←Back to structures

NS5-like_protein

Euk-Vir

Wuhan_flea_virus

NS5-like_protein__YP_009179403__Wuhan_flea_virus__1746071

Identity

Accession:
YP_009179403 ↗
Protein ID:
NS5-like_protein
Kingdom:
euk

Quality

78.2 mean pLDDT

Taxonomy

Orthornavirae› Kitrinoviricota› Flasuviricetes› Amarillovirales› Flaviviridae› Wuhan_flea_virus

TaxID: 1746071

Cluster

View cluster (51 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 96-262
PDB
Domain cluster: rep: IMGVR_UViG_3300009616_000257-3300009616-Ga0116111_100275611__D486-632
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF01728.26 best FtsJ 36.2 8.40e-09 98.2% 87.8%
D2 high residues 733-893
PDB
Domain cluster: rep: RNA-dependent_RNA_polymerase_NS5__YP_009268628__Hanko_virus__1125677__D698-878
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF20483.4 best Flavi_NS5_thumb 203.8 2.30e-60 95.7% 92.1%
CATH (2)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3b0pA02 1.20.120.1460 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › 0.54 25.0 3.49e-01 77.0% 92.0%
1e8yA03 1.25.40.70 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Phosphatidylinositol 3-kinase, accessory domain (PIK) 0.52 31.0 3.00e-01 87.6% 50.0%
ECOD (3)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
None — 0.83 76.0 6.94e-01 100.0% 75.2%
3010831 4967.1.1.14 ↗ alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › Flavi_NS5_thumb 0.79 73.0 6.61e-01 100.0% 74.8%
3747617 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.56 39.0 3.41e-01 70.2% 91.1%
D3 medium residues 28-95_263-286
PDB
Domain cluster: representative
CATH (21)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1wrdA00 1.20.58.160 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.67 34.0 3.35e-01 95.7% 46.9%
2yb5F01 1.20.1280.250 Mainly Alpha › Up-down Bundle › Monooxygenase › 0.59 42.0 4.39e-01 95.7% 80.2%
5c5sB00 1.10.555.10 Mainly Alpha › Orthogonal Bundle › Phosphatidylinositol 3-kinase; Chain A › Rho GTPase activation protein 0.59 44.0 3.46e-01 91.3% 36.6%
4dlqA02 1.25.40.610 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.59 33.0 3.35e-01 78.3% 53.7%
2r7rA03 1.10.10.1990 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Viral RNA-directed RNA polymerase, 4-helical domain 0.58 40.0 4.31e-01 93.5% 86.8%
2ptfB02 1.20.58.290 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Hypothetical membrane protein ta0354_69_121. 0.58 35.0 4.15e-01 82.6% 96.5%
1i5nB00 1.20.120.160 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain 0.56 51.0 4.65e-01 100.0% 81.5%
2mbgA01 1.10.555.10 Mainly Alpha › Orthogonal Bundle › Phosphatidylinositol 3-kinase; Chain A › Rho GTPase activation protein 0.56 43.0 3.39e-01 92.4% 38.7%
1juqC00 1.25.40.90 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.55 38.0 3.32e-01 72.8% 89.9%
4iggB02 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.55 48.0 4.36e-01 95.7% 94.2%
4griA05 1.10.10.350 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › 0.53 39.0 3.90e-01 94.6% 74.2%
4k7bA00 1.20.120.1740 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Sodium ion translocating NADH-quinone reductase subunit C-like 0.53 44.0 4.13e-01 92.4% 74.8%
1sxjE03 1.20.272.10 Mainly Alpha › Up-down Bundle › Zinc Finger, Delta Prime; domain 3 › 0.52 40.0 3.98e-01 82.6% 99.0%
2yksA02 1.20.58.390 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Neurotransmitter-gated ion-channel transmembrane domain 0.52 46.0 4.23e-01 97.8% 91.5%
1cnt200 1.20.1250.10 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › 0.52 44.0 3.96e-01 93.5% 96.9%
3dzaA01 1.20.120.1940 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › YfdX protein domain 0.52 44.0 4.08e-01 93.5% 82.1%
5z7cA01 1.10.3210.10 Mainly Alpha › Orthogonal Bundle › Hypothetical protein af1432 › Hypothetical protein af1432 0.52 40.0 3.26e-01 83.7% 98.3%
2xq9A02 1.20.58.390 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Neurotransmitter-gated ion-channel transmembrane domain 0.51 45.0 4.13e-01 97.8% 88.4%
1j5wA02 1.20.58.180 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Class II aaRS and biotin synthetases; domain 2 0.51 33.0 3.54e-01 82.6% 77.9%
5djsA01 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.51 35.0 3.15e-01 73.9% 80.4%
4ebjA02 1.20.120.330 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 0.50 43.0 3.84e-01 94.6% 80.0%
ECOD (16)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
5011995 601.3.1.0 ↗ alpha bundles › Four-helical up-and-down bundle › Histidine-containing phosphotransfer domain, HPT domain › Histidine-containing phosphotransfer domain, HPT domain 0.66 50.0 4.89e-01 94.6% 73.0%
3940891 3291.1.1.0 ↗ alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related 0.57 33.0 2.83e-01 96.7% 36.6%
4002355 5050.1.1.1 ↗ alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Sugar_tr 0.56 48.0 3.54e-01 94.6% 42.1%
4525372 601.18.1.24 ↗ alpha bundles › Four-helical up-and-down bundle › Oxygen-evolving enhancer protein 3 › Oxygen-evolving enhancer protein 3 › Spore_YpjB 0.55 47.0 4.77e-01 93.5% 100.0%
3472981 601.1.1.0 ↗ alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin 0.55 47.0 3.91e-01 94.6% 76.9%
1503807 150.1.1.0 ↗ alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin 0.55 47.0 4.39e-01 94.6% 95.7%
4480624 601.50.1.0 ↗ alpha bundles › Four-helical up-and-down bundle › Flagellar cap protein FliD helical bundle domain › Flagellar cap protein FliD helical bundle domain 0.53 45.0 3.91e-01 94.6% 96.4%
5024781 5050.1.1.0 ↗ alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter 0.53 44.0 3.64e-01 94.6% 64.0%
4940421 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.52 37.0 3.07e-01 73.9% 77.6%
3497347 601.1.1.0 ↗ alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin 0.52 45.0 4.07e-01 95.7% 83.2%
3317539 603.1.1.0 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.51 36.0 3.39e-01 72.8% 83.5%
2754934 5057.1.1.0 ↗ alpha bundles › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore 0.51 44.0 3.93e-01 95.7% 79.9%
3248938 5050.1.1.40 ↗ alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › PGAP2IP_TM_1nd 0.51 43.0 3.43e-01 94.6% 62.1%
3244120 5050.1.1.1 ↗ alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Sugar_tr 0.51 43.0 3.20e-01 93.5% 39.2%
3617250 109.27.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › BACK domain › BACK domain 0.51 30.0 3.11e-01 85.9% 58.9%
2157267 109.4.1.204 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › HEAT_EZ 0.50 35.0 3.32e-01 72.8% 94.8%
D4 medium residues 315-356_368-395_444-456_471-503_597-617
PDB
Domain cluster: representative
ECOD (2)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
1279063 304.48.1.13 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Flavi_NS5 0.87 82.0 5.59e-01 100.0% 73.0%
None — 0.72 60.0 4.33e-01 88.3% 77.0%
D5 medium residues 396-424_516-596_618-649
PDB
Domain cluster: rep: NS5-like_protein__YP_009179378__Wuhan_aphid_virus_2__1746068__D395-425_499-662
D6 medium residues 650-732
PDB
Domain cluster: rep: putative_NS5-like_protein__YP_009351917__Mogiana_tick_virus__1172985__D684-749
CATH (10)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
5jxsA02 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.68 56.0 4.69e-01 100.0% 52.8%
7pliA03 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.58 36.0 3.77e-01 79.5% 68.0%
8dvhB01 3.30.230.10 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 › 0.55 44.0 3.51e-01 89.2% 96.1%
1mukA02 3.90.1850.10 Alpha Beta › Alpha-Beta Complex › RNA-directed RNA polymerase lambda-3 › RNA-directed RNA polymerase lambda-3 0.54 48.0 2.92e-01 97.6% 72.2%
1rzmA01 3.30.70.1140 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Phospho-2-dehydro-3-deoxyheptonate aldolase; domain 1 0.53 37.0 3.78e-01 88.0% 77.5%
3vsjA00 3.40.830.10 Alpha Beta › 3-Layer(aba) Sandwich › Protocatechuate 4,5-dioxygenase; Chain B › LigB-like 0.52 40.0 2.87e-01 85.5% 52.2%
3lxqA01 3.30.1120.80 Alpha Beta › 2-Layer Sandwich › Arylsulfatase, C-terminal domain › 0.52 35.0 3.36e-01 88.0% 58.6%
2h21B01 3.90.1410.10 Alpha Beta › Alpha-Beta Complex › set domain protein methyltransferase, domain 1 › set domain protein methyltransferase, domain 1 0.51 35.0 2.61e-01 73.5% 71.0%
2epjA01 3.90.1150.10 Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1 0.51 38.0 3.01e-01 85.5% 38.1%
2pb2B01 3.90.1150.10 Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1 0.50 33.0 2.86e-01 84.3% 39.4%
ECOD (9)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4998680 304.3.1.0 ↗ a+b two layers › Alpha-beta plaits › HMA-related › HMA, heavy metal-associated domain 0.60 36.0 3.90e-01 78.3% 70.0%
3301018 304.3.1.0 ↗ a+b two layers › Alpha-beta plaits › HMA-related › HMA, heavy metal-associated domain 0.57 35.0 4.09e-01 77.1% 92.7%
3555679 304.126.1.1 ↗ a+b two layers › Alpha-beta plaits › ferredoxin-like domain in vacuolar ATP synthase subunit C › ferredoxin-like domain in vacuolar ATP synthase subunit C › V_ATPase_I 0.55 34.0 3.33e-01 78.3% 53.7%
4003797 3016.1.1.2 ↗ a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › Aminotran_3 0.52 34.0 3.03e-01 81.9% 44.0%
3503012 3016.1.1.2 ↗ a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › Aminotran_3 0.52 33.0 3.01e-01 83.1% 45.4%
3675128 304.9.1.20 ↗ a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_8 0.51 37.0 3.94e-01 75.9% 90.0%
2617501 3016.1.1.2 ↗ a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › Aminotran_3 0.51 34.0 3.20e-01 84.3% 55.4%
4097938 3016.1.1.2 ↗ a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › Aminotran_3 0.51 34.0 3.17e-01 84.3% 52.7%
2534080 3016.1.1.0 ↗ a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases 0.50 32.0 3.00e-01 85.5% 49.1%