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NC_020865.1__YP_007676326.1__CYZG_00004__00004

Bact-Vir

NC_020865.1__YP_007676326.1__CYZG_00004__00004

Identity

Accession:
NC_020865 ↗
Kingdom:
phage

Quality

73.3 mean pLDDT

Cluster

Singleton — not in a non-trivial cluster

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 264-370
PDB
Domain cluster: representative
CATH (14)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1u8bA02 1.10.10.60 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Homeodomain-like 0.66 36.0 4.47e-01 71.0% 91.8%
3bruB00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.60 54.0 4.50e-01 100.0% 68.8%
1ldjA04 1.20.1310.10 Mainly Alpha › Up-down Bundle › 5 helical Cullin repeat like › Cullin Repeats 0.59 49.0 4.82e-01 96.3% 84.3%
4q5qB00 1.20.1050.130 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.57 45.0 3.85e-01 100.0% 50.5%
2fbnA00 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.56 46.0 4.10e-01 98.1% 62.1%
1x9fD00 1.10.490.10 Mainly Alpha › Orthogonal Bundle › Globin-like › Globins 0.56 44.0 4.06e-01 85.0% 65.7%
2wzkA02 1.20.1310.10 Mainly Alpha › Up-down Bundle › 5 helical Cullin repeat like › Cullin Repeats 0.54 47.0 4.51e-01 100.0% 98.4%
4ap2B01 1.20.1310.10 Mainly Alpha › Up-down Bundle › 5 helical Cullin repeat like › Cullin Repeats 0.53 46.0 4.33e-01 100.0% 93.3%
1zu4A01 1.20.120.140 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › SRP54, nucleotide-binding domain 0.52 33.0 3.60e-01 96.3% 78.2%
6vudA01 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.51 36.0 3.67e-01 74.8% 93.6%
7e84A03 1.10.287.70 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.51 27.0 2.65e-01 81.3% 46.3%
4rfsS00 1.10.1760.20 Mainly Alpha › Orthogonal Bundle › Arp2/3 complex 21 kDa subunit ARPC3 › 0.50 42.0 3.60e-01 94.4% 71.1%
5l0wB01 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.50 44.0 4.10e-01 97.2% 84.8%
4akgA16 1.10.8.720 Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Region D6 of dynein motor 0.50 40.0 3.47e-01 100.0% 55.8%
ECOD (8)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3278832 106.1.1.11 alpha arrays › Globin-like › Globin-like › Globin-like › RsbRD_N 0.58 43.0 4.03e-01 78.5% 70.4%
5017483 604.39.1.5 alpha bundles › Spectrin repeat-like › S-component of energy-coupling factor (ECF) transporters › S-component of energy-coupling factor (ECF) transporters › ECF_trnsprt 0.56 38.0 3.30e-01 89.7% 43.5%
3694241 149.1.1.1 alpha arrays › Cytochrome P450 › Cytochrome P450 › Cytochrome P450 › p450 0.56 45.0 2.88e-01 86.9% 69.1%
4120792 4229.1.1.2 alpha bundles › Indolic compounds 2,3-dioxygenase-like › Indolic compounds 2,3-dioxygenase-like › Indolic compounds 2,3-dioxygenase-like › Trp_dioxygenase 0.54 46.0 3.40e-01 94.4% 77.5%
3344721 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.52 46.0 3.69e-01 100.0% 59.8%
3809828 5069.1.1.0 alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes 0.51 46.0 3.58e-01 100.0% 82.9%
3990286 109.3.1.2 alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat › Ank,Ank_2 0.50 39.0 3.03e-01 84.1% 88.8%
3954667 141.1.1.1 alpha bundles › Terpenoid synthases › Terpenoid synthases › Terpenoid synthases › polyprenyl_synt 0.50 44.0 3.14e-01 100.0% 44.6%
D2 high residues 598-696
PDB
Domain cluster: representative
CATH (13)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1cjaA02 1.10.1070.11 Mainly Alpha › Orthogonal Bundle › Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, Domain 5 › Phosphatidylinositol 3-/4-kinase, catalytic domain 0.66 49.0 4.05e-01 78.8% 74.6%
2dg8D00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.61 50.0 4.22e-01 91.9% 57.8%
4lqkA00 1.10.437.20 Mainly Alpha › Orthogonal Bundle › Apoptosis Regulator Bcl-x › dsDNA poxvirus 0.58 41.0 3.78e-01 92.9% 55.3%
2c0kB00 1.10.490.10 Mainly Alpha › Orthogonal Bundle › Globin-like › Globins 0.58 49.0 4.28e-01 92.9% 61.7%
1f5oA00 1.10.490.10 Mainly Alpha › Orthogonal Bundle › Globin-like › Globins 0.57 44.0 3.86e-01 92.9% 55.0%
3tl4X02 1.10.10.2420 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › 0.57 37.0 4.05e-01 73.7% 88.9%
3q23A04 6.10.140.1370 Special › Helix non-globular › Helix Hairpins › 0.56 35.0 3.59e-01 73.7% 65.9%
1jt6A02 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.54 44.0 4.09e-01 92.9% 83.9%
1yhuB00 1.10.490.10 Mainly Alpha › Orthogonal Bundle › Globin-like › Globins 0.53 42.0 3.76e-01 90.9% 59.0%
5dikA00 1.20.1290.10 Mainly Alpha › Up-down Bundle › AhpD-like › AhpD-like 0.53 36.0 3.48e-01 100.0% 60.7%
5cqgA03 1.10.10.2210 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › 0.52 33.0 3.57e-01 70.7% 77.2%
4ga4A01 1.20.970.10 Mainly Alpha › Up-down Bundle › Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 › Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 0.51 30.0 3.52e-01 94.9% 85.1%
2ew2A02 1.10.1040.10 Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 0.50 36.0 3.29e-01 75.8% 58.2%
ECOD (5)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3191588 610.3.1.0 alpha arrays › ERP29 C domain-like › GatB/GatE C-terminal domain › GatB/GatE C-terminal domain 0.56 40.0 3.21e-01 75.8% 35.8%
5079962 601.28.1.4 alpha bundles › Four-helical up-and-down bundle › VPS28 C-terminal domain-like › VPS28 C-terminal domain-like › DUF4129 0.55 44.0 4.26e-01 96.0% 78.2%
3994046 129.1.1.9 alpha arrays › 6-phosphogluconate dehydrogenase C-terminal domain-like › 6-phosphogluconate dehydrogenase C-terminal domain-like › 6-phosphogluconate dehydrogenase C-terminal domain-like › NAD_Gly3P_dh_C 0.52 36.0 3.60e-01 73.7% 70.5%
5034596 101.1.2.0 alpha arrays › HTH › HTH › winged helix domain 0.51 37.0 3.35e-01 90.9% 54.8%
3704638 109.4.1.17 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Cullin 0.50 43.0 3.53e-01 99.0% 73.0%
D3 medium residues 161-192_213-263
PDB
Domain cluster: representative
CATH (38)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2e9xB02 1.20.58.1020 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.65 45.0 4.16e-01 100.0% 55.0%
4l8jA04 1.10.287.470 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin 0.63 35.0 4.08e-01 75.9% 76.3%
3pubA01 1.10.10.2400 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Lepidopteran low molecular weight (30 kD) lipoprotein, N-terminal domain 0.62 40.0 4.21e-01 84.3% 73.0%
2b8iA00 1.20.1280.100 Mainly Alpha › Up-down Bundle › Monooxygenase › Pas factor, saposin domain 0.62 42.0 4.38e-01 86.7% 75.3%
1icrA00 3.40.109.10 Alpha Beta › 3-Layer(aba) Sandwich › NADH Oxidase › NADH Oxidase 0.60 45.0 3.33e-01 79.5% 44.4%
4hehA01 1.10.1240.10 Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › Methionine synthase domain 0.60 46.0 4.65e-01 90.4% 83.1%
4aciA00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.60 55.0 4.24e-01 100.0% 47.7%
4iv6B01 1.10.540.10 Mainly Alpha › Orthogonal Bundle › Butyryl-Coa Dehydrogenase, subunit A; domain 1 › Acyl-CoA dehydrogenase/oxidase, N-terminal domain 0.59 47.0 4.21e-01 86.7% 66.4%
2d2sA02 1.20.58.1220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Exo84p, C-terminal helical domain 0.59 46.0 4.32e-01 100.0% 70.3%
4id0A02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.58 40.0 3.69e-01 90.4% 54.5%
4kf8B00 1.25.10.70 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › 0.58 43.0 3.14e-01 96.4% 26.4%
2jifA01 1.10.540.10 Mainly Alpha › Orthogonal Bundle › Butyryl-Coa Dehydrogenase, subunit A; domain 1 › Acyl-CoA dehydrogenase/oxidase, N-terminal domain 0.58 46.0 4.09e-01 86.7% 65.3%
4gx0A01 1.10.287.70 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.58 38.0 3.56e-01 96.4% 54.4%
7shlA02 1.20.1310.10 Mainly Alpha › Up-down Bundle › 5 helical Cullin repeat like › Cullin Repeats 0.57 47.0 4.20e-01 92.8% 71.3%
3mq1A01 1.20.58.970 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.57 36.0 3.49e-01 81.9% 57.6%
2ix5A01 1.10.540.10 Mainly Alpha › Orthogonal Bundle › Butyryl-Coa Dehydrogenase, subunit A; domain 1 › Acyl-CoA dehydrogenase/oxidase, N-terminal domain 0.57 45.0 3.88e-01 86.7% 56.0%
3sf6A01 1.10.540.10 Mainly Alpha › Orthogonal Bundle › Butyryl-Coa Dehydrogenase, subunit A; domain 1 › Acyl-CoA dehydrogenase/oxidase, N-terminal domain 0.57 46.0 4.00e-01 89.2% 61.2%
2e9fB01 1.10.275.10 Mainly Alpha › Orthogonal Bundle › Fumarase C; Chain B, domain 1 › Fumarase/aspartase (N-terminal domain) 0.56 37.0 3.60e-01 78.3% 59.4%
8ciwB01 1.10.540.10 Mainly Alpha › Orthogonal Bundle › Butyryl-Coa Dehydrogenase, subunit A; domain 1 › Acyl-CoA dehydrogenase/oxidase, N-terminal domain 0.55 48.0 4.37e-01 100.0% 77.4%
4abmD00 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.54 37.0 3.89e-01 71.1% 92.2%
1urfA00 1.10.287.160 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat 0.54 33.0 3.35e-01 79.5% 61.7%
5gj7A01 1.10.540.10 Mainly Alpha › Orthogonal Bundle › Butyryl-Coa Dehydrogenase, subunit A; domain 1 › Acyl-CoA dehydrogenase/oxidase, N-terminal domain 0.54 43.0 3.86e-01 98.8% 60.0%
2b1eA04 1.20.1280.170 Mainly Alpha › Up-down Bundle › Monooxygenase › Exocyst complex component Exo70 0.54 46.0 4.07e-01 98.8% 74.0%
2v6yA00 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.53 38.0 3.96e-01 79.5% 81.3%
2wgmA01 1.20.20.10 Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C 0.53 36.0 3.67e-01 72.3% 72.0%
6qumQ00 1.20.20.10 Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C 0.53 35.0 3.63e-01 72.3% 75.7%
1vf7A03 1.10.287.470 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin 0.52 35.0 3.88e-01 74.7% 93.3%
3ic8A02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.52 46.0 4.33e-01 98.8% 81.2%
4v1gA00 1.20.20.10 Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C 0.52 36.0 3.62e-01 73.5% 70.6%
1pw4A02 1.20.1250.20 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains 0.52 44.0 3.39e-01 97.6% 76.4%
4uyeA00 1.20.920.10 Mainly Alpha › Up-down Bundle › Histone Acetyltransferase; Chain A › Bromodomain-like 0.52 41.0 3.78e-01 86.7% 82.6%
6ljaA01 1.50.10.100 Mainly Alpha › Alpha/alpha barrel › Glycosyltransferase › Chondroitin AC/alginate lyase 0.52 42.0 2.80e-01 97.6% 20.8%
3mpiA01 1.10.540.10 Mainly Alpha › Orthogonal Bundle › Butyryl-Coa Dehydrogenase, subunit A; domain 1 › Acyl-CoA dehydrogenase/oxidase, N-terminal domain 0.51 42.0 3.81e-01 94.0% 65.3%
1nafA02 1.20.58.160 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.51 44.0 4.41e-01 96.4% 100.0%
1j5wA02 1.20.58.180 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Class II aaRS and biotin synthetases; domain 2 0.51 41.0 4.20e-01 100.0% 97.4%
3k2jA00 1.20.920.10 Mainly Alpha › Up-down Bundle › Histone Acetyltransferase; Chain A › Bromodomain-like 0.51 40.0 3.57e-01 86.7% 79.3%
2zgyA02 3.30.420.40 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain 0.51 40.0 3.37e-01 85.5% 86.4%
2lw1A00 1.10.287.380 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Valyl-tRNA synthetase, C-terminal domain 0.50 37.0 3.68e-01 77.1% 75.3%
ECOD (49)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4624818 621.1.1.0 alpha bundles › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain 0.69 61.0 5.96e-01 98.8% 97.8%
4933446 4952.1.1.0 alpha arrays › L-aspartase N-terminal domain-like › L-aspartase N-terminal domain-like › L-aspartase N-terminal domain-like 0.65 42.0 3.93e-01 74.7% 54.0%
3722363 310.2.1.0 a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF 0.65 53.0 4.29e-01 90.4% 68.8%
3848681 101.1.1.21 alpha arrays › HTH › HTH › Three-helical HTH › HTH_Tnp_Tc5 0.63 45.0 5.01e-01 85.5% 96.9%
4025790 601.4.1.0 alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains 0.62 54.0 4.66e-01 100.0% 71.9%
3919099 621.1.1.8 alpha bundles › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain › GVIN1 0.62 53.0 4.61e-01 100.0% 86.7%
3504161 109.4.1.17 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Cullin 0.60 53.0 3.86e-01 100.0% 48.3%
3389963 1134.1.1.0 alpha bundles › C-terminal helical domain of alanine-tRNA ligase › C-terminal helical domain of alanine-tRNA ligase › Eukaryotic C-Ala helical domain 0.60 47.0 5.06e-01 94.0% 100.0%
5069390 3236.1.1.1 alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Na_H_Exchanger 0.60 50.0 3.27e-01 92.8% 19.7%
4646569 4994.1.1.1 alpha duplicates or obligate multimers › EF2458-like › EF2458-like › EF2458-like › DUF1507 0.60 53.0 5.09e-01 100.0% 94.7%
4024521 109.25.1.0 alpha superhelices › Repetitive alpha hairpins › GPCR-autoproteolysis inducing domain subdomain A › GPCR-autoproteolysis inducing domain subdomain A 0.60 47.0 4.52e-01 100.0% 74.7%
4862621 304.103.1.1 a+b two layers › Alpha-beta plaits › FMN-dependent nitroreductase-like › FMN-dependent nitroreductase-like › Nitroreductase 0.60 45.0 3.29e-01 79.5% 44.9%
3288436 150.5.1.11 alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › ESAT-6 like › ESAT-6 like › T7SS_ESX_EspC 0.60 36.0 3.35e-01 74.7% 47.6%
3518933 101.1.1.21 alpha arrays › HTH › HTH › Three-helical HTH › HTH_Tnp_Tc5 0.59 43.0 4.77e-01 84.3% 96.9%
3596608 1134.1.1.0 alpha bundles › C-terminal helical domain of alanine-tRNA ligase › C-terminal helical domain of alanine-tRNA ligase › Eukaryotic C-Ala helical domain 0.59 49.0 4.87e-01 98.8% 88.2%
3912405 109.4.1.219 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TINF2_N 0.59 48.0 3.71e-01 100.0% 37.6%
3880410 164.1.1.3 alpha bundles › Chorismate mutase II › Chorismate mutase II › Chorismate mutase II › Get2_like 0.58 49.0 4.48e-01 97.6% 73.0%
3216384 197.1.1.0 alpha bundles › Acyl-CoA binding protein-like › Acyl-CoA binding protein-like › Acyl-CoA binding protein-like 0.57 46.0 4.12e-01 91.6% 60.0%
3405583 5054.1.1.0 alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels 0.57 40.0 3.53e-01 74.7% 86.9%
3498448 604.3.1.0 alpha bundles › Spectrin repeat-like › BAG domain › BAG domain 0.57 49.0 5.05e-01 97.6% 100.0%
3641172 101.1.1.295 alpha arrays › HTH › HTH › Three-helical HTH › HTH_70 0.57 42.0 4.12e-01 95.2% 73.3%
3289278 3236.1.1.1 alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Na_H_Exchanger 0.57 47.0 2.99e-01 92.8% 18.2%
3286136 4033.1.1.1 alpha arrays › Acyl-CoA dehydrogenase N-terminal domain-like › Acyl-CoA dehydrogenase N-terminal domain-like › Acyl-CoA dehydrogenase N-terminal domain-like › Acyl-CoA_dh_N 0.56 44.0 4.10e-01 84.3% 70.5%
3967813 5086.1.1.93 alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › HH_EMRA 0.56 42.0 3.71e-01 81.9% 100.0%
4311347 604.24.1.0 alpha bundles › Spectrin repeat-like › Helical bundle domain in putative transcriptional regulator Jann_0659-related proteins › Helical bundle domain in putative transcriptional regulator Jann_0659-related proteins 0.56 47.0 4.76e-01 100.0% 96.2%
4942070 5050.1.1.87 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › LPG_synthase_TM 0.56 45.0 3.23e-01 92.8% 29.2%
3600987 5050.1.1.0 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter 0.56 47.0 3.84e-01 97.6% 93.5%
3670388 2004.1.1.0 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.55 43.0 3.76e-01 94.0% 53.3%
3714072 5050.1.1.4 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Nucleoside_tran 0.55 47.0 3.83e-01 97.6% 97.0%
4982233 5060.2.1.0 alpha bundles › V-type ATP synthase subunit C › Toxin coregulated pilus biosynthesis protein E cytoplasmic domain › Toxin coregulated pilus biosynthesis protein E cytoplasmic domain 0.55 45.0 4.10e-01 92.8% 73.9%
4032384 604.3.1.0 alpha bundles › Spectrin repeat-like › BAG domain › BAG domain 0.55 47.0 4.79e-01 97.6% 100.0%
3240575 4266.2.1.0 alpha bundles › Hyaluronidase domain-like › TTHA0068-like › TTHA0068-like 0.54 47.0 4.18e-01 100.0% 100.0%
4526671 604.5.1.0 alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) 0.54 48.0 3.42e-01 100.0% 48.8%
3309012 604.3.1.1 alpha bundles › Spectrin repeat-like › BAG domain › BAG domain › BAG 0.54 47.0 4.27e-01 100.0% 77.4%
3664940 192.4.1.22 alpha bundles › Long alpha-hairpin › Ribosomal protein L29 (L29p) › Ribosomal protein L29 (L29p) › PF26575 0.54 45.0 4.58e-01 97.6% 97.5%
3972478 603.1.1.0 alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.54 46.0 4.19e-01 100.0% 69.7%
3998627 7558.1.1.6 a/b three-layered sandwiches › Glycerol-3-phosphate (1)-acyltransferase › Glycerol-3-phosphate (1)-acyltransferase › Glycerol-3-phosphate (1)-acyltransferase › Acyltransf_C 0.53 45.0 3.09e-01 96.4% 46.1%
3796158 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.53 46.0 3.96e-01 97.6% 80.0%
3446288 601.4.1.0 alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains 0.53 45.0 3.90e-01 100.0% 58.6%
3624728 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.52 44.0 4.43e-01 100.0% 94.1%
4000733 5050.1.1.1 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Sugar_tr 0.52 45.0 3.95e-01 100.0% 63.8%
3733195 632.22.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats 0.51 44.0 3.63e-01 98.8% 51.2%
3638435 1073.1.1.14 alpha arrays › Mitochondrial calcium uniporter (MCU) › Mitochondrial calcium uniporter (MCU) › Mitochondrial calcium uniporter (MCU) › LMBR1 0.51 41.0 3.69e-01 86.7% 99.1%
3403695 5054.1.1.0 alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels 0.51 38.0 3.35e-01 78.3% 86.4%
4018806 3718.1.1.0 alpha bundles › Flagellar protein fliT › Flagellar protein fliT › Flagellar protein fliT 0.51 40.0 3.82e-01 90.4% 73.7%
5005480 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.51 45.0 3.56e-01 100.0% 80.0%
4938202 601.7.1.0 alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain 0.50 36.0 3.37e-01 75.9% 78.1%
53436 4033.1.1.0 alpha arrays › Acyl-CoA dehydrogenase N-terminal domain-like › Acyl-CoA dehydrogenase N-terminal domain-like › Acyl-CoA dehydrogenase N-terminal domain-like 0.50 41.0 3.64e-01 91.6% 61.6%
3564169 3939.1.1.0 alpha duplicates or obligate multimers › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain 0.50 36.0 2.32e-01 74.7% 80.0%
D4 medium residues 374-439
PDB
Domain cluster: representative
CATH (56)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3gn4A00 6.10.220.10 Special › Helix non-globular › Helical scaffold and wing domains of SecA › 0.81 56.0 4.48e-01 72.7% 37.2%
8ek4A01 1.20.120.20 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Apolipoprotein 0.81 73.0 5.72e-01 100.0% 88.7%
4oe8C00 1.10.8.1170 Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › 0.79 56.0 5.07e-01 74.2% 59.8%
4okvE00 6.10.140.1890 Special › Helix non-globular › Helix Hairpins › 0.77 54.0 5.44e-01 72.7% 73.8%
3fd9A03 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.77 52.0 5.03e-01 75.8% 63.0%
3onjA00 1.20.58.400 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › t-snare proteins 0.77 56.0 4.90e-01 77.3% 70.1%
2icwG01 1.20.120.390 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Hla class ii histocompatibility antigen, dr alpha chain. Chain D, domain 1 0.76 53.0 4.35e-01 74.2% 43.5%
2cazD00 6.10.140.820 Special › Helix non-globular › Helix Hairpins › 0.76 54.0 5.60e-01 75.8% 81.7%
2ewfA02 1.20.1270.310 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.76 49.0 4.60e-01 74.2% 54.3%
6xxvC00 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.76 66.0 5.60e-01 100.0% 98.2%
2wzkA03 1.20.1310.10 Mainly Alpha › Up-down Bundle › 5 helical Cullin repeat like › Cullin Repeats 0.75 65.0 5.53e-01 98.5% 76.4%
2oc5A01 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.74 53.0 3.63e-01 74.2% 23.3%
1cxzB00 1.10.287.160 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat 0.72 52.0 4.74e-01 75.8% 60.5%
3juiA00 1.25.40.180 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.70 62.0 4.57e-01 100.0% 50.0%
4asvA00 1.20.5.420 Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › Immunoglobulin FC, subunit C 0.69 49.0 4.62e-01 80.3% 62.0%
5ux2B01 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.69 53.0 3.66e-01 81.8% 31.3%
1wp7A00 1.10.287.770 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › YojJ-like 0.69 50.0 5.08e-01 75.8% 78.1%
2v6eA01 1.10.287.3180 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.69 58.0 5.57e-01 92.4% 97.3%
4d3dB02 1.10.1040.10 Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 0.69 47.0 3.77e-01 71.2% 37.2%
2gtvX00 1.20.59.10 Mainly Alpha › Up-down Bundle › Chorismate Mutase Domain, subunit A › Chorismate mutase 0.69 59.0 5.00e-01 92.4% 78.8%
3rmiA00 1.20.59.10 Mainly Alpha › Up-down Bundle › Chorismate Mutase Domain, subunit A › Chorismate mutase 0.68 54.0 4.60e-01 86.4% 65.7%
4nsmA00 6.10.250.2770 Special › Helix non-globular › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › 0.67 48.0 4.72e-01 75.8% 100.0%
1v07A00 1.10.490.10 Mainly Alpha › Orthogonal Bundle › Globin-like › Globins 0.67 59.0 4.93e-01 97.0% 100.0%
4cqiA00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.67 49.0 4.13e-01 81.8% 47.7%
4v1gA00 1.20.20.10 Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C 0.66 46.0 4.30e-01 74.2% 60.0%
2gl2B00 1.10.287.1700 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.66 47.0 3.92e-01 72.7% 81.7%
4cpgA00 1.20.5.420 Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › Immunoglobulin FC, subunit C 0.66 45.0 4.46e-01 77.3% 68.1%
2fp1B00 1.20.59.10 Mainly Alpha › Up-down Bundle › Chorismate Mutase Domain, subunit A › Chorismate mutase 0.66 52.0 3.89e-01 86.4% 40.2%
1vpdA02 1.10.1040.10 Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 0.65 55.0 4.44e-01 95.5% 96.2%
3qhaB02 1.10.1040.10 Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 0.65 48.0 3.94e-01 80.3% 43.7%
4ol9A02 1.10.1040.10 Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 0.64 54.0 4.47e-01 97.0% 57.5%
3ck6C02 1.20.58.340 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Magnesium transport protein CorA, transmembrane region 0.64 54.0 4.60e-01 100.0% 83.2%
4adnA01 1.20.1280.250 Mainly Alpha › Up-down Bundle › Monooxygenase › 0.64 52.0 4.90e-01 95.5% 75.3%
2ew2A02 1.10.1040.10 Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 0.64 53.0 4.33e-01 97.0% 57.5%
3hwrA02 1.10.1040.10 Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 0.64 51.0 4.24e-01 92.4% 56.6%
2w9zA01 1.10.472.10 Mainly Alpha › Orthogonal Bundle › Cyclin A; domain 1 › Cyclin-like 0.64 51.0 4.08e-01 87.9% 76.7%
1n81A00 1.10.3030.10 Mainly Alpha › Orthogonal Bundle › Gametocyte protein Pfg27 › Gametocyte protein Pfg27 0.64 54.0 4.00e-01 98.5% 43.5%
1yhuB00 1.10.490.10 Mainly Alpha › Orthogonal Bundle › Globin-like › Globins 0.63 50.0 4.00e-01 90.9% 91.0%
1ks9A02 1.10.1040.10 Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 0.62 53.0 4.39e-01 97.0% 58.5%
1u5pA01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.62 53.0 4.62e-01 100.0% 91.7%
1quuA01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.62 55.0 4.46e-01 100.0% 81.7%
4x5mA00 1.20.1280.290 Mainly Alpha › Up-down Bundle › Monooxygenase › 0.62 52.0 4.85e-01 100.0% 93.0%
1ailA00 1.10.287.10 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › S15/NS1, RNA-binding 0.61 46.0 4.58e-01 86.4% 77.1%
1xwyA00 3.20.20.140 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Metal-dependent hydrolases 0.60 46.0 3.12e-01 89.4% 21.5%
1b0bA00 1.10.490.10 Mainly Alpha › Orthogonal Bundle › Globin-like › Globins 0.60 48.0 3.94e-01 95.5% 92.9%
2j9wB00 1.20.120.1130 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Vps28 C-terminal domain 0.59 48.0 4.33e-01 97.0% 85.9%
2c0kB00 1.10.490.10 Mainly Alpha › Orthogonal Bundle › Globin-like › Globins 0.58 47.0 3.83e-01 98.5% 92.6%
3n98A01 3.20.110.10 Alpha Beta › Alpha-Beta Barrel › 7-stranded beta/alpha barrel › Glycoside hydrolase 38, N terminal domain 0.58 51.0 3.13e-01 100.0% 19.0%
4wvaB00 1.50.10.10 Mainly Alpha › Alpha/alpha barrel › Glycosyltransferase › 0.57 48.0 3.04e-01 100.0% 22.2%
2go7A02 1.10.150.240 Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 0.57 41.0 4.12e-01 87.9% 74.6%
2rp5A00 1.10.150.830 Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › 0.57 43.0 3.62e-01 92.4% 47.0%
3vayA02 1.20.120.1600 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › 0.54 44.0 4.05e-01 92.4% 77.0%
3zgyA02 1.10.1040.10 Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 0.52 43.0 3.55e-01 93.9% 72.1%
3h4cA02 1.10.472.110 Mainly Alpha › Orthogonal Bundle › Cyclin A; domain 1 › 0.52 43.0 3.74e-01 97.0% 85.5%
6smyB02 1.10.1040.10 Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 0.52 43.0 3.60e-01 95.5% 82.5%
4qgpB00 1.10.287.1080 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › MazG-like 0.52 36.0 3.20e-01 75.8% 49.5%
ECOD (59)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3479092 603.1.1.0 alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.83 72.0 6.22e-01 95.5% 85.0%
4237257 632.15.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Staphylococcal complement inhibitor (SCIN) › Staphylococcal complement inhibitor (SCIN) 0.82 58.0 5.20e-01 74.2% 55.6%
4988447 192.29.1.0 alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) 0.81 53.0 4.39e-01 74.2% 39.1%
3636496 7022.1.1.1 alpha bundles › central core domain of D-alanyl transfer protein › central core domain of D-alanyl transfer protein › central core domain of D-alanyl transfer protein › MBOAT 0.80 71.0 4.43e-01 100.0% 25.4%
3849657 192.4.1.0 alpha bundles › Long alpha-hairpin › Ribosomal protein L29 (L29p) › Ribosomal protein L29 (L29p) 0.79 70.0 5.99e-01 95.5% 95.0%
5019536 3755.1.1.0 alpha bundles › YscO-like › Putative type III secretion protein YscO-related › Putative type III secretion protein YscO-related 0.78 60.0 4.07e-01 81.8% 57.8%
3530124 386.1.1.0 few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers 0.78 68.0 6.34e-01 100.0% 78.8%
3281127 150.5.1.0 alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › ESAT-6 like › ESAT-6 like 0.77 54.0 4.90e-01 74.2% 56.7%
3618077 603.1.1.149 alpha bundles › STAT-like › t-snare proteins › t-snare proteins › Frag1 0.77 54.0 4.29e-01 72.7% 38.4%
3865967 310.2.1.0 a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF 0.77 54.0 4.20e-01 74.2% 52.1%
5047770 601.28.1.0 alpha bundles › Four-helical up-and-down bundle › VPS28 C-terminal domain-like › VPS28 C-terminal domain-like 0.76 64.0 5.70e-01 92.4% 88.2%
3997796 170.1.1.0 alpha bundles › Retrovirus capsid protein › Retrovirus capsid protein-C › Retrovirus capsid protein-C 0.75 63.0 5.47e-01 95.5% 61.0%
3545387 3602.1.1.0 alpha bundles › Kinase suppressor of Ras 1 helical hairpin domain › Kinase suppressor of Ras 1 helical hairpin domain › Kinase suppressor of Ras 1 helical hairpin domain 0.75 49.0 4.14e-01 75.8% 40.9%
4436309 4044.1.1.1 alpha bundles › Helical bundle domain in prismane-like proteins › Helical bundle domain in prismane-like proteins › Helical bundle domain in prismane-like proteins › Prismane 0.75 50.0 4.44e-01 75.8% 48.4%
4886448 7586.1.1.1 a/b three-layered sandwiches › Rossmann-like domain in prismane-like proteins › Rossmann-like domain in prismane-like proteins › Rossmann-like domain in prismane-like proteins › Prismane 0.74 50.0 4.26e-01 75.8% 43.8%
3868748 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.74 64.0 4.42e-01 100.0% 51.2%
3784055 192.24.1.0 alpha bundles › Long alpha-hairpin › RPC62 helical hairpin domain › RPC62 helical hairpin domain 0.74 51.0 4.10e-01 72.7% 37.7%
4026671 603.1.1.0 alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.73 65.0 5.42e-01 100.0% 81.7%
3962373 106.1.1.11 alpha arrays › Globin-like › Globin-like › Globin-like › RsbRD_N 0.73 58.0 4.58e-01 86.4% 67.4%
3405261 604.22.1.1 alpha bundles › Spectrin repeat-like › tubulin binding cofactor C N-terminal domain › tubulin binding cofactor C N-terminal domain › TBCC_N 0.73 64.0 5.31e-01 100.0% 69.2%
3530376 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.72 61.0 5.45e-01 95.5% 96.8%
3892495 604.1.1.7 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › SR_plectin_7 0.72 64.0 5.25e-01 100.0% 87.5%
4268621 320.6.1.1 a+b two layers › R3H domain-like › Cysteine methyltransferase effector NleE › Cysteine methyltransferase effector NleE › NleE 0.71 50.0 3.52e-01 75.8% 23.6%
3741234 605.2.1.3 alpha duplicates or obligate multimers › ROP-like › Hypothetical protein D-63 › Hypothetical protein D-63 › Seryl_tRNA_N 0.71 51.0 4.19e-01 75.8% 45.2%
4600569 3236.1.1.5 alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Na_H_antiport_1 0.70 61.0 4.11e-01 98.5% 26.5%
3792592 4003.1.1.1 alpha arrays › Helical bundle domain in YebC-like proteins › Helical bundle domain in YebC-like proteins › Helical bundle domain in YebC-like proteins › TACO1_YebC_N 0.70 57.0 5.60e-01 93.9% 84.3%
4311002 4198.1.1.2 alpha arrays › TerB-like › TerB-like › TerB-like › ThylakoidFormat 0.70 56.0 3.99e-01 89.4% 33.7%
3547406 604.1.1.153 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › DUF4455 0.70 61.0 4.53e-01 100.0% 80.6%
3456370 192.2.1.0 alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin 0.70 49.0 3.73e-01 74.2% 32.3%
3880637 3755.3.1.465 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › KIF21A 0.69 49.0 3.87e-01 75.8% 42.1%
4043484 192.7.1.2 alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm › Seryl_tRNA_N 0.69 49.0 4.17e-01 75.8% 47.3%
4091184 4044.1.1.1 alpha bundles › Helical bundle domain in prismane-like proteins › Helical bundle domain in prismane-like proteins › Helical bundle domain in prismane-like proteins › Prismane 0.69 48.0 3.98e-01 72.7% 47.0%
4175087 192.7.1.2 alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm › Seryl_tRNA_N 0.69 49.0 4.14e-01 75.8% 60.0%
3509826 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.68 61.0 4.87e-01 100.0% 87.7%
3845878 621.1.1.0 alpha bundles › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain 0.68 57.0 5.53e-01 95.5% 97.3%
3275 106.1.1.1 alpha arrays › Globin-like › Globin-like › Globin-like › Globin 0.67 56.0 4.39e-01 92.4% 91.5%
3927845 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.67 58.0 4.72e-01 100.0% 93.1%
3410979 3745.1.1.1 alpha bundles › Sodium/Calcium exchanger › Sodium/Calcium exchanger › Sodium/Calcium exchanger › Na_Ca_ex 0.67 56.0 3.65e-01 98.5% 46.5%
4948274 164.1.1.1 alpha bundles › Chorismate mutase II › Chorismate mutase II › Chorismate mutase II › CM_2 0.67 53.0 5.10e-01 86.4% 89.3%
5047035 4009.1.1.0 alpha bundles › alpha-helical domain in AF1104-like proteins › alpha-helical domain in AF1104-like proteins › alpha-helical domain in AF1104-like proteins 0.66 42.0 4.39e-01 71.2% 71.7%
988057 6067.1.1.1 alpha arrays › Dimerization domain of Sgt2 › Dimerization domain of Sgt2 › Dimerization domain of Sgt2 › SGTA_dimer 0.66 47.0 4.82e-01 80.3% 78.5%
4426344 101.35.1.4 alpha arrays › HTH › DNA repair regulatory protein RecX › DNA repair regulatory protein RecX › RecX_HTH3 0.65 53.0 5.30e-01 92.4% 88.2%
3471712 604.8.1.0 alpha bundles › Spectrin repeat-like › Smac/diablo › Smac/diablo 0.65 55.0 4.60e-01 100.0% 90.4%
4946854 3291.1.1.0 alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related 0.64 54.0 4.39e-01 93.9% 82.3%
3198443 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.64 54.0 3.09e-01 100.0% 8.1%
3682591 109.4.1.1472 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Tho2, Thoc2, THOC2_N 0.63 50.0 2.82e-01 92.4% 6.7%
3226467 174.1.1.0 few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain 0.62 53.0 4.20e-01 93.9% 72.6%
3680914 3291.1.1.116 alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › GIDE 0.62 45.0 4.32e-01 75.8% 78.7%
3934928 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.62 52.0 4.73e-01 100.0% 100.0%
1300229 159.1.1.2 alpha bundles › all-alpha NTP pyrophosphatases › all-alpha NTP pyrophosphatases › Hypothetical protein AF_0060 › MazG-like 0.61 44.0 3.94e-01 78.8% 69.0%
3996708 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.60 49.0 4.06e-01 93.9% 85.4%
4934951 164.1.1.1 alpha bundles › Chorismate mutase II › Chorismate mutase II › Chorismate mutase II › CM_2 0.60 53.0 4.77e-01 97.0% 82.2%
4231284 192.7.1.2 alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm › Seryl_tRNA_N 0.60 43.0 3.68e-01 77.3% 53.6%
3307895 5000.3.1.8 alpha arrays › Toxins' membrane translocation domains › Bcl-2 inhibitors of programmed cell death › Bcl-2 inhibitors of programmed cell death › SPARK 0.60 50.0 3.75e-01 97.0% 43.9%
3683741 192.13.1.1 alpha bundles › Long alpha-hairpin › ISY1 N-terminal domain-like › ISY1 N-terminal domain-like › Isy1 0.59 53.0 4.81e-01 100.0% 73.3%
4935669 601.33.1.1 alpha bundles › Four-helical up-and-down bundle › CHAD domain › CHAD domain › CHAD 0.58 49.0 3.94e-01 97.0% 82.9%
3932692 604.6.1.0 alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain 0.58 47.0 4.37e-01 95.5% 98.9%
4294975 563.1.1.1 alpha bundles › ATPD N-terminal domain-like › N-terminal domain of the delta subunit of the F1F0-ATP synthase › N-terminal domain of the delta subunit of the F1F0-ATP synthase › OSCP 0.56 45.0 3.38e-01 90.9% 57.8%
3948115 2004.1.1.5 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ABC_tran 0.55 44.0 2.58e-01 86.4% 18.9%
D5 medium residues 496-588
PDB
Domain cluster: representative
CATH (39)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3eupB00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.72 50.0 3.80e-01 80.6% 32.5%
4m70B00 1.10.246.200 Mainly Alpha › Orthogonal Bundle › Serum Albumin; Chain A, Domain 1 › WPP domain 0.68 55.0 5.62e-01 97.8% 89.0%
3vprA02 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.68 43.0 3.73e-01 75.3% 41.4%
1qsdA00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.67 47.0 4.62e-01 73.1% 84.3%
2fsfB04 1.10.3060.10 Mainly Alpha › Orthogonal Bundle › Helical scaffold and wing domains of SecA › Helical scaffold and wing domains of SecA 0.66 56.0 4.34e-01 94.6% 81.6%
2w9zA01 1.10.472.10 Mainly Alpha › Orthogonal Bundle › Cyclin A; domain 1 › Cyclin-like 0.66 46.0 4.16e-01 97.8% 51.9%
3s84A02 1.20.120.20 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Apolipoprotein 0.65 57.0 4.83e-01 97.8% 79.0%
2e9xA01 1.20.58.1030 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.65 45.0 4.02e-01 71.0% 52.3%
3nbxX03 1.20.58.1510 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.65 47.0 4.56e-01 74.2% 68.3%
2x2vA00 1.20.20.10 Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C 0.65 44.0 5.01e-01 80.6% 95.6%
5af7B03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.65 50.0 4.29e-01 82.8% 92.6%
1rx0A03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.64 49.0 4.16e-01 81.7% 89.0%
4wqoD00 1.20.1310.10 Mainly Alpha › Up-down Bundle › 5 helical Cullin repeat like › Cullin Repeats 0.64 44.0 3.83e-01 81.7% 46.8%
5zw7A03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.63 49.0 4.17e-01 82.8% 90.1%
3gi7A00 1.20.1270.180 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.63 50.0 4.93e-01 89.2% 81.6%
3iylB02 1.10.2050.10 Mainly Alpha › Orthogonal Bundle › Protein mu-1, chain B, domain 3 › Protein mu-1, chain B, domain 3 0.60 44.0 3.94e-01 78.5% 88.8%
7abaA01 1.10.630.10 Mainly Alpha › Orthogonal Bundle › Cytochrome p450 › Cytochrome P450 0.59 48.0 3.26e-01 89.2% 37.5%
3l1nA02 1.20.1280.140 Mainly Alpha › Up-down Bundle › Monooxygenase › 0.59 42.0 4.35e-01 78.5% 78.2%
1br0A00 1.20.58.70 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.59 42.0 3.90e-01 74.2% 72.5%
1ma1A01 1.10.287.990 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Fe,Mn superoxide dismutase (SOD) domain 0.59 39.0 4.69e-01 80.6% 100.0%
2i53A02 1.10.472.10 Mainly Alpha › Orthogonal Bundle › Cyclin A; domain 1 › Cyclin-like 0.59 42.0 3.96e-01 100.0% 62.2%
3l8rA00 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.58 42.0 4.13e-01 75.3% 68.6%
3r2qA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.58 40.0 3.76e-01 74.2% 58.4%
4v1gA00 1.20.20.10 Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C 0.57 45.0 4.66e-01 82.8% 92.9%
2iw3A02 1.20.1390.20 Mainly Alpha › Up-down Bundle › PWI domain › 0.57 39.0 4.03e-01 98.9% 73.3%
3nrgA00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.56 42.0 3.28e-01 79.6% 74.2%
6tqfA01 1.20.1560.10 Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain 0.56 44.0 2.99e-01 88.2% 50.9%
4q20A01 1.10.287.130 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Signal transduction histidine kinase, dimerisation/phosphotransfer (DHp) domain 0.56 40.0 4.31e-01 76.3% 89.0%
2b7mA00 1.20.1280.170 Mainly Alpha › Up-down Bundle › Monooxygenase › Exocyst complex component Exo70 0.55 48.0 3.03e-01 97.8% 17.3%
4aflA00 6.10.140.1740 Special › Helix non-globular › Helix Hairpins › 0.55 43.0 4.16e-01 81.7% 84.3%
1x04A00 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.54 48.0 3.72e-01 96.8% 77.5%
2f2cA02 1.10.472.10 Mainly Alpha › Orthogonal Bundle › Cyclin A; domain 1 › Cyclin-like 0.53 40.0 3.86e-01 97.8% 70.8%
1jkwA02 1.10.472.10 Mainly Alpha › Orthogonal Bundle › Cyclin A; domain 1 › Cyclin-like 0.53 40.0 3.91e-01 100.0% 74.3%
3keyA01 1.10.10.1080 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Stn1, N-terminal wHTH domain 0.52 36.0 3.76e-01 90.3% 77.0%
4w8pA02 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.52 43.0 3.90e-01 100.0% 66.2%
2q9rA01 1.20.1590.10 Mainly Alpha › Up-down Bundle › YP_001051499.1 fold like › YP_001051499.1 domain like 0.52 43.0 3.49e-01 93.5% 86.2%
4x28C03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.52 47.0 4.05e-01 100.0% 64.3%
1rq0A01 6.10.140.160 Special › Helix non-globular › Helix Hairpins › 0.51 41.0 4.36e-01 86.0% 100.0%
1f7uA02 1.10.730.10 Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1 0.51 42.0 3.79e-01 93.5% 65.6%
ECOD (42)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3961186 103.9.1.0 alpha arrays › RuvA-C › RanGAP2 N-terminal domain › RanGAP2 N-terminal domain 0.78 64.0 6.26e-01 87.1% 96.0%
3605109 101.1.10.7 alpha arrays › HTH › HTH › Cyclin-like › Cyclin_C 0.74 59.0 4.93e-01 88.2% 51.0%
3927006 603.1.1.99 alpha bundles › STAT-like › t-snare proteins › t-snare proteins › PF27021 0.73 51.0 5.18e-01 73.1% 74.4%
3287765 191.1.1.0 alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain 0.72 47.0 4.31e-01 77.4% 50.4%
3700820 101.1.10.0 alpha arrays › HTH › HTH › Cyclin-like 0.71 55.0 5.62e-01 88.2% 84.4%
3237954 603.1.1.139 alpha bundles › STAT-like › t-snare proteins › t-snare proteins › V-SNARE_C, PF27021 0.71 51.0 4.25e-01 74.2% 44.5%
3464462 101.1.2.0 alpha arrays › HTH › HTH › winged helix domain 0.70 59.0 4.59e-01 93.5% 85.1%
3669701 603.1.1.160 alpha bundles › STAT-like › t-snare proteins › t-snare proteins › 14-3-3 0.70 48.0 4.48e-01 71.0% 64.3%
3739839 5063.1.1.0 alpha bundles › Photosystem I reaction center subunit X, PsaK › Photosystem I reaction center subunit X, PsaK › Photosystem I reaction center subunit X, PsaK 0.70 61.0 5.77e-01 96.8% 90.0%
4511937 603.1.1.139 alpha bundles › STAT-like › t-snare proteins › t-snare proteins › V-SNARE_C, PF27021 0.69 50.0 4.22e-01 75.3% 46.7%
3224585 603.1.1.99 alpha bundles › STAT-like › t-snare proteins › t-snare proteins › PF27021 0.69 50.0 4.69e-01 75.3% 63.6%
3215295 632.22.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats 0.68 53.0 5.59e-01 94.6% 96.2%
4031352 6026.1.1.43 alpha duplicates or obligate multimers › cwf21 domain › cwf21 domain › cwf21 domain › DUF1024 0.67 46.0 4.81e-01 77.4% 78.6%
3903775 192.8.1.419 alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain › PF27603 0.66 47.0 4.34e-01 79.6% 57.5%
5002537 1075.5.1.1 alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › MatE 0.66 58.0 4.35e-01 97.8% 84.3%
3714155 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.66 42.0 4.19e-01 72.0% 63.2%
4985507 604.10.1.0 alpha bundles › Spectrin repeat-like › Enzyme IIa from lactose specific PTS, IIa-lac › Enzyme IIa from lactose specific PTS, IIa-lac 0.65 43.0 4.40e-01 75.3% 70.0%
3919099 621.1.1.8 alpha bundles › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain › GVIN1 0.64 48.0 4.25e-01 79.6% 54.8%
4010442 5067.1.1.1 alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › ACR_tran 0.63 58.0 4.37e-01 100.0% 74.9%
3483993 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.63 45.0 4.42e-01 74.2% 76.0%
3864552 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.62 44.0 4.36e-01 74.2% 76.0%
3241234 101.44.1.0 alpha arrays › HTH › Helical domain in DNA-Damage-Inducible 2 (Ddi2) (DEPRECATED) › Helical domain in DNA-Damage-Inducible 2 (Ddi2) (DEPRECATED) 0.62 38.0 3.84e-01 72.0% 60.0%
3977737 3831.1.1.1 alpha bundles › Secreted protein of unknown function DUF1311 › Secreted protein of unknown function DUF1311 › Secreted protein of unknown function DUF1311 › LprI 0.61 53.0 4.98e-01 100.0% 80.0%
4481525 141.1.1.36 alpha bundles › Terpenoid synthases › Terpenoid synthases › Terpenoid synthases › Virul_fac_BrkB 0.61 54.0 3.84e-01 97.8% 50.4%
3311490 622.1.1.1 alpha bundles › YvfG-like › HSC20 (HSCB), C-terminal oligomerisation domain › HSC20 (HSCB), C-terminal oligomerisation domain › HSCB_C 0.60 43.0 4.51e-01 77.4% 81.2%
3982940 5067.1.1.1 alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › ACR_tran 0.60 53.0 3.84e-01 100.0% 64.9%
5029437 3558.1.1.0 alpha arrays › HSDR subunit helical domain › HSDR subunit helical domain › HSDR subunit helical domain 0.59 32.0 3.07e-01 72.0% 43.6%
3222941 5054.1.1.59 alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels › Ion_trans, Ion_trans_2 0.59 45.0 3.62e-01 81.7% 93.0%
1503721 632.22.1.1 alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats › EzrA 0.58 52.0 4.94e-01 100.0% 84.7%
3739018 5050.1.1.40 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › PGAP2IP_TM_1nd 0.58 43.0 3.49e-01 80.6% 94.7%
3511230 632.2.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Bacterial immunoglobulin/albumin-binding domains › Bacterial immunoglobulin/albumin-binding domains 0.56 40.0 4.01e-01 87.1% 71.6%
3420557 5069.1.1.0 alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes 0.56 51.0 4.14e-01 98.9% 62.4%
3470544 604.1.1.1 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin 0.55 39.0 3.91e-01 73.1% 77.9%
5057208 632.15.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Staphylococcal complement inhibitor (SCIN) › Staphylococcal complement inhibitor (SCIN) 0.54 44.0 4.28e-01 86.0% 83.0%
4212453 603.1.1.0 alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.54 40.0 3.31e-01 78.5% 42.9%
3992612 604.6.1.1 alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain › GAT 0.53 37.0 3.76e-01 73.1% 74.4%
4641864 223.1.1.83 a+b three layers › Profilin-like › sensor domains › sensor domains › PAS_13 0.53 45.0 3.47e-01 98.9% 74.2%
3486453 310.2.1.0 a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF 0.53 43.0 4.16e-01 91.4% 78.1%
3493397 133.1.1.1 alpha bundles › DH domain-like › DBL homology domain (DH-domain) › DBL homology domain (DH-domain) › RhoGEF 0.52 47.0 3.72e-01 100.0% 53.2%
4928705 212.1.1.22 a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Topo-VIb_trans 0.51 44.0 3.39e-01 97.8% 41.9%
3935027 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.51 36.0 3.54e-01 74.2% 71.0%
3991274 3291.1.1.137 alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Patched 0.51 43.0 3.73e-01 91.4% 65.7%
D6 medium residues 752-902
PDB