←Back to structures

NS5

Euk-Vir

Murray_Valley_encephalitis_virus

NS5__NP_722539__Murray_Valley_encephalitis_virus__11079

Identity

Accession:: NP_722539 ↗
Protein ID:: NS5
Kingdom:: euk

Quality

85.4 mean pLDDT

Taxonomy

Orthornavirae› Kitrinoviricota› Flasuviricetes› Amarillovirales› Flaviviridae› Orthoflavivirus› Murray_Valley_encephalitis_virus

TaxID: 11079

Cluster

View cluster (51 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 8-256

PDB

Domain cluster: rep: IMGVR_UViG_3300009616_000257-3300009616-Ga0116111_100275611__D486-632

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF01728.26 best	FtsJ	80.8	1.70e-22	69.5%	97.8%

D2 high residues 323-341_714-894

PDB

Domain cluster: rep: RNA-dependent_RNA_polymerase_NS5__YP_009268628__Hanko_virus__1125677__D698-878

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF20483.4 best	Flavi_NS5_thumb	236.7	1.80e-70	80.5%	96.3%

D3 medium residues 272-319_589-600

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00972.26 best	Flavi_NS5	63.6	1.90e-17	96.7%	12.0%

CATH (8)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
6wczB02	3.30.70.2840	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Flavivirus RNA-directed RNA polymerase, thumb domain	0.92	65.0	6.52e-01	73.3%	73.3%
2hfzA01	3.30.70.2840	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Flavivirus RNA-directed RNA polymerase, thumb domain	0.89	82.0	6.99e-01	96.7%	100.0%
2fclA00	3.30.460.40	Alpha Beta › 2-Layer Sandwich › Beta Polymerase; domain 2 ›	0.62	47.0	3.52e-01	88.3%	32.1%
2zxkA00	3.40.1500.20	Alpha Beta › 3-Layer(aba) Sandwich › oxygen-dependent coproporphyrinogen oxidase ›	0.59	51.0	3.36e-01	100.0%	32.0%
3obqA00	3.10.110.10	Alpha Beta › Roll › Ubiquitin Conjugating Enzyme › Ubiquitin Conjugating Enzyme	0.59	50.0	3.89e-01	100.0%	48.2%
2zxrA01	2.40.50.460	Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) ›	0.53	43.0	3.25e-01	93.3%	94.9%
1ayeA02	3.40.630.10	Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Zn peptidases	0.52	42.0	2.76e-01	95.0%	37.4%
4lbhA00	3.30.70.1060	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Dimeric alpha+beta barrel	0.51	43.0	3.79e-01	100.0%	78.7%

ECOD (17)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1279063	304.48.1.13 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Flavi_NS5	0.94	89.0	5.16e-01	100.0%	75.1%
4955450	331.1.1.0 ↗	a+b two layers › TBP-like › TATA-box binding protein-like › TATA-box binding protein-like	0.61	49.0	3.92e-01	90.0%	92.0%
4966859	304.51.1.8 ↗	a+b two layers › Alpha-beta plaits › CRISPR transcript (pre-crRNA) processing endoribonuclease-related › CRISPR transcript (pre-crRNA) processing endoribonuclease-related › Cas6b_C	0.61	33.0	3.08e-01	93.3%	38.7%
5082037	331.10.2.0 ↗	a+b two layers › TBP-like › S-adenosylmethionine decarboxylase-related › Bacterial S-adenosylmethionine decarboxylase	0.59	48.0	4.27e-01	95.0%	63.8%
3212496	243.1.1.0 ↗	a+b two layers › Cystatin-like › NTF2-like › NTF2-like	0.57	48.0	4.30e-01	98.3%	72.2%
3662612	304.48.1.37 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_2	0.56	42.0	2.78e-01	83.3%	48.8%
3502586	304.48.1.0 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like	0.54	44.0	3.43e-01	96.7%	55.5%
3295358	237.1.1.0 ↗	a+b complex topology › ADP-ribosylation › ADP-ribosylation › ADP-ribosylation	0.53	43.0	3.02e-01	100.0%	72.1%
4976136	331.10.2.0 ↗	a+b two layers › TBP-like › S-adenosylmethionine decarboxylase-related › Bacterial S-adenosylmethionine decarboxylase	0.52	42.0	3.77e-01	96.7%	64.2%
3761570	330.1.1.22 ↗	a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like › PF26536	0.52	40.0	3.35e-01	88.3%	47.8%
3882304	330.1.1.0 ↗	a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like	0.51	39.0	3.33e-01	88.3%	50.0%
3592192	316.1.1.36 ↗	a+b three layers › Nucleotidyltransferase-like › Nucleotidyltransferase › Nucleotidyltransferase › MTPAP-like_central	0.51	40.0	3.18e-01	96.7%	38.6%
3678439	246.3.1.4 ↗	a+b four layers › Carbon-nitrogen hydrolase-like › DNase I-like › DNase I-like › Exo_endo_phos2	0.51	37.0	2.67e-01	80.0%	89.4%
1832709	10.2.1.41 ↗	beta sandwiches › jelly-roll › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Capsid_NCLDV	0.51	34.0	3.46e-01	95.0%	71.7%
4488509	220.1.1.66 ↗	beta barrels › PH domain-like › PH domain-like › PH domain-like › SOS1_NGEF_PH	0.50	39.0	3.04e-01	90.0%	51.3%
4014419	206.1.1.10 ↗	a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Choline_kinase	0.50	41.0	2.60e-01	100.0%	70.9%
3176281	896.1.1.3 ↗	a+b two layers › SRP9/14-like › Signal recognition particle alu RNA binding heterodimer SRP9/14-related › Signal recognition particle alu RNA binding heterodimer SRP9/14-related › SRP9-21	0.50	40.0	3.78e-01	95.0%	73.3%

D4 medium residues 342-364_395-488_553-588

PDB

Domain cluster: rep: RNA-dependent_RNA_polymerase_NS5__NP_776022__West_Nile_virus__11082__D339-361_378-392_453-479_545-600

Pfam (3)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00972.26 best	Flavi_NS5	181.3	3.80e-53	64.7%	21.3%
PF00972.26	Flavi_NS5	29.0	5.80e-07	24.8%	8.0%
PF00972.26	Flavi_NS5	33.8	2.10e-08	15.7%	4.9%

D5 medium residues 365-394_489-552_601-650

PDB

Domain cluster: rep: RNA-dependent_RNA_polymerase_NS5__YP_009333115__Cacipacore_virus__64305__D369-395_486-508_600-654

Pfam (2)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00972.26 best	Flavi_NS5	118.0	6.20e-34	46.5%	14.4%
PF00972.26	Flavi_NS5	51.7	8.00e-14	35.4%	10.2%

D6 medium residues 651-701

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00972.26 best	Flavi_NS5	84.0	1.20e-23	100.0%	11.3%

CATH (2)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2x49A04	3.40.50.12790	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › FHIPEP family, domain 4	0.52	35.0	2.90e-01	70.6%	75.8%
2dy1A01	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.51	41.0	2.71e-01	100.0%	70.9%

ECOD (6)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3386464	3255.1.1.1 ↗	a/b three-layered sandwiches › a/b domain in flagellar biosynthesis protein flhA › a/b domain in flagellar biosynthesis protein flhA › a/b domain in flagellar biosynthesis protein flhA › FHIPEP	0.56	39.0	3.17e-01	76.5%	74.3%
4488195	3016.1.1.0 ↗	a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases	0.54	37.0	3.32e-01	84.3%	47.5%
4392997	3255.1.1.1 ↗	a/b three-layered sandwiches › a/b domain in flagellar biosynthesis protein flhA › a/b domain in flagellar biosynthesis protein flhA › a/b domain in flagellar biosynthesis protein flhA › FHIPEP	0.53	37.0	2.98e-01	70.6%	71.4%
2832047	3255.1.1.1 ↗	a/b three-layered sandwiches › a/b domain in flagellar biosynthesis protein flhA › a/b domain in flagellar biosynthesis protein flhA › a/b domain in flagellar biosynthesis protein flhA › FHIPEP	0.51	34.0	2.79e-01	70.6%	64.5%
3259134	109.2.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › alpha/alpha toroid › alpha/alpha toroid	0.51	41.0	2.63e-01	98.0%	41.0%
3279300	101.1.2.0 ↗	alpha arrays › HTH › HTH › winged helix domain	0.51	38.0	2.80e-01	86.3%	65.6%