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NSMP-2,_non-structural_mature_protein_2
Euk-VirHuman_astrovirus
NSMP-2,_non-structural_mature_protein_2__NP_751906__Human_astrovirus__1868658
Identity
- Accession:
- NP_751906 ↗
- Protein ID:
- NSMP-2,_non-structural_mature_protein_2
- Kingdom:
- euk
Quality
73.4
mean pLDDT
Taxonomy
TaxID: 1868658
Cluster
Singleton — not in a non-trivial cluster
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 99-214
Domain cluster:
rep: non-structural_protein__YP_003275952__HMO_Astrovirus_A__682382__D294-402
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF19415.4 best | Astro_1A | 253.0 | 4.80e-75 | 100.0% | 47.5% |
CATH (29)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1u89A00 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.72 | 51.0 | 4.76e-01 | 71.6% | 81.3% |
| 1zoyD00 | 1.20.1300.10 | Mainly Alpha › Up-down Bundle › 3 helical TM bundles of succinate and fumarate reductases › Fumarate reductase/succinate dehydrogenase, transmembrane subunit | 0.61 | 42.0 | 4.52e-01 | 93.1% | 81.4% |
| 5gl7A01 | 1.10.730.10 | Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1 | 0.60 | 53.0 | 4.69e-01 | 95.7% | 100.0% |
| 2i76A02 | 1.10.1040.20 | Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › ProC-like, C-terminal domain | 0.60 | 35.0 | 3.69e-01 | 77.6% | 62.5% |
| 3f4mA00 | 1.20.1440.160 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › Tumor necrosis factor alpha-induced protein 8-like | 0.60 | 47.0 | 4.32e-01 | 84.5% | 87.7% |
| 3hiuD00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.60 | 47.0 | 4.29e-01 | 82.8% | 85.5% |
| 2rldA00 | 1.20.1440.60 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 23S rRNA-intervening sequence | 0.60 | 36.0 | 3.69e-01 | 80.2% | 60.5% |
| 1nfvA00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.60 | 49.0 | 4.39e-01 | 90.5% | 83.4% |
| 4hhyC01 | 1.20.142.10 | Mainly Alpha › Up-down Bundle › Poly(ADP-ribose) Polymerase; domain 1 › Poly(ADP-ribose) polymerase, regulatory domain | 0.59 | 44.0 | 4.21e-01 | 77.6% | 87.8% |
| 5ffdA00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.59 | 45.0 | 4.29e-01 | 81.9% | 88.3% |
| 1zs3A00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.59 | 45.0 | 3.97e-01 | 81.0% | 78.4% |
| 4ymuD00 | 1.10.3720.10 | Mainly Alpha › Orthogonal Bundle › MetI-like fold › MetI-like | 0.59 | 45.0 | 3.69e-01 | 81.0% | 82.8% |
| 2gfpA00 | 1.20.1720.10 | Mainly Alpha › Up-down Bundle › Multidrug resistance protein D › Multidrug resistance protein D | 0.59 | 52.0 | 3.67e-01 | 99.1% | 77.3% |
| 8sbeA02 | 1.20.1250.20 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains | 0.58 | 44.0 | 3.87e-01 | 82.8% | 74.9% |
| 4tpjA00 | 1.20.1250.20 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains | 0.57 | 45.0 | 3.05e-01 | 83.6% | 78.2% |
| 4nwpD00 | 1.20.1200.10 | Mainly Alpha › Up-down Bundle › Hypothetical Protein Ta1238; Chain: A; › Cobalamin adenosyltransferase-like | 0.57 | 43.0 | 4.02e-01 | 79.3% | 85.2% |
| 1s3qG00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.57 | 46.0 | 4.17e-01 | 87.9% | 90.8% |
| 1yg2A02 | 6.10.140.190 | Special › Helix non-globular › Helix Hairpins › | 0.56 | 42.0 | 4.68e-01 | 81.9% | 100.0% |
| 1yvwA00 | 1.10.287.1080 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › MazG-like | 0.55 | 41.0 | 4.43e-01 | 98.3% | 98.9% |
| 2aplA01 | 1.10.8.330 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › PG0816-like | 0.54 | 32.0 | 3.99e-01 | 87.1% | 98.5% |
| 4fxdA04 | 3.90.1600.10 | Alpha Beta › Alpha-Beta Complex › Palm domain of DNA polymerase › B family DNA polymerase, palm domain | 0.54 | 43.0 | 3.92e-01 | 83.6% | 86.9% |
| 3agtA00 | 1.20.120.50 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Hemerythrin-like | 0.54 | 41.0 | 3.95e-01 | 81.0% | 79.7% |
| 6tblB01 | 1.25.10.10 | Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant | 0.53 | 38.0 | 3.91e-01 | 74.1% | 82.0% |
| 4dloB02 | 1.25.40.610 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.53 | 40.0 | 4.05e-01 | 80.2% | 92.3% |
| 2qkwA00 | 1.20.1270.140 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › AvrPto | 0.53 | 33.0 | 3.53e-01 | 76.7% | 71.3% |
| 3h37A03 | 1.20.58.1960 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.52 | 35.0 | 3.48e-01 | 93.1% | 62.5% |
| 2q14B01 | 1.10.3210.10 | Mainly Alpha › Orthogonal Bundle › Hypothetical protein af1432 › Hypothetical protein af1432 | 0.52 | 45.0 | 3.63e-01 | 97.4% | 91.0% |
| 2c5uA02 | 1.10.3550.20 | Mainly Alpha › Orthogonal Bundle › eoxyguanosinetriphosphate triphosphohydrolase fold › | 0.51 | 37.0 | 3.59e-01 | 75.0% | 89.3% |
| 1hwyA03 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.50 | 41.0 | 3.15e-01 | 90.5% | 87.1% |
ECOD (39)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4003821 | 5067.1.1.3 ↗ | alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Patched | 0.73 | 57.0 | 4.41e-01 | 83.6% | 68.2% |
| 3539335 | 3874.1.1.4 ↗ | extended segments › Agnoprotein › Agnoprotein › Agnoprotein › UPF0220 | 0.71 | 50.0 | 4.67e-01 | 71.6% | 93.6% |
| 3757672 | 604.6.1.23 ↗ | alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain › UPF0220 | 0.71 | 50.0 | 4.67e-01 | 71.6% | 93.6% |
| 3979768 | 633.12.1.0 ↗ | alpha bundles › Bromodomain-like › Ta0600-like › Ta0600-like | 0.70 | 49.0 | 5.17e-01 | 70.7% | 100.0% |
| 3480976 | 601.1.2.100 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › PF31009 | 0.69 | 48.0 | 4.08e-01 | 70.7% | 73.5% |
| 5032080 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.67 | 36.0 | 3.66e-01 | 71.6% | 52.2% |
| 4019714 | 633.21.1.0 ↗ | alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 | 0.66 | 47.0 | 4.72e-01 | 74.1% | 98.3% |
| 3259409 | 150.1.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin | 0.63 | 44.0 | 4.15e-01 | 71.6% | 68.6% |
| 4025695 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.63 | 52.0 | 4.23e-01 | 86.2% | 64.9% |
| 5064482 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.62 | 32.0 | 2.85e-01 | 72.4% | 35.2% |
| 4003862 | 4177.1.1.0 ↗ | alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like | 0.62 | 44.0 | 3.56e-01 | 74.1% | 80.4% |
| 4949583 | 1075.5.1.4 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › Polysacc_synt | 0.62 | 52.0 | 4.44e-01 | 92.2% | 78.4% |
| 3993119 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.62 | 51.0 | 3.58e-01 | 91.4% | 69.7% |
| 4997633 | 150.1.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin | 0.61 | 44.0 | 4.31e-01 | 75.0% | 75.2% |
| 3276591 | 5001.1.1.129 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › PF29730 | 0.61 | 54.0 | 4.22e-01 | 99.1% | 78.4% |
| 3731369 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.60 | 48.0 | 4.33e-01 | 86.2% | 82.3% |
| 3479320 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.60 | 47.0 | 3.73e-01 | 81.9% | 80.4% |
| 3222647 | 5001.1.1.33 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7TM_GPCR_Srh | 0.59 | 53.0 | 3.87e-01 | 100.0% | 81.8% |
| 5010685 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.59 | 44.0 | 4.11e-01 | 79.3% | 74.7% |
| 5079439 | 601.1.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin | 0.59 | 38.0 | 4.03e-01 | 90.5% | 72.4% |
| 3621372 | 3345.1.1.2 ↗ | alpha arrays › MRG domain › MRG domain › MRG domain › PCAF_N | 0.59 | 45.0 | 4.21e-01 | 80.2% | 96.4% |
| 4987972 | 5076.2.1.0 ↗ | alpha complex topology › Mitochondrial ADP/ATP carrier-like › Putative sulfate permease CysZ › Putative sulfate permease CysZ | 0.59 | 42.0 | 3.23e-01 | 74.1% | 98.0% |
| 4007760 | 7014.1.1.2 ↗ | alpha bundles › Undecaprenyl pyrophosphate phosphatase (UppP) transmembrane domain › Undecaprenyl pyrophosphate phosphatase (UppP) transmembrane domain › Undecaprenyl pyrophosphate phosphatase (UppP) transmembrane domain › TauE | 0.58 | 45.0 | 4.53e-01 | 86.2% | 79.2% |
| 3856242 | 5001.1.1.43 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › V1R | 0.58 | 50.0 | 3.59e-01 | 93.1% | 69.4% |
| 3958018 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.58 | 44.0 | 3.82e-01 | 82.8% | 70.8% |
| 3904019 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.58 | 40.0 | 3.61e-01 | 71.6% | 63.0% |
| 5045049 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.58 | 44.0 | 3.61e-01 | 81.0% | 58.2% |
| 5064803 | 607.1.1.1 ↗ | alpha arrays › Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain › Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain › Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain › PEP-utilisers_N | 0.57 | 47.0 | 4.58e-01 | 88.8% | 84.8% |
| 3489998 | 5001.1.1.1 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1 | 0.57 | 51.0 | 3.63e-01 | 100.0% | 73.7% |
| 5054041 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.57 | 41.0 | 3.61e-01 | 74.1% | 100.0% |
| 3172226 | 603.1.1.17 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins › SNARE | 0.56 | 44.0 | 3.41e-01 | 81.9% | 72.0% |
| 4973788 | 7064.1.1.1 ↗ | alpha bundles › Transmembrane domain of VIT1 › Transmembrane domain of VIT1 › Transmembrane domain of VIT1 › VIT1 | 0.56 | 42.0 | 4.00e-01 | 81.0% | 75.9% |
| 4567147 | 605.4.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › ROP protein › ROP protein | 0.55 | 37.0 | 3.99e-01 | 92.2% | 82.1% |
| 3844641 | 5001.1.1.1 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1 | 0.54 | 47.0 | 3.53e-01 | 97.4% | 82.6% |
| 4438075 | 141.1.1.3 ↗ | alpha bundles › Terpenoid synthases › Terpenoid synthases › Terpenoid synthases › UbiA | 0.54 | 47.0 | 3.59e-01 | 97.4% | 78.5% |
| 3292918 | 5001.1.1.32 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Solute_trans_a | 0.54 | 46.0 | 3.66e-01 | 100.0% | 77.4% |
| 3749171 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.52 | 39.0 | 3.19e-01 | 80.2% | 53.6% |
| 4079211 | 7014.1.1.1 ↗ | alpha bundles › Undecaprenyl pyrophosphate phosphatase (UppP) transmembrane domain › Undecaprenyl pyrophosphate phosphatase (UppP) transmembrane domain › Undecaprenyl pyrophosphate phosphatase (UppP) transmembrane domain › BacA | 0.51 | 41.0 | 4.13e-01 | 87.1% | 86.1% |
| 5024880 | 7014.1.1.2 ↗ | alpha bundles › Undecaprenyl pyrophosphate phosphatase (UppP) transmembrane domain › Undecaprenyl pyrophosphate phosphatase (UppP) transmembrane domain › Undecaprenyl pyrophosphate phosphatase (UppP) transmembrane domain › TauE | 0.51 | 39.0 | 4.01e-01 | 88.8% | 85.2% |
D2
medium
residues 12-75