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NS5-like_protein

Euk-Vir

Jingmen_tick_virus

NS5-like_protein__YP_009029999__Jingmen_tick_virus__1491393

Identity

Accession:: YP_009029999 ↗
Protein ID:: NS5-like_protein
Kingdom:: euk

Quality

72.4 mean pLDDT

Taxonomy

Orthornavirae› Kitrinoviricota› Flasuviricetes› Amarillovirales› Flaviviridae› Jingmen_tick_virus

TaxID: 1491393

Cluster

View cluster (51 members)

3D Structure

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Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 766-870

PDB

D2 medium residues 61-87_101-126_229-256_275-290

PDB

Domain cluster: representative

CATH (7)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3a98A02	1.20.1270.350	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Dedicator of cytokinesis N-terminal subdomain	0.54	40.0	4.18e-01	100.0%	86.2%
2jnsA01	1.20.1270.220	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 ›	0.54	35.0	3.80e-01	100.0%	79.0%
3a06B03	1.10.1740.10	Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › RNA polymerase sigma factor, region 2, helix turn helix motif	0.54	30.0	3.15e-01	97.9%	60.2%
1gvnA00	1.10.8.130	Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 ›	0.53	36.0	3.82e-01	100.0%	79.3%
3rguB00	1.20.5.420	Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › Immunoglobulin FC, subunit C	0.52	37.0	3.86e-01	100.0%	83.9%
3iieB03	1.10.1740.10	Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › RNA polymerase sigma factor, region 2, helix turn helix motif	0.52	30.0	3.22e-01	100.0%	64.7%
1e1dA02	1.20.1270.20	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 ›	0.51	33.0	3.53e-01	100.0%	77.4%

ECOD (3)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3505328	109.4.1.166 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › DUF3535	0.57	40.0	2.58e-01	72.2%	69.4%
3172454	192.29.1.0 ↗	alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding)	0.51	34.0	3.04e-01	100.0%	47.9%
3234384	2004.1.1.171 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Smg8_Smg9	0.51	39.0	2.73e-01	82.5%	90.3%

D3 medium residues 329-414_498-514

PDB

Domain cluster: representative

ECOD (2)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1279063	304.48.1.13 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Flavi_NS5	0.77	71.0	4.60e-01	100.0%	43.2%
2702788	304.48.1.13 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Flavi_NS5	0.75	61.0	5.10e-01	87.4%	93.1%

D4 medium residues 415-443_537-682

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00972.26 best	Flavi_NS5	40.8	1.60e-10	84.6%	25.9%

CATH (4)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2r7rA05	1.10.357.80	Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 ›	0.63	49.0	4.92e-01	80.6%	94.9%
6qs7C01	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.55	22.0	2.47e-01	96.0%	43.9%
2fdoA00	3.30.1970.10	Alpha Beta › 2-Layer Sandwich › AF2331-like fold › AF2331-like	0.53	26.0	3.29e-01	82.3%	78.5%
2ot4A03	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.51	22.0	2.82e-01	93.7%	66.4%

ECOD (4)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4875416	304.48.1.13 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Flavi_NS5	0.97	95.0	6.99e-01	100.0%	64.5%
1279063	304.48.1.13 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Flavi_NS5	0.92	89.0	6.35e-01	100.0%	66.1%
3169451	109.4.1.3193 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › HAT, Suf, HAT_Syf1_CNRKL1_C, HAT_Syf1_CNRKL1_N, HAT_PRP39_N	0.52	25.0	1.73e-01	73.7%	11.2%
4972532	878.1.1.1 ↗	a+b two layers › Hypothetical protein MTH677 › Hypothetical protein MTH677 › Hypothetical protein MTH677 › DUF3194	0.50	23.0	3.17e-01	93.7%	84.4%

D5 medium residues 444-497_515-536

PDB

Domain cluster: representative

CATH (2)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2hcnA03	1.10.260.90	Mainly Alpha › Orthogonal Bundle › 434 Repressor (Amino-terminal Domain) ›	0.69	54.0	5.72e-01	100.0%	95.5%
6g85A01	3.90.190.10	Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily	0.51	38.0	3.20e-01	82.9%	60.7%

ECOD (1)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4875416	304.48.1.13 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Flavi_NS5	0.94	91.0	5.52e-01	100.0%	19.9%

D6 medium residues 683-765

PDB

Domain cluster: rep: putative_NS5-like_protein__YP_009351917__Mogiana_tick_virus__1172985__D684-749