › Formate/glycerate dehydrogenase catalytic domain-like › 2-Hacid_dh	0.59	52.0	4.71e-01	97.2%	93.8%
5053615	7584.1.1.1 ↗	a/b three-layered sandwiches › Rossmann-like domain in Acetyl-CoA synthetase-like proteins › Rossmann-like domain in Acetyl-CoA synthetase-like proteins › Rossmann-like domain in Acetyl-CoA synthetase-like proteins › AMP-binding	0.59	51.0	4.29e-01	99.1%	55.3%
3990119	2007.1.2.10 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › Peripla_BP_3	0.59	52.0	4.94e-01	100.0%	84.6%
5004895	7584.1.1.1 ↗	a/b three-layered sandwiches › Rossmann-like domain in Acetyl-CoA synthetase-like proteins › Rossmann-like domain in Acetyl-CoA synthetase-like proteins › Rossmann-like domain in Acetyl-CoA synthetase-like proteins › AMP-binding	0.59	49.0	4.21e-01	100.0%	56.6%
3989169	2003.1.1.28 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › TrkA_N	0.59	52.0	4.81e-01	100.0%	86.4%
1173034	2007.1.2.10 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › Peripla_BP_3	0.59	52.0	4.88e-01	100.0%	85.6%
3633362	7574.1.1.7 ↗	a/b three-layered sandwiches › Thiamin diphosphate-binding fold (THDP-binding) › Thiamin diphosphate-binding fold (THDP-binding) › Thiamin diphosphate-binding fold (THDP-binding) › TPP_enzyme_N	0.58	51.0	4.26e-01	100.0%	74.0%
3729631	2003.1.11.1 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › Formate/glycerate dehydrogenase catalytic domain-like › 2-Hacid_dh	0.58	53.0	4.77e-01	100.0%	90.3%
2896532	2007.1.2.5 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › Bmp	0.58	50.0	5.07e-01	100.0%	96.2%
1759439	2007.1.2.10 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › Peripla_BP_3	0.58	51.0	4.89e-01	100.0%	85.2%
4503778	2003.1.1.28 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › TrkA_N	0.58	51.0	4.74e-01	100.0%	86.4%
4956678	7589.1.1.2 ↗	a/b three-layered sandwiches › YgbK-like › YgbK-like › YgbK-like › NBD_C	0.58	51.0	4.63e-01	99.1%	93.8%
3973683	2007.1.2.0 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I	0.58	49.0	4.62e-01	96.3%	80.7%
4945275	2007.1.4.0 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Phosphofructokinase N-terminal domain	0.57	49.0	4.79e-01	96.3%	94.2%
4946250	2007.1.3.0 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › CheY-like	0.57	51.0	4.58e-01	100.0%	79.3%
4157117	7574.1.1.7 ↗	a/b three-layered sandwiches › Thiamin diphosphate-binding fold (THDP-binding) › Thiamin diphosphate-binding fold (THDP-binding) › Thiamin diphosphate-binding fold (THDP-binding) › TPP_enzyme_N	0.57	49.0	4.13e-01	100.0%	81.5%
1281082	2007.1.2.5 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › Bmp	0.57	49.0	5.02e-01	100.0%	97.1%
3508868	2007.1.10.1 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › PrpR receptor domain-like › PrpR_N	0.57	45.0	4.65e-01	94.4%	92.0%
4464684	2007.1.2.5 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › Bmp	0.57	50.0	3.64e-01	100.0%	52.8%
5032949	2003.1.1.7 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › ELFV_dehydrog	0.56	49.0	4.21e-01	99.1%	97.2%
5053099	2007.3.1.3 ↗	a/b three-layered sandwiches › Flavodoxin-like › Succinyl-CoA synthetase domains › Succinyl-CoA synthetase domains › Succ_CoA_lig	0.56	50.0	4.36e-01	100.0%	79.4%
4029062	2007.25.1.0 ↗	a/b three-layered sandwiches › Flavodoxin-like › Rossmann-like domain in Ribosomal protein L1 › Rossmann-like domain in Ribosomal protein L1	0.56	46.0	4.69e-01	98.1%	92.4%
377629	2003.1.11.1 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › Formate/glycerate dehydrogenase catalytic domain-like › 2-Hacid_dh	0.56	49.0	4.77e-01	96.3%	87.5%
4927395	2007.1.2.5 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › Bmp	0.56	47.0	4.46e-01	96.3%	78.4%
4969700	7584.1.1.1 ↗	a/b three-layered sandwiches › Rossmann-like domain in Acetyl-CoA synthetase-like proteins › Rossmann-like domain in Acetyl-CoA synthetase-like proteins › Rossmann-like domain in Acetyl-CoA synthetase-like proteins › AMP-binding	0.55	49.0	4.02e-01	100.0%	55.6%
1513137	2007.1.2.5 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › Bmp	0.55	48.0	4.64e-01	100.0%	87.0%
1144768	2007.1.2.5 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › Bmp	0.55	47.0	4.68e-01	96.3%	95.5%
2770009	2007.1.2.10 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › Peripla_BP_3	0.55	48.0	4.57e-01	100.0%	84.7%
3988402	2007.1.2.10 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › Peripla_BP_3	0.55	47.0	4.42e-01	100.0%	82.1%
4988970	7545.1.1.0 ↗	a/b three-layered sandwiches › YchN-like › YchN-like › YchN-like	0.55	41.0	4.26e-01	99.1%	87.8%
3235584	7590.1.1.2 ↗	a/b three-layered sandwiches › Middle domain in Argonaute homologs › Middle domain in Argonaute homologs › Middle domain in Argonaute homologs › Piwi	0.53	44.0	3.91e-01	93.5%	72.1%
3660518	7577.1.1.9 ↗	a/b three-layered sandwiches › PLP-dependent transferases › PLP-dependent transferases › PLP-dependent transferases › OKR_DC_1	0.53	41.0	3.47e-01	85.0%	81.6%

D4 high residues 287-387

PDB

Domain cluster: representative

CATH (72)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1wcwA02	3.40.50.10090	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold ›	0.85	79.0	7.40e-01	99.0%	100.0%
3mw8A02	3.40.50.10090	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold ›	0.82	77.0	7.25e-01	100.0%	95.0%
1jr2A02	3.40.50.10090	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold ›	0.82	76.0	6.74e-01	100.0%	92.1%
3p9zA02	3.40.50.10090	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold ›	0.79	71.0	7.08e-01	97.0%	100.0%
3p9zA01	3.40.50.10090	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold ›	0.72	52.0	5.33e-01	94.1%	77.6%
2h6eA02	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.69	61.0	5.48e-01	100.0%	83.2%
4gmkA01	3.40.50.1360	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold ›	0.69	62.0	5.47e-01	100.0%	78.8%
1m0sA01	3.40.50.1360	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold ›	0.68	62.0	5.47e-01	100.0%	76.0%
4pioA02	3.40.50.150	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39	0.68	61.0	5.03e-01	100.0%	74.6%
5bseA01	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.68	56.0	4.72e-01	91.1%	69.9%
2hoqA01	3.40.50.1000	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HAD superfamily/HAD-like	0.67	54.0	4.66e-01	87.1%	74.1%
3ixqA01	3.40.50.1360	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold ›	0.67	60.0	5.33e-01	100.0%	78.2%
4obxA00	3.40.50.150	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39	0.67	59.0	4.57e-01	100.0%	58.7%
1zh8A01	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.66	53.0	4.81e-01	88.1%	68.5%
1h0hA03	3.40.228.10	Alpha Beta › 3-Layer(aba) Sandwich › Dimethylsulfoxide Reductase; domain 2 › Dimethylsulfoxide Reductase, domain 2	0.66	60.0	4.41e-01	100.0%	74.0%
3gt0A01	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.66	54.0	4.68e-01	88.1%	75.0%
4f3nA00	3.40.50.12710	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold ›	0.66	58.0	3.99e-01	100.0%	48.4%
1jvbA02	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.66	58.0	5.25e-01	100.0%	83.7%
2cf5A02	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.66	59.0	5.11e-01	100.0%	71.3%
1zkdA02	3.40.50.150	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39	0.66	58.0	4.91e-01	100.0%	75.6%
2yjnA01	3.40.50.2000	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Glycogen Phosphorylase B;	0.66	52.0	3.98e-01	87.1%	62.3%
1h2bA02	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.65	57.0	5.22e-01	100.0%	84.3%
2napA03	3.40.228.10	Alpha Beta › 3-Layer(aba) Sandwich › Dimethylsulfoxide Reductase; domain 2 › Dimethylsulfoxide Reductase, domain 2	0.65	59.0	4.48e-01	100.0%	86.1%
3louA02	3.40.50.170	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Formyl transferase, N-terminal domain	0.64	52.0	4.21e-01	88.1%	86.8%
3lkdA02	3.40.50.150	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39	0.64	57.0	4.17e-01	100.0%	70.6%
3twoA02	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.64	56.0	4.96e-01	100.0%	69.3%
6jzqD01	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.64	56.0	5.07e-01	100.0%	81.7%
2bm8B02	3.40.50.150	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39	0.64	56.0	4.79e-01	100.0%	72.4%
2jhpA02	3.40.50.150	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39	0.64	56.0	4.09e-01	100.0%	52.6%
2e7zA03	3.40.228.10	Alpha Beta › 3-Layer(aba) Sandwich › Dimethylsulfoxide Reductase; domain 2 › Dimethylsulfoxide Reductase, domain 2	0.63	51.0	4.09e-01	89.1%	82.4%
3s1sA02	3.40.50.12420	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold ›	0.62	54.0	3.69e-01	100.0%	40.8%
3c85A00	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.62	49.0	4.37e-01	86.1%	80.7%
3phhA02	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.62	55.0	5.10e-01	100.0%	94.6%
4xqcA01	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.62	53.0	4.45e-01	96.0%	86.5%
8a0cA01	3.40.50.11820	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › CDP-glycerol glycerophosphotransferase, N-terminal domain	0.62	49.0	4.25e-01	87.1%	58.3%
2pbfA00	3.40.50.150	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39	0.62	54.0	4.28e-01	100.0%	72.5%
2iyeA01	3.40.50.1000	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HAD superfamily/HAD-like	0.61	53.0	4.66e-01	98.0%	76.4%
1qfjA02	3.40.50.80	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module	0.61	50.0	4.59e-01	92.1%	97.0%
2az4A02	3.40.50.10710	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Metallo-hydrolase/oxidoreductase	0.60	53.0	4.66e-01	100.0%	94.2%
1q14A01	3.40.50.1220	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › TPP-binding domain	0.60	53.0	4.37e-01	99.0%	65.6%
1vmiA01	3.40.50.10950	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold ›	0.60	50.0	4.29e-01	94.1%	84.9%
1r5jA01	3.40.50.10950	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold ›	0.60	51.0	4.34e-01	96.0%	88.4%
2xdqA03	3.40.50.1980	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Nitrogenase molybdenum iron protein domain	0.59	44.0	4.18e-01	88.1%	65.3%
3dnfB01	3.40.1010.20	Alpha Beta › 3-Layer(aba) Sandwich › Cobalt-precorrin-4 Transmethylase; domain 1 › 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, catalytic domain	0.59	47.0	4.78e-01	93.1%	87.0%
2gkgA00	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.58	40.0	3.82e-01	71.3%	64.8%
1pjqA04	3.40.1010.10	Alpha Beta › 3-Layer(aba) Sandwich › Cobalt-precorrin-4 Transmethylase; domain 1 › Tetrapyrrole methylase, N-terminal domain	0.58	52.0	5.04e-01	100.0%	90.4%
2qjtB01	3.40.50.620	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HUPs	0.58	46.0	3.75e-01	87.1%	67.3%
3zokA01	3.40.50.1970	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold ›	0.57	51.0	4.30e-01	100.0%	64.9%
4pyrA02	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.57	49.0	4.68e-01	100.0%	82.5%
2jfqA02	3.40.50.1860	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold ›	0.56	50.0	4.82e-01	99.0%	100.0%
6m8oA00	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.56	42.0	4.06e-01	86.1%	68.6%
5ygrB01	3.40.50.1100	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold ›	0.56	48.0	3.67e-01	98.0%	63.2%
3outA02	3.40.50.1860	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold ›	0.55	49.0	4.81e-01	99.0%	100.0%
2zg5A02	3.40.640.10	Alpha Beta › 3-Layer(aba) Sandwich › Aspartate Aminotransferase; domain 2 › Type I PLP-dependent aspartate aminotransferase-like (Major domain)	0.55	49.0	3.86e-01	100.0%	48.4%
3f3kA00	3.40.50.1240	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Phosphoglycerate mutase-like	0.55	44.0	3.40e-01	91.1%	89.6%
2yzkA00	3.40.50.2020	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold ›	0.55	49.0	4.08e-01	100.0%	64.2%
3cu5B00	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.55	42.0	3.89e-01	86.1%	64.3%
2jfnA02	3.40.50.1860	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold ›	0.55	48.0	4.65e-01	99.0%	100.0%
2npnA01	3.40.1010.10	Alpha Beta › 3-Layer(aba) Sandwich › Cobalt-precorrin-4 Transmethylase; domain 1 › Tetrapyrrole methylase, N-terminal domain	0.55	49.0	4.52e-01	100.0%	93.8%
4y9tA02	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.54	47.0	4.02e-01	100.0%	80.7%
1o2dA01	3.40.50.1970	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold ›	0.54	48.0	4.06e-01	100.0%	93.6%
4ritA02	3.40.640.10	Alpha Beta › 3-Layer(aba) Sandwich › Aspartate Aminotransferase; domain 2 › Type I PLP-dependent aspartate aminotransferase-like (Major domain)	0.53	46.0	3.63e-01	100.0%	65.7%
6khnA01	3.40.640.10	Alpha Beta › 3-Layer(aba) Sandwich › Aspartate Aminotransferase; domain 2 › Type I PLP-dependent aspartate aminotransferase-like (Major domain)	0.53	46.0	3.48e-01	100.0%	46.4%
3hurA02	3.20.20.10	Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Alanine racemase	0.53	46.0	3.60e-01	97.0%	96.9%
1wdeA01	3.40.1010.10	Alpha Beta › 3-Layer(aba) Sandwich › Cobalt-precorrin-4 Transmethylase; domain 1 › Tetrapyrrole methylase, N-terminal domain	0.53	46.0	4.49e-01	100.0%	93.0%
2vk2A02	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.53	45.0	3.97e-01	100.0%	86.1%
3onmA01	3.40.190.10	Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II	0.53	35.0	3.60e-01	91.1%	70.8%
2pd2A00	3.40.1260.10	Alpha Beta › 3-Layer(aba) Sandwich › Hypothetical Protein Ychn; Chain: A, › DsrEFH-like	0.53	45.0	4.45e-01	97.0%	92.6%
5hn3A00	3.40.718.10	Alpha Beta › 3-Layer(aba) Sandwich › Isopropylmalate Dehydrogenase › Isopropylmalate Dehydrogenase	0.52	44.0	3.14e-01	95.0%	31.3%
4ntcA02	3.50.50.60	Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain	0.52	45.0	4.30e-01	99.0%	87.9%
3h75A02	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.52	43.0	3.98e-01	97.0%	100.0%
1z6tA02	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.50	43.0	3.69e-01	100.0%	87.0%

ECOD (84)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4345958	2007.1.8.0 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Uroporphyrinogen III synthase (U3S, HemD)	0.88	82.0	8.25e-01	100.0%	99.0%
3951169	2007.1.8.1 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Uroporphyrinogen III synthase (U3S, HemD) › HEM4	0.86	81.0	7.27e-01	100.0%	97.0%
4123075	2007.1.8.1 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Uroporphyrinogen III synthase (U3S, HemD) › HEM4	0.86	79.0	7.33e-01	99.0%	97.6%
4404034	2007.1.8.1 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Uroporphyrinogen III synthase (U3S, HemD) › HEM4	0.84	78.0	7.30e-01	98.0%	100.0%
4931980	2007.1.8.1 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Uroporphyrinogen III synthase (U3S, HemD) › HEM4	0.84	79.0	7.30e-01	100.0%	98.4%
10444	2007.1.8.1 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Uroporphyrinogen III synthase (U3S, HemD) › HEM4	0.82	76.0	6.91e-01	100.0%	98.5%
4928955	2007.1.8.1 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Uroporphyrinogen III synthase (U3S, HemD) › HEM4	0.81	76.0	6.79e-01	100.0%	97.8%
3416693	2007.1.8.1 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Uroporphyrinogen III synthase (U3S, HemD) › HEM4	0.80	73.0	6.76e-01	99.0%	100.0%
141227	2007.1.8.1 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Uroporphyrinogen III synthase (U3S, HemD) › HEM4	0.79	73.0	7.13e-01	100.0%	98.2%
3411424	2007.1.8.1 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Uroporphyrinogen III synthase (U3S, HemD) › HEM4	0.76	54.0	5.02e-01	73.3%	67.5%
4627238	2007.1.8.1 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Uroporphyrinogen III synthase (U3S, HemD) › HEM4	0.73	56.0	4.94e-01	92.1%	57.9%
3659367	2003.1.7.10 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NagB/RpiA/CoA transferase-like › Rib_5-P_isom_A	0.72	66.0	5.49e-01	100.0%	72.4%
4104971	2003.1.7.10 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NagB/RpiA/CoA transferase-like › Rib_5-P_isom_A	0.71	65.0	5.63e-01	100.0%	77.8%
5036299	2003.1.7.10 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NagB/RpiA/CoA transferase-like › Rib_5-P_isom_A	0.70	64.0	5.52e-01	100.0%	74.8%
4950484	2003.1.1.46 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › F420_oxidored	0.70	56.0	4.85e-01	87.1%	74.4%
2329746	2003.1.5.67 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_12	0.70	62.0	4.62e-01	100.0%	52.1%
4187712	129.1.1.0 ↗	alpha arrays › 6-phosphogluconate dehydrogenase C-terminal domain-like › 6-phosphogluconate dehydrogenase C-terminal domain-like › 6-phosphogluconate dehydrogenase C-terminal domain-like	0.70	57.0	4.37e-01	87.1%	51.8%
4280547	2003.1.7.10 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NagB/RpiA/CoA transferase-like › Rib_5-P_isom_A	0.69	63.0	5.52e-01	100.0%	76.0%
4534162	2007.1.4.3 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Phosphofructokinase N-terminal domain › NAD_kinase	0.69	52.0	4.82e-01	86.1%	62.3%
3516428	2003.1.5.47 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › PRMT5	0.69	60.0	5.12e-01	98.0%	77.1%
3285211	2003.2.1.0 ↗	a/b three-layered sandwiches › Rossmann-like › Formate dehydrogenase/DMSO reductase, domains 2 and 3 › Formate dehydrogenase/DMSO reductase, domains 2 and 3	0.69	60.0	5.11e-01	96.0%	82.4%
3800740	2003.1.7.10 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NagB/RpiA/CoA transferase-like › Rib_5-P_isom_A	0.69	62.0	5.26e-01	100.0%	70.9%
4225586	2003.1.7.10 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NagB/RpiA/CoA transferase-like › Rib_5-P_isom_A	0.68	61.0	5.28e-01	100.0%	72.5%
4932894	2003.1.7.10 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NagB/RpiA/CoA transferase-like › Rib_5-P_isom_A	0.68	62.0	5.47e-01	100.0%	78.6%
4954296	2003.2.1.0 ↗	a/b three-layered sandwiches › Rossmann-like › Formate dehydrogenase/DMSO reductase, domains 2 and 3 › Formate dehydrogenase/DMSO reductase, domains 2 and 3	0.68	59.0	5.65e-01	94.1%	98.3%
4383106	2003.1.5.67 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_12	0.67	60.0	4.41e-01	100.0%	48.4%
4991289	2003.1.5.66 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11	0.67	60.0	5.05e-01	100.0%	64.6%
4329082	2003.1.5.67 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_12	0.67	59.0	4.25e-01	100.0%	65.2%
3243377	2003.1.5.26 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_28	0.67	59.0	4.00e-01	100.0%	52.0%
3259946	2003.1.1.5 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › ADH_zinc_N	0.67	59.0	4.85e-01	100.0%	67.9%
4106775	101.1.2.0 ↗	alpha arrays › HTH › HTH › winged helix domain	0.66	58.0	3.82e-01	100.0%	28.5%
3250958	2003.1.1.0 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains	0.66	59.0	4.79e-01	100.0%	70.3%
4200761	2003.1.5.81 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_25	0.66	58.0	4.30e-01	100.0%	88.7%
4587300	2003.1.5.25 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › GidB	0.66	58.0	4.67e-01	100.0%	57.1%
3170077	2003.1.5.73 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_16	0.66	58.0	4.47e-01	100.0%	62.5%
3287448	2003.1.5.46 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › MTS	0.66	58.0	4.37e-01	100.0%	59.2%
5045654	2003.2.1.1 ↗	a/b three-layered sandwiches › Rossmann-like › Formate dehydrogenase/DMSO reductase, domains 2 and 3 › Formate dehydrogenase/DMSO reductase, domains 2 and 3 › Molybdopterin	0.66	59.0	4.72e-01	99.0%	96.5%
5051217	2006.1.1.18 ↗	a/b three-layered sandwiches › HAD domain-like › HAD domain-related › HAD-like › HAD_2	0.65	54.0	4.18e-01	90.1%	88.4%
3626353	2003.1.1.46 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › F420_oxidored	0.65	55.0	4.55e-01	94.1%	76.2%
3213946	2003.1.7.2 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NagB/RpiA/CoA transferase-like › IF-2B	0.65	57.0	4.67e-01	99.0%	61.0%
3838991	2003.2.1.0 ↗	a/b three-layered sandwiches › Rossmann-like › Formate dehydrogenase/DMSO reductase, domains 2 and 3 › Formate dehydrogenase/DMSO reductase, domains 2 and 3	0.65	55.0	4.42e-01	92.1%	90.5%
5049309	2003.1.5.79 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_23	0.65	57.0	4.42e-01	100.0%	51.5%
4013650	2003.1.5.0 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases	0.65	57.0	4.03e-01	100.0%	45.7%
3387588	7512.1.1.30 ↗	a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › Glyco_transf_4	0.65	51.0	4.31e-01	86.1%	64.6%
4133812	2003.1.1.46 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › F420_oxidored	0.65	53.0	4.37e-01	91.1%	66.8%
3610521	2006.1.4.10 ↗	a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like › PIN_4	0.65	55.0	4.79e-01	94.1%	99.4%
4970683	2007.1.4.3 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Phosphofructokinase N-terminal domain › NAD_kinase	0.64	52.0	4.58e-01	90.1%	58.1%
4010980	2003.1.5.8 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Ubie_methyltran	0.64	56.0	4.17e-01	100.0%	80.2%
None	—		0.64	57.0	4.64e-01	100.0%	60.5%
5009877	7512.1.1.3 ↗	a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › Glycos_transf_1	0.64	51.0	4.28e-01	86.1%	68.6%
4978254	2007.1.4.3 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Phosphofructokinase N-terminal domain › NAD_kinase	0.64	51.0	4.75e-01	87.1%	67.7%
4967515	2003.1.5.82 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_31	0.64	56.0	4.23e-01	100.0%	74.5%
4123589	2003.1.5.53 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › tRNA_U5-meth_tr	0.63	56.0	3.82e-01	100.0%	40.9%
3965531	2006.1.1.1 ↗	a/b three-layered sandwiches › HAD domain-like › HAD domain-related › HAD-like › Hydrolase	0.63	55.0	4.55e-01	96.0%	65.6%
4090144	2003.1.1.0 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains	0.63	56.0	3.91e-01	100.0%	40.0%
4288608	101.1.2.0 ↗	alpha arrays › HTH › HTH › winged helix domain	0.63	55.0	3.75e-01	98.0%	34.5%
5023484	2003.1.4.8 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › DHS-like NAD/FAD-binding domain › CO_dh	0.62	54.0	4.76e-01	96.0%	85.3%
3639959	2003.1.5.81 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_25	0.62	54.0	3.81e-01	100.0%	87.5%
4104264	2003.1.4.1 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › DHS-like NAD/FAD-binding domain › TPP_enzyme_M	0.61	54.0	4.40e-01	100.0%	63.0%
4984498	7592.1.1.0 ↗	a/b three-layered sandwiches › CARF (CRISPR-associated Rossmann fold) domains › CARF (CRISPR-associated Rossmann fold) domains › CARF (CRISPR-associated Rossmann fold) domains	0.61	49.0	4.50e-01	87.1%	88.7%
3676950	7516.1.1.52 ↗	a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotid_trans	0.61	49.0	3.48e-01	87.1%	78.7%
3833723	7516.1.1.52 ↗	a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotid_trans	0.61	49.0	3.42e-01	87.1%	73.6%
3632527	2003.1.5.79 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_23	0.60	52.0	3.89e-01	100.0%	43.9%
4338740	7512.1.1.10 ↗	a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › Glyco_transf_28	0.60	48.0	4.18e-01	88.1%	73.8%
3433556	7516.1.1.0 ↗	a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases	0.60	48.0	3.64e-01	87.1%	88.4%
4220626	2003.1.14.1 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › Aspartate/ornithine carbamoyltransferase › OTCace	0.60	50.0	4.36e-01	94.1%	74.4%
3562576	2003.1.5.81 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_25	0.59	48.0	4.16e-01	89.1%	68.1%
3694264	2003.1.1.11 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 3Beta_HSD	0.59	47.0	3.24e-01	88.1%	47.7%
3679893	7516.1.1.52 ↗	a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotid_trans	0.59	48.0	3.38e-01	87.1%	79.9%
5036261	7573.1.1.1 ↗	a/b three-layered sandwiches › PRTase-like › PRTase-like › PRTase-like › Pribosyltran	0.59	52.0	4.12e-01	100.0%	57.7%
3872984	2003.1.5.67 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_12	0.58	48.0	4.11e-01	93.1%	61.1%
5079489	2003.1.10.21 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › PreATP-grasp domain › PylC-like_N	0.58	45.0	4.38e-01	84.2%	91.3%
1513011	2007.1.2.11 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › Peripla_BP_4	0.58	52.0	4.69e-01	100.0%	85.0%
5060318	7597.1.1.0 ↗	a/b three-layered sandwiches › Endolysin C-terminal domain › Endolysin C-terminal domain › Endolysin C-terminal domain	0.58	48.0	4.83e-01	90.1%	90.0%
4151741	7573.1.1.1 ↗	a/b three-layered sandwiches › PRTase-like › PRTase-like › PRTase-like › Pribosyltran	0.57	50.0	3.95e-01	100.0%	54.7%
3958409	2003.1.1.355 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › Carb_kinase	0.57	48.0	4.02e-01	94.1%	61.7%
5071174	7573.1.1.0 ↗	a/b three-layered sandwiches › PRTase-like › PRTase-like › PRTase-like	0.56	50.0	3.88e-01	100.0%	55.9%
3941532	2010.1.1.3 ↗	a/b three-layered sandwiches › EDD domain › EDD domain › EDD domain › EIIA-man	0.55	45.0	4.15e-01	88.1%	71.5%
4288612	7523.1.1.30 ↗	a/b three-layered sandwiches › Periplasmic binding protein-like II › Periplasmic binding protein-like II › Periplasmic binding protein-like II › SBP_bac_11	0.55	48.0	4.80e-01	100.0%	99.0%
2834131	7523.1.1.15 ↗	a/b three-layered sandwiches › Periplasmic binding protein-like II › Periplasmic binding protein-like II › Periplasmic binding protein-like II › LysR_substrate	0.54	37.0	4.11e-01	88.1%	93.4%
3587634	2007.1.7.0 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Rossmann-like domain in dehydroquinate synthase-like enzymes	0.54	47.0	4.08e-01	99.0%	87.9%
4941552	2007.1.4.0 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Phosphofructokinase N-terminal domain	0.54	39.0	4.13e-01	90.1%	85.6%
1630481	2007.1.2.11 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › Peripla_BP_4	0.53	42.0	3.39e-01	87.1%	47.8%
3265607	2007.1.4.9 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Phosphofructokinase N-terminal domain › Pacs-1	0.51	43.0	3.65e-01	93.1%	94.7%