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NS3

Euk-Vir

Cell_fusing_agent_virus

NS3__YP_009259297__Cell_fusing_agent_virus__31658

Identity

Accession:: YP_009259297 ↗
Protein ID:: NS3
Kingdom:: euk

Quality

80.5 mean pLDDT

Taxonomy

Orthornavirae› Kitrinoviricota› Flasuviricetes› Amarillovirales› Flaviviridae› Orthoflavivirus› Cell_fusing_agent_virus

TaxID: 31658

Cluster

View cluster (28 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 4-83

PDB

Domain cluster: rep: peptidase_S7__YP_009553732__Kampung_Karu_virus__2045186__D3-61

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00949.28 best	Peptidase_S7	23.8	5.00e-05	78.8%	45.8%

D2 high residues 98-167

PDB

Domain cluster: rep: nonstructural_protein_NS3__NP_740299__Langat_virus__11085__D113-168

D3 high residues 184-308

PDB

Domain cluster: rep: LD_Run2_08_scaffold_35_prodigal-single.1__X__X__00177__D121-323

Pfam (2)

Accession	Name	Score	E-value	Q cov	HMM cov
PF07652.21 best	Flavi_DEAD	165.7	9.80e-49	100.0%	85.8%
PF00270.36	DEAD	26.5	6.80e-06	99.2%	74.2%

D4 high residues 324-459

PDB

Domain cluster: rep: B962L__YP_009703129__African_swine_fever_virus__10497__D237-425

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00271.38 best	Helicase_C	25.7	1.60e-05	83.8%	41.8%

D5 high residues 504-586

PDB

Domain cluster: rep: non-structural_protein_NS3__NP_776005__Yellow_fever_virus__11089__D541-620

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF20907.3 best	Flav_NS3-hel_C	27.3	3.80e-06	96.4%	52.1%

CATH (18)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
7by3B01	3.40.50.1010	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 5'-nuclease	0.69	42.0	3.75e-01	97.6%	43.9%
1r6bX04	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.62	47.0	3.53e-01	98.8%	33.5%
4eeiA03	1.10.40.30	Mainly Alpha › Orthogonal Bundle › Ribonucleotide Reductase Protein R1; domain 1 › Fumarase/aspartase (C-terminal domain)	0.62	37.0	3.87e-01	98.8%	64.1%
2d6fC03	1.10.150.380	Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › GatB domain, N-terminal subdomain	0.61	33.0	4.13e-01	71.1%	86.5%
2kz6A01	6.10.140.1310	Special › Helix non-globular › Helix Hairpins ›	0.59	30.0	3.05e-01	97.6%	48.1%
4r2bA01	3.40.190.10	Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II	0.58	50.0	3.88e-01	100.0%	70.1%
4gcvC00	1.10.10.10	Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	0.54	32.0	2.71e-01	88.0%	33.3%
2kjwA00	3.30.70.60	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Ribosomal protein S6/Translation elongation factor EF1B	0.54	37.0	3.58e-01	100.0%	61.5%
2l4eA00	1.10.8.10	Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Ubiquitin-associated (UBA) domain	0.54	31.0	3.64e-01	84.3%	84.2%
7o49B01	3.30.70.2110	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.54	35.0	3.45e-01	97.6%	60.4%
2c35A00	1.20.1250.40	Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › RNA Polymerase II, Rpb4 subunit	0.52	46.0	4.04e-01	100.0%	82.8%
2wa0A01	1.10.10.1200	Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › MAGE homology domain, winged helix WH1 motif	0.52	28.0	2.67e-01	90.4%	41.6%
1uzxA00	3.10.110.10	Alpha Beta › Roll › Ubiquitin Conjugating Enzyme › Ubiquitin Conjugating Enzyme	0.52	36.0	3.07e-01	72.3%	86.4%
4djgB00	1.20.5.440	Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › ATP synthase delta/epsilon subunit, C-terminal domain	0.52	28.0	3.62e-01	92.8%	95.7%
2d4aA02	3.90.110.10	Alpha Beta › Alpha-Beta Complex › L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2 › Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal	0.51	38.0	3.13e-01	96.4%	41.2%
4at0A01	3.50.50.60	Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain	0.51	44.0	2.92e-01	96.4%	74.2%
2od4B01	3.30.70.100	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.51	34.0	3.41e-01	98.8%	66.3%
3qp1A00	3.30.450.80	Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › Transcription factor LuxR-like, autoinducer-binding domain	0.50	42.0	3.41e-01	97.6%	82.0%

ECOD (8)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
53546	5101.1.1.0 ↗	alpha arrays › C-terminal helical domain of RNA helicase › C-terminal helical domain of RNA helicase › C-terminal helical domain of RNA helicase	0.79	72.0	6.05e-01	100.0%	69.1%
4878071	5101.1.1.1 ↗	alpha arrays › C-terminal helical domain of RNA helicase › C-terminal helical domain of RNA helicase › C-terminal helical domain of RNA helicase › Flav_NS3-hel_C	0.78	70.0	5.79e-01	100.0%	65.1%
4967548	2006.1.4.0 ↗	a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like	0.67	41.0	3.72e-01	96.4%	45.5%
3847449	102.1.1.0 ↗	alpha arrays › HhH/H2TH › SAM/DNA-glycosylase › SAM domain-like	0.62	45.0	4.61e-01	95.2%	80.0%
4974573	4953.1.1.0 ↗	beta barrels › L-aspartase C-terminal domain-like › L-aspartase C-terminal domain-like › L-aspartase C-terminal domain-like	0.57	40.0	4.21e-01	97.6%	81.3%
3182090	304.8.1.0 ↗	a+b two layers › Alpha-beta plaits › ACT-like › ACT-like	0.56	35.0	3.68e-01	97.6%	70.7%
3705051	310.3.1.0 ↗	a+b two layers › RRF/tRNA synthetase additional domain-like › General secretion pathway protein M (EpsM) periplasmic domain-related › General secretion pathway protein M (EpsM) periplasmic domain-related	0.52	37.0	4.01e-01	94.0%	96.9%
4967627	4070.1.1.0 ↗	alpha arrays › FtsH protease domain-like › FtsH protease domain-like › FtsH protease domain-like	0.52	37.0	2.91e-01	96.4%	35.4%