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NS4B
Euk-VirMurray_Valley_encephalitis_virus
NS4B__NP_722538__Murray_Valley_encephalitis_virus__11079
Identity
- Accession:
- NP_722538 ↗
- Protein ID:
- NS4B
- Kingdom:
- euk
Quality
78.9
mean pLDDT
Taxonomy
Orthornavirae›
Kitrinoviricota›
Flasuviricetes›
Amarillovirales›
Flaviviridae›
Orthoflavivirus›
Murray_Valley_encephalitis_virus
TaxID: 11079
Cluster
View cluster (29 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 40-150_162-191
Domain cluster:
rep: non-structural_protein_NS4b__NP_776008__Yellow_fever_virus__11089__D37-154
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01349.23 best | Flavi_NS4B | 108.3 | 6.30e-31 | 100.0% | 46.8% |
D2
medium
residues 192-250
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01349.23 best | Flavi_NS4B | 35.0 | 1.50e-08 | 94.9% | 20.6% |
CATH (30)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4v1gA00 | 1.20.20.10 | Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C | 0.73 | 51.0 | 4.48e-01 | 72.9% | 58.8% |
| 2xokP00 | 1.20.20.10 | Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C | 0.71 | 48.0 | 4.50e-01 | 72.9% | 56.8% |
| 6z74C02 | 1.20.120.530 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › GntR ligand-binding domain-like | 0.69 | 60.0 | 4.44e-01 | 100.0% | 47.8% |
| 3l8kA01 | 3.50.50.60 | Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain | 0.68 | 47.0 | 3.13e-01 | 74.6% | 19.4% |
| 1pn9B02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.66 | 48.0 | 3.79e-01 | 79.7% | 63.8% |
| 2jqqA00 | 1.20.58.1240 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.66 | 54.0 | 4.07e-01 | 94.9% | 43.5% |
| 4g1tA01 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.66 | 54.0 | 4.39e-01 | 96.6% | 51.2% |
| 6muwB00 | 3.60.20.10 | Alpha Beta › 4-Layer Sandwich › Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1 › Aminohydrolase, N-terminal nucleophile (Ntn) domain | 0.63 | 47.0 | 3.15e-01 | 81.4% | 40.2% |
| 7lxuE01 | 3.60.20.10 | Alpha Beta › 4-Layer Sandwich › Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1 › Aminohydrolase, N-terminal nucleophile (Ntn) domain | 0.60 | 45.0 | 3.11e-01 | 83.1% | 42.5% |
| 3d5lA03 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.59 | 40.0 | 4.18e-01 | 74.6% | 80.8% |
| 2pjqA01 | 1.10.472.50 | Mainly Alpha › Orthogonal Bundle › Cyclin A; domain 1 › HD-domain/PDEase-like | 0.59 | 48.0 | 4.25e-01 | 93.2% | 74.2% |
| 3e3vA03 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.58 | 39.0 | 4.04e-01 | 76.3% | 75.0% |
| 2gfhA02 | 1.20.120.710 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Haloacid dehalogenase hydrolase-like domain | 0.57 | 47.0 | 4.23e-01 | 96.6% | 75.6% |
| 3ddhA02 | 1.10.150.240 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 | 0.57 | 40.0 | 3.67e-01 | 79.7% | 55.6% |
| 2no4A02 | 1.10.150.240 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 | 0.56 | 41.0 | 3.84e-01 | 79.7% | 84.0% |
| 1xo0A01 | 1.10.150.130 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Tyrosine recombinase, N-terminal domain | 0.56 | 49.0 | 4.02e-01 | 98.3% | 72.1% |
| 2oxlA00 | 1.20.5.5260 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › | 0.56 | 41.0 | 4.09e-01 | 78.0% | 91.9% |
| 5kdiA00 | 1.10.3520.10 | Mainly Alpha › Orthogonal Bundle › Glycolipid transfer protein, GLTP › Glycolipid transfer protein | 0.56 | 48.0 | 3.32e-01 | 98.3% | 62.1% |
| 1bqbA02 | 1.10.390.10 | Mainly Alpha › Orthogonal Bundle › Neutral Protease; domain 2 › Neutral Protease Domain 2 | 0.56 | 45.0 | 3.59e-01 | 98.3% | 90.3% |
| 1yisA01 | 1.10.275.10 | Mainly Alpha › Orthogonal Bundle › Fumarase C; Chain B, domain 1 › Fumarase/aspartase (N-terminal domain) | 0.55 | 46.0 | 3.90e-01 | 94.9% | 73.8% |
| 3vr4B04 | 1.10.1140.10 | Mainly Alpha › Orthogonal Bundle › Bovine Mitochondrial F1-ATPase, ATP Synthase Beta Chain; Chain D, domain3 › Bovine Mitochondrial F1-atpase; Atp Synthase Beta Chain; Chain D, domain 3 | 0.55 | 44.0 | 3.45e-01 | 96.6% | 69.5% |
| 2do9A01 | 1.10.533.10 | Mainly Alpha › Orthogonal Bundle › Death Domain, Fas › Death Domain, Fas | 0.55 | 41.0 | 3.78e-01 | 86.4% | 72.6% |
| 1rypK00 | 3.60.20.10 | Alpha Beta › 4-Layer Sandwich › Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1 › Aminohydrolase, N-terminal nucleophile (Ntn) domain | 0.53 | 47.0 | 3.23e-01 | 98.3% | 32.3% |
| 4p63D00 | 3.40.910.10 | Alpha Beta › 3-Layer(aba) Sandwich › Deoxyhypusine Synthase › Deoxyhypusine synthase | 0.53 | 42.0 | 2.75e-01 | 93.2% | 19.2% |
| 3cmnA01 | 1.20.150.30 | Mainly Alpha › Up-down Bundle › Lysin › Zincin-like metallopeptidase, N-terminal domain | 0.53 | 43.0 | 3.58e-01 | 96.6% | 99.1% |
| 2vl7A02 | 1.10.275.30 | Mainly Alpha › Orthogonal Bundle › Fumarase C; Chain B, domain 1 › | 0.52 | 42.0 | 3.56e-01 | 94.9% | 56.4% |
| 2vpkA00 | 3.30.710.10 | Alpha Beta › 2-Layer Sandwich › Potassium Channel Kv1.1; Chain A › Potassium Channel Kv1.1; Chain A | 0.52 | 41.0 | 3.44e-01 | 91.5% | 73.9% |
| 5a29A01 | 1.50.10.20 | Mainly Alpha › Alpha/alpha barrel › Glycosyltransferase › | 0.52 | 45.0 | 2.73e-01 | 100.0% | 94.1% |
| 6qm7J00 | 3.60.20.10 | Alpha Beta › 4-Layer Sandwich › Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1 › Aminohydrolase, N-terminal nucleophile (Ntn) domain | 0.51 | 42.0 | 2.94e-01 | 94.9% | 66.7% |
| 3k6qA02 | 3.30.160.620 | Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › | 0.50 | 34.0 | 3.06e-01 | 71.2% | 64.0% |
ECOD (24)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3208712 | 5043.1.1.9 ↗ | extended segments › Sensor proteins transmembrane domains › Htr2 transmembrane domain-like › Htr2 transmembrane domain-like › Rrn7_cyclin_N | 0.78 | 53.0 | 5.22e-01 | 74.6% | 65.6% |
| 5068187 | 632.11.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like | 0.71 | 48.0 | 4.45e-01 | 76.3% | 55.4% |
| 3608416 | 4336.2.1.0 ↗ | alpha duplicates or obligate multimers › YheA/YmcA-like › Protein SUS1 › Protein SUS1 | 0.70 | 49.0 | 4.39e-01 | 74.6% | 52.9% |
| 5058631 | 632.15.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Staphylococcal complement inhibitor (SCIN) › Staphylococcal complement inhibitor (SCIN) | 0.69 | 47.0 | 4.66e-01 | 74.6% | 66.2% |
| 3713190 | 4336.2.1.1 ↗ | alpha duplicates or obligate multimers › YheA/YmcA-like › Protein SUS1 › Protein SUS1 › EnY2 | 0.68 | 48.0 | 4.14e-01 | 76.3% | 51.6% |
| 3482082 | 3476.1.1.0 ↗ | alpha arrays › RecQL4 helicase N-terminal domain › RecQL4 helicase N-terminal domain › RecQL4 helicase N-terminal domain | 0.65 | 45.0 | 4.28e-01 | 72.9% | 80.0% |
| 3849192 | 4015.1.1.1 ↗ | alpha complex topology › alpha-helical domain in sec1/munc18-like (SM) proteins › alpha-helical domain in sec1/munc18-like (SM) proteins › alpha-helical domain in sec1/munc18-like (SM) proteins › Sec1 | 0.63 | 43.0 | 2.89e-01 | 71.2% | 25.1% |
| 4993593 | 198.1.1.27 ↗ | alpha arrays › Saposin-like › Saposin-like › Saposin-like › PF27234 | 0.63 | 42.0 | 3.79e-01 | 83.1% | 51.2% |
| 3672805 | 109.4.1.2679 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR, PPR_3, TPR_24, TPR_At1g68980 | 0.61 | 48.0 | 2.89e-01 | 89.8% | 11.2% |
| 4096162 | 103.2.1.2 ↗ | alpha arrays › RuvA-C › ATP cone › ATP cone › ATP-cone | 0.60 | 44.0 | 3.79e-01 | 79.7% | 53.0% |
| 4600617 | 101.1.2.25 ↗ | alpha arrays › HTH › HTH › winged helix domain › FUR | 0.59 | 50.0 | 3.75e-01 | 96.6% | 46.0% |
| 3734687 | 2004.1.1.159 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Mur_ligase_M | 0.59 | 49.0 | 3.18e-01 | 94.9% | 30.9% |
| 1068638 | 101.35.1.4 ↗ | alpha arrays › HTH › DNA repair regulatory protein RecX › DNA repair regulatory protein RecX › RecX_HTH3 | 0.58 | 39.0 | 4.04e-01 | 76.3% | 75.0% |
| 3234110 | 2007.2.3.1 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › Y_phosphatase | 0.57 | 44.0 | 3.06e-01 | 83.1% | 57.9% |
| 3428642 | 101.35.1.0 ↗ | alpha arrays › HTH › DNA repair regulatory protein RecX › DNA repair regulatory protein RecX | 0.57 | 40.0 | 4.17e-01 | 74.6% | 94.5% |
| 3943035 | 639.2.1.0 ↗ | alpha arrays › HHA-like › Regulator of acid resistance influenced by indole (AriR) › Regulator of acid resistance influenced by indole (AriR) | 0.56 | 45.0 | 4.33e-01 | 84.7% | 90.8% |
| 4009408 | 639.2.1.1 ↗ | alpha arrays › HHA-like › Regulator of acid resistance influenced by indole (AriR) › Regulator of acid resistance influenced by indole (AriR) › YmgB | 0.56 | 40.0 | 3.78e-01 | 74.6% | 77.9% |
| 5014976 | 7516.1.1.2 ↗ | a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Glycos_transf_2 | 0.56 | 46.0 | 3.04e-01 | 98.3% | 31.0% |
| 4009124 | 639.2.1.5 ↗ | alpha arrays › HHA-like › Regulator of acid resistance influenced by indole (AriR) › Regulator of acid resistance influenced by indole (AriR) › PF27475 | 0.55 | 41.0 | 4.08e-01 | 78.0% | 96.7% |
| 4010412 | 639.2.1.0 ↗ | alpha arrays › HHA-like › Regulator of acid resistance influenced by indole (AriR) › Regulator of acid resistance influenced by indole (AriR) | 0.55 | 41.0 | 4.29e-01 | 79.7% | 98.2% |
| 4169956 | 604.12.1.26 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › HemX | 0.54 | 44.0 | 4.15e-01 | 96.6% | 84.0% |
| 4980637 | 186.1.1.0 ↗ | alpha arrays › lambda integrase-N-like › lambda integrase-N › lambda integrase-N | 0.53 | 46.0 | 3.86e-01 | 96.6% | 77.0% |
| 3269762 | 226.1.1.1 ↗ | a+b two layers › POZ domain › POZ domain › POZ domain › BTB | 0.52 | 45.0 | 3.49e-01 | 100.0% | 85.2% |
| 5083837 | 148.1.3.0 ↗ | alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain | 0.51 | 39.0 | 3.71e-01 | 84.7% | 100.0% |