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NS5

Euk-Vir

Anopheles_flavivirus_variant_1

NS5__YP_009305401__Anopheles_flavivirus_variant_1__1903340

Identity

Accession:: YP_009305401 ↗
Protein ID:: NS5
Kingdom:: euk

Quality

85.5 mean pLDDT

Taxonomy

Orthornavirae› Kitrinoviricota› Flasuviricetes› Amarillovirales› Flaviviridae› Anopheles_flavivirus_variant_1

TaxID: 1903340

Cluster

View cluster (51 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 699-877

PDB

Domain cluster: rep: RNA-dependent_RNA_polymerase_NS5__YP_009268628__Hanko_virus__1125677__D698-878

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF20483.4 best	Flavi_NS5_thumb	181.8	1.40e-53	87.2%	92.7%

D2 medium residues 47-142

PDB

Domain cluster: rep: RNA-dependent_RNA_polymerase__NP_740729__Louping_ill_virus__11086__D71-170

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF01728.26 best	FtsJ	42.3	1.10e-10	99.0%	51.9%

D3 medium residues 143-234

PDB

Domain cluster: rep: RNA-dependent_RNA_polymerase_NS5__YP_009329957__Saint_Louis_encephalitis_virus__11080__D147-245

D4 medium residues 256-307_567-598

PDB

Domain cluster: rep: NS5__NP_722539__Murray_Valley_encephalitis_virus__11079__D272-319_589-600

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00972.26 best	Flavi_NS5	36.3	3.70e-09	67.9%	10.2%

CATH (3)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2hfzA01	3.30.70.2840	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Flavivirus RNA-directed RNA polymerase, thumb domain	0.87	71.0	6.98e-01	84.5%	100.0%
2nzcB00	3.30.70.1150	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT-like. Chain A, domain 2	0.53	37.0	3.79e-01	73.8%	87.7%
6ofsA04	3.30.830.10	Alpha Beta › 2-Layer Sandwich › Cytochrome Bc1 Complex; Chain A, domain 1 › Metalloenzyme, LuxS/M16 peptidase-like	0.52	37.0	2.95e-01	75.0%	88.0%

ECOD (5)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1279063	304.48.1.13 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Flavi_NS5	0.89	84.0	5.09e-01	97.6%	76.9%
5082037	331.10.2.0 ↗	a+b two layers › TBP-like › S-adenosylmethionine decarboxylase-related › Bacterial S-adenosylmethionine decarboxylase	0.67	45.0	4.34e-01	84.5%	61.7%
4997832	873.1.1.0 ↗	a+b complex topology › H-NOX domain › H-NOX domain › H-NOX domain	0.55	41.0	2.88e-01	81.0%	30.5%
3593549	70.3.1.1 ↗	beta barrels › beta-clip › SET domain-like › SET domain-like › SET	0.54	41.0	2.83e-01	81.0%	97.4%
5037035	274.1.1.0 ↗	a+b two layers › Pili subunits › Pili subunits › Pili subunits	0.50	35.0	2.91e-01	85.7%	39.0%

D5 medium residues 308-355_444-465

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00972.26 best	Flavi_NS5	39.9	3.00e-10	71.4%	10.2%

D6 medium residues 356-381_489-545_599-698

PDB

Domain cluster: rep: hypothetical_protein_2__YP_009337040__Changjiang_tombus-like_virus_21__1922815__D1-47_99-181

Pfam (2)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00972.26 best	Flavi_NS5	67.8	1.00e-18	50.3%	20.8%
PF00972.26	Flavi_NS5	38.2	9.60e-10	43.2%	14.4%

D7 medium residues 382-443_466-488_546-566

PDB

Domain cluster: rep: RNA-dependent_RNA_polymerase_NS5__YP_009268596__Lammi_virus__649187__D407-459_478-493_550-580

Pfam (2)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00972.26 best	Flavi_NS5	61.7	7.20e-17	60.4%	14.4%
PF00972.26	Flavi_NS5	35.8	5.30e-09	28.3%	5.1%