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NS2
Euk-VirSimian_pegivirus
NS2__YP_009045176__Simian_pegivirus__1454041
Identity
- Accession:
- YP_009045176 ↗
- Protein ID:
- NS2
- Kingdom:
- euk
Quality
79.5
mean pLDDT
Taxonomy
Orthornavirae›
Kitrinoviricota›
Flasuviricetes›
Amarillovirales›
Flaviviridae›
Pegivirus›
Simian_pegivirus
TaxID: 1454041
Cluster
Singleton — not in a non-trivial cluster
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 19-122
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01538.24 best | HCV_NS2 | 36.7 | 5.10e-09 | 100.0% | 47.7% |
CATH (48)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3h3mA00 | 1.20.58.380 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Flagellar protein flit. | 0.76 | 48.0 | 5.14e-01 | 83.7% | 74.2% |
| 3ieeA02 | 1.20.58.820 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Uncharacterised protein PF12889, C-terminal DUF3829 | 0.74 | 47.0 | 4.79e-01 | 86.5% | 65.0% |
| 3a98A02 | 1.20.1270.350 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Dedicator of cytokinesis N-terminal subdomain | 0.72 | 40.0 | 4.33e-01 | 71.2% | 64.4% |
| 4i0xH00 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.72 | 49.0 | 5.62e-01 | 76.0% | 97.4% |
| 3edvB01 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.71 | 58.0 | 5.30e-01 | 91.3% | 66.2% |
| 1t72A02 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.69 | 51.0 | 5.30e-01 | 90.4% | 82.7% |
| 3ck6C02 | 1.20.58.340 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Magnesium transport protein CorA, transmembrane region | 0.68 | 54.0 | 5.19e-01 | 91.3% | 74.8% |
| 2okuA00 | 1.20.120.470 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Acyl-CoA dehydrogenase, C-terminal domain | 0.67 | 41.0 | 3.87e-01 | 70.2% | 50.8% |
| 2x1dA02 | 1.10.10.2120 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › | 0.67 | 30.0 | 3.48e-01 | 88.5% | 55.4% |
| 3fb2A01 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.67 | 51.0 | 5.09e-01 | 86.5% | 79.0% |
| 1vctA01 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.67 | 50.0 | 4.92e-01 | 90.4% | 74.3% |
| 2i0mA02 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.67 | 49.0 | 5.05e-01 | 91.3% | 80.2% |
| 1hs7A00 | 1.20.58.70 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.66 | 46.0 | 4.75e-01 | 91.3% | 77.3% |
| 2gl2B00 | 1.10.287.1700 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.66 | 49.0 | 4.84e-01 | 77.9% | 74.3% |
| 1wp7A00 | 1.10.287.770 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › YojJ-like | 0.66 | 40.0 | 4.97e-01 | 72.1% | 100.0% |
| 2l3lA01 | 1.20.58.1250 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Tubulin Binding Cofactor C, N-terminal domain | 0.66 | 40.0 | 3.99e-01 | 76.9% | 58.5% |
| 4dylA02 | 1.10.287.160 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat | 0.65 | 47.0 | 4.93e-01 | 78.8% | 84.0% |
| 3vkgA02 | 1.20.140.100 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Dynein motor heavy chain, linker domain, N-terminal subdomain | 0.64 | 42.0 | 3.77e-01 | 76.0% | 46.9% |
| 2zdiC00 | 1.10.287.370 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.64 | 47.0 | 4.16e-01 | 76.9% | 89.2% |
| 2i0mA01 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.64 | 48.0 | 4.81e-01 | 91.3% | 78.3% |
| 2oduA02 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.63 | 49.0 | 4.89e-01 | 90.4% | 81.0% |
| 1t72A01 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.63 | 49.0 | 4.76e-01 | 91.3% | 74.4% |
| 6q45G01 | 1.10.287.80 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ATP synthase, gamma subunit, helix hairpin domain | 0.63 | 47.0 | 4.19e-01 | 78.8% | 59.6% |
| 1wleA01 | 1.10.287.40 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain | 0.63 | 47.0 | 4.55e-01 | 77.9% | 71.1% |
| 4ioeA00 | 1.10.287.850 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HP0062-like domain | 0.63 | 45.0 | 4.84e-01 | 76.0% | 89.7% |
| 2dw4A03 | 1.10.287.80 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ATP synthase, gamma subunit, helix hairpin domain | 0.63 | 46.0 | 4.69e-01 | 77.9% | 79.2% |
| 1kxpD02 | 1.10.246.10 | Mainly Alpha › Orthogonal Bundle › Serum Albumin; Chain A, Domain 1 › | 0.62 | 34.0 | 3.63e-01 | 75.0% | 60.2% |
| 3efzB00 | 1.20.190.20 | Mainly Alpha › Up-down Bundle › Delta-Endotoxin; domain 1 › 14-3-3 domain | 0.62 | 46.0 | 3.62e-01 | 80.8% | 36.0% |
| 1i4dA00 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.62 | 46.0 | 3.80e-01 | 77.9% | 53.2% |
| 1bdp002 | 1.20.1060.10 | Mainly Alpha › Up-down Bundle › Taq DNA Polymerase; Chain T, domain 4 › Taq DNA Polymerase; Chain T, domain 4 | 0.62 | 47.0 | 4.62e-01 | 78.8% | 88.1% |
| 1sumB01 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.62 | 49.0 | 4.86e-01 | 94.2% | 82.2% |
| 1owaA02 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.62 | 48.0 | 4.81e-01 | 91.3% | 82.1% |
| 4rngC00 | 1.20.1280.290 | Mainly Alpha › Up-down Bundle › Monooxygenase › | 0.61 | 44.0 | 4.77e-01 | 100.0% | 94.0% |
| 3zbhA00 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.61 | 43.0 | 4.60e-01 | 76.0% | 85.6% |
| 6ynwH01 | 1.20.20.10 | Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C | 0.60 | 38.0 | 4.45e-01 | 71.2% | 90.5% |
| 1wn0A00 | 1.20.120.160 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain | 0.60 | 41.0 | 3.87e-01 | 72.1% | 100.0% |
| 6r1nA01 | 1.10.287.40 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain | 0.59 | 44.0 | 4.47e-01 | 77.9% | 80.6% |
| 7p3rA01 | 1.20.1170.10 | Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; › | 0.59 | 49.0 | 3.53e-01 | 93.3% | 82.5% |
| 1cnt200 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.58 | 40.0 | 3.77e-01 | 72.1% | 68.5% |
| 2wgmA01 | 1.20.20.10 | Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C | 0.57 | 36.0 | 3.98e-01 | 71.2% | 80.5% |
| 1wpaA01 | 6.10.140.340 | Special › Helix non-globular › Helix Hairpins › | 0.57 | 42.0 | 4.34e-01 | 77.9% | 82.8% |
| 4v1gA00 | 1.20.20.10 | Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C | 0.57 | 41.0 | 4.44e-01 | 75.0% | 94.1% |
| 3l1nA02 | 1.20.1280.140 | Mainly Alpha › Up-down Bundle › Monooxygenase › | 0.57 | 44.0 | 4.69e-01 | 98.1% | 100.0% |
| 1orqC01 | 1.10.287.70 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.55 | 40.0 | 3.20e-01 | 76.0% | 47.2% |
| 1dd5A01 | 1.10.132.20 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor | 0.54 | 50.0 | 4.96e-01 | 100.0% | 96.3% |
| 3wirA02 | 1.50.10.10 | Mainly Alpha › Alpha/alpha barrel › Glycosyltransferase › | 0.52 | 45.0 | 3.03e-01 | 95.2% | 26.4% |
| 3umbA02 | 1.10.150.240 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 | 0.50 | 31.0 | 3.56e-01 | 79.8% | 82.3% |
| 8sbeA02 | 1.20.1250.20 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains | 0.50 | 39.0 | 3.32e-01 | 100.0% | 47.6% |
ECOD (28)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3808 | 604.1.1.1 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin | 0.70 | 56.0 | 5.64e-01 | 91.3% | 84.0% |
| 3484031 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.69 | 56.0 | 5.17e-01 | 91.3% | 67.4% |
| 5011123 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.68 | 45.0 | 4.50e-01 | 90.4% | 65.7% |
| 3585899 | 604.1.1.1 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin | 0.68 | 52.0 | 5.11e-01 | 91.3% | 77.3% |
| 4013477 | 1025.1.1.0 ↗ | alpha bundles › Stonustoxin helical domain › Stonustoxin helical domain › Stonustoxin helical domain | 0.67 | 47.0 | 4.68e-01 | 74.0% | 69.1% |
| 3511227 | 601.15.1.2 ↗ | alpha bundles › Four-helical up-and-down bundle › Proteasome activator reg(alpha) › Proteasome activator reg(alpha) › PA28_C | 0.66 | 47.0 | 3.88e-01 | 77.9% | 41.1% |
| 3979099 | 361.1.1.0 ↗ | few secondary structure elements › DnaJ/Hsp40 cysteine-rich domain › DnaJ/Hsp40 cysteine-rich domain › DnaJ/Hsp40 cysteine-rich domain | 0.65 | 47.0 | 4.12e-01 | 75.0% | 53.5% |
| 3484929 | 604.1.1.1 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin | 0.65 | 50.0 | 5.13e-01 | 90.4% | 86.0% |
| 3875112 | 3291.1.1.0 ↗ | alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related | 0.65 | 48.0 | 3.35e-01 | 77.9% | 30.9% |
| 4374392 | 2004.1.1.429 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N, AAA_15 | 0.65 | 47.0 | 3.15e-01 | 78.8% | 19.6% |
| 5062668 | 3755.1.1.0 ↗ | alpha bundles › YscO-like › Putative type III secretion protein YscO-related › Putative type III secretion protein YscO-related | 0.65 | 47.0 | 4.43e-01 | 76.0% | 68.8% |
| 3889547 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.64 | 47.0 | 3.85e-01 | 76.9% | 48.9% |
| 3522868 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.62 | 47.0 | 4.54e-01 | 78.8% | 73.9% |
| 4448955 | 2004.1.1.480 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N, AAA_21, AAA_29 | 0.62 | 46.0 | 3.07e-01 | 77.9% | 21.4% |
| 3589446 | 2004.1.1.301 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_27 | 0.62 | 45.0 | 2.92e-01 | 78.8% | 16.6% |
| 4554754 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.62 | 48.0 | 4.11e-01 | 83.7% | 65.3% |
| 3784055 | 192.24.1.0 ↗ | alpha bundles › Long alpha-hairpin › RPC62 helical hairpin domain › RPC62 helical hairpin domain | 0.62 | 50.0 | 4.74e-01 | 90.4% | 91.5% |
| 3709562 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.61 | 51.0 | 4.56e-01 | 91.3% | 93.3% |
| 3667914 | 6155.1.1.1 ↗ | alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter › MtN3_slv | 0.61 | 44.0 | 4.46e-01 | 99.0% | 77.0% |
| 4604091 | 192.2.1.0 ↗ | alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin | 0.61 | 46.0 | 4.67e-01 | 78.8% | 82.0% |
| 3795373 | 4177.1.1.2 ↗ | alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › BAR | 0.61 | 43.0 | 3.37e-01 | 77.9% | 32.5% |
| 4060120 | 192.29.1.127 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › ApoL | 0.61 | 45.0 | 4.47e-01 | 78.8% | 94.5% |
| 3712648 | 3755.4.1.0 ↗ | alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain | 0.60 | 44.0 | 3.64e-01 | 77.9% | 43.7% |
| 3388215 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.59 | 52.0 | 4.55e-01 | 99.0% | 75.8% |
| 4933737 | 3567.1.1.192 ↗ | a+b duplicates or obligate multimers › MPER trimer › MPER trimer › MPER trimer › EMC3_TMCO1 | 0.59 | 41.0 | 4.35e-01 | 72.1% | 95.8% |
| 3704098 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.57 | 42.0 | 3.64e-01 | 77.9% | 55.9% |
| 4944766 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.57 | 45.0 | 3.66e-01 | 86.5% | 60.0% |
| 3436288 | 6155.1.1.1 ↗ | alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter › MtN3_slv | 0.56 | 41.0 | 3.86e-01 | 100.0% | 62.3% |
D2
medium
residues 158-238
Domain cluster:
rep: nonstructural_protein_NS2__YP_009679008__Hepacivirus_N__2008773__D147-204
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01538.24 best | HCV_NS2 | 77.3 | 1.80e-21 | 71.6% | 29.7% |
CATH (2)
ECOD (3)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1281177 | 304.9.1.35 ↗ | a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › Hera_RBD | 0.53 | 37.0 | 3.62e-01 | 74.1% | 84.4% |
| 3507667 | 390.1.1.1 ↗ | few secondary structure elements › Hairpin loop containing domain-like › Hairpin loop containing domain-like › Hairpin loop containing domain-like › PAN_1 | 0.51 | 40.0 | 4.08e-01 | 98.8% | 86.3% |
| 3494022 | 11.1.1.97 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › I-set | 0.51 | 37.0 | 3.14e-01 | 80.2% | 45.0% |