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NS5-like_protein

Euk-Vir

Wuhan_aphid_virus_1

NS5-like_protein__YP_009179388__Wuhan_aphid_virus_1__1746067

Identity

Accession:
YP_009179388 ↗
Protein ID:
NS5-like_protein
Kingdom:
euk

Quality

76.8 mean pLDDT

Taxonomy

Orthornavirae› Kitrinoviricota› Flasuviricetes› Amarillovirales› Flaviviridae› Wuhan_aphid_virus_1

TaxID: 1746067

Cluster

View cluster (51 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 84-263
PDB
Domain cluster: rep: RNA-dependent_RNA_polymerase_NS5__YP_009259288__Mercadeo_virus__1708574__D63-201
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF01728.26 best FtsJ 59.0 8.30e-16 97.2% 97.8%
D2 high residues 715-902
PDB
Domain cluster: rep: RNA-dependent_RNA_polymerase_NS5__YP_009268628__Hanko_virus__1125677__D698-878
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF20483.4 best Flavi_NS5_thumb 237.4 1.10e-70 89.4% 100.0%
D3 medium residues 25-75_264-281
PDB
Domain cluster: rep: NS5-like_protein__YP_009179403__Wuhan_flea_virus__1746071__D28-95_263-286
CATH (34)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
8sbeA02 1.20.1250.20 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains 0.63 54.0 4.02e-01 98.6% 68.4%
2psmA00 1.20.1250.70 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › Interleukin-15/Interleukin-21 0.63 51.0 4.36e-01 92.8% 96.6%
6t0bc02 1.20.120.80 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c oxidase, subunit III, four-helix bundle 0.62 52.0 3.89e-01 97.1% 61.3%
2ovjA00 1.10.555.10 Mainly Alpha › Orthogonal Bundle › Phosphatidylinositol 3-kinase; Chain A › Rho GTPase activation protein 0.62 52.0 3.77e-01 94.2% 36.3%
5c5sB00 1.10.555.10 Mainly Alpha › Orthogonal Bundle › Phosphatidylinositol 3-kinase; Chain A › Rho GTPase activation protein 0.62 51.0 3.73e-01 94.2% 36.1%
2osaA00 1.10.555.10 Mainly Alpha › Orthogonal Bundle › Phosphatidylinositol 3-kinase; Chain A › Rho GTPase activation protein 0.61 52.0 3.78e-01 94.2% 38.3%
7wf8B01 1.10.167.10 Mainly Alpha › Orthogonal Bundle › Regulator of G-protein Signalling 4; domain 2 › Regulator of G-protein Signalling 4, domain 2 0.60 51.0 4.28e-01 95.7% 57.0%
2xq9A02 1.20.58.390 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Neurotransmitter-gated ion-channel transmembrane domain 0.60 50.0 4.30e-01 98.6% 90.1%
3kuqA00 1.10.555.10 Mainly Alpha › Orthogonal Bundle › Phosphatidylinositol 3-kinase; Chain A › Rho GTPase activation protein 0.60 50.0 3.72e-01 95.7% 38.5%
3u8vA00 1.20.120.660 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › IL-4 antagonist (De novo design) like domain 0.60 50.0 4.81e-01 98.6% 100.0%
2acxA01 1.10.167.10 Mainly Alpha › Orthogonal Bundle › Regulator of G-protein Signalling 4; domain 2 › Regulator of G-protein Signalling 4, domain 2 0.60 50.0 3.63e-01 95.7% 36.1%
3nynA03 1.10.167.10 Mainly Alpha › Orthogonal Bundle › Regulator of G-protein Signalling 4; domain 2 › Regulator of G-protein Signalling 4, domain 2 0.59 49.0 4.75e-01 95.7% 91.4%
3h36A00 1.10.10.400 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Polyribonucleotide nucleotidyltransferase, RNA-binding domain 0.59 46.0 4.49e-01 87.0% 84.6%
3c4wB01 1.10.167.10 Mainly Alpha › Orthogonal Bundle › Regulator of G-protein Signalling 4; domain 2 › Regulator of G-protein Signalling 4, domain 2 0.58 48.0 3.59e-01 97.1% 36.5%
3o2tA00 1.25.10.10 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant 0.58 43.0 2.85e-01 81.2% 19.1%
2gomA00 1.10.10.1270 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Sbi, C3 binding domain IV 0.58 41.0 4.26e-01 82.6% 85.2%
1iurA01 1.10.287.110 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › DnaJ domain 0.58 44.0 4.57e-01 84.1% 98.4%
2l3lA01 1.20.58.1250 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Tubulin Binding Cofactor C, N-terminal domain 0.57 42.0 3.71e-01 79.7% 66.0%
1wtyA00 1.20.120.330 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 0.57 48.0 4.14e-01 97.1% 96.6%
3f1xA01 1.10.3130.10 Mainly Alpha › Orthogonal Bundle › serine acetyltransferase, domain 1 › serine acetyltransferase, domain 1 0.57 48.0 3.78e-01 95.7% 77.2%
2gnoA03 1.20.272.10 Mainly Alpha › Up-down Bundle › Zinc Finger, Delta Prime; domain 3 › 0.56 41.0 3.77e-01 82.6% 99.0%
2i0mA01 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.55 41.0 3.62e-01 81.2% 86.8%
5t3wA00 1.20.120.1160 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › 0.55 47.0 3.87e-01 100.0% 81.0%
3qnfA04 1.10.3480.20 Mainly Alpha › Orthogonal Bundle › TorD-like › 0.55 42.0 3.22e-01 87.0% 58.2%
1ywfA00 3.90.190.10 Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily 0.54 45.0 3.13e-01 92.8% 85.1%
2pz9A00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.54 42.0 3.22e-01 87.0% 72.1%
1aj3A00 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.54 40.0 3.60e-01 81.2% 88.8%
5dvwA00 1.20.120.1160 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › 0.53 45.0 3.73e-01 100.0% 86.4%
1j5wA02 1.20.58.180 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Class II aaRS and biotin synthetases; domain 2 0.52 38.0 3.72e-01 81.2% 88.3%
1yxrA01 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.52 37.0 3.72e-01 78.3% 94.6%
4ksaA02 1.20.140.90 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Malonyl-CoA decarboxylase, oligemerization domain 0.52 45.0 3.64e-01 100.0% 90.5%
2ouwB00 1.20.1290.10 Mainly Alpha › Up-down Bundle › AhpD-like › AhpD-like 0.51 41.0 3.34e-01 89.9% 64.0%
1vmgA00 1.10.287.1080 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › MazG-like 0.51 35.0 3.39e-01 73.9% 76.8%
2vxgA02 1.10.220.100 Mainly Alpha › Orthogonal Bundle › Annexin V; domain 1 › conserved c-terminal region of ge- 1 0.51 38.0 3.60e-01 82.6% 87.1%
ECOD (22)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4660264 192.7.1.3 ↗ alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm › Phe_tRNA-synt_N 0.64 47.0 4.34e-01 78.3% 87.8%
4887646 4030.1.1.2 ↗ alpha bundles › alpha-helical domain in subunits of heterodimeric actin filament capping protein Capz › alpha-helical domain in subunits of heterodimeric actin filament capping protein Capz › alpha-helical domain in subunits of heterodimeric actin filament capping protein Capz › F-actin_cap_A 0.64 44.0 4.82e-01 88.4% 89.3%
4111609 192.7.1.3 ↗ alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm › Phe_tRNA-synt_N 0.63 48.0 4.42e-01 82.6% 86.7%
3825264 4030.1.1.2 ↗ alpha bundles › alpha-helical domain in subunits of heterodimeric actin filament capping protein Capz › alpha-helical domain in subunits of heterodimeric actin filament capping protein Capz › alpha-helical domain in subunits of heterodimeric actin filament capping protein Capz › F-actin_cap_A 0.62 42.0 4.65e-01 89.9% 87.3%
3902188 185.1.3.1 ↗ alpha superhelices › Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin-like › Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin/Protein HNS-dependent expression A HdeA › GDNF receptor › GDNF 0.62 49.0 4.74e-01 88.4% 75.0%
2890324 189.1.1.2 ↗ alpha bundles › GTPase activation domain, GAP › GTPase activation domain, GAP › GTPase activation domain, GAP › RhoGAP 0.61 51.0 3.91e-01 94.2% 42.9%
2072360 1075.5.1.1 ↗ alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › MatE 0.60 53.0 3.74e-01 97.1% 50.2%
4284928 314.1.1.0 ↗ a+b three layers › Class II aaRS and biotin synthetases › Class II aaRS and biotin synthetases › Class II aaRS and biotin synthetases 0.60 45.0 2.87e-01 81.2% 22.3%
3563871 603.1.1.121 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins › PF30821 0.60 49.0 4.13e-01 89.9% 74.8%
4900526 185.1.3.1 ↗ alpha superhelices › Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin-like › Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin/Protein HNS-dependent expression A HdeA › GDNF receptor › GDNF 0.58 48.0 4.50e-01 92.8% 74.7%
3287135 6164.1.1.2 ↗ alpha bundles › Bestrophin › Bestrophin › Bestrophin › DUF4239 0.57 48.0 3.31e-01 95.7% 61.2%
3262554 198.1.1.0 ↗ alpha arrays › Saposin-like › Saposin-like › Saposin-like 0.56 46.0 4.53e-01 94.2% 98.7%
3758241 198.1.1.1 ↗ alpha arrays › Saposin-like › Saposin-like › Saposin-like › SapB_2 0.54 43.0 4.05e-01 92.8% 78.9%
3261028 198.1.1.2 ↗ alpha arrays › Saposin-like › Saposin-like › Saposin-like › SapB_2,SapB_1 0.53 43.0 4.13e-01 95.7% 84.7%
5039781 5045.1.1.3 ↗ alpha bundles › F1F0 ATP synthase subunit A › F1F0 ATP synthase subunit A › F1F0 ATP synthase subunit A › V_ATPase_I 0.53 44.0 2.94e-01 95.7% 43.3%
5078844 604.12.1.0 ↗ alpha bundles › Spectrin repeat-like › MIT domain › MIT domain 0.53 38.0 3.69e-01 78.3% 85.0%
4991399 603.1.1.0 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.53 41.0 3.88e-01 87.0% 91.8%
None — 0.52 39.0 2.83e-01 84.1% 50.9%
3750030 604.12.1.15 ↗ alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › Mito_morph_reg 0.52 41.0 3.80e-01 88.4% 80.0%
3443885 605.1.1.0 ↗ alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase 0.51 44.0 3.31e-01 95.7% 90.6%
351198 109.1.1.1 ↗ alpha superhelices › Repetitive alpha hairpins › Glutathione S-transferase (GST)-C › Glutathione S-transferase (GST)-C › GST_C 0.51 38.0 3.13e-01 84.1% 83.2%
371700 109.1.1.1 ↗ alpha superhelices › Repetitive alpha hairpins › Glutathione S-transferase (GST)-C › Glutathione S-transferase (GST)-C › GST_C 0.51 39.0 3.14e-01 84.1% 78.9%
D4 medium residues 398-423_516-591_619-708
PDB
Domain cluster: rep: NS5-like_protein__YP_009179378__Wuhan_aphid_virus_2__1746068__D395-425_499-662
D5 medium residues 424-515_592-618
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00972.26 best Flavi_NS5 25.7 6.10e-06 78.1% 15.5%
CATH (3)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2pggA01 3.90.1730.10 Alpha Beta › Alpha-Beta Complex › Infectious bursal virus vp1 polymerase fold › Infectious bursal virus vp1 polymerase domain 0.72 67.0 4.74e-01 100.0% 60.1%
2hcnA03 1.10.260.90 Mainly Alpha › Orthogonal Bundle › 434 Repressor (Amino-terminal Domain) › 0.70 39.0 5.10e-01 77.3% 100.0%
4k1pE00 1.20.1170.10 Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; › 0.50 36.0 2.67e-01 73.9% 84.6%
ECOD (12)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
1279063 304.48.1.13 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Flavi_NS5 0.87 82.0 5.40e-01 100.0% 47.8%
4875416 304.48.1.13 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Flavi_NS5 0.82 78.0 5.23e-01 100.0% 48.2%
3789227 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.77 71.0 5.13e-01 100.0% 66.5%
3877925 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.76 71.0 4.85e-01 100.0% 52.2%
3884315 304.48.1.0 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.76 70.0 4.34e-01 100.0% 32.0%
1699894 304.48.2.2 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › 'palm' domain in birnaviruse RNA-dependent RNA polymerase › Permu_RdRp_palm 0.75 69.0 4.43e-01 100.0% 46.2%
3680609 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.75 55.0 4.88e-01 77.3% 54.7%
3938749 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.74 68.0 4.72e-01 100.0% 55.1%
3937215 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.73 67.0 4.60e-01 100.0% 53.4%
3651623 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.66 58.0 4.53e-01 95.0% 72.2%
3768112 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.62 56.0 4.69e-01 98.3% 79.0%
3517751 389.1.2.0 ↗ few secondary structure elements › EGF-like › EGF-related › Complement control module/SCR domain 0.55 21.0 3.13e-01 89.1% 86.7%