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NS4A
Euk-VirKampung_Karu_virus
NS4A__YP_009553734__Kampung_Karu_virus__2045186
Identity
- Accession:
- YP_009553734 ↗
- Protein ID:
- NS4A
- Kingdom:
- euk
Quality
88.5
mean pLDDT
Taxonomy
Orthornavirae›
Kitrinoviricota›
Flasuviricetes›
Amarillovirales›
Flaviviridae›
Orthoflavivirus›
Kampung_Karu_virus
TaxID: 2045186
Cluster
View cluster (21 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 2-69
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01350.22 best | Flavi_NS4A | 52.2 | 9.20e-14 | 100.0% | 45.8% |
CATH (46)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1uurA01 | 1.20.58.240 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › STAT; domain 1 | 0.74 | 53.0 | 4.49e-01 | 75.0% | 46.4% |
| 4fz4A00 | 1.20.140.130 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › | 0.73 | 56.0 | 4.23e-01 | 80.9% | 36.4% |
| 1x4tA01 | 1.10.287.660 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.73 | 49.0 | 5.30e-01 | 72.1% | 82.8% |
| 4e6nA02 | 6.10.140.1010 | Special › Helix non-globular › Helix Hairpins › | 0.71 | 49.0 | 5.01e-01 | 72.1% | 90.9% |
| 3fxdB00 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.71 | 46.0 | 4.90e-01 | 70.6% | 77.6% |
| 3mpxA01 | 1.20.900.10 | Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain | 0.69 | 52.0 | 3.71e-01 | 80.9% | 35.9% |
| 1zhcA00 | 6.10.280.50 | Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.68 | 48.0 | 4.70e-01 | 88.2% | 67.1% |
| 1t72A01 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.68 | 50.0 | 4.14e-01 | 77.9% | 46.2% |
| 4okvE00 | 6.10.140.1890 | Special › Helix non-globular › Helix Hairpins › | 0.67 | 45.0 | 4.67e-01 | 76.5% | 72.3% |
| 4nb5B02 | 1.10.287.160 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat | 0.67 | 47.0 | 4.87e-01 | 75.0% | 79.7% |
| 1wpaA01 | 6.10.140.340 | Special › Helix non-globular › Helix Hairpins › | 0.67 | 53.0 | 4.71e-01 | 88.2% | 89.9% |
| 6c1qB02 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.66 | 49.0 | 3.28e-01 | 82.4% | 19.7% |
| 2zgyA02 | 3.30.420.40 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain | 0.66 | 52.0 | 4.16e-01 | 86.8% | 55.7% |
| 6yz2A01 | 1.20.120.350 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Voltage-gated potassium channels. Chain C | 0.66 | 58.0 | 4.86e-01 | 100.0% | 96.7% |
| 4iggA01 | 1.10.287.160 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat | 0.66 | 48.0 | 4.92e-01 | 80.9% | 79.1% |
| 4i5sB03 | 1.10.287.130 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Signal transduction histidine kinase, dimerisation/phosphotransfer (DHp) domain | 0.65 | 50.0 | 4.90e-01 | 88.2% | 74.7% |
| 4gyvE00 | 1.20.900.10 | Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain | 0.65 | 55.0 | 3.96e-01 | 100.0% | 78.6% |
| 2jqqA00 | 1.20.58.1240 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.65 | 57.0 | 4.39e-01 | 100.0% | 72.7% |
| 3gnlB02 | 1.10.287.1890 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.64 | 44.0 | 4.46e-01 | 76.5% | 72.1% |
| 4gczA03 | 1.10.287.130 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Signal transduction histidine kinase, dimerisation/phosphotransfer (DHp) domain | 0.64 | 49.0 | 5.05e-01 | 88.2% | 86.2% |
| 1hs7A00 | 1.20.58.70 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.64 | 47.0 | 4.25e-01 | 80.9% | 79.4% |
| 2qkwA00 | 1.20.1270.140 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › AvrPto | 0.63 | 50.0 | 4.42e-01 | 86.8% | 58.4% |
| 4uyeA00 | 1.20.920.10 | Mainly Alpha › Up-down Bundle › Histone Acetyltransferase; Chain A › Bromodomain-like | 0.63 | 44.0 | 3.82e-01 | 75.0% | 96.3% |
| 3mqmA00 | 1.20.920.10 | Mainly Alpha › Up-down Bundle › Histone Acetyltransferase; Chain A › Bromodomain-like | 0.62 | 47.0 | 3.92e-01 | 83.8% | 91.3% |
| 2rkhA02 | 1.20.1280.20 | Mainly Alpha › Up-down Bundle › Monooxygenase › HscB, C-terminal domain | 0.62 | 46.0 | 4.46e-01 | 77.9% | 69.7% |
| 5pg1A00 | 1.20.920.10 | Mainly Alpha › Up-down Bundle › Histone Acetyltransferase; Chain A › Bromodomain-like | 0.62 | 42.0 | 3.57e-01 | 70.6% | 87.8% |
| 2pvqA02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.62 | 50.0 | 4.37e-01 | 89.7% | 95.3% |
| 4h63K00 | 1.10.287.3490 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.61 | 50.0 | 4.42e-01 | 89.7% | 62.2% |
| 3lnnB03 | 1.10.287.470 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.61 | 48.0 | 4.88e-01 | 85.3% | 89.6% |
| 1zpyA00 | 6.10.140.1960 | Special › Helix non-globular › Helix Hairpins › | 0.61 | 52.0 | 4.73e-01 | 95.6% | 86.8% |
| 1tjlA00 | 1.20.120.910 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › DksA, coiled-coil domain | 0.60 | 50.0 | 4.03e-01 | 97.1% | 69.7% |
| 1vctA01 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.60 | 50.0 | 4.29e-01 | 94.1% | 57.8% |
| 2jdiG01 | 1.10.287.80 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ATP synthase, gamma subunit, helix hairpin domain | 0.59 | 46.0 | 4.80e-01 | 88.2% | 96.7% |
| 5ulcX00 | 1.20.920.10 | Mainly Alpha › Up-down Bundle › Histone Acetyltransferase; Chain A › Bromodomain-like | 0.59 | 49.0 | 4.18e-01 | 97.1% | 99.2% |
| 2yevA02 | 1.10.287.70 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.59 | 42.0 | 4.11e-01 | 88.2% | 68.9% |
| 2dw4A03 | 1.10.287.80 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ATP synthase, gamma subunit, helix hairpin domain | 0.58 | 48.0 | 4.20e-01 | 89.7% | 62.4% |
| 2r40D00 | 1.10.565.10 | Mainly Alpha › Orthogonal Bundle › Retinoid X Receptor › Retinoid X Receptor | 0.58 | 46.0 | 3.23e-01 | 88.2% | 40.3% |
| 1sumB01 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.56 | 43.0 | 3.80e-01 | 85.3% | 84.1% |
| 4n4gA01 | 1.20.920.10 | Mainly Alpha › Up-down Bundle › Histone Acetyltransferase; Chain A › Bromodomain-like | 0.56 | 45.0 | 3.85e-01 | 86.8% | 82.9% |
| 2wmmA01 | 1.20.5.420 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › Immunoglobulin FC, subunit C | 0.56 | 38.0 | 4.16e-01 | 72.1% | 98.0% |
| 4dkcB00 | 1.20.1250.80 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › Interleukin-34 | 0.55 | 48.0 | 3.65e-01 | 97.1% | 68.1% |
| 4wr4A02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.55 | 44.0 | 3.87e-01 | 91.2% | 95.2% |
| 3d36B02 | 1.10.287.130 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Signal transduction histidine kinase, dimerisation/phosphotransfer (DHp) domain | 0.54 | 42.0 | 4.40e-01 | 94.1% | 100.0% |
| 1qguB04 | 1.20.89.10 | Mainly Alpha › Up-down Bundle › Nitrogenase Molybdenum-iron Protein, subunit B; domain 4 › Nitrogenase Molybdenum-iron Protein, subunit B, domain 4 | 0.54 | 40.0 | 3.74e-01 | 77.9% | 81.9% |
| 1srqA01 | 3.30.1120.160 | Alpha Beta › 2-Layer Sandwich › Arylsulfatase, C-terminal domain › | 0.51 | 46.0 | 3.62e-01 | 100.0% | 95.7% |
| 3k2jA00 | 1.20.920.10 | Mainly Alpha › Up-down Bundle › Histone Acetyltransferase; Chain A › Bromodomain-like | 0.51 | 46.0 | 3.79e-01 | 100.0% | 68.6% |
ECOD (53)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3473142 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.79 | 54.0 | 4.22e-01 | 72.1% | 35.7% |
| 4883924 | 605.1.1.1 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › HisKA | 0.76 | 54.0 | 5.14e-01 | 76.5% | 63.7% |
| 3254975 | 603.2.1.2 ↗ | alpha bundles › STAT-like › STAT › STAT › Dict-STAT-coil | 0.75 | 52.0 | 4.35e-01 | 72.1% | 53.9% |
| 3399701 | 174.1.1.1 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin | 0.75 | 51.0 | 4.06e-01 | 72.1% | 35.7% |
| 3098420 | 4006.1.1.1 ↗ | alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF | 0.74 | 66.0 | 5.64e-01 | 100.0% | 68.8% |
| 3844040 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.71 | 52.0 | 5.37e-01 | 83.8% | 80.0% |
| 4966687 | 192.3.1.1 ↗ | alpha bundles › Long alpha-hairpin › Fe,Mn superoxide dismutase (SOD), N-terminal domain › Fe,Mn superoxide dismutase (SOD), N-terminal domain › Sod_Fe_N | 0.71 | 57.0 | 5.31e-01 | 86.8% | 69.4% |
| 4643003 | 605.1.1.108 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › GrpE | 0.71 | 37.0 | 3.98e-01 | 70.6% | 58.3% |
| 3874130 | 133.1.1.5 ↗ | alpha bundles › DH domain-like › DBL homology domain (DH-domain) › DBL homology domain (DH-domain) › DH_Alsin | 0.71 | 52.0 | 3.64e-01 | 77.9% | 44.3% |
| 3671258 | 632.22.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats | 0.70 | 52.0 | 4.15e-01 | 77.9% | 40.8% |
| 3583169 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.70 | 53.0 | 5.06e-01 | 88.2% | 68.8% |
| 4667859 | 192.7.1.2 ↗ | alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm › Seryl_tRNA_N | 0.70 | 50.0 | 4.21e-01 | 76.5% | 47.0% |
| 4146694 | 192.29.1.277 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › Dynamitin | 0.69 | 48.0 | 4.94e-01 | 72.1% | 75.4% |
| 4977429 | 2484.1.1.124 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › OrfB_IS605 | 0.69 | 53.0 | 4.14e-01 | 89.7% | 39.3% |
| 3240465 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.69 | 54.0 | 4.48e-01 | 85.3% | 77.5% |
| 3613914 | 3922.1.1.0 ↗ | alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 | 0.68 | 51.0 | 4.95e-01 | 82.4% | 72.0% |
| 3611163 | 2004.1.1.480 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N, AAA_21, AAA_29 | 0.68 | 52.0 | 3.14e-01 | 82.4% | 12.8% |
| 3795985 | 622.4.1.0 ↗ | alpha bundles › YvfG-like › Mite allergen Der p 5-related › Mite allergen Der p 5-related | 0.66 | 48.0 | 4.47e-01 | 75.0% | 60.0% |
| 5038847 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.66 | 49.0 | 4.94e-01 | 88.2% | 78.6% |
| 4958744 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.66 | 50.0 | 4.26e-01 | 82.4% | 50.0% |
| 4234530 | 192.7.1.2 ↗ | alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm › Seryl_tRNA_N | 0.66 | 51.0 | 4.24e-01 | 82.4% | 57.4% |
| 3657123 | 192.2.1.0 ↗ | alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin | 0.66 | 55.0 | 4.98e-01 | 94.1% | 100.0% |
| 5047797 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.66 | 47.0 | 4.61e-01 | 76.5% | 70.7% |
| 4958743 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.64 | 49.0 | 4.13e-01 | 82.4% | 48.7% |
| 1566346 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.64 | 44.0 | 4.37e-01 | 77.9% | 69.0% |
| 3495233 | 133.1.1.1 ↗ | alpha bundles › DH domain-like › DBL homology domain (DH-domain) › DBL homology domain (DH-domain) › RhoGEF | 0.64 | 47.0 | 3.72e-01 | 80.9% | 90.3% |
| 3167364 | 2004.1.1.481 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N, AAA_29 | 0.64 | 51.0 | 3.13e-01 | 88.2% | 20.0% |
| 3830963 | 603.1.1.100 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins › PF27017 | 0.64 | 52.0 | 4.30e-01 | 88.2% | 79.2% |
| 3512539 | 133.1.1.1 ↗ | alpha bundles › DH domain-like › DBL homology domain (DH-domain) › DBL homology domain (DH-domain) › RhoGEF | 0.64 | 50.0 | 3.55e-01 | 86.8% | 34.0% |
| 4176828 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.64 | 45.0 | 4.48e-01 | 75.0% | 100.0% |
| 4565383 | 192.6.1.0 ↗ | alpha bundles › Long alpha-hairpin › Epsilon subunit of F1F0-ATP synthase C-terminal domain › Epsilon subunit of F1F0-ATP synthase C-terminal domain | 0.64 | 42.0 | 4.77e-01 | 75.0% | 94.0% |
| 5032045 | 4163.1.1.0 ↗ | alpha bundles › GINS helical bundle-like › GINS helical bundle-like › PSF1 N-terminal domain-like | 0.63 | 50.0 | 4.39e-01 | 85.3% | 77.0% |
| 3813837 | 622.4.1.0 ↗ | alpha bundles › YvfG-like › Mite allergen Der p 5-related › Mite allergen Der p 5-related | 0.63 | 50.0 | 4.86e-01 | 86.8% | 78.7% |
| 3787907 | 622.4.1.0 ↗ | alpha bundles › YvfG-like › Mite allergen Der p 5-related › Mite allergen Der p 5-related | 0.63 | 50.0 | 4.90e-01 | 88.2% | 80.0% |
| 4774281 | 1147.1.1.1 ↗ | alpha bundles › RNA polymerase II elongation factor ELL2 C-terminal domain › RNA polymerase II elongation factor ELL2 C-terminal domain › RNA polymerase II elongation factor ELL2 C-terminal domain › Occludin_ELL | 0.63 | 52.0 | 4.53e-01 | 94.1% | 84.4% |
| 4881130 | 5057.1.1.1 ↗ | alpha bundles › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore › Neur_chan_memb | 0.63 | 51.0 | 4.60e-01 | 86.8% | 86.7% |
| 3530780 | 310.2.1.2 ↗ | a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF › MIX23 | 0.62 | 50.0 | 4.11e-01 | 91.2% | 93.8% |
| 4001786 | 1203.1.2.1 ↗ | alpha bundles › Shroom domain 2 › Shroom domain 2 › Human SD2 › ASD2 | 0.62 | 49.0 | 3.50e-01 | 88.2% | 34.4% |
| 3676043 | 5076.2.1.10 ↗ | alpha complex topology › Mitochondrial ADP/ATP carrier-like › Putative sulfate permease CysZ › Putative sulfate permease CysZ › PF29520 | 0.61 | 50.0 | 3.29e-01 | 89.7% | 95.1% |
| 4547644 | 109.4.1.228 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Exo84_C | 0.61 | 48.0 | 3.42e-01 | 86.8% | 41.9% |
| 3582116 | 1147.1.1.1 ↗ | alpha bundles › RNA polymerase II elongation factor ELL2 C-terminal domain › RNA polymerase II elongation factor ELL2 C-terminal domain › RNA polymerase II elongation factor ELL2 C-terminal domain › Occludin_ELL | 0.61 | 46.0 | 3.73e-01 | 80.9% | 45.0% |
| 3192393 | 2004.1.1.430 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ABC_tran, ABC_tran_Xtn | 0.60 | 50.0 | 2.98e-01 | 100.0% | 26.0% |
| 5028289 | 7516.1.1.2 ↗ | a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Glycos_transf_2 | 0.60 | 52.0 | 3.40e-01 | 98.5% | 25.8% |
| 3739924 | 6155.1.1.2 ↗ | alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter › PQ-loop | 0.60 | 43.0 | 3.82e-01 | 80.9% | 50.5% |
| 3201381 | 192.8.1.139 ↗ | alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain › Fung_rhodopsin | 0.59 | 40.0 | 3.96e-01 | 72.1% | 65.3% |
| 3428852 | 3755.4.1.0 ↗ | alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain | 0.58 | 48.0 | 3.86e-01 | 92.6% | 72.6% |
| 3286637 | 2484.1.1.124 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › OrfB_IS605 | 0.57 | 46.0 | 3.52e-01 | 89.7% | 37.0% |
| 3376917 | 192.24.1.8 ↗ | alpha bundles › Long alpha-hairpin › RPC62 helical hairpin domain › RPC62 helical hairpin domain › CDK5RAP3 | 0.57 | 46.0 | 4.42e-01 | 89.7% | 78.8% |
| 3696767 | 4121.1.1.0 ↗ | a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like | 0.57 | 49.0 | 3.08e-01 | 100.0% | 26.0% |
| 4998819 | 2484.1.1.124 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › OrfB_IS605 | 0.56 | 46.0 | 3.74e-01 | 89.7% | 46.9% |
| 4999337 | 2484.1.1.124 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › OrfB_IS605 | 0.56 | 46.0 | 3.52e-01 | 89.7% | 39.4% |
| 5005094 | 2484.1.1.124 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › OrfB_IS605 | 0.54 | 45.0 | 3.24e-01 | 89.7% | 31.8% |
| 5017725 | 2484.1.1.302 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › Cas12f1-like_TNB | 0.54 | 45.0 | 3.21e-01 | 89.7% | 31.8% |
D2
high
residues 76-142
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01350.22 best | Flavi_NS4A | 52.9 | 5.40e-14 | 100.0% | 45.1% |
CATH (21)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1jt6A02 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.83 | 49.0 | 3.82e-01 | 71.6% | 29.2% |
| 1gzsB00 | 1.10.4120.10 | Mainly Alpha › Orthogonal Bundle › SopE-like GEF fold › SopE-like, GEF domain | 0.73 | 50.0 | 3.67e-01 | 71.6% | 63.0% |
| 4d7sA01 | 1.10.287.630 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.70 | 52.0 | 5.24e-01 | 79.1% | 97.0% |
| 3hr0B01 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.67 | 45.0 | 4.31e-01 | 70.1% | 87.3% |
| 3b9qA01 | 1.20.120.140 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › SRP54, nucleotide-binding domain | 0.66 | 54.0 | 4.88e-01 | 100.0% | 65.2% |
| 1b8dA00 | 1.10.490.20 | Mainly Alpha › Orthogonal Bundle › Globin-like › Phycocyanins | 0.64 | 55.0 | 4.25e-01 | 100.0% | 50.0% |
| 3vouB00 | 1.10.287.70 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.64 | 44.0 | 3.59e-01 | 73.1% | 57.4% |
| 3triA02 | 1.10.3730.10 | Mainly Alpha › Orthogonal Bundle › ProC C-terminal domain-like fold › ProC C-terminal domain-like | 0.64 | 43.0 | 3.77e-01 | 85.1% | 44.7% |
| 1l0oA00 | 3.30.565.10 | Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain | 0.63 | 55.0 | 4.40e-01 | 100.0% | 88.7% |
| 2a3vB01 | 1.10.150.130 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Tyrosine recombinase, N-terminal domain | 0.63 | 56.0 | 4.91e-01 | 95.5% | 97.9% |
| 2hh7A00 | 1.20.58.1000 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Metal-sensitive repressor, helix protomer | 0.62 | 43.0 | 4.05e-01 | 73.1% | 60.0% |
| 2mpkA00 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.62 | 42.0 | 4.16e-01 | 74.6% | 66.2% |
| 2sasA00 | 1.10.238.10 | Mainly Alpha › Orthogonal Bundle › Recoverin; domain 1 › EF-hand | 0.60 | 50.0 | 3.71e-01 | 95.5% | 44.9% |
| 5l3wA01 | 1.20.120.140 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › SRP54, nucleotide-binding domain | 0.60 | 52.0 | 4.80e-01 | 100.0% | 75.0% |
| 3ddhA02 | 1.10.150.240 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 | 0.59 | 36.0 | 3.49e-01 | 77.6% | 49.4% |
| 2hpsA00 | 1.10.238.10 | Mainly Alpha › Orthogonal Bundle › Recoverin; domain 1 › EF-hand | 0.59 | 51.0 | 3.78e-01 | 100.0% | 43.5% |
| 1cm5A00 | 3.20.70.20 | Alpha Beta › Alpha-Beta Barrel › Anaerobic Ribonucleotide-triphosphate Reductase Large Chain › | 0.58 | 50.0 | 2.88e-01 | 100.0% | 53.8% |
| 3qa8A04 | 1.20.1270.250 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.58 | 47.0 | 3.34e-01 | 94.0% | 69.1% |
| 3ihuA02 | 1.20.120.530 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › GntR ligand-binding domain-like | 0.57 | 47.0 | 3.88e-01 | 100.0% | 73.4% |
| 2ex3B02 | 1.20.1270.230 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › DNA terminal protein Gp3, priming domain | 0.54 | 46.0 | 4.31e-01 | 91.0% | 87.7% |
| 3oqiA00 | 3.40.50.11710 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Cyclodipeptide synthase | 0.54 | 49.0 | 3.37e-01 | 100.0% | 53.2% |
ECOD (29)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3607406 | 6026.1.1.0 ↗ | alpha duplicates or obligate multimers › cwf21 domain › cwf21 domain › cwf21 domain | 0.78 | 55.0 | 5.17e-01 | 73.1% | 61.3% |
| 3965046 | 604.12.1.76 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › IspA | 0.78 | 53.0 | 5.21e-01 | 71.6% | 67.1% |
| 3573038 | 4207.1.1.99 ↗ | alpha duplicates or obligate multimers › Mediator hinge subcomplex-like › Mediator hinge subcomplex-like › RNA polymerase II holoenzyme component SRB7 (MED21) › PF28139 | 0.73 | 51.0 | 4.63e-01 | 73.1% | 62.2% |
| 3999900 | 1016.1.1.0 ↗ | alpha arrays › Dimerization domain in caprin-1 and PAN3 › Dimerization domain in caprin-1 and PAN3 › Dimerization domain in caprin-1 and PAN3 | 0.72 | 61.0 | 5.02e-01 | 94.0% | 71.7% |
| 4198887 | 186.1.1.0 ↗ | alpha arrays › lambda integrase-N-like › lambda integrase-N › lambda integrase-N | 0.70 | 64.0 | 5.46e-01 | 100.0% | 76.2% |
| 3782787 | 632.11.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like | 0.70 | 55.0 | 5.38e-01 | 89.6% | 78.7% |
| 3698292 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.70 | 47.0 | 3.67e-01 | 70.1% | 37.9% |
| 5022016 | 186.1.1.4 ↗ | alpha arrays › lambda integrase-N-like › lambda integrase-N › lambda integrase-N › Phage_int_SAM_4 | 0.66 | 58.0 | 5.07e-01 | 94.0% | 98.9% |
| 3867744 | 3939.1.1.0 ↗ | alpha duplicates or obligate multimers › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain | 0.66 | 57.0 | 4.13e-01 | 100.0% | 34.5% |
| 3889409 | 10.12.1.1 ↗ | beta sandwiches › jelly-roll › Double-stranded beta-helix › Double-stranded beta-helix › cNMP_binding | 0.65 | 60.0 | 4.08e-01 | 98.5% | 74.9% |
| 3463388 | 150.1.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin | 0.64 | 55.0 | 4.38e-01 | 100.0% | 53.1% |
| 5010451 | 186.1.1.4 ↗ | alpha arrays › lambda integrase-N-like › lambda integrase-N › lambda integrase-N › Phage_int_SAM_4 | 0.64 | 57.0 | 4.76e-01 | 95.5% | 94.5% |
| 3423806 | 101.1.1.196 ↗ | alpha arrays › HTH › HTH › Three-helical HTH › RWP-RK | 0.64 | 49.0 | 4.12e-01 | 83.6% | 65.2% |
| 4243491 | 632.24.1.4 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › GBS CAMP factor C-terminal domain › GBS CAMP factor C-terminal domain › FIVAR | 0.63 | 49.0 | 4.80e-01 | 94.0% | 76.0% |
| 3243399 | 4044.1.1.0 ↗ | alpha bundles › Helical bundle domain in prismane-like proteins › Helical bundle domain in prismane-like proteins › Helical bundle domain in prismane-like proteins | 0.63 | 48.0 | 4.74e-01 | 95.5% | 80.0% |
| 3992791 | 3843.1.1.0 ↗ | alpha complex topology › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K | 0.63 | 54.0 | 4.86e-01 | 100.0% | 78.9% |
| 4945541 | 140.1.1.7 ↗ | alpha bundles › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › DALR_2 | 0.61 | 44.0 | 3.42e-01 | 77.6% | 32.5% |
| 4088535 | 230.3.1.1 ↗ | a+b two layers › T-fold › Elongation factor Ts (EF-Ts), dimerisation domain › Elongation factor Ts (EF-Ts), dimerisation domain › EF_TS | 0.61 | 45.0 | 3.48e-01 | 82.1% | 38.2% |
| 3412191 | 632.1.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain | 0.61 | 45.0 | 4.25e-01 | 89.6% | 64.7% |
| 5068278 | 181.1.1.1 ↗ | alpha bundles › Domain of the SRP/SRP receptor G proteins-like › Domain of the SRP/SRP receptor G-proteins › Domain of the SRP/SRP receptor G-proteins › SRP54_N | 0.59 | 53.0 | 4.54e-01 | 100.0% | 62.9% |
| 5038476 | 181.1.1.1 ↗ | alpha bundles › Domain of the SRP/SRP receptor G proteins-like › Domain of the SRP/SRP receptor G-proteins › Domain of the SRP/SRP receptor G-proteins › SRP54_N | 0.59 | 54.0 | 5.31e-01 | 100.0% | 94.3% |
| 3841109 | 192.29.1.293 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › SHCBP_N | 0.59 | 50.0 | 4.42e-01 | 95.5% | 94.0% |
| 1154557 | 108.1.1.0 ↗ | alpha arrays › EF-hand › EF-hand-related › EF-hand | 0.58 | 49.0 | 4.35e-01 | 94.0% | 72.4% |
| 3929607 | 106.1.1.0 ↗ | alpha arrays › Globin-like › Globin-like › Globin-like | 0.58 | 50.0 | 3.78e-01 | 100.0% | 53.5% |
| 5032600 | 2004.1.1.197 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Sulfotransfer_3 | 0.56 | 45.0 | 2.92e-01 | 94.0% | 67.4% |
| 4120017 | 230.3.1.1 ↗ | a+b two layers › T-fold › Elongation factor Ts (EF-Ts), dimerisation domain › Elongation factor Ts (EF-Ts), dimerisation domain › EF_TS | 0.55 | 41.0 | 3.31e-01 | 82.1% | 45.7% |
| 3177702 | 4177.1.1.0 ↗ | alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like | 0.52 | 43.0 | 3.12e-01 | 100.0% | 72.3% |
| 3881712 | 129.1.1.15 ↗ | alpha arrays › 6-phosphogluconate dehydrogenase C-terminal domain-like › 6-phosphogluconate dehydrogenase C-terminal domain-like › 6-phosphogluconate dehydrogenase C-terminal domain-like › P5CR_dimer | 0.51 | 42.0 | 3.49e-01 | 100.0% | 48.9% |
| 3803646 | 327.11.2.0 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Eukaryotic type KH-domain (KH-domain type I) | 0.50 | 42.0 | 4.34e-01 | 100.0% | 96.9% |