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NS5

Euk-Vir

Cell_fusing_agent_virus

NS5__YP_009259301__Cell_fusing_agent_virus__31658

Identity

Accession:: YP_009259301 ↗
Protein ID:: NS5
Kingdom:: euk

Quality

85.6 mean pLDDT

Taxonomy

Orthornavirae› Kitrinoviricota› Flasuviricetes› Amarillovirales› Flaviviridae› Orthoflavivirus› Cell_fusing_agent_virus

TaxID: 31658

Cluster

View cluster (51 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 698-877

PDB

Domain cluster: rep: RNA-dependent_RNA_polymerase_NS5__YP_009268628__Hanko_virus__1125677__D698-878

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF20483.4 best	Flavi_NS5_thumb	186.9	3.60e-55	87.2%	95.7%

D2 medium residues 41-146

PDB

Domain cluster: rep: RNA-dependent_RNA_polymerase__NP_740729__Louping_ill_virus__11086__D71-170

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF01728.26 best	FtsJ	64.2	2.20e-17	98.1%	55.8%

D3 medium residues 147-235

PDB

Domain cluster: rep: RNA-dependent_RNA_polymerase_NS5__YP_009329957__Saint_Louis_encephalitis_virus__11080__D147-245

D4 medium residues 263-486_525-629

PDB

Domain cluster: rep: RNA-dependent_RNA_polymerase__YP_009337183__Beihai_weivirus-like_virus_12__1922741__D286-574_646-655

Pfam (2)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00972.26 best	Flavi_NS5	248.8	1.20e-73	68.4%	49.0%
PF00972.26	Flavi_NS5	100.8	9.80e-29	32.8%	22.4%

CATH (3)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2hfzA01	3.30.70.2840	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Flavivirus RNA-directed RNA polymerase, thumb domain	0.93	25.0	5.68e-01	88.1%	98.9%
3luyA03	3.30.70.260	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain	0.52	14.0	2.71e-01	85.4%	80.9%
1y0hB00	3.30.70.100	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.50	16.0	2.83e-01	84.8%	87.8%

ECOD (9)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1279063	304.48.1.13 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Flavi_NS5	0.95	94.0	8.30e-01	100.0%	85.4%
4875416	304.48.1.13 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Flavi_NS5	0.82	71.0	6.58e-01	88.4%	77.3%
5366	304.48.1.15 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_3	0.81	68.0	6.27e-01	85.7%	86.2%
1875037	304.48.1.8 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_1	0.77	69.0	6.53e-01	93.6%	86.8%
217141	304.48.1.15 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_3	0.70	67.0	6.50e-01	98.5%	91.9%
3258406	304.48.1.1 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1	0.68	56.0	4.57e-01	83.9%	61.2%
3918122	304.48.1.1 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1	0.68	56.0	5.24e-01	84.5%	82.0%
3938749	304.48.1.1 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1	0.65	54.0	5.20e-01	85.4%	84.9%
3932886	304.8.1.0 ↗	a+b two layers › Alpha-beta plaits › ACT-like › ACT-like	0.52	15.0	2.87e-01	85.4%	85.3%

D5 medium residues 487-524_630-697

PDB

Domain cluster: rep: RNA-dependent_RNA_polymerase_NS5__YP_009259365__Quang_Binh_virus__643132__D492-530_608-683

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00972.26 best	Flavi_NS5	30.8	1.70e-07	58.5%	12.4%