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NODE_12_length_310542_cov_175.846709.1__X__X__00267
Bact-VirNODE_12_length_310542_cov_175.846709.1__X__X__00267
Identity
- Kingdom:
- phage
Quality
88.0
mean pLDDT
Cluster
Singleton — not in a non-trivial cluster
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 22-75_113-176
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF18501.8 best | REC1 | 39.7 | 7.40e-10 | 59.3% | 24.6% |
CATH (33)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2q00B00 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.66 | 42.0 | 4.16e-01 | 72.0% | 61.5% |
| 2ic6A00 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.65 | 33.0 | 4.15e-01 | 76.3% | 81.7% |
| 2i0mA02 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.64 | 34.0 | 3.68e-01 | 78.8% | 59.4% |
| 2lm9A00 | 1.20.58.970 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.62 | 34.0 | 3.80e-01 | 79.7% | 66.7% |
| 3tbiB02 | 6.10.140.1670 | Special › Helix non-globular › Helix Hairpins › | 0.61 | 42.0 | 4.49e-01 | 78.0% | 83.0% |
| 3whjA00 | 6.10.140.1710 | Special › Helix non-globular › Helix Hairpins › | 0.59 | 33.0 | 3.41e-01 | 73.7% | 57.7% |
| 2fji101 | 1.10.357.50 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › | 0.59 | 50.0 | 4.07e-01 | 89.8% | 88.0% |
| 2gtsA00 | 1.10.287.850 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HP0062-like domain | 0.59 | 35.0 | 4.27e-01 | 79.7% | 90.9% |
| 1wu3I00 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.58 | 41.0 | 3.72e-01 | 81.4% | 53.4% |
| 3f4mA00 | 1.20.1440.160 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › Tumor necrosis factor alpha-induced protein 8-like | 0.57 | 45.0 | 4.15e-01 | 84.7% | 87.7% |
| 1zvuA03 | 1.10.268.10 | Mainly Alpha › Orthogonal Bundle › Topoisomerase; domain 3 › Topoisomerase, domain 3 | 0.57 | 44.0 | 4.13e-01 | 80.5% | 80.7% |
| 3ejbH02 | 1.10.630.10 | Mainly Alpha › Orthogonal Bundle › Cytochrome p450 › Cytochrome P450 | 0.56 | 46.0 | 3.61e-01 | 100.0% | 40.8% |
| 4v1gA00 | 1.20.20.10 | Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C | 0.56 | 36.0 | 4.22e-01 | 76.3% | 91.8% |
| 1t98A02 | 1.20.58.590 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Chromosome partition protein MukF, middle domain | 0.55 | 50.0 | 4.50e-01 | 99.2% | 86.5% |
| 4dxwA02 | 1.10.287.70 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.55 | 38.0 | 3.95e-01 | 72.0% | 78.6% |
| 4oydB00 | 1.10.132.20 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor | 0.54 | 45.0 | 4.54e-01 | 88.1% | 99.1% |
| 3s84A02 | 1.20.120.20 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Apolipoprotein | 0.54 | 39.0 | 3.58e-01 | 75.4% | 86.0% |
| 6ircA01 | 1.20.1230.10 | Mainly Alpha › Up-down Bundle › Phospholipase C Beta; Chain: A › Phospholipase C beta, distal C-terminal domain | 0.54 | 35.0 | 2.91e-01 | 73.7% | 38.4% |
| 4aflA00 | 6.10.140.1740 | Special › Helix non-globular › Helix Hairpins › | 0.53 | 36.0 | 3.92e-01 | 72.9% | 80.4% |
| 2kiwA01 | 1.10.150.130 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Tyrosine recombinase, N-terminal domain | 0.53 | 34.0 | 3.88e-01 | 71.2% | 88.4% |
| 1sumB01 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.53 | 41.0 | 4.33e-01 | 86.4% | 91.6% |
| 1ydxA02 | 1.10.287.1120 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Bipartite methylase S protein | 0.53 | 34.0 | 3.85e-01 | 83.9% | 86.7% |
| 3vkgA12 | 1.10.287.2610 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.52 | 42.0 | 3.44e-01 | 85.6% | 61.4% |
| 1b5lA00 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.52 | 37.0 | 3.43e-01 | 72.9% | 100.0% |
| 3nbxX03 | 1.20.58.1510 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.52 | 38.0 | 4.05e-01 | 80.5% | 88.1% |
| 6q45G01 | 1.10.287.80 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ATP synthase, gamma subunit, helix hairpin domain | 0.51 | 41.0 | 3.85e-01 | 88.1% | 68.5% |
| 6b8hO01 | 1.10.520.20 | Mainly Alpha › Orthogonal Bundle › Peroxidase; domain 1 › N-terminal domain of the delta subunit of the F1F0-ATP synthase | 0.51 | 36.0 | 3.84e-01 | 74.6% | 85.9% |
| 5xdcB01 | 1.10.540.10 | Mainly Alpha › Orthogonal Bundle › Butyryl-Coa Dehydrogenase, subunit A; domain 1 › Acyl-CoA dehydrogenase/oxidase, N-terminal domain | 0.51 | 32.0 | 3.32e-01 | 78.8% | 66.7% |
| 1m62A00 | 1.20.58.120 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain | 0.51 | 33.0 | 3.76e-01 | 82.2% | 90.8% |
| 1wcrA00 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.51 | 39.0 | 4.16e-01 | 85.6% | 93.2% |
| 3n3wA00 | 1.10.1520.10 | Mainly Alpha › Orthogonal Bundle › Ribonuclease iii, N-terminal Endonuclease Domain; Chain A › Ribonuclease III domain | 0.50 | 36.0 | 3.37e-01 | 74.6% | 59.7% |
| 1f45B00 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.50 | 36.0 | 3.46e-01 | 74.6% | 64.7% |
| 2b5uA02 | 1.10.287.620 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix Hairpins | 0.50 | 41.0 | 3.68e-01 | 86.4% | 68.3% |
ECOD (30)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4267909 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.72 | 41.0 | 3.41e-01 | 86.4% | 33.8% |
| 3720226 | 3860.1.1.0 ↗ | alpha bundles › Myosin VI lever arm › Myosin VI lever arm › Myosin VI lever arm | 0.64 | 31.0 | 3.03e-01 | 71.2% | 40.7% |
| 5013382 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.61 | 46.0 | 3.86e-01 | 80.5% | 50.5% |
| 3424514 | 606.1.1.0 ↗ | alpha complex topology › Nop N-terminal domain › Nop N-terminal domain › Nop N-terminal domain | 0.59 | 45.0 | 4.50e-01 | 83.9% | 78.3% |
| 4086322 | 5086.1.1.205 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › PF30209 | 0.59 | 39.0 | 3.51e-01 | 85.6% | 47.3% |
| 3214189 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.59 | 35.0 | 3.70e-01 | 78.8% | 63.8% |
| 3188597 | 604.12.1.0 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain | 0.59 | 31.0 | 3.52e-01 | 76.3% | 65.6% |
| 4609538 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.56 | 40.0 | 4.13e-01 | 95.8% | 76.5% |
| 3957065 | 3755.1.1.13 ↗ | alpha bundles › YscO-like › Putative type III secretion protein YscO-related › Putative type III secretion protein YscO-related › MMPL | 0.56 | 40.0 | 3.56e-01 | 87.3% | 53.8% |
| 3770066 | 3291.1.1.169 ↗ | alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › KIF21A_4th | 0.56 | 39.0 | 3.28e-01 | 84.7% | 43.6% |
| 3538350 | 3755.1.1.0 ↗ | alpha bundles › YscO-like › Putative type III secretion protein YscO-related › Putative type III secretion protein YscO-related | 0.54 | 42.0 | 3.98e-01 | 80.5% | 94.1% |
| 3739377 | 4177.1.1.1 ↗ | alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › FCH | 0.54 | 42.0 | 3.08e-01 | 81.4% | 65.1% |
| 4968762 | 604.5.1.2 ↗ | alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › PhoU | 0.54 | 45.0 | 4.55e-01 | 94.1% | 91.3% |
| 3715891 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.54 | 41.0 | 3.63e-01 | 79.7% | 84.2% |
| 3968781 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.54 | 41.0 | 3.80e-01 | 85.6% | 64.8% |
| 3788347 | 1075.1.2.0 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type II ABC exporter transmembrane domain-related › MacB transmembrane domain | 0.53 | 46.0 | 4.31e-01 | 96.6% | 76.6% |
| 3562849 | 148.1.3.254 ↗ | alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain › KIF21A_4th | 0.53 | 39.0 | 3.10e-01 | 77.1% | 58.3% |
| 3843224 | 3291.1.1.0 ↗ | alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related | 0.53 | 43.0 | 3.37e-01 | 86.4% | 60.0% |
| 3712411 | 3939.1.1.0 ↗ | alpha duplicates or obligate multimers › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain | 0.52 | 41.0 | 3.14e-01 | 81.4% | 58.4% |
| 4946898 | 375.1.9.0 ↗ | few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Zinc-nucleated domain of serine integrase | 0.52 | 31.0 | 3.78e-01 | 77.1% | 93.3% |
| 3733697 | 4121.1.1.0 ↗ | a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like | 0.52 | 46.0 | 3.11e-01 | 98.3% | 65.8% |
| 4682501 | 4006.1.1.1 ↗ | alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF | 0.52 | 33.0 | 3.57e-01 | 80.5% | 76.0% |
| 3913300 | 3755.3.1.303 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › KIF21A_4th | 0.51 | 40.0 | 3.66e-01 | 80.5% | 87.3% |
| 56672 | 150.3.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › 4-helical cytokines › 4-helical cytokine | 0.51 | 35.0 | 3.31e-01 | 70.3% | 69.9% |
| 3718093 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.51 | 46.0 | 4.13e-01 | 97.5% | 88.1% |
| 3589446 | 2004.1.1.301 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_27 | 0.51 | 41.0 | 2.67e-01 | 85.6% | 20.8% |
| 5050919 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.51 | 41.0 | 4.30e-01 | 88.1% | 100.0% |
| 4959593 | 3755.4.1.0 ↗ | alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain | 0.50 | 41.0 | 3.92e-01 | 88.1% | 93.6% |
| 5063996 | 4121.1.1.1 ↗ | a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like › CorA | 0.50 | 43.0 | 3.52e-01 | 94.9% | 69.3% |
| 3584530 | 5054.1.1.9 ↗ | alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels › PKD_channel | 0.50 | 38.0 | 3.64e-01 | 79.7% | 77.8% |
D2
medium
residues 177-285
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF18501.8 best | REC1 | 66.8 | 4.00e-18 | 95.4% | 47.9% |
CATH (21)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2rldA00 | 1.20.1440.60 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 23S rRNA-intervening sequence | 0.69 | 61.0 | 6.09e-01 | 98.2% | 99.1% |
| 5figA00 | 1.20.1270.360 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.68 | 59.0 | 6.12e-01 | 91.7% | 100.0% |
| 1y4cA03 | 1.20.120.660 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › IL-4 antagonist (De novo design) like domain | 0.66 | 49.0 | 4.91e-01 | 79.8% | 75.2% |
| 2yfaA02 | 1.20.1440.210 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › | 0.65 | 55.0 | 5.45e-01 | 93.6% | 100.0% |
| 4rm7A03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.64 | 56.0 | 5.18e-01 | 97.2% | 93.5% |
| 5zw7A03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.64 | 57.0 | 5.13e-01 | 100.0% | 90.8% |
| 2pg0A03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.64 | 55.0 | 5.03e-01 | 98.2% | 97.3% |
| 4nleA01 | 1.20.200.10 | Mainly Alpha › Up-down Bundle › Fumarase C; Chain A, domain 2 › Fumarase/aspartase (Central domain) | 0.63 | 56.0 | 4.30e-01 | 99.1% | 69.5% |
| 1egdA03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.63 | 54.0 | 4.99e-01 | 96.3% | 95.0% |
| 5iduC03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.62 | 55.0 | 4.89e-01 | 100.0% | 86.8% |
| 4doyA03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.62 | 54.0 | 4.62e-01 | 99.1% | 84.2% |
| 1y9qA01 | 1.10.260.40 | Mainly Alpha › Orthogonal Bundle › 434 Repressor (Amino-terminal Domain) › lambda repressor-like DNA-binding domains | 0.61 | 46.0 | 5.07e-01 | 87.2% | 100.0% |
| 3owaA03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.61 | 53.0 | 4.63e-01 | 99.1% | 95.3% |
| 4od4A02 | 1.20.120.1780 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › UbiA prenyltransferase | 0.58 | 42.0 | 4.13e-01 | 79.8% | 69.7% |
| 3r31A01 | 3.40.605.10 | Alpha Beta › 3-Layer(aba) Sandwich › Aldehyde Dehydrogenase; Chain A, domain 1 › Aldehyde Dehydrogenase; Chain A, domain 1 | 0.56 | 48.0 | 3.72e-01 | 95.4% | 75.1% |
| 4abmD00 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.55 | 37.0 | 4.40e-01 | 97.2% | 97.4% |
| 2wy4A00 | 1.10.490.10 | Mainly Alpha › Orthogonal Bundle › Globin-like › Globins | 0.55 | 41.0 | 3.84e-01 | 79.8% | 96.4% |
| 1jwnA00 | 1.10.490.10 | Mainly Alpha › Orthogonal Bundle › Globin-like › Globins | 0.54 | 46.0 | 4.23e-01 | 96.3% | 100.0% |
| 2h5gB01 | 3.40.605.10 | Alpha Beta › 3-Layer(aba) Sandwich › Aldehyde Dehydrogenase; Chain A, domain 1 › Aldehyde Dehydrogenase; Chain A, domain 1 | 0.53 | 41.0 | 3.17e-01 | 85.3% | 64.6% |
| 5azsC01 | 1.20.1600.10 | Mainly Alpha › Up-down Bundle › Outer membrane efflux proteins (OEP) › Outer membrane efflux proteins (OEP) | 0.53 | 47.0 | 3.26e-01 | 96.3% | 89.4% |
| 1t98A02 | 1.20.58.590 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Chromosome partition protein MukF, middle domain | 0.53 | 37.0 | 3.31e-01 | 73.4% | 78.5% |
ECOD (18)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3833042 | 633.4.1.1 ↗ | alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI | 0.72 | 65.0 | 5.58e-01 | 98.2% | 96.5% |
| 4019714 | 633.21.1.0 ↗ | alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 | 0.72 | 62.0 | 6.06e-01 | 93.6% | 100.0% |
| 3425999 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.72 | 56.0 | 4.58e-01 | 81.7% | 72.6% |
| 3184118 | 633.10.1.0 ↗ | alpha bundles › Bromodomain-like › IVS-encoded protein-like › IVS-encoded protein-like | 0.71 | 62.0 | 5.23e-01 | 94.5% | 71.1% |
| 5075066 | 633.21.1.0 ↗ | alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 | 0.68 | 59.0 | 5.94e-01 | 93.6% | 100.0% |
| 3964011 | 633.21.1.1 ↗ | alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 › DUF326 | 0.68 | 61.0 | 6.13e-01 | 97.2% | 100.0% |
| 2581428 | 633.6.1.1 ↗ | alpha bundles › Bromodomain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA_dh_1 | 0.63 | 54.0 | 4.84e-01 | 98.2% | 97.5% |
| 3988781 | 604.6.1.63 ↗ | alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain › DUF3169 | 0.62 | 43.0 | 4.00e-01 | 70.6% | 95.6% |
| 3228669 | 601.4.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains | 0.61 | 45.0 | 3.95e-01 | 77.1% | 63.0% |
| 4010984 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.60 | 42.0 | 3.37e-01 | 70.6% | 60.6% |
| 5049761 | 633.6.1.1 ↗ | alpha bundles › Bromodomain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA_dh_1 | 0.59 | 51.0 | 4.33e-01 | 98.2% | 69.1% |
| 5051683 | 192.5.1.0 ↗ | alpha bundles › Long alpha-hairpin › HR1 repeat › HR1 repeat | 0.58 | 35.0 | 3.55e-01 | 97.2% | 60.0% |
| 4461599 | 150.5.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › ESAT-6 like › ESAT-6 like | 0.57 | 40.0 | 3.76e-01 | 73.4% | 91.1% |
| 4967801 | 3921.1.1.1 ↗ | alpha complex topology › Na(+)-translocating NADH-quinone reductase subunit D › Na(+)-translocating NADH-quinone reductase subunit D › Na(+)-translocating NADH-quinone reductase subunit D › Rnf-Nqr | 0.53 | 38.0 | 3.21e-01 | 74.3% | 48.1% |
| 4988975 | 5069.1.1.95 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes › Nitrate_red_gam | 0.53 | 39.0 | 3.40e-01 | 78.9% | 66.1% |
| 4626187 | 2484.1.1.21 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › BcrAD_BadFG | 0.52 | 42.0 | 3.22e-01 | 88.1% | 50.0% |
| 3472559 | 150.5.1.93 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › ESAT-6 like › ESAT-6 like › Mito_morph_reg | 0.50 | 39.0 | 3.49e-01 | 82.6% | 85.2% |
| 3467082 | 304.1.1.1 ↗ | a+b two layers › Alpha-beta plaits › GHMP Kinase, C-terminal domain › GHMP Kinase, C-terminal domain › GHMP_kinases_C | 0.50 | 42.0 | 3.64e-01 | 89.9% | 75.2% |
D3
medium
residues 286-331_413-510
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF21918.3 best | cas_Cpf1_2nd | 57.7 | 2.30e-15 | 63.2% | 31.7% |
CATH (49)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 5figA00 | 1.20.1270.360 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.70 | 48.0 | 5.58e-01 | 86.1% | 100.0% |
| 1cnt200 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.66 | 42.0 | 4.43e-01 | 87.5% | 70.0% |
| 1wfdA00 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.64 | 39.0 | 4.64e-01 | 72.2% | 91.4% |
| 4u7iA00 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.64 | 40.0 | 4.83e-01 | 70.1% | 97.8% |
| 1w07A03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.63 | 52.0 | 4.95e-01 | 88.2% | 92.9% |
| 6jpaE00 | 1.20.140.150 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › | 0.63 | 54.0 | 5.18e-01 | 93.8% | 93.5% |
| 1ciyA01 | 1.20.190.10 | Mainly Alpha › Up-down Bundle › Delta-Endotoxin; domain 1 › Pesticidal crystal protein, N-terminal domain | 0.62 | 50.0 | 4.36e-01 | 85.4% | 61.5% |
| 7zxkC01 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.62 | 44.0 | 4.40e-01 | 94.4% | 70.7% |
| 2a3qA00 | 1.10.287.1080 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › MazG-like | 0.61 | 38.0 | 4.18e-01 | 96.5% | 77.0% |
| 4ie5A02 | 1.20.58.1470 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › FTO C-terminal domain | 0.61 | 40.0 | 4.17e-01 | 77.8% | 70.9% |
| 6dlzA01 | 1.20.140.150 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › | 0.61 | 51.0 | 4.75e-01 | 90.3% | 99.4% |
| 1z23A00 | 1.20.120.830 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Serine-rich domain | 0.61 | 43.0 | 4.13e-01 | 70.8% | 70.6% |
| 8cdaB03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.61 | 51.0 | 4.96e-01 | 90.3% | 95.0% |
| 1lkoA01 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.61 | 45.0 | 4.51e-01 | 91.7% | 75.2% |
| 1rj1A00 | 1.20.140.40 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Invertase/pectin methylesterase inhibitor family protein | 0.60 | 52.0 | 5.18e-01 | 96.5% | 91.2% |
| 2jqqA00 | 1.20.58.1240 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.60 | 42.0 | 4.14e-01 | 87.5% | 66.2% |
| 2yw6B00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.60 | 45.0 | 4.46e-01 | 91.7% | 74.7% |
| 1jvmB00 | 1.10.287.70 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.59 | 39.0 | 4.51e-01 | 93.8% | 96.0% |
| 3axjB02 | 1.20.58.200 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 2 | 0.59 | 33.0 | 4.09e-01 | 70.1% | 90.6% |
| 2k73A00 | 1.20.1550.10 | Mainly Alpha › Up-down Bundle › Bromodomain-like › DsbB-like | 0.59 | 51.0 | 4.73e-01 | 94.4% | 92.3% |
| 2gtaA00 | 1.10.287.1080 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › MazG-like | 0.58 | 34.0 | 3.95e-01 | 94.4% | 82.5% |
| 2crbA00 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.58 | 34.0 | 4.06e-01 | 72.9% | 85.6% |
| 1oahA02 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.58 | 42.0 | 4.28e-01 | 78.5% | 76.8% |
| 2dnxA00 | 1.20.58.70 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.57 | 41.0 | 4.27e-01 | 72.9% | 91.5% |
| 4cmyA00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.57 | 44.0 | 4.28e-01 | 92.4% | 71.8% |
| 3unoE00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.57 | 43.0 | 4.14e-01 | 91.7% | 67.7% |
| 1wrdA00 | 1.20.58.160 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.57 | 38.0 | 4.34e-01 | 72.2% | 96.9% |
| 1qdbA02 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.57 | 40.0 | 4.04e-01 | 77.1% | 72.0% |
| 2i0mA01 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.56 | 35.0 | 4.00e-01 | 100.0% | 84.9% |
| 1v9dB00 | 1.20.58.2220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Formin, FH2 domain | 0.56 | 42.0 | 3.33e-01 | 79.9% | 73.8% |
| 6p73A02 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.56 | 38.0 | 3.88e-01 | 75.0% | 70.6% |
| 4egwA02 | 1.20.58.340 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Magnesium transport protein CorA, transmembrane region | 0.55 | 40.0 | 4.30e-01 | 74.3% | 94.1% |
| 2vkjA00 | 1.20.58.2030 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.55 | 27.0 | 3.11e-01 | 75.0% | 61.3% |
| 1s3qG00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.54 | 41.0 | 4.01e-01 | 91.0% | 70.6% |
| 2jbwA01 | 1.20.1440.110 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › acylaminoacyl peptidase | 0.54 | 33.0 | 3.76e-01 | 85.4% | 81.6% |
| 1ugoA00 | 1.20.58.120 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain | 0.54 | 34.0 | 3.96e-01 | 75.0% | 89.9% |
| 1oj7A02 | 1.20.1090.10 | Mainly Alpha › Up-down Bundle › Dehydroquinate synthase-like, alpha domain › Dehydroquinate synthase-like - alpha domain | 0.54 | 36.0 | 3.25e-01 | 77.1% | 48.0% |
| 4gc0A01 | 1.20.1250.20 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains | 0.54 | 46.0 | 3.85e-01 | 92.4% | 83.5% |
| 1e7pC00 | 1.20.1300.10 | Mainly Alpha › Up-down Bundle › 3 helical TM bundles of succinate and fumarate reductases › Fumarate reductase/succinate dehydrogenase, transmembrane subunit | 0.54 | 38.0 | 3.18e-01 | 71.5% | 67.3% |
| 7e84A03 | 1.10.287.70 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.54 | 37.0 | 4.00e-01 | 95.1% | 82.9% |
| 4rngC00 | 1.20.1280.290 | Mainly Alpha › Up-down Bundle › Monooxygenase › | 0.54 | 29.0 | 3.73e-01 | 97.2% | 91.6% |
| 4iggB02 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.53 | 38.0 | 4.11e-01 | 74.3% | 89.3% |
| 2r6tB01 | 1.20.1200.10 | Mainly Alpha › Up-down Bundle › Hypothetical Protein Ta1238; Chain: A; › Cobalamin adenosyltransferase-like | 0.53 | 42.0 | 4.01e-01 | 91.7% | 72.3% |
| 1t72A02 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.53 | 35.0 | 4.03e-01 | 75.7% | 96.9% |
| 1sumB02 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.53 | 37.0 | 4.02e-01 | 72.2% | 98.3% |
| 3purA03 | 1.20.58.1360 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.52 | 37.0 | 4.12e-01 | 79.9% | 95.5% |
| 1m56C02 | 1.20.120.80 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c oxidase, subunit III, four-helix bundle | 0.51 | 42.0 | 3.86e-01 | 89.6% | 77.6% |
| 2l6jA00 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.50 | 32.0 | 3.55e-01 | 91.7% | 81.1% |
| 1fewA00 | 1.20.58.70 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.50 | 35.0 | 3.36e-01 | 71.5% | 81.5% |
ECOD (64)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4017168 | 150.1.1.114 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › PF30036 | 0.70 | 60.0 | 5.90e-01 | 91.7% | 96.8% |
| 3221127 | 633.21.1.0 ↗ | alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 | 0.68 | 58.0 | 5.65e-01 | 92.4% | 95.0% |
| 3765032 | 633.23.1.34 ↗ | alpha bundles › Bromodomain-like › Claudin › Claudin › CD20 | 0.68 | 58.0 | 5.84e-01 | 92.4% | 97.2% |
| 3183672 | 174.1.1.0 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain | 0.67 | 56.0 | 5.60e-01 | 91.7% | 98.0% |
| 3918623 | 174.1.1.43 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › CD20 | 0.67 | 57.0 | 5.72e-01 | 92.4% | 93.8% |
| 3619883 | 633.23.1.0 ↗ | alpha bundles › Bromodomain-like › Claudin › Claudin | 0.67 | 56.0 | 5.67e-01 | 89.6% | 95.7% |
| 4557092 | 633.23.1.32 ↗ | alpha bundles › Bromodomain-like › Claudin › Claudin › CASP_dom | 0.66 | 56.0 | 5.62e-01 | 91.7% | 99.3% |
| 3213348 | 633.23.1.22 ↗ | alpha bundles › Bromodomain-like › Claudin › Claudin › MARVEL | 0.66 | 56.0 | 5.74e-01 | 89.6% | 97.8% |
| 4241363 | 3636.1.1.0 ↗ | a+b two layers › XPD arch domain › XPD arch domain › XPD arch domain | 0.66 | 58.0 | 5.37e-01 | 95.8% | 88.1% |
| 3913234 | 633.21.1.23 ↗ | alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 › CD20 | 0.66 | 56.0 | 5.80e-01 | 93.1% | 97.8% |
| 3192001 | 633.23.1.22 ↗ | alpha bundles › Bromodomain-like › Claudin › Claudin › MARVEL | 0.66 | 55.0 | 5.62e-01 | 89.6% | 98.6% |
| 5066783 | 150.1.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin | 0.66 | 59.0 | 5.62e-01 | 96.5% | 91.5% |
| 3617743 | 633.21.1.0 ↗ | alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 | 0.66 | 56.0 | 5.64e-01 | 91.7% | 99.3% |
| 3520105 | 174.1.1.0 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain | 0.66 | 57.0 | 5.57e-01 | 93.1% | 87.7% |
| 54240 | 633.7.1.0 ↗ | alpha bundles › Bromodomain-like › Bacillus cereus metalloprotein-like › Bacillus cereus metalloprotein-like | 0.66 | 54.0 | 5.59e-01 | 89.6% | 96.2% |
| 3996622 | 174.1.1.0 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain | 0.65 | 55.0 | 5.49e-01 | 93.8% | 88.3% |
| 3923182 | 174.1.1.43 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › CD20 | 0.65 | 56.0 | 5.54e-01 | 92.4% | 92.7% |
| 3704559 | 174.1.1.32 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Transmemb_17 | 0.65 | 54.0 | 5.37e-01 | 91.7% | 85.6% |
| 3194196 | 633.23.1.22 ↗ | alpha bundles › Bromodomain-like › Claudin › Claudin › MARVEL | 0.65 | 55.0 | 5.56e-01 | 91.0% | 95.7% |
| 3326634 | 633.4.1.1 ↗ | alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI | 0.64 | 57.0 | 5.34e-01 | 97.2% | 89.1% |
| 4525096 | 633.4.1.1 ↗ | alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI | 0.64 | 57.0 | 5.46e-01 | 97.2% | 88.5% |
| 4152787 | 601.14.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Hemerythrin › Hemerythrin | 0.64 | 54.0 | 5.08e-01 | 93.1% | 91.7% |
| 3490929 | 133.1.1.0 ↗ | alpha bundles › DH domain-like › DBL homology domain (DH-domain) › DBL homology domain (DH-domain) | 0.63 | 54.0 | 4.33e-01 | 94.4% | 81.4% |
| 3724935 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.62 | 44.0 | 4.46e-01 | 73.6% | 93.1% |
| 3596769 | 174.1.1.0 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain | 0.62 | 53.0 | 5.31e-01 | 93.1% | 93.1% |
| 3245184 | 601.14.1.3 ↗ | alpha bundles › Four-helical up-and-down bundle › Hemerythrin › Hemerythrin › PF31009 | 0.62 | 51.0 | 5.17e-01 | 90.3% | 98.6% |
| 3868848 | 601.1.2.47 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › MARVEL | 0.62 | 52.0 | 5.45e-01 | 90.3% | 100.0% |
| 3939799 | 174.1.1.0 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain | 0.61 | 51.0 | 5.21e-01 | 91.0% | 100.0% |
| 4878354 | 5057.1.1.1 ↗ | alpha bundles › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore › Neur_chan_memb | 0.60 | 37.0 | 4.40e-01 | 76.4% | 94.6% |
| 3801787 | 604.5.1.39 ↗ | alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › PF26581 | 0.59 | 41.0 | 4.22e-01 | 70.1% | 100.0% |
| 3511717 | 601.15.1.2 ↗ | alpha bundles › Four-helical up-and-down bundle › Proteasome activator reg(alpha) › Proteasome activator reg(alpha) › PA28_C | 0.59 | 41.0 | 3.77e-01 | 71.5% | 67.7% |
| 3933939 | 626.1.1.1 ↗ | alpha complex topology › Formin homology 2 domain (FH2 domain) › Formin homology 2 domain (FH2 domain) › Formin homology 2 domain (FH2 domain) › FH2 | 0.59 | 44.0 | 3.41e-01 | 79.2% | 71.5% |
| 3218065 | 3684.1.1.0 ↗ | alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like | 0.59 | 41.0 | 4.18e-01 | 70.8% | 72.9% |
| 3688934 | 603.2.1.23 ↗ | alpha bundles › STAT-like › STAT › STAT › DUF7607 | 0.59 | 38.0 | 4.25e-01 | 98.6% | 84.5% |
| 3736340 | 622.1.1.7 ↗ | alpha bundles › YvfG-like › HSC20 (HSCB), C-terminal oligomerisation domain › HSC20 (HSCB), C-terminal oligomerisation domain › DUF7607 | 0.58 | 38.0 | 4.19e-01 | 100.0% | 82.6% |
| 4943286 | 633.10.1.0 ↗ | alpha bundles › Bromodomain-like › IVS-encoded protein-like › IVS-encoded protein-like | 0.58 | 51.0 | 5.08e-01 | 96.5% | 100.0% |
| 3711574 | 3755.1.1.0 ↗ | alpha bundles › YscO-like › Putative type III secretion protein YscO-related › Putative type III secretion protein YscO-related | 0.58 | 40.0 | 3.48e-01 | 70.1% | 74.8% |
| 4011171 | 192.15.1.126 ↗ | alpha bundles › Long alpha-hairpin › Endosomal sorting complex assembly domains › Endosomal sorting complex assembly domains › DUF7607 | 0.58 | 38.0 | 4.20e-01 | 100.0% | 82.6% |
| 3578418 | 604.12.1.0 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain | 0.58 | 47.0 | 4.88e-01 | 89.6% | 94.8% |
| 1411937 | 150.1.1.1 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › Ferritin | 0.57 | 44.0 | 4.28e-01 | 92.4% | 71.8% |
| 3968786 | 7516.1.1.102 ↗ | a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Glycos_transf_2, Glyco_trans_2_3 | 0.57 | 49.0 | 3.30e-01 | 93.8% | 53.3% |
| 2980596 | 150.1.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin | 0.56 | 43.0 | 4.05e-01 | 91.0% | 65.0% |
| 3893919 | 604.3.1.0 ↗ | alpha bundles › Spectrin repeat-like › BAG domain › BAG domain | 0.56 | 37.0 | 4.31e-01 | 70.8% | 100.0% |
| 5052771 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.55 | 38.0 | 4.21e-01 | 74.3% | 87.8% |
| 4567957 | 603.1.1.0 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins | 0.55 | 39.0 | 4.24e-01 | 75.7% | 90.4% |
| 3887313 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.55 | 38.0 | 4.15e-01 | 70.1% | 97.4% |
| 3236786 | 174.1.1.0 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain | 0.55 | 47.0 | 4.75e-01 | 93.1% | 94.3% |
| 4191463 | 150.1.1.1 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › Ferritin | 0.55 | 41.0 | 3.96e-01 | 91.0% | 67.9% |
| 3591388 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.55 | 39.0 | 4.04e-01 | 72.9% | 97.0% |
| 3983403 | 622.4.1.0 ↗ | alpha bundles › YvfG-like › Mite allergen Der p 5-related › Mite allergen Der p 5-related | 0.55 | 38.0 | 3.55e-01 | 70.1% | 85.9% |
| 4022273 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.55 | 40.0 | 4.06e-01 | 76.4% | 94.5% |
| 4031338 | 605.1.1.304 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › DUF443 | 0.55 | 33.0 | 3.64e-01 | 94.4% | 73.9% |
| 3980693 | 3755.3.1.15 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › MscS_porin | 0.54 | 47.0 | 3.83e-01 | 94.4% | 86.5% |
| 4369332 | 5039.1.1.1 ↗ | alpha bundles › Cytochrome c oxidase subunit III-like › Cytochrome c oxidase subunit III-like › Cytochrome c oxidase subunit III-like › COX3 | 0.54 | 45.0 | 4.14e-01 | 89.6% | 75.0% |
| 3865201 | 150.3.1.1 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › 4-helical cytokines › 4-helical cytokine › Hormone_1 | 0.54 | 48.0 | 4.24e-01 | 97.9% | 66.7% |
| 3228159 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.54 | 39.0 | 3.86e-01 | 74.3% | 73.3% |
| 3871897 | 150.3.1.1 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › 4-helical cytokines › 4-helical cytokine › Hormone_1 | 0.53 | 48.0 | 4.25e-01 | 99.3% | 67.6% |
| 3440148 | 611.7.1.2 ↗ | alpha bundles › N-cbl like › Mixed lineage kinase domain-like (MLKL) N-terminal domain › Mixed lineage kinase domain-like (MLKL) N-terminal domain › MCAfunc | 0.53 | 32.0 | 3.38e-01 | 93.8% | 63.7% |
| 3488291 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.53 | 38.0 | 4.24e-01 | 73.6% | 100.0% |
| 4933774 | 5069.1.1.0 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes | 0.52 | 45.0 | 3.83e-01 | 95.1% | 82.9% |
| 3830706 | 5050.1.1.25 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › TLC | 0.50 | 43.0 | 3.65e-01 | 91.7% | 97.0% |
| 3544536 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.50 | 35.0 | 4.00e-01 | 82.6% | 98.1% |
| 3177793 | 603.1.1.0 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins | 0.50 | 35.0 | 3.62e-01 | 71.5% | 94.3% |
| 3297359 | 604.5.1.7 ↗ | alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › ALMT | 0.50 | 36.0 | 3.97e-01 | 74.3% | 96.5% |
D4
medium
residues 332-412
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF21918.3 best | cas_Cpf1_2nd | 45.5 | 1.20e-11 | 97.5% | 33.0% |
CATH (11)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 5zr4A01 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.64 | 50.0 | 4.62e-01 | 82.7% | 98.0% |
| 3tp3A02 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.59 | 40.0 | 3.34e-01 | 70.4% | 74.3% |
| 3fkeA01 | 1.10.8.950 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Filoviridae VP35, C-terminal inhibitory domain, helical subdomain | 0.55 | 35.0 | 3.71e-01 | 91.4% | 73.2% |
| 2xzmV01 | 1.10.60.20 | Mainly Alpha › Orthogonal Bundle › Diphtheria Toxin Repressor; domain 2 › Ribosomal protein S17 | 0.55 | 33.0 | 3.68e-01 | 79.0% | 78.7% |
| 1l1lA01 | 3.20.70.20 | Alpha Beta › Alpha-Beta Barrel › Anaerobic Ribonucleotide-triphosphate Reductase Large Chain › | 0.54 | 43.0 | 2.71e-01 | 91.4% | 82.0% |
| 8adbA01 | 3.90.70.120 | Alpha Beta › Alpha-Beta Complex › Cathepsin B; Chain A › | 0.52 | 40.0 | 3.10e-01 | 85.2% | 88.4% |
| 3ejbH02 | 1.10.630.10 | Mainly Alpha › Orthogonal Bundle › Cytochrome p450 › Cytochrome P450 | 0.52 | 40.0 | 2.85e-01 | 84.0% | 60.3% |
| 1e3pA02 | 1.10.10.400 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Polyribonucleotide nucleotidyltransferase, RNA-binding domain | 0.52 | 34.0 | 3.39e-01 | 70.4% | 63.9% |
| 2a5yB01 | 1.10.533.10 | Mainly Alpha › Orthogonal Bundle › Death Domain, Fas › Death Domain, Fas | 0.52 | 44.0 | 4.03e-01 | 97.5% | 83.5% |
| 4ztkA00 | 3.40.710.10 | Alpha Beta › 3-Layer(aba) Sandwich › Beta-lactamase › DD-peptidase/beta-lactamase superfamily | 0.51 | 42.0 | 3.01e-01 | 95.1% | 84.3% |
| 2r5uC00 | 1.10.860.10 | Mainly Alpha › Orthogonal Bundle › DNAb Helicase; Chain A › DNAb Helicase; Chain A | 0.51 | 38.0 | 3.24e-01 | 96.3% | 47.8% |
ECOD (10)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1830960 | 1071.1.1.1 ↗ | alpha complex topology › CRISPR-associated endonuclease Cpf1 second helical domain › CRISPR-associated endonuclease Cpf1 second helical domain › CRISPR-associated endonuclease Cpf1 second helical domain › cas_Cpf1_2nd | 0.76 | 70.0 | 5.09e-01 | 100.0% | 39.1% |
| 3930371 | 190.1.1.0 ↗ | alpha arrays › HMG-box-like › HMG-box › HMG-box | 0.66 | 43.0 | 3.34e-01 | 70.4% | 31.2% |
| 5037974 | 4004.1.1.1 ↗ | beta sandwiches › NAD kinase beta sandwich domain-like › NAD kinase beta sandwich domain-like › NAD kinase beta sandwich domain-like › YegS_C | 0.65 | 44.0 | 3.37e-01 | 70.4% | 81.1% |
| 4993180 | 183.1.1.1 ↗ | alpha duplicates or obligate multimers › Iron-dependent repressor protein, dimerization domain › Iron-dependent repressor protein, dimerization domain › Iron-dependent repressor protein, dimerization domain › Fe_dep_repr_C | 0.63 | 50.0 | 4.34e-01 | 88.9% | 99.2% |
| 4351860 | 101.8.1.2 ↗ | alpha arrays › HTH › An anticodon-binding domain of class I aminoacyl-tRNA synthetases › An anticodon-binding domain of class I aminoacyl-tRNA synthetases › Anticodon_2 | 0.53 | 40.0 | 3.30e-01 | 88.9% | 43.5% |
| 4045980 | 2007.1.14.3 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Chelatase-like › Ferrochelatase | 0.53 | 42.0 | 3.46e-01 | 87.7% | 60.7% |
| 4991809 | 206.1.3.3 ↗ | a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › PPDK_N | 0.52 | 43.0 | 2.86e-01 | 97.5% | 59.0% |
| 4524125 | 1037.1.1.1 ↗ | alpha bundles › Prolipoprotein diacylglyceryl transferase › Prolipoprotein diacylglyceryl transferase › Prolipoprotein diacylglyceryl transferase › LGT | 0.52 | 42.0 | 3.15e-01 | 95.1% | 47.8% |
| 2485687 | 4953.2.1.0 ↗ | beta barrels › L-aspartase C-terminal domain-like › Lid-like insertion of Propionyl-CoA synthase (PCS) ligase domain › Lid-like insertion of Propionyl-CoA synthase (PCS) ligase domain | 0.50 | 42.0 | 4.17e-01 | 93.8% | 92.9% |
| 4472146 | 108.1.1.0 ↗ | alpha arrays › EF-hand › EF-hand-related › EF-hand | 0.50 | 43.0 | 4.03e-01 | 96.3% | 96.0% |
D5
medium
residues 511-597_656-702
Domain cluster:
representative
CATH (1)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3vn5A02 | 3.30.420.10 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H | 0.62 | 34.0 | 3.03e-01 | 86.6% | 38.2% |
ECOD (3)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4888772 | 2.21.1.0 ↗ | beta barrels › OB-fold › Small protein B (SmpB) › Small protein B (SmpB) | 0.91 | 66.0 | 4.93e-01 | 100.0% | 34.3% |
| 3814715 | 319.1.1.1 ↗ | beta sandwiches › HSP20-like › HSP20-like chaperones › HSP20-like chaperones › HSP20 | 0.62 | 26.0 | 2.93e-01 | 85.8% | 48.0% |
| 1837658 | 2484.1.1.16 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RNase_HII | 0.61 | 34.0 | 3.07e-01 | 93.3% | 39.4% |
D6
medium
residues 598-655
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF22222.2 best | Cpf1_PI-like | 61.6 | 1.20e-16 | 100.0% | 60.4% |
CATH (2)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2lpeA01 | 6.10.140.1120 | Special › Helix non-globular › Helix Hairpins › | 0.59 | 42.0 | 3.93e-01 | 79.3% | 80.8% |
| 7ud0A01 | 1.10.579.10 | Mainly Alpha › Orthogonal Bundle › DNA Cyclobutane Dipyrimidine Photolyase, subunit A; domain 3 › DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3 | 0.54 | 47.0 | 3.23e-01 | 94.8% | 93.7% |
D7
medium
residues 752-823
Domain cluster:
representative
CATH (6)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3w1eA03 | 2.40.10.410 | Mainly Beta › Beta Barrel › Thrombin, subunit H › FlgT, C-terminal domain | 0.58 | 46.0 | 4.31e-01 | 87.5% | 75.3% |
| 4c97A02 | 3.30.70.1900 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.54 | 45.0 | 3.69e-01 | 93.1% | 72.4% |
| 1ci3M02 | 2.40.50.100 | Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain | 0.53 | 28.0 | 3.00e-01 | 75.0% | 55.2% |
| 1g8lA04 | 2.40.340.10 | Mainly Beta › Beta Barrel › Beta-clip › MoeA, C-terminal, domain IV | 0.53 | 36.0 | 3.66e-01 | 100.0% | 71.6% |
| 2jkgA00 | 3.30.450.30 | Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › Dynein light chain 2a, cytoplasmic | 0.52 | 39.0 | 3.11e-01 | 84.7% | 67.3% |
| 1aroP05 | 1.10.150.20 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › 5' to 3' exonuclease, C-terminal subdomain | 0.50 | 41.0 | 3.01e-01 | 93.1% | 52.2% |
ECOD (10)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3638157 | 207.1.1.0 ↗ | beta duplicates or obligate multimers › Single-stranded right-handed beta-helix › Leucine-rich repeats › Leucine-rich repeats | 0.52 | 40.0 | 2.69e-01 | 84.7% | 21.9% |
| 3512923 | 223.1.1.0 ↗ | a+b three layers › Profilin-like › sensor domains › sensor domains | 0.52 | 40.0 | 3.26e-01 | 83.3% | 70.0% |
| 4250601 | 186.1.1.0 ↗ | alpha arrays › lambda integrase-N-like › lambda integrase-N › lambda integrase-N | 0.52 | 42.0 | 3.22e-01 | 88.9% | 65.3% |
| 3880796 | 5001.1.1.1 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1 | 0.52 | 39.0 | 2.60e-01 | 86.1% | 85.7% |
| 3501234 | 5001.1.1.1 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1 | 0.52 | 39.0 | 2.64e-01 | 86.1% | 88.5% |
| 4928248 | 101.1.2.0 ↗ | alpha arrays › HTH › HTH › winged helix domain | 0.51 | 35.0 | 2.97e-01 | 70.8% | 91.5% |
| 4002132 | 5001.1.1.1 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1 | 0.51 | 38.0 | 2.60e-01 | 84.7% | 89.2% |
| 3794379 | 3935.1.1.0 ↗ | extended segments › 4E-BP2 › 4E-BP2 › 4E-BP2 | 0.51 | 30.0 | 3.38e-01 | 77.8% | 82.0% |
| 3196868 | 378.1.1.9 ↗ | few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases › HNH_2 | 0.51 | 38.0 | 3.17e-01 | 83.3% | 86.7% |
| 3188358 | 206.1.1.1 ↗ | a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase | 0.51 | 35.0 | 2.26e-01 | 73.6% | 39.2% |
D8
medium
residues 842-889_1018-1037
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF18516.8 best | RuvC_1 | 46.4 | 4.50e-12 | 69.1% | 17.2% |
CATH (5)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4gs5A01 | 3.40.50.12780 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › ANL, N-terminal domain | 0.57 | 45.0 | 3.18e-01 | 89.7% | 82.8% |
| 2xefA01 | 3.40.630.10 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Zn peptidases | 0.54 | 39.0 | 2.64e-01 | 80.9% | 93.6% |
| 1di2A00 | 3.30.160.20 | Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › | 0.53 | 29.0 | 2.97e-01 | 70.6% | 50.7% |
| 1ii2B01 | 3.40.449.10 | Alpha Beta › 3-Layer(aba) Sandwich › Phosphoenolpyruvate Carboxykinase; domain 1 › Phosphoenolpyruvate Carboxykinase, domain 1 | 0.51 | 38.0 | 2.85e-01 | 80.9% | 78.1% |
| 1ylhA01 | 3.40.449.10 | Alpha Beta › 3-Layer(aba) Sandwich › Phosphoenolpyruvate Carboxykinase; domain 1 › Phosphoenolpyruvate Carboxykinase, domain 1 | 0.51 | 35.0 | 2.53e-01 | 72.1% | 55.8% |
ECOD (6)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3721350 | 312.1.1.11 ↗ | a+b three layers › HIT-like › HIT-related › HIT-related › Ap4A_phos_N | 0.55 | 42.0 | 3.15e-01 | 83.8% | 99.4% |
| 4873705 | 71.1.1.2 ↗ | beta meanders › Lipoprotein localization factors LolAB › Lipoprotein localization factors LolAB › Lipoprotein localization factors LolAB › LolA | 0.54 | 37.0 | 3.10e-01 | 72.1% | 97.7% |
| 5024396 | 239.4.1.1 ↗ | beta barrels › Ribosomal protein L25-like › Glutamine synthetase, N-terminal domain › Glutamine synthetase, N-terminal domain › Gln-synt_N | 0.54 | 39.0 | 3.51e-01 | 77.9% | 89.0% |
| 3669158 | 219.1.1.16 ↗ | a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C48 | 0.54 | 46.0 | 3.12e-01 | 92.6% | 55.7% |
| 5075798 | 3740.1.1.4 ↗ | alpha arrays › F420-reducing hydrogenase subunit beta › F420-reducing hydrogenase subunit beta › F420-reducing hydrogenase subunit beta › FrhB_FdhB_C | 0.53 | 37.0 | 2.55e-01 | 76.5% | 22.5% |
| 4944695 | 327.5.1.0 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › a+b domain in acetyl-CoA synthetase-like proteins › a+b domain in acetyl-CoA synthetase-like proteins | 0.52 | 31.0 | 2.68e-01 | 79.4% | 37.3% |
D9
medium
residues 890-1017
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF18516.8 best | RuvC_1 | 160.2 | 7.90e-47 | 100.0% | 52.0% |
CATH (6)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 5lbmA00 | 1.20.58.1000 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Metal-sensitive repressor, helix protomer | 0.66 | 38.0 | 4.68e-01 | 87.5% | 89.2% |
| 4adzA00 | 1.20.58.1000 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Metal-sensitive repressor, helix protomer | 0.62 | 41.0 | 4.83e-01 | 72.7% | 95.6% |
| 3a8pA02 | 6.10.140.680 | Special › Helix non-globular › Helix Hairpins › | 0.59 | 44.0 | 4.65e-01 | 76.6% | 91.2% |
| 2r1iA01 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.54 | 36.0 | 3.59e-01 | 72.7% | 66.2% |
| 4wr4A02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.51 | 33.0 | 3.60e-01 | 93.0% | 80.0% |
| 3mfnB00 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.50 | 35.0 | 3.56e-01 | 71.1% | 95.2% |
ECOD (10)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3954762 | 3826.1.1.1 ↗ | alpha bundles › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) › Trns_repr_metal | 0.64 | 40.0 | 4.86e-01 | 92.2% | 96.4% |
| 3950461 | 3826.1.1.1 ↗ | alpha bundles › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) › Trns_repr_metal | 0.58 | 42.0 | 4.67e-01 | 96.9% | 94.0% |
| 3222586 | 109.4.1.235 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › SRP68 | 0.56 | 48.0 | 3.87e-01 | 90.6% | 73.2% |
| 3608809 | 2006.1.6.0 ↗ | a/b three-layered sandwiches › HAD domain-like › HAD domain-related › vWA-like | 0.54 | 35.0 | 3.23e-01 | 89.8% | 48.0% |
| 3710423 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.53 | 37.0 | 3.82e-01 | 71.9% | 96.0% |
| 3704864 | 603.1.1.0 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins | 0.53 | 37.0 | 3.82e-01 | 71.1% | 97.5% |
| 3270682 | 109.4.1.532 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › DUF4704 | 0.53 | 47.0 | 3.14e-01 | 100.0% | 23.5% |
| 3304272 | 109.4.1.1257 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR_1, PPR_2 | 0.53 | 40.0 | 3.85e-01 | 91.4% | 68.0% |
| 3611089 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.52 | 37.0 | 3.81e-01 | 75.0% | 96.0% |
| 3238219 | 109.4.1.177 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Cnd3 | 0.51 | 45.0 | 2.68e-01 | 98.4% | 18.6% |
D10
medium
residues 1047-1168
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF18510.8 best | NUC | 92.3 | 6.80e-26 | 100.0% | 74.8% |
CATH (2)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1sjwA00 | 3.10.450.50 | Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › | 0.53 | 38.0 | 3.61e-01 | 97.5% | 64.1% |
| 3fehA02 | 2.30.29.30 | Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) | 0.50 | 30.0 | 3.01e-01 | 88.5% | 56.5% |
ECOD (4)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1830958 | 1068.1.1.1 ↗ | few secondary structure elements › CRISPR-associated endonuclease Cpf1 nuclease domain › CRISPR-associated endonuclease Cpf1 nuclease domain › CRISPR-associated endonuclease Cpf1 nuclease domain › NUC | 0.90 | 87.0 | 7.46e-01 | 100.0% | 76.1% |
| 1830976 | 1068.1.1.1 ↗ | few secondary structure elements › CRISPR-associated endonuclease Cpf1 nuclease domain › CRISPR-associated endonuclease Cpf1 nuclease domain › CRISPR-associated endonuclease Cpf1 nuclease domain › NUC | 0.87 | 82.0 | 7.23e-01 | 100.0% | 72.3% |
| 2468447 | 1068.1.1.1 ↗ | few secondary structure elements › CRISPR-associated endonuclease Cpf1 nuclease domain › CRISPR-associated endonuclease Cpf1 nuclease domain › CRISPR-associated endonuclease Cpf1 nuclease domain › NUC | 0.85 | 80.0 | 7.17e-01 | 100.0% | 76.8% |
| 4615629 | 4.1.1.449 ↗ | beta barrels › SH3 › SH3 › SH3 › DUF1292 | 0.57 | 32.0 | 3.77e-01 | 90.2% | 80.0% |
D11
medium
residues 1201-1256
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF18516.8 best | RuvC_1 | 43.3 | 3.90e-11 | 94.6% | 21.7% |
CATH (10)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 7vwtA01 | 1.10.600.10 | Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase | 0.64 | 44.0 | 2.78e-01 | 73.2% | 15.2% |
| 1e1hB01 | 1.20.58.540 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.62 | 52.0 | 4.29e-01 | 94.6% | 87.4% |
| 3gvpA01 | 3.40.50.1480 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Adenosylhomocysteinase-like | 0.62 | 50.0 | 3.27e-01 | 89.3% | 84.0% |
| 3vkgA11 | 1.20.920.20 | Mainly Alpha › Up-down Bundle › Histone Acetyltransferase; Chain A › | 0.61 | 50.0 | 4.09e-01 | 92.9% | 64.5% |
| 1nnfA01 | 3.40.190.10 | Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II | 0.59 | 42.0 | 3.12e-01 | 76.8% | 76.8% |
| 1is8A01 | 1.10.286.10 | Mainly Alpha › Orthogonal Bundle › GTP Cyclohydrolase I; Chain A, domain 1 › GTP cyclohydrolase I, N-terminal domain | 0.57 | 45.0 | 4.47e-01 | 92.9% | 83.3% |
| 6b1pA03 | 1.10.1160.10 | Mainly Alpha › Orthogonal Bundle › Glutamyl-tRNA Synthetase; domain 2 › Glutamyl-trna Synthetase; Domain 2 | 0.56 | 43.0 | 3.88e-01 | 87.5% | 81.9% |
| 6mgiA03 | 1.20.1440.90 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › Phosphoenolpyruvate/pyruvate domain | 0.54 | 44.0 | 3.26e-01 | 87.5% | 49.6% |
| 4bmhA00 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.53 | 46.0 | 3.19e-01 | 100.0% | 71.8% |
| 3natA01 | 3.40.50.11250 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Protein of unknown function DUF3013 | 0.50 | 40.0 | 3.17e-01 | 100.0% | 92.5% |
ECOD (9)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3500507 | 101.1.2.166 ↗ | alpha arrays › HTH › HTH › winged helix domain › MCM6_C | 0.65 | 52.0 | 4.29e-01 | 89.3% | 47.6% |
| 4020856 | 650.1.1.0 ↗ | alpha bundles › Chaperone J-domain › Chaperone J-domain › Chaperone J-domain | 0.62 | 47.0 | 3.49e-01 | 80.4% | 33.3% |
| 3787527 | 142.3.1.1 ↗ | alpha complex topology › Sigma2 domain-like › Mitochondrial morphogenesis protein Sld7 C-terminal domain › Mitochondrial morphogenesis protein Sld7 C-terminal domain › Sld7_C | 0.59 | 47.0 | 4.11e-01 | 87.5% | 57.6% |
| 3516926 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.59 | 47.0 | 3.09e-01 | 87.5% | 22.2% |
| 3361577 | 109.4.1.601 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PLU-1 | 0.56 | 40.0 | 3.32e-01 | 75.0% | 51.0% |
| 4949383 | 3646.1.1.1 ↗ | alpha complex topology › T-component of energy-coupling factor (ECF) transporters › T-component of energy-coupling factor (ECF) transporters › T-component of energy-coupling factor (ECF) transporters › CbiQ | 0.56 | 43.0 | 3.00e-01 | 89.3% | 25.8% |
| 3680048 | 604.6.1.2 ↗ | alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain › ANTH | 0.56 | 47.0 | 3.28e-01 | 91.1% | 50.6% |
| 3187789 | 2002.1.1.111 ↗ | a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels › HpcH_HpaI | 0.54 | 43.0 | 2.65e-01 | 87.5% | 21.8% |
| 3315776 | 109.4.1.601 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PLU-1 | 0.53 | 39.0 | 2.62e-01 | 80.4% | 24.0% |