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NS2A
Euk-VirKampung_Karu_virus
NS2A__YP_009553730__Kampung_Karu_virus__2045186
Identity
- Accession:
- YP_009553730 ↗
- Protein ID:
- NS2A
- Kingdom:
- euk
Quality
77.0
mean pLDDT
Taxonomy
Orthornavirae›
Kitrinoviricota›
Flasuviricetes›
Amarillovirales›
Flaviviridae›
Orthoflavivirus›
Kampung_Karu_virus
TaxID: 2045186
Cluster
View cluster (21 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 1-67
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01005.25 best | Flavi_NS2A | 33.0 | 8.00e-08 | 100.0% | 29.8% |
CATH (22)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4hehA01 | 1.10.1240.10 | Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › Methionine synthase domain | 0.72 | 54.0 | 5.05e-01 | 89.6% | 66.3% |
| 4jgiA01 | 1.10.1240.10 | Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › Methionine synthase domain | 0.71 | 53.0 | 5.04e-01 | 80.6% | 87.5% |
| 2odmA00 | 1.10.287.750 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › SO2669-like | 0.71 | 53.0 | 5.08e-01 | 80.6% | 81.0% |
| 3cl3A01 | 1.10.533.10 | Mainly Alpha › Orthogonal Bundle › Death Domain, Fas › Death Domain, Fas | 0.70 | 44.0 | 4.11e-01 | 77.6% | 51.2% |
| 1j5wA02 | 1.20.58.180 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Class II aaRS and biotin synthetases; domain 2 | 0.66 | 48.0 | 4.58e-01 | 76.1% | 77.9% |
| 3s64A00 | 1.10.225.10 | Mainly Alpha › Orthogonal Bundle › NK-Lysin › Saposin-like | 0.66 | 56.0 | 5.35e-01 | 100.0% | 92.6% |
| 3fdqA01 | 1.20.120.1030 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Motility repressor MogR, DNA-binding domain | 0.66 | 57.0 | 4.74e-01 | 100.0% | 84.4% |
| 3bulA01 | 1.10.1240.10 | Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › Methionine synthase domain | 0.64 | 47.0 | 4.41e-01 | 86.6% | 62.1% |
| 2yn7A00 | 1.10.3160.10 | Mainly Alpha › Orthogonal Bundle › Bbcrasp-1 › Bbcrasp-1 | 0.63 | 50.0 | 3.54e-01 | 86.6% | 63.1% |
| 2cdqA02 | 1.20.120.1320 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Aspartokinase, catalytic domain | 0.62 | 54.0 | 4.85e-01 | 100.0% | 79.4% |
| 1ks9A02 | 1.10.1040.10 | Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 | 0.57 | 45.0 | 3.82e-01 | 91.0% | 56.1% |
| 2mqaA00 | 1.10.274.60 | Mainly Alpha › Orthogonal Bundle › Enzyme I; Chain A, domain 2 › Spidroin, repetitive domain | 0.56 | 43.0 | 3.57e-01 | 85.1% | 71.2% |
| 1v9vA01 | 1.20.1480.20 | Mainly Alpha › Up-down Bundle › hypothetical protein mp506/mpn330, domain 1 › MAST3 pre-PK domain-like | 0.56 | 38.0 | 3.46e-01 | 71.6% | 60.0% |
| 1bm9A00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.55 | 47.0 | 3.99e-01 | 100.0% | 74.2% |
| 4m70I00 | 1.20.5.4130 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › | 0.55 | 46.0 | 3.97e-01 | 94.0% | 75.0% |
| 3s63A00 | 1.10.225.10 | Mainly Alpha › Orthogonal Bundle › NK-Lysin › Saposin-like | 0.55 | 47.0 | 4.38e-01 | 100.0% | 76.1% |
| 3b9qA01 | 1.20.120.140 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › SRP54, nucleotide-binding domain | 0.53 | 43.0 | 4.01e-01 | 100.0% | 70.8% |
| 3h4cA01 | 1.10.472.10 | Mainly Alpha › Orthogonal Bundle › Cyclin A; domain 1 › Cyclin-like | 0.53 | 41.0 | 3.73e-01 | 88.1% | 90.6% |
| 2nn4A00 | 1.10.287.760 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › YqgQ-like | 0.52 | 39.0 | 4.10e-01 | 80.6% | 91.9% |
| 2m6uA00 | 1.20.81.20 | Mainly Alpha › Up-down Bundle › Receptor-associated Protein › | 0.52 | 41.0 | 3.85e-01 | 85.1% | 79.3% |
| 5azpB01 | 1.20.1600.10 | Mainly Alpha › Up-down Bundle › Outer membrane efflux proteins (OEP) › Outer membrane efflux proteins (OEP) | 0.52 | 43.0 | 2.74e-01 | 97.0% | 26.6% |
| 4nqwA01 | 1.10.1740.10 | Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › RNA polymerase sigma factor, region 2, helix turn helix motif | 0.51 | 41.0 | 3.77e-01 | 85.1% | 86.9% |
ECOD (23)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 5078867 | 603.1.1.0 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins | 0.76 | 58.0 | 5.18e-01 | 80.6% | 83.3% |
| 5023560 | 180.1.1.0 ↗ | alpha bundles › Acid phosphatase/Vanadium-dependent haloperoxidase › Acid phosphatase/Vanadium-dependent haloperoxidase › Acid phosphatase/Vanadium-dependent haloperoxidase | 0.74 | 59.0 | 4.43e-01 | 89.6% | 71.3% |
| 5057844 | 180.1.1.1 ↗ | alpha bundles › Acid phosphatase/Vanadium-dependent haloperoxidase › Acid phosphatase/Vanadium-dependent haloperoxidase › Acid phosphatase/Vanadium-dependent haloperoxidase › PAP2 | 0.74 | 60.0 | 4.90e-01 | 89.6% | 56.0% |
| 5003027 | 4995.1.1.1 ↗ | alpha arrays › Methionine synthase domain-like › Methionine synthase domain-like › Methionine synthase domain-like › B12-binding_2 | 0.72 | 53.0 | 4.82e-01 | 89.6% | 58.9% |
| 3593388 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.67 | 53.0 | 3.37e-01 | 88.1% | 22.9% |
| 5011074 | 1111.1.1.8 ↗ | alpha complex topology › Trimeric intracellular cation (TRIC) channel › Trimeric intracellular cation (TRIC) channel › Trimeric intracellular cation (TRIC) channel › DUF2070 | 0.65 | 58.0 | 4.33e-01 | 100.0% | 53.6% |
| 3185204 | 109.4.1.1223 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_DOP1B | 0.65 | 52.0 | 3.80e-01 | 89.6% | 32.3% |
| 3973636 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.63 | 41.0 | 3.96e-01 | 79.1% | 58.7% |
| 3791357 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.63 | 41.0 | 3.06e-01 | 76.1% | 27.3% |
| 3974231 | 5086.1.1.84 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › HH_MFP_RND | 0.62 | 40.0 | 4.00e-01 | 79.1% | 62.9% |
| 5035910 | 1030.1.1.1 ↗ | alpha duplicates or obligate multimers › Crispr-associated protein Csm2 › Crispr-associated protein Csm2 › Crispr-associated protein Csm2 › Csm2_III-A | 0.61 | 52.0 | 4.26e-01 | 100.0% | 54.8% |
| 3259335 | 150.1.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin | 0.60 | 46.0 | 3.20e-01 | 82.1% | 43.0% |
| 3269593 | 198.1.1.2 ↗ | alpha arrays › Saposin-like › Saposin-like › Saposin-like › SapB_2,SapB_1 | 0.60 | 50.0 | 4.85e-01 | 100.0% | 85.0% |
| 4999255 | 601.37.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Photosystem II lipoprotein Psb27 › Photosystem II lipoprotein Psb27 | 0.59 | 50.0 | 4.68e-01 | 100.0% | 90.0% |
| 3307626 | 109.4.1.1295 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR, PPR_2, PPR_3, TPR_24 | 0.58 | 47.0 | 3.24e-01 | 88.1% | 48.2% |
| 4967463 | 601.7.1.2 ↗ | alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain › HEPN | 0.58 | 39.0 | 3.23e-01 | 70.1% | 97.6% |
| 3934315 | 198.1.1.1 ↗ | alpha arrays › Saposin-like › Saposin-like › Saposin-like › SapB_2 | 0.57 | 47.0 | 4.63e-01 | 100.0% | 90.7% |
| 3713784 | 632.7.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Heat shock protein 70kD (HSP70), C-terminal subdomain › Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.57 | 44.0 | 4.06e-01 | 85.1% | 64.7% |
| 3269592 | 198.1.1.2 ↗ | alpha arrays › Saposin-like › Saposin-like › Saposin-like › SapB_2,SapB_1 | 0.55 | 45.0 | 4.29e-01 | 100.0% | 84.7% |
| 4259821 | 138.1.1.2 ↗ | alpha arrays › DNA polymerase III clamp loader subunits, C-terminal domain › DNA polymerase III clamp loader subunits, C-terminal domain › DNA polymerase III clamp loader subunits, C-terminal domain › Rep_fac_C | 0.54 | 46.0 | 4.25e-01 | 100.0% | 95.6% |
| 4808037 | 3838.1.1.3 ↗ | alpha arrays › SidM Rab1-activation domain › SidM Rab1-activation domain › SidM Rab1-activation domain › SidM_N | 0.52 | 46.0 | 3.74e-01 | 100.0% | 82.2% |
| 4623581 | 142.1.1.3 ↗ | alpha complex topology › Sigma2 domain-like › Sigma2 domain of RNA polymerase sigma factors › Sigma2 domain of RNA polymerase sigma factors › Sigma70_r2 | 0.52 | 41.0 | 3.52e-01 | 85.1% | 69.5% |
| 3191686 | 102.1.4.4 ↗ | alpha arrays › HhH/H2TH › SAM/DNA-glycosylase › Nop C-terminal domain › PF25871 | 0.51 | 42.0 | 3.72e-01 | 98.5% | 85.3% |
D2
medium
residues 68-171
Domain cluster:
representative
CATH (20)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4x5mA00 | 1.20.1280.290 | Mainly Alpha › Up-down Bundle › Monooxygenase › | 0.63 | 39.0 | 4.27e-01 | 84.6% | 75.6% |
| 5z62E00 | 1.25.40.40 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Cytochrome c oxidase, subunit Va/VI | 0.60 | 44.0 | 4.36e-01 | 76.9% | 94.5% |
| 1t98A02 | 1.20.58.590 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Chromosome partition protein MukF, middle domain | 0.60 | 41.0 | 3.52e-01 | 70.2% | 99.4% |
| 1owlA02 | 1.25.40.80 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.58 | 40.0 | 3.78e-01 | 74.0% | 58.5% |
| 3f4mA00 | 1.20.1440.160 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › Tumor necrosis factor alpha-induced protein 8-like | 0.58 | 45.0 | 3.99e-01 | 82.7% | 100.0% |
| 3qhbA00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.57 | 45.0 | 3.76e-01 | 84.6% | 91.1% |
| 2gscC00 | 1.20.1440.60 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 23S rRNA-intervening sequence | 0.56 | 42.0 | 4.14e-01 | 77.9% | 87.3% |
| 1ia6A00 | 1.50.10.10 | Mainly Alpha › Alpha/alpha barrel › Glycosyltransferase › | 0.56 | 46.0 | 3.12e-01 | 91.3% | 30.0% |
| 1sumB02 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.56 | 42.0 | 4.05e-01 | 77.9% | 85.6% |
| 1cqxA01 | 1.10.490.10 | Mainly Alpha › Orthogonal Bundle › Globin-like › Globins | 0.56 | 51.0 | 4.49e-01 | 100.0% | 86.7% |
| 2yfaA02 | 1.20.1440.210 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › | 0.55 | 43.0 | 4.15e-01 | 81.7% | 90.5% |
| 3o4zA02 | 1.25.40.720 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tel2 C-terminal domain | 0.55 | 43.0 | 3.58e-01 | 86.5% | 45.9% |
| 2xqyA01 | 3.30.500.50 | Alpha Beta › 2-Layer Sandwich › Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1 › | 0.55 | 45.0 | 3.77e-01 | 89.4% | 93.3% |
| 3ly7A02 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.55 | 46.0 | 3.97e-01 | 91.3% | 82.6% |
| 2lseA00 | 1.20.120.1360 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › | 0.54 | 45.0 | 4.63e-01 | 94.2% | 92.1% |
| 5a29A01 | 1.50.10.20 | Mainly Alpha › Alpha/alpha barrel › Glycosyltransferase › | 0.54 | 47.0 | 3.22e-01 | 100.0% | 58.2% |
| 2jqqA00 | 1.20.58.1240 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.53 | 43.0 | 3.80e-01 | 88.5% | 77.9% |
| 4it4A02 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.53 | 35.0 | 3.75e-01 | 71.2% | 78.0% |
| 4dloB02 | 1.25.40.610 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.53 | 41.0 | 3.98e-01 | 83.7% | 84.6% |
| 1a36A04 | 1.10.132.10 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › | 0.51 | 41.0 | 3.50e-01 | 88.5% | 91.4% |
ECOD (18)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3424864 | 633.22.1.0 ↗ | alpha bundles › Bromodomain-like › Vitamin K epoxide reductase (VKOR) › Vitamin K epoxide reductase (VKOR) | 0.64 | 47.0 | 3.97e-01 | 76.0% | 82.9% |
| 3716106 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.61 | 51.0 | 2.94e-01 | 91.3% | 29.2% |
| 3714093 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.61 | 46.0 | 4.69e-01 | 81.7% | 93.0% |
| 3773479 | 633.21.1.23 ↗ | alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 › CD20 | 0.58 | 45.0 | 4.20e-01 | 81.7% | 94.6% |
| 3272276 | 109.6.1.1 ↗ | alpha superhelices › Repetitive alpha hairpins › Ras GEF › Ras GEF › RasGEF | 0.57 | 44.0 | 3.39e-01 | 83.7% | 48.6% |
| 3472555 | 109.6.1.1 ↗ | alpha superhelices › Repetitive alpha hairpins › Ras GEF › Ras GEF › RasGEF | 0.57 | 44.0 | 3.30e-01 | 83.7% | 53.3% |
| 3530696 | 109.4.1.942 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › NOT1_connector | 0.57 | 50.0 | 3.92e-01 | 97.1% | 62.7% |
| 3930703 | 632.22.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats | 0.56 | 43.0 | 4.41e-01 | 81.7% | 92.0% |
| 3504301 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.55 | 38.0 | 3.76e-01 | 70.2% | 90.0% |
| 3783972 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.54 | 44.0 | 2.74e-01 | 90.4% | 19.4% |
| 4943370 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.54 | 43.0 | 2.94e-01 | 88.5% | 56.6% |
| 3716092 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.53 | 43.0 | 3.44e-01 | 90.4% | 87.8% |
| 3313848 | 1128.1.1.1 ↗ | alpha bundles › LYR protein › LYR protein › LYR protein › Complex1_LYR | 0.53 | 37.0 | 4.08e-01 | 80.8% | 95.0% |
| 3592870 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.53 | 40.0 | 4.06e-01 | 79.8% | 85.0% |
| 3683579 | 188.1.1.5 ↗ | alpha arrays › Nuclear receptor ligand-binding domain › Nuclear receptor ligand-binding domain › Nuclear receptor ligand-binding domain › Tcp11 | 0.52 | 38.0 | 2.94e-01 | 75.0% | 43.3% |
| 3735131 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.52 | 40.0 | 3.68e-01 | 84.6% | 71.0% |
| 3678569 | 109.4.1.2687 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PF28645 | 0.52 | 44.0 | 3.36e-01 | 99.0% | 76.5% |
| 3956181 | 3291.1.1.0 ↗ | alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related | 0.52 | 40.0 | 3.68e-01 | 82.7% | 70.4% |