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NC_070856.1__YP_010658322.1__PP750_gp12__00012

Bact-Vir

NC_070856.1__YP_010658322.1__PP750_gp12__00012

Identity

Accession:
NC_070856 ↗
Kingdom:
phage

Quality

75.6 mean pLDDT

Cluster

Singleton — not in a non-trivial cluster

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 1-58
PDB
Domain cluster: representative
CATH (68)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1pd3A00 1.10.287.230 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.87 72.0 7.49e-01 100.0% 94.4%
2gtsA00 1.10.287.850 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HP0062-like domain 0.87 75.0 6.74e-01 100.0% 70.1%
2yevC00 6.10.280.110 Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.84 74.0 7.20e-01 100.0% 88.9%
4gczA03 1.10.287.130 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Signal transduction histidine kinase, dimerisation/phosphotransfer (DHp) domain 0.84 72.0 6.91e-01 100.0% 83.1%
4ioeA00 1.10.287.850 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HP0062-like domain 0.83 72.0 6.23e-01 100.0% 63.2%
4aflA00 6.10.140.1740 Special › Helix non-globular › Helix Hairpins › 0.82 67.0 5.47e-01 100.0% 50.0%
4gzrB00 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.81 69.0 6.30e-01 100.0% 71.4%
4w4kA00 1.10.287.850 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HP0062-like domain 0.81 74.0 6.51e-01 100.0% 72.0%
2bduA02 1.10.150.340 Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Pyrimidine 5'-nucleotidase (UMPH-1), N-terminal domain 0.80 57.0 5.21e-01 100.0% 58.1%
1l8nA03 3.90.1330.10 Alpha Beta › Alpha-Beta Complex › Alpha-d-glucuronidase, C-terminal Domain › Alpha-glucuronidase, C-terminal domain 0.80 68.0 4.64e-01 100.0% 26.8%
2rkhA02 1.20.1280.20 Mainly Alpha › Up-down Bundle › Monooxygenase › HscB, C-terminal domain 0.80 69.0 6.30e-01 94.8% 77.6%
1nt2B02 1.10.287.660 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin 0.79 72.0 6.87e-01 100.0% 97.0%
6tkvA01 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.79 67.0 6.36e-01 100.0% 80.9%
3favD00 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.77 67.0 6.17e-01 100.0% 74.4%
2rdcA00 1.10.287.800 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › protein ne1242 0.77 66.0 5.04e-01 100.0% 42.1%
4i0xG00 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.77 67.0 6.33e-01 96.6% 97.1%
6ynwH01 1.20.20.10 Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C 0.77 64.0 5.90e-01 100.0% 73.0%
1b3qA01 1.10.287.560 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Histidine kinase CheA-like, homodimeric domain 0.76 61.0 6.00e-01 96.6% 83.9%
4nb5B02 1.10.287.160 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat 0.76 67.0 6.51e-01 98.3% 98.4%
1zkeA00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.76 69.0 6.11e-01 100.0% 92.6%
1skvA00 1.10.287.660 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin 0.76 69.0 6.68e-01 100.0% 98.4%
2cazD00 6.10.140.820 Special › Helix non-globular › Helix Hairpins › 0.75 66.0 6.57e-01 100.0% 98.3%
2q1kA00 1.20.5.420 Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › Immunoglobulin FC, subunit C 0.75 57.0 6.01e-01 82.8% 100.0%
7ymiZ01 1.10.287.740 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Photosystem II PsbZ, reaction centre 0.75 64.0 6.49e-01 96.6% 100.0%
1fs0G02 1.10.287.80 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ATP synthase, gamma subunit, helix hairpin domain 0.74 66.0 5.73e-01 100.0% 68.5%
4a17U01 1.10.287.310 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.74 65.0 5.92e-01 96.6% 72.7%
2ic6A00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.74 66.0 6.20e-01 100.0% 81.7%
1i4dA00 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.74 66.0 4.58e-01 100.0% 31.9%
8fbnB01 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.74 64.0 4.32e-01 100.0% 32.4%
2etnB01 1.10.287.180 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Transcription elongation factor, GreA/GreB, N-terminal domain 0.73 61.0 5.62e-01 100.0% 71.1%
3rq9A00 1.10.287.2500 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.73 61.0 5.62e-01 100.0% 70.5%
2bdeA03 1.20.58.1160 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.73 66.0 5.99e-01 100.0% 75.3%
2ke4A00 6.10.140.470 Special › Helix non-globular › Helix Hairpins › 0.73 64.0 5.42e-01 100.0% 66.3%
1a36A04 1.10.132.10 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › 0.73 64.0 4.56e-01 100.0% 33.1%
2az0B00 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.73 64.0 6.01e-01 100.0% 81.7%
1p49A02 1.10.287.550 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin 0.72 64.0 6.45e-01 100.0% 100.0%
2fcwA00 1.20.81.10 Mainly Alpha › Up-down Bundle › Receptor-associated Protein › RAP domain 0.72 65.0 5.29e-01 100.0% 74.5%
6lumD01 1.20.1300.10 Mainly Alpha › Up-down Bundle › 3 helical TM bundles of succinate and fumarate reductases › Fumarate reductase/succinate dehydrogenase, transmembrane subunit 0.72 61.0 4.82e-01 98.3% 50.4%
3hpcX00 3.30.1520.10 Alpha Beta › 2-Layer Sandwich › PX Domain › Phox-like domain 0.72 60.0 4.41e-01 100.0% 34.8%
3h6pC00 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.72 58.0 5.89e-01 98.3% 94.6%
4kzsA02 6.10.140.1870 Special › Helix non-globular › Helix Hairpins › 0.72 62.0 5.82e-01 96.6% 78.6%
3r84B00 6.10.280.160 Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Mediator of RNA polymerase II transcription subunit 22 0.72 62.0 5.63e-01 100.0% 90.0%
7sgrA02 1.20.1560.10 Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain 0.71 61.0 3.86e-01 100.0% 23.9%
4dylA02 1.10.287.160 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat 0.71 62.0 5.32e-01 100.0% 87.2%
2gd5A00 6.10.140.1230 Special › Helix non-globular › Helix Hairpins › 0.70 60.0 4.61e-01 100.0% 60.6%
2hujA00 1.20.120.440 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › YppE-like 0.70 58.0 4.67e-01 98.3% 100.0%
3lphC00 6.10.140.630 Special › Helix non-globular › Helix Hairpins › 0.69 57.0 5.79e-01 93.1% 100.0%
5svlA01 1.10.287.940 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › atp-gated p2x4 ion channel 0.69 61.0 5.83e-01 98.3% 85.3%
6xm1A02 3.90.830.10 Alpha Beta › Alpha-Beta Complex › Syntaxin Binding Protein 1; Chain A, domain 2 › Sec1/Munc18 (SM) protein, domain 3a 0.69 59.0 4.76e-01 96.6% 58.4%
2r9iA00 1.10.287.80 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ATP synthase, gamma subunit, helix hairpin domain 0.69 56.0 5.37e-01 100.0% 78.9%
1zpyA00 6.10.140.1960 Special › Helix non-globular › Helix Hairpins › 0.69 57.0 5.02e-01 100.0% 61.5%
2rbdA01 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.69 56.0 4.29e-01 100.0% 37.3%
2fb5A01 1.10.287.770 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › YojJ-like 0.68 59.0 5.59e-01 100.0% 88.9%
1l8dA00 1.10.287.510 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin 0.68 57.0 4.86e-01 100.0% 98.1%
4l0rB00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.68 58.0 5.43e-01 100.0% 83.6%
2kp8A00 1.20.5.170 Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › 0.66 56.0 5.28e-01 100.0% 80.6%
6h9xA01 1.10.287.40 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain 0.66 57.0 4.82e-01 100.0% 57.8%
2x2vA00 1.20.20.10 Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C 0.65 54.0 5.24e-01 98.3% 100.0%
1ij5A01 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.65 54.0 5.03e-01 100.0% 75.0%
4e4eA01 1.10.287.990 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Fe,Mn superoxide dismutase (SOD) domain 0.64 55.0 5.18e-01 98.3% 83.1%
2wzkA03 1.20.1310.10 Mainly Alpha › Up-down Bundle › 5 helical Cullin repeat like › Cullin Repeats 0.62 52.0 4.34e-01 98.3% 76.4%
4b6xA00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.62 51.0 4.92e-01 100.0% 85.5%
2y39A00 1.20.120.1490 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › 0.61 54.0 4.40e-01 100.0% 54.5%
1grjA01 1.10.287.180 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Transcription elongation factor, GreA/GreB, N-terminal domain 0.61 52.0 4.87e-01 100.0% 82.4%
2da7A00 1.10.10.60 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Homeodomain-like 0.60 42.0 3.97e-01 75.9% 60.6%
1h3lB00 1.10.1740.10 Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › RNA polymerase sigma factor, region 2, helix turn helix motif 0.58 45.0 4.17e-01 87.9% 67.9%
2fh5A01 3.30.450.60 Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › 0.58 45.0 3.56e-01 86.2% 68.0%
2e62A01 6.10.140.420 Special › Helix non-globular › Helix Hairpins › 0.56 44.0 4.64e-01 91.4% 100.0%
ECOD (44)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4998773 3755.3.1.305 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › Rad50_zn_hook 0.86 79.0 5.32e-01 100.0% 33.3%
5018636 605.1.1.3 alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › HisKA_2 0.84 73.0 6.78e-01 100.0% 77.1%
3992452 150.5.1.74 alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › ESAT-6 like › ESAT-6 like › CUX1_N 0.82 74.0 6.65e-01 100.0% 91.3%
4942789 4323.1.1.0 alpha bundles › helical bundle domain in vacuolar ATP synthase subunit C › helical bundle domain in vacuolar ATP synthase subunit C › helical bundle domain in vacuolar ATP synthase subunit C 0.82 75.0 5.52e-01 100.0% 46.4%
3986220 605.1.1.0 alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase 0.82 74.0 5.82e-01 100.0% 50.4%
3768858 192.29.1.1 alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB_dom 0.80 75.0 6.19e-01 100.0% 61.1%
3594486 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.80 74.0 5.69e-01 100.0% 48.3%
5046057 605.1.1.0 alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase 0.79 71.0 6.82e-01 98.3% 89.2%
4998774 2004.1.1.198 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_23 0.79 72.0 4.17e-01 100.0% 12.3%
5067713 192.7.1.2 alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm › Seryl_tRNA_N 0.78 72.0 5.69e-01 100.0% 52.7%
3192846 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.77 71.0 5.40e-01 100.0% 60.8%
3776400 192.5.1.1 alpha bundles › Long alpha-hairpin › HR1 repeat › HR1 repeat › HR1 0.77 70.0 6.27e-01 100.0% 77.5%
3397165 375.1.1.0 few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related 0.77 64.0 6.39e-01 89.7% 98.3%
5002089 2004.1.1.144 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DEAD_2 0.76 69.0 4.25e-01 100.0% 18.4%
3784126 196.1.1.1 alpha bundles › Regulator of G-protein signaling, RGS › Regulator of G-protein signaling, RGS › Regulator of G-protein signaling, RGS › RGS 0.76 68.0 4.87e-01 100.0% 43.1%
4562953 2004.1.1.43 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SRP54 0.75 67.0 4.23e-01 100.0% 20.4%
4081214 605.1.1.290 alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › Phage_Nu1 0.75 65.0 6.13e-01 100.0% 81.4%
3999381 174.1.1.31 few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › DUF7027 0.74 68.0 4.79e-01 100.0% 47.6%
3849547 4992.1.1.25 extended segments › RelB-like › RelB-like › RelB-like › SHCBP_N 0.74 64.0 5.51e-01 100.0% 63.2%
3386352 4207.1.1.104 alpha duplicates or obligate multimers › Mediator hinge subcomplex-like › Mediator hinge subcomplex-like › RNA polymerase II holoenzyme component SRB7 (MED21) › Bac_export_2 0.73 59.0 4.79e-01 93.1% 47.3%
3784740 3712.1.1.1 a+b complex topology › Mediator of RNA polymerase II transcription subunit 11 › Mediator of RNA polymerase II transcription subunit 11 › Mediator of RNA polymerase II transcription subunit 11 › Med11 0.72 62.0 5.75e-01 100.0% 77.3%
4026047 310.2.1.0 a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF 0.72 61.0 5.37e-01 98.3% 64.7%
4798159 603.1.1.0 alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.71 61.0 5.68e-01 100.0% 90.8%
4684 192.15.1.2 alpha bundles › Long alpha-hairpin › Endosomal sorting complex assembly domains › Endosomal sorting complex assembly domains › Mod_r 0.71 58.0 5.65e-01 100.0% 84.6%
3697208 604.7.1.0 alpha bundles › Spectrin repeat-like › Tubulin chaperone cofactor A › Tubulin chaperone cofactor A 0.71 60.0 4.79e-01 100.0% 49.6%
4827920 4268.2.1.2 alpha duplicates or obligate multimers › EspA/CesA-like › EspA chaperone CesA › EspA chaperone CesA › Rx_N 0.70 63.0 5.86e-01 100.0% 85.9%
4174467 3291.1.1.0 alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related 0.70 58.0 5.08e-01 100.0% 61.1%
4110261 3748.1.1.2 extended segments › 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain › 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain › 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain › CSN5_C 0.69 59.0 5.27e-01 100.0% 69.4%
3166880 906.1.1.0 few secondary structure elements › CCCH zinc finger › CCCH zinc finger › CCCH zinc finger 0.69 59.0 5.59e-01 100.0% 84.3%
4265467 2486.1.1.6 a/b three-layered sandwiches › ClpP/crotonase › ClpP/crotonase › ClpP/crotonase › ACCA 0.68 57.0 3.63e-01 98.3% 17.3%
3253210 633.6.1.2 alpha bundles › Bromodomain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA dehydrogenase C-terminal domain-like › ACOX 0.68 59.0 4.12e-01 100.0% 33.3%
4029478 604.7.1.0 alpha bundles › Spectrin repeat-like › Tubulin chaperone cofactor A › Tubulin chaperone cofactor A 0.68 58.0 4.81e-01 100.0% 54.3%
4223425 4006.1.1.1 alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF 0.68 57.0 4.84e-01 100.0% 58.1%
4951266 2004.1.1.87 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N 0.67 54.0 3.22e-01 100.0% 12.7%
3862724 605.1.1.0 alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase 0.67 58.0 4.83e-01 100.0% 65.7%
4066758 4006.1.1.1 alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF 0.67 54.0 4.68e-01 100.0% 56.0%
4060910 4006.1.1.1 alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF 0.65 55.0 4.69e-01 100.0% 58.1%
3876590 3291.1.1.0 alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related 0.65 56.0 4.99e-01 100.0% 70.6%
3915380 192.5.1.25 alpha bundles › Long alpha-hairpin › HR1 repeat › HR1 repeat › PTHB1_hp 0.64 54.0 4.81e-01 100.0% 65.6%
4200274 4006.1.1.1 alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF 0.64 51.0 4.38e-01 100.0% 53.3%
3814771 192.8.1.0 alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain 0.63 49.0 4.40e-01 91.4% 58.8%
3501761 5054.1.1.0 alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels 0.61 53.0 3.40e-01 100.0% 19.7%
3857804 3567.1.1.0 a+b duplicates or obligate multimers › MPER trimer › MPER trimer › MPER trimer 0.61 51.0 4.48e-01 98.3% 98.9%
3663990 192.8.1.0 alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain 0.60 50.0 4.78e-01 96.6% 80.0%