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NS4B
Euk-VirCell_fusing_agent_virus
NS4B__YP_009259300__Cell_fusing_agent_virus__31658
Identity
- Accession:
- YP_009259300 ↗
- Protein ID:
- NS4B
- Kingdom:
- euk
Quality
67.4
mean pLDDT
Taxonomy
Orthornavirae›
Kitrinoviricota›
Flasuviricetes›
Amarillovirales›
Flaviviridae›
Orthoflavivirus›
Cell_fusing_agent_virus
TaxID: 31658
Cluster
View cluster (29 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 45-160
Domain cluster:
rep: nonstructural_protein_NS4B__YP_009259364__Quang_Binh_virus__643132__D49-163
CATH (21)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1t72A02 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.66 | 34.0 | 3.70e-01 | 92.2% | 58.2% |
| 1wwmA00 | 1.20.910.10 | Mainly Alpha › Up-down Bundle › Heme Oxygenase; Chain A › Heme oxygenase-like | 0.63 | 46.0 | 3.92e-01 | 79.3% | 47.8% |
| 1gu9C00 | 1.20.1290.10 | Mainly Alpha › Up-down Bundle › AhpD-like › AhpD-like | 0.63 | 34.0 | 3.00e-01 | 81.9% | 35.1% |
| 2f8lA01 | 1.10.150.470 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › | 0.62 | 42.0 | 4.98e-01 | 72.4% | 100.0% |
| 1fs0G02 | 1.10.287.80 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ATP synthase, gamma subunit, helix hairpin domain | 0.59 | 33.0 | 3.79e-01 | 81.9% | 73.0% |
| 6v9zA02 | 1.20.1560.10 | Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain | 0.56 | 48.0 | 3.50e-01 | 93.1% | 80.0% |
| 6k4yI00 | 1.10.1810.10 | Mainly Alpha › Orthogonal Bundle › Anti-sigma factor AsiA › Anti-Sigma Factor A | 0.54 | 35.0 | 3.98e-01 | 73.3% | 87.5% |
| 1ydxA02 | 1.10.287.1120 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Bipartite methylase S protein | 0.53 | 32.0 | 3.53e-01 | 82.8% | 74.4% |
| 6e1kA01 | 1.10.287.70 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.52 | 37.0 | 3.81e-01 | 94.0% | 75.9% |
| 7dwqL01 | 1.20.1240.10 | Mainly Alpha › Up-down Bundle › Photosystem 1 Reaction Centre Subunit Xi; Chain: L; › Photosystem I PsaL, reaction centre subunit XI | 0.52 | 41.0 | 4.08e-01 | 84.5% | 88.8% |
| 6grjB01 | 1.20.1170.10 | Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; › | 0.52 | 43.0 | 3.14e-01 | 88.8% | 67.3% |
| 2efkA01 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.52 | 44.0 | 3.42e-01 | 93.1% | 88.9% |
| 1rcwB00 | 1.20.910.10 | Mainly Alpha › Up-down Bundle › Heme Oxygenase; Chain A › Heme oxygenase-like | 0.52 | 46.0 | 3.81e-01 | 100.0% | 72.9% |
| 4m70I00 | 1.20.5.4130 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › | 0.51 | 38.0 | 3.98e-01 | 77.6% | 89.8% |
| 1jgcA00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.51 | 44.0 | 4.01e-01 | 96.6% | 93.8% |
| 1nfvA00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.51 | 43.0 | 3.90e-01 | 97.4% | 89.9% |
| 6v3zA00 | 1.20.141.10 | Mainly Alpha › Up-down Bundle › Chitosanase, subunit A; domain 1 › Chitosanase, subunit A, domain 1 | 0.51 | 37.0 | 3.21e-01 | 76.7% | 51.1% |
| 3cazB00 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.50 | 43.0 | 3.56e-01 | 94.0% | 91.0% |
| 1x04A00 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.50 | 42.0 | 3.57e-01 | 93.1% | 90.5% |
| 3r2kA00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.50 | 43.0 | 3.94e-01 | 95.7% | 97.4% |
| 3hiuD00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.50 | 42.0 | 3.89e-01 | 93.1% | 98.0% |
ECOD (14)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 5047089 | 603.1.1.0 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins | 0.68 | 57.0 | 5.84e-01 | 93.1% | 93.6% |
| 4527588 | 3755.1.1.25 ↗ | alpha bundles › YscO-like › Putative type III secretion protein YscO-related › Putative type III secretion protein YscO-related › H-kinase_dim | 0.68 | 36.0 | 3.84e-01 | 86.2% | 57.1% |
| 3482907 | 3291.1.1.0 ↗ | alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related | 0.65 | 50.0 | 5.06e-01 | 81.9% | 94.8% |
| 4388471 | 1075.4.1.0 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold | 0.62 | 48.0 | 3.54e-01 | 81.9% | 45.1% |
| 3402974 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.62 | 43.0 | 3.97e-01 | 72.4% | 91.0% |
| 3279105 | 1075.4.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane | 0.60 | 51.0 | 3.76e-01 | 92.2% | 85.5% |
| 3387248 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.57 | 51.0 | 4.37e-01 | 100.0% | 85.8% |
| 3560229 | 3291.1.1.230 ↗ | alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › TBCA_PH | 0.56 | 40.0 | 3.79e-01 | 73.3% | 99.3% |
| 3628964 | 5050.1.1.1 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Sugar_tr | 0.56 | 50.0 | 4.00e-01 | 100.0% | 83.0% |
| 4310125 | 1075.4.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane | 0.55 | 46.0 | 3.43e-01 | 92.2% | 83.1% |
| 3628960 | 5050.1.1.1 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Sugar_tr | 0.55 | 49.0 | 3.90e-01 | 100.0% | 77.9% |
| 3281779 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.54 | 47.0 | 4.06e-01 | 98.3% | 87.4% |
| 3250573 | 150.1.2.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Heme oxygenase/Ribonucleotide reductase | 0.52 | 46.0 | 3.87e-01 | 97.4% | 73.9% |
| 3600869 | 3567.1.1.0 ↗ | a+b duplicates or obligate multimers › MPER trimer › MPER trimer › MPER trimer | 0.51 | 39.0 | 4.01e-01 | 84.5% | 83.5% |
D2
medium
residues 161-246
Domain cluster:
rep: nonstructural_protein_NS4B__YP_009268611__Nakiwogo_virus__667516__D164-242
CATH (18)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 6umqA01 | 1.20.930.60 | Mainly Alpha › Up-down Bundle › Transcription Elongation Factor S-II; Chain A › | 0.77 | 56.0 | 5.08e-01 | 76.7% | 100.0% |
| 5ffdA00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.76 | 57.0 | 4.86e-01 | 79.1% | 92.0% |
| 3m7gA02 | 1.10.8.1010 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › | 0.76 | 57.0 | 5.49e-01 | 77.9% | 89.5% |
| 3a98A02 | 1.20.1270.350 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Dedicator of cytokinesis N-terminal subdomain | 0.74 | 53.0 | 5.34e-01 | 75.6% | 88.5% |
| 1td6A01 | 1.20.1480.10 | Mainly Alpha › Up-down Bundle › hypothetical protein mp506/mpn330, domain 1 › hypothetical protein mp506/mpn330, domain 1 | 0.73 | 47.0 | 4.45e-01 | 72.1% | 54.9% |
| 1n5uA01 | 1.10.246.10 | Mainly Alpha › Orthogonal Bundle › Serum Albumin; Chain A, Domain 1 › | 0.70 | 58.0 | 5.46e-01 | 89.5% | 90.3% |
| 4mudC00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.69 | 54.0 | 4.01e-01 | 83.7% | 63.2% |
| 2m6uA00 | 1.20.81.20 | Mainly Alpha › Up-down Bundle › Receptor-associated Protein › | 0.66 | 51.0 | 5.19e-01 | 81.4% | 98.8% |
| 3rlfF01 | 1.20.58.370 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › MalF N-terminal region-like | 0.64 | 49.0 | 4.94e-01 | 83.7% | 86.0% |
| 6yz2A01 | 1.20.120.350 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Voltage-gated potassium channels. Chain C | 0.60 | 49.0 | 4.48e-01 | 90.7% | 66.7% |
| 4ip8A00 | 1.10.132.110 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Serum amyloid A protein | 0.59 | 46.0 | 4.34e-01 | 83.7% | 92.4% |
| 6k9pB02 | 1.20.1300.20 | Mainly Alpha › Up-down Bundle › 3 helical TM bundles of succinate and fumarate reductases › Peptidase C65 Otubain, subdomain 2 | 0.58 | 43.0 | 3.63e-01 | 80.2% | 77.6% |
| 2hujA00 | 1.20.120.440 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › YppE-like | 0.58 | 43.0 | 3.85e-01 | 80.2% | 63.2% |
| 1cpyA02 | 1.10.287.410 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.58 | 39.0 | 4.21e-01 | 70.9% | 97.2% |
| 4lqqB00 | 1.20.140.30 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › MOB kinase activator | 0.55 | 46.0 | 3.88e-01 | 91.9% | 80.1% |
| 2k3qA00 | 1.10.274.70 | Mainly Alpha › Orthogonal Bundle › Enzyme I; Chain A, domain 2 › Spidroin, N-terminal domain | 0.54 | 41.0 | 3.72e-01 | 81.4% | 65.3% |
| 2ff4A02 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.51 | 44.0 | 3.49e-01 | 96.5% | 84.6% |
| 1kplA00 | 1.10.3080.10 | Mainly Alpha › Orthogonal Bundle › Clc chloride channel › Clc chloride channel | 0.51 | 41.0 | 2.70e-01 | 90.7% | 22.8% |
ECOD (26)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4970979 | 633.21.1.0 ↗ | alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 | 0.77 | 59.0 | 5.50e-01 | 80.2% | 77.1% |
| 4949711 | 150.1.1.3 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › Rubrerythrin | 0.77 | 61.0 | 5.07e-01 | 83.7% | 97.9% |
| 4970978 | 633.21.1.0 ↗ | alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 | 0.76 | 59.0 | 5.51e-01 | 82.6% | 76.2% |
| 3737705 | 605.4.1.4 ↗ | alpha duplicates or obligate multimers › ROP-like › ROP protein › ROP protein › DUF202 | 0.74 | 58.0 | 5.55e-01 | 83.7% | 96.0% |
| 3750261 | 192.8.1.421 ↗ | alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain › DUF4745 | 0.74 | 59.0 | 5.04e-01 | 84.9% | 91.1% |
| 3419702 | 633.4.1.1 ↗ | alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI | 0.74 | 58.0 | 4.73e-01 | 83.7% | 71.6% |
| 4024597 | 174.1.1.0 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain | 0.74 | 54.0 | 4.44e-01 | 76.7% | 54.0% |
| 3603132 | 633.12.1.0 ↗ | alpha bundles › Bromodomain-like › Ta0600-like › Ta0600-like | 0.72 | 50.0 | 5.23e-01 | 75.6% | 78.8% |
| 3676709 | 633.4.1.1 ↗ | alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI | 0.71 | 55.0 | 4.37e-01 | 82.6% | 70.0% |
| 3190257 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.71 | 58.0 | 4.82e-01 | 87.2% | 62.1% |
| 4966172 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.70 | 53.0 | 3.72e-01 | 80.2% | 31.2% |
| 3673192 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.68 | 51.0 | 4.11e-01 | 80.2% | 94.1% |
| 4034431 | 632.15.1.1 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Staphylococcal complement inhibitor (SCIN) › Staphylococcal complement inhibitor (SCIN) › CompInhib_SCIN | 0.66 | 50.0 | 5.07e-01 | 79.1% | 84.5% |
| 3788896 | 5082.1.1.0 ↗ | alpha bundles › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like | 0.66 | 52.0 | 3.99e-01 | 86.0% | 74.0% |
| 3385577 | 601.14.1.1 ↗ | alpha bundles › Four-helical up-and-down bundle › Hemerythrin › Hemerythrin › Hemerythrin | 0.65 | 49.0 | 4.31e-01 | 81.4% | 63.8% |
| 3784429 | 632.11.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like | 0.65 | 49.0 | 4.61e-01 | 81.4% | 72.4% |
| 3451761 | 633.22.1.7 ↗ | alpha bundles › Bromodomain-like › Vitamin K epoxide reductase (VKOR) › Vitamin K epoxide reductase (VKOR) › Tmemb_14 | 0.64 | 51.0 | 4.64e-01 | 86.0% | 73.0% |
| 4964440 | 601.7.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain | 0.64 | 54.0 | 4.21e-01 | 95.3% | 67.7% |
| 3443603 | 5069.1.3.70 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Fumarate reductase respiratory complex transmembrane subunits › Tmemb_14 | 0.63 | 49.0 | 4.58e-01 | 83.7% | 78.1% |
| 3697925 | 3755.4.1.0 ↗ | alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain | 0.62 | 46.0 | 3.82e-01 | 79.1% | 82.5% |
| 3325799 | 5050.1.1.1 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Sugar_tr | 0.61 | 46.0 | 4.17e-01 | 82.6% | 68.0% |
| 4029997 | 3636.1.1.0 ↗ | a+b two layers › XPD arch domain › XPD arch domain › XPD arch domain | 0.60 | 50.0 | 4.08e-01 | 89.5% | 83.2% |
| 3933306 | 5001.1.1.44 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7TM_GPCR_Srv | 0.59 | 49.0 | 3.71e-01 | 96.5% | 60.8% |
| 4964146 | 3579.1.1.0 ↗ | extended segments › NADH-quinone oxidoreductase subunit J › NADH-quinone oxidoreductase subunit J › NADH-quinone oxidoreductase subunit J | 0.52 | 46.0 | 3.53e-01 | 97.7% | 78.5% |
| 4064450 | 316.1.1.17 ↗ | a+b three layers › Nucleotidyltransferase-like › Nucleotidyltransferase › Nucleotidyltransferase › DNA_pol3_alpha | 0.52 | 43.0 | 3.10e-01 | 94.2% | 47.8% |
| 4065433 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.50 | 37.0 | 2.57e-01 | 77.9% | 34.6% |