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NS5-like_protein

Euk-Vir

Shuangao_insect_virus_7

NS5-like_protein__YP_009179401__Shuangao_insect_virus_7__1746063

Identity

Accession:
YP_009179401 ↗
Protein ID:
NS5-like_protein
Kingdom:
euk

Quality

76.9 mean pLDDT

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 106-257
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF01728.26 best FtsJ 25.5 1.60e-05 99.3% 83.4%
D2 high residues 719-900
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF20483.4 best Flavi_NS5_thumb 209.1 5.40e-62 89.0% 96.3%
D3 medium residues 25-105_258-281
PDB
CATH (9)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3kr9A02 1.10.287.1890 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.73 31.0 4.14e-01 95.2% 72.1%
2ii2A04 1.10.220.10 Mainly Alpha › Orthogonal Bundle › Annexin V; domain 1 › Annexin 0.64 33.0 3.69e-01 94.3% 63.3%
1i6zA00 1.20.58.120 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain 0.55 32.0 2.89e-01 97.1% 44.4%
3purA03 1.20.58.1360 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.55 29.0 2.85e-01 98.1% 47.3%
6dkuA01 1.10.8.950 Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Filoviridae VP35, C-terminal inhibitory domain, helical subdomain 0.54 27.0 3.14e-01 78.1% 67.1%
1f7cA00 1.10.555.10 Mainly Alpha › Orthogonal Bundle › Phosphatidylinositol 3-kinase; Chain A › Rho GTPase activation protein 0.52 42.0 3.51e-01 98.1% 50.0%
2jnsA01 1.20.1270.220 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.52 31.0 3.51e-01 81.9% 77.8%
4i0xG00 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.50 32.0 3.92e-01 97.1% 98.5%
6t0bc02 1.20.120.80 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c oxidase, subunit III, four-helix bundle 0.50 44.0 3.64e-01 97.1% 70.2%
ECOD (14)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3437243 632.15.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Staphylococcal complement inhibitor (SCIN) › Staphylococcal complement inhibitor (SCIN) 0.71 33.0 2.99e-01 97.1% 35.6%
3322308 192.8.1.0 alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain 0.63 31.0 3.17e-01 97.1% 48.6%
3686783 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.61 29.0 2.92e-01 98.1% 42.9%
3724802 109.4.1.381 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Rrn11 0.59 43.0 3.17e-01 77.1% 71.1%
3505328 109.4.1.166 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › DUF3535 0.59 43.0 2.89e-01 77.1% 67.6%
3642838 109.4.1.1185 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › BTB-POZ_ANK-like 0.57 42.0 3.22e-01 77.1% 95.5%
3978129 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.53 47.0 3.85e-01 98.1% 60.5%
5024781 5050.1.1.0 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter 0.51 45.0 3.81e-01 98.1% 64.6%
5023842 601.19.1.62 alpha bundles › Four-helical up-and-down bundle › Apolipoprotein › Apolipoprotein › SpoIIM 0.51 45.0 3.76e-01 98.1% 96.2%
3939708 601.24.1.0 alpha bundles › Four-helical up-and-down bundle › FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) › FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) 0.51 45.0 4.42e-01 95.2% 97.3%
3181183 5050.1.1.0 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter 0.50 45.0 3.54e-01 99.0% 57.3%
3445405 192.29.1.0 alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) 0.50 45.0 4.34e-01 98.1% 93.3%
4263900 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.50 44.0 3.57e-01 98.1% 54.8%
5054999 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.50 45.0 3.65e-01 98.1% 58.8%
D4 medium residues 334-349_460-517_594-618
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00972.26 best Flavi_NS5 35.0 9.30e-09 70.7% 14.2%
D5 medium residues 391-459_518-533_562-593
PDB
Domain cluster: representative
ECOD (1)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4875416 304.48.1.13 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Flavi_NS5 0.90 86.0 5.73e-01 100.0% 50.0%
D6 medium residues 534-561_619-718
PDB
CATH (35)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3h5xA03 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.84 71.0 7.47e-01 96.9% 96.6%
1s48A04 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.82 62.0 6.71e-01 100.0% 91.0%
1ra6A02 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.81 64.0 7.05e-01 93.8% 100.0%
5jxsA02 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.80 69.0 6.66e-01 100.0% 81.0%
1gx5A03 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.80 69.0 7.06e-01 100.0% 93.4%
2ckwA03 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.79 66.0 6.99e-01 96.9% 96.6%
1khvA03 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.77 70.0 6.99e-01 100.0% 94.6%
1hi8A03 3.30.70.1600 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.71 65.0 5.81e-01 98.4% 84.7%
1bqnA02 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.70 49.0 5.51e-01 96.9% 97.9%
1in0A01 3.30.70.860 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.69 39.0 5.01e-01 82.8% 100.0%
7pliA03 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.67 40.0 4.96e-01 82.0% 100.0%
3ofgB00 3.30.70.260 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain 0.67 44.0 5.20e-01 85.9% 97.7%
3mmlF01 3.30.1360.40 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › 0.64 33.0 4.05e-01 70.3% 78.5%
7uinD01 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.63 58.0 5.30e-01 100.0% 83.2%
6vudA02 3.30.1360.40 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › 0.61 35.0 4.38e-01 71.9% 94.7%
2ebbA00 3.30.1360.20 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › Transcriptional coactivator/pterin dehydratase 0.60 36.0 4.08e-01 72.7% 78.1%
3tj8A02 3.30.70.790 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › UreE, C-terminal domain 0.60 32.0 3.99e-01 89.1% 86.5%
6gdxA00 3.30.70.120 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.59 40.0 4.31e-01 85.2% 81.3%
2cpcA01 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.58 33.0 3.84e-01 83.6% 80.5%
6eibD00 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.58 51.0 4.80e-01 96.1% 86.5%
3hvwA00 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.57 51.0 4.72e-01 96.9% 84.3%
6zxbA02 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.57 52.0 4.98e-01 99.2% 96.5%
3pjxA01 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.57 51.0 4.58e-01 99.2% 82.3%
4qmfB01 3.30.1370.10 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › K Homology domain, type 1 0.56 33.0 3.91e-01 70.3% 87.8%
8b6jb01 3.30.830.10 Alpha Beta › 2-Layer Sandwich › Cytochrome Bc1 Complex; Chain A, domain 1 › Metalloenzyme, LuxS/M16 peptidase-like 0.55 43.0 3.72e-01 84.4% 80.5%
1s5jA03 3.90.1600.10 Alpha Beta › Alpha-Beta Complex › Palm domain of DNA polymerase › B family DNA polymerase, palm domain 0.54 47.0 4.45e-01 96.1% 96.2%
3bf4A01 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.53 39.0 4.40e-01 82.8% 100.0%
1s12A00 3.30.70.1490 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Cysteine protease Prp 0.53 35.0 3.97e-01 82.0% 90.4%
1vdhA01 3.30.70.1030 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Apc35880; domain 1 0.53 40.0 4.11e-01 85.9% 83.5%
4v19J00 3.30.70.1730 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Ribosomal protein L10, N-terminal RNA-binding domain 0.52 41.0 3.77e-01 96.9% 64.3%
3cuqB03 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.51 24.0 3.04e-01 85.2% 75.4%
2mh2A00 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.51 24.0 3.23e-01 85.9% 85.9%
1xviA02 3.30.980.20 Alpha Beta › 2-Layer Sandwich › Threonyl-tRNA Synthetase; Chain A, domain 2 › Putative mannosyl-3-phosphoglycerate phosphatase; domain 2 0.51 34.0 3.87e-01 80.5% 93.6%
2vxzA01 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.51 24.0 3.02e-01 85.2% 77.3%
1mg7A01 3.30.70.1000 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Switch protein XOL-1, GHMP-like 0.50 42.0 3.86e-01 93.0% 85.7%
ECOD (40)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4875416 304.48.1.13 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Flavi_NS5 0.91 87.0 5.90e-01 100.0% 49.5%
1279063 304.48.1.13 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Flavi_NS5 0.89 80.0 5.27e-01 93.0% 44.2%
5366 304.48.1.15 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_3 0.81 72.0 4.91e-01 93.8% 42.5%
4954322 304.3.1.0 a+b two layers › Alpha-beta plaits › HMA-related › HMA, heavy metal-associated domain 0.75 42.0 5.50e-01 83.6% 100.0%
4882532 304.48.1.0 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.75 71.0 5.09e-01 100.0% 55.2%
217141 304.48.1.15 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_3 0.74 70.0 4.89e-01 100.0% 47.9%
4977937 304.3.1.0 a+b two layers › Alpha-beta plaits › HMA-related › HMA, heavy metal-associated domain 0.73 41.0 5.35e-01 84.4% 100.0%
4970115 304.3.1.0 a+b two layers › Alpha-beta plaits › HMA-related › HMA, heavy metal-associated domain 0.73 41.0 5.30e-01 86.7% 100.0%
5071792 304.3.1.0 a+b two layers › Alpha-beta plaits › HMA-related › HMA, heavy metal-associated domain 0.73 40.0 5.09e-01 84.4% 92.0%
1586993 304.48.1.0 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.72 65.0 4.25e-01 96.1% 34.8%
4998680 304.3.1.0 a+b two layers › Alpha-beta plaits › HMA-related › HMA, heavy metal-associated domain 0.72 40.0 5.19e-01 83.6% 100.0%
4955127 304.163.1.0 a+b two layers › Alpha-beta plaits › ATP-binding protein TM_1403 insertion domain › ATP-binding protein TM_1403 insertion domain 0.72 40.0 5.21e-01 83.6% 100.0%
5369 304.48.1.8 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_1 0.71 65.0 4.26e-01 96.9% 38.3%
4940659 304.3.1.0 a+b two layers › Alpha-beta plaits › HMA-related › HMA, heavy metal-associated domain 0.71 40.0 5.10e-01 83.6% 98.6%
5061378 304.3.1.0 a+b two layers › Alpha-beta plaits › HMA-related › HMA, heavy metal-associated domain 0.70 40.0 5.08e-01 84.4% 100.0%
5040248 304.3.1.0 a+b two layers › Alpha-beta plaits › HMA-related › HMA, heavy metal-associated domain 0.70 42.0 5.22e-01 85.2% 100.0%
5083546 304.3.1.0 a+b two layers › Alpha-beta plaits › HMA-related › HMA, heavy metal-associated domain 0.69 43.0 5.29e-01 87.5% 100.0%
5072231 304.3.1.0 a+b two layers › Alpha-beta plaits › HMA-related › HMA, heavy metal-associated domain 0.69 39.0 4.96e-01 80.5% 100.0%
4974988 304.3.1.0 a+b two layers › Alpha-beta plaits › HMA-related › HMA, heavy metal-associated domain 0.68 39.0 4.93e-01 83.6% 100.0%
4978228 305.2.1.0 a+b two layers › DCoH-like › Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH) › Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH) 0.68 36.0 4.75e-01 72.7% 100.0%
4985405 5104.1.1.1 a+b three layers › C-terminal domain in DHH phosphoesterases › C-terminal domain in DHH phosphoesterases › C-terminal domain in DHH phosphoesterases › DHHA1 0.66 36.0 3.68e-01 72.7% 53.6%
3626328 304.117.1.1 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in YebC › Ferredoxin-like domain in YebC › Transcrip_reg 0.65 40.0 4.89e-01 89.1% 97.5%
4995642 5104.1.1.0 a+b three layers › C-terminal domain in DHH phosphoesterases › C-terminal domain in DHH phosphoesterases › C-terminal domain in DHH phosphoesterases 0.65 32.0 3.45e-01 71.1% 52.7%
5039768 3501.1.1.0 a+b two layers › protein PCC1 › protein PCC1 › protein PCC1 0.63 37.0 4.52e-01 82.8% 98.7%
1827765 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.63 57.0 4.35e-01 100.0% 53.1%
3989356 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.62 57.0 5.04e-01 100.0% 84.9%
3622300 304.9.1.16 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_3 0.62 43.0 4.54e-01 91.4% 80.0%
3723903 304.9.1.38 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › SET_assoc 0.60 40.0 4.61e-01 93.8% 97.8%
3934202 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.59 54.0 5.23e-01 100.0% 92.4%
3407163 304.48.1.6 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_A 0.59 48.0 5.00e-01 88.3% 95.0%
3532818 327.11.2.1 a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Eukaryotic type KH-domain (KH-domain type I) › KH_1 0.58 33.0 4.05e-01 71.9% 88.7%
1186663 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.57 52.0 4.23e-01 100.0% 58.1%
3984781 304.48.1.1 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.57 45.0 4.25e-01 85.9% 80.0%
3608339 304.48.1.6 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_A 0.56 47.0 4.62e-01 89.1% 92.6%
3591785 304.48.1.0 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.56 46.0 4.39e-01 88.3% 80.0%
3698721 321.2.1.1 a+b two layers › Glutamine synthetase-like › C-terminal domain in urocanase › C-terminal domain in urocanase › Urocanase_C 0.55 44.0 3.63e-01 85.9% 81.7%
3516510 304.48.1.6 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_A 0.54 44.0 4.58e-01 88.3% 95.8%
4343896 5104.1.1.1 a+b three layers › C-terminal domain in DHH phosphoesterases › C-terminal domain in DHH phosphoesterases › C-terminal domain in DHH phosphoesterases › DHHA1 0.52 29.0 3.11e-01 98.4% 59.1%
5080660 101.1.2.0 alpha arrays › HTH › HTH › winged helix domain 0.52 26.0 2.88e-01 89.1% 54.3%
5225 304.1.1.2 a+b two layers › Alpha-beta plaits › GHMP Kinase, C-terminal domain › GHMP Kinase, C-terminal domain › Xol-1_GHMP-like 0.51 44.0 3.91e-01 96.1% 92.0%