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NSP12

Euk-Vir

Duck_coronavirus

NSP12__YP_009825029__Duck_coronavirus__300188

Identity

Accession:
YP_009825029 ↗
Protein ID:
NSP12
Kingdom:
euk

Quality

89.5 mean pLDDT

Taxonomy

Orthornavirae› Pisuviricota› Pisoniviricetes› Nidovirales› Coronaviridae› Gammacoronavirus› Duck_coronavirus

TaxID: 300188

Cluster

View cluster (23 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 836-945
PDB
Domain cluster: representative
CATH (25)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3nyjA00 1.20.120.770 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Amyloid precursor protein, E2 domain 0.71 50.0 4.24e-01 72.7% 88.4%
2clbA01 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.65 48.0 4.22e-01 76.4% 96.2%
5dn7A00 1.25.10.10 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant 0.65 45.0 3.45e-01 100.0% 32.5%
2d2sA01 1.20.58.1210 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Exo84p, N-terminal helical domain 0.63 49.0 4.86e-01 91.8% 77.6%
2yw6B00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.62 48.0 4.29e-01 80.9% 99.3%
2d9dA00 1.20.58.120 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain 0.61 44.0 4.81e-01 80.9% 93.3%
3mekA04 1.25.40.970 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.61 40.0 4.55e-01 81.8% 91.3%
4i4cB00 3.40.50.1820 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain 0.60 53.0 3.64e-01 99.1% 63.1%
3eabE00 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.59 44.0 4.86e-01 76.4% 100.0%
3woyA00 1.25.10.10 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant 0.59 42.0 3.30e-01 98.2% 33.3%
1yz5B00 1.20.190.20 Mainly Alpha › Up-down Bundle › Delta-Endotoxin; domain 1 › 14-3-3 domain 0.58 51.0 4.09e-01 99.1% 75.5%
2pybA00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.57 45.0 4.05e-01 83.6% 99.3%
4f92B10 1.10.3380.10 Mainly Alpha › Orthogonal Bundle › Sec63 N-terminal domain-like fold › Sec63 N-terminal domain-like domain 0.57 39.0 3.58e-01 70.0% 90.2%
4dloB02 1.25.40.610 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.56 44.0 4.40e-01 99.1% 79.5%
2w3cA01 1.25.10.10 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant 0.56 41.0 3.10e-01 96.4% 31.3%
6whbA01 1.25.10.10 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant 0.56 45.0 3.42e-01 100.0% 35.4%
2pmvA01 1.50.10.20 Mainly Alpha › Alpha/alpha barrel › Glycosyltransferase › 0.55 49.0 3.74e-01 100.0% 64.4%
1aluA00 1.20.1250.10 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › 0.55 43.0 3.82e-01 82.7% 62.4%
2uvaG01 1.20.1050.120 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.53 40.0 3.75e-01 79.1% 77.9%
1jm6B02 1.20.140.20 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain 0.53 41.0 3.68e-01 82.7% 61.1%
7w9wA01 1.20.1070.10 Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins 0.53 47.0 3.63e-01 100.0% 89.7%
5k7fA02 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.53 46.0 4.27e-01 98.2% 76.1%
1k8kG00 1.25.40.190 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Actin-related protein 2/3 complex subunit 5 0.52 43.0 4.06e-01 91.8% 89.2%
2khmA01 1.10.10.1350 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Spidroin domain, C-terminal domain 0.51 37.0 3.78e-01 76.4% 78.7%
1paqA00 1.25.40.180 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.51 36.0 3.25e-01 74.5% 88.2%
ECOD (50)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
2994348 304.48.1.9 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_1,CoV_RPol_N 0.86 82.0 4.70e-01 100.0% 11.8%
4527327 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.71 52.0 4.44e-01 85.5% 48.0%
3413781 109.4.1.22 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Adaptin_N 0.70 53.0 3.35e-01 80.0% 16.3%
3743628 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.65 50.0 4.08e-01 81.8% 56.7%
3721248 622.4.1.31 ↗ alpha bundles › YvfG-like › Mite allergen Der p 5-related › Mite allergen Der p 5-related › TPR_SYVN1_N 0.64 49.0 3.63e-01 80.9% 41.1%
3465126 603.1.1.0 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.64 48.0 4.45e-01 79.1% 80.0%
3614041 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.64 50.0 2.95e-01 84.5% 10.1%
3810544 604.6.1.0 ↗ alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain 0.63 49.0 4.57e-01 80.9% 75.6%
3373578 109.4.1.163 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › SYMPK_PTA1_N 0.63 49.0 4.15e-01 98.2% 50.0%
4464029 5000.6.1.1 ↗ alpha arrays › Toxins' membrane translocation domains › Tethering factor for nuclear proteasome cut8 › Tethering factor for nuclear proteasome cut8 › Cut8 0.63 55.0 4.43e-01 96.4% 56.7%
3728445 551.1.1.0 ↗ alpha arrays › Hsp90 co-chaperone CDC37 middle domain › Hsp90 co-chaperone CDC37 middle domain › Hsp90 co-chaperone CDC37 middle domain 0.63 48.0 4.47e-01 80.0% 98.5%
4973584 604.3.1.51 ↗ alpha bundles › Spectrin repeat-like › BAG domain › BAG domain › 8xMP 0.63 47.0 5.15e-01 77.3% 98.9%
3789289 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.63 49.0 4.01e-01 84.5% 51.9%
3822899 611.3.1.0 ↗ alpha bundles › N-cbl like › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 0.62 50.0 4.44e-01 97.3% 60.0%
3499494 109.4.1.522 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › RPAP1_C 0.60 54.0 3.33e-01 98.2% 31.9%
3168467 109.4.1.623 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Cnd1 0.60 47.0 3.60e-01 84.5% 40.8%
3659912 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.59 41.0 3.36e-01 99.1% 38.0%
3727956 2006.1.2.1 ↗ a/b three-layered sandwiches › HAD domain-like › HAD domain-related › DHH phosphoesterases › DHH 0.59 54.0 3.77e-01 100.0% 47.4%
3786622 109.4.1.682 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › RasGEF_N 0.58 45.0 3.62e-01 84.5% 59.2%
3682586 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.58 52.0 3.20e-01 98.2% 27.1%
3958289 2004.1.1.0 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.58 42.0 2.81e-01 75.5% 59.8%
3479038 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.58 50.0 3.82e-01 99.1% 61.4%
3449262 604.6.1.2 ↗ alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain › ANTH 0.57 50.0 4.42e-01 95.5% 71.2%
3251937 109.4.1.84 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › API5 0.57 40.0 3.44e-01 99.1% 45.1%
3490435 109.4.1.1834 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › HEAT_DAAF5, TPR_DNAAF5 0.57 49.0 3.33e-01 98.2% 38.0%
3738396 109.4.1.546 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Ecm29 0.57 46.0 4.82e-01 96.4% 95.0%
3694837 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.57 45.0 3.00e-01 86.4% 46.9%
4980470 6155.1.1.0 ↗ alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter 0.57 39.0 4.19e-01 70.9% 85.3%
3469472 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.56 49.0 3.16e-01 98.2% 25.1%
3720075 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.56 46.0 3.49e-01 90.0% 85.2%
3978380 5069.1.1.0 ↗ alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes 0.56 41.0 3.68e-01 75.5% 69.0%
4374346 3579.1.1.0 ↗ extended segments › NADH-quinone oxidoreductase subunit J › NADH-quinone oxidoreductase subunit J › NADH-quinone oxidoreductase subunit J 0.56 37.0 3.43e-01 79.1% 52.1%
4000388 109.4.1.1361 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_CAND1 0.55 49.0 3.46e-01 99.1% 38.6%
3724044 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.54 48.0 4.01e-01 98.2% 66.2%
3416008 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.54 48.0 3.65e-01 96.4% 48.6%
3497022 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.54 43.0 3.16e-01 86.4% 61.3%
4191594 109.4.1.337 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Ipi1_N 0.54 47.0 3.24e-01 98.2% 53.2%
3603261 109.47.1.1 ↗ alpha superhelices › Repetitive alpha hairpins › Helical C-terminal domain in magnesium chelatase catalytic subunit › Helical C-terminal domain in magnesium chelatase catalytic subunit › CobN-Mg_chel 0.53 47.0 4.27e-01 99.1% 89.3%
3581983 109.4.1.816 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › RALGAPB_N 0.53 47.0 3.79e-01 100.0% 71.6%
3681919 109.4.1.35 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › HEAT,HEAT_2 0.53 46.0 4.09e-01 99.1% 65.5%
3740087 633.15.1.1 ↗ alpha bundles › Bromodomain-like › alpha-ketoacid dehydrogenase kinase-N › alpha-ketoacid dehydrogenase kinase-N › BCDHK_Adom3 0.53 45.0 3.98e-01 95.5% 70.3%
3948656 601.4.1.2 ↗ alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains › NIT 0.53 38.0 3.41e-01 76.4% 58.1%
3221040 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.52 46.0 3.79e-01 95.5% 68.7%
3784535 109.4.1.1973 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PF28685 0.52 47.0 2.92e-01 100.0% 17.6%
3173970 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.52 45.0 3.89e-01 95.5% 72.4%
3625666 109.4.1.17 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Cullin 0.52 45.0 3.06e-01 99.1% 42.4%
3251262 109.3.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat 0.51 44.0 3.38e-01 96.4% 55.0%
3710262 109.4.1.33 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › HEAT 0.51 45.0 3.31e-01 100.0% 54.2%
4998480 109.4.1.207 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › HEAT_2 0.50 41.0 2.47e-01 90.0% 18.0%
3970612 3651.1.1.1 ↗ alpha bundles › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › IF-2B 0.50 40.0 3.70e-01 85.5% 77.1%
D2 medium residues 26-130
PDB
Domain cluster: rep: nsp12__YP_008439222__Bat_coronavirus_CDPHE15_USA_2006__1384461__D18-119
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF06478.20 best CoV_RPol_N 105.0 6.20e-30 100.0% 28.3%
CATH (41)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3akjA01 3.30.200.120 Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › 0.71 44.0 5.09e-01 100.0% 86.5%
4feuF01 3.30.200.20 Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › Phosphorylase Kinase; domain 1 0.71 45.0 5.31e-01 95.2% 93.2%
3zduA01 3.30.200.20 Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › Phosphorylase Kinase; domain 1 0.70 47.0 5.40e-01 99.0% 93.4%
2if1A00 3.30.780.10 Alpha Beta › 2-Layer Sandwich › Translation Initiation Factor Eif1 › SUI1-like domain 0.67 40.0 3.75e-01 72.4% 49.2%
1s2oA02 3.90.1070.10 Alpha Beta › Alpha-Beta Complex › Hypothetical Protein Ta0175; Chain: A, domain 2 › 0.67 34.0 4.09e-01 90.5% 73.2%
5cemA01 3.30.200.20 Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › Phosphorylase Kinase; domain 1 0.66 44.0 5.15e-01 95.2% 100.0%
2dchX01 3.10.28.10 Alpha Beta › Roll › Endonuclease I-creI › Homing endonucleases 0.64 41.0 4.34e-01 86.7% 73.1%
2uv8A06 3.30.70.2490 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.61 32.0 3.94e-01 76.2% 77.6%
6lpnA04 3.30.70.2740 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.61 35.0 3.72e-01 100.0% 62.1%
2rioA01 3.30.200.20 Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › Phosphorylase Kinase; domain 1 0.58 42.0 4.71e-01 92.4% 97.6%
3bm7A00 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.58 37.0 3.73e-01 90.5% 63.2%
4gf3A00 3.30.1460.10 Alpha Beta › 2-Layer Sandwich › Yope Regulator; Chain: A, › 0.58 42.0 4.04e-01 100.0% 65.0%
4qjvA01 3.30.1360.10 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › RNA polymerase, RBP11-like subunit 0.58 35.0 3.76e-01 71.4% 69.7%
3c0wA02 3.10.28.10 Alpha Beta › Roll › Endonuclease I-creI › Homing endonucleases 0.58 42.0 4.26e-01 86.7% 76.7%
6gmhK00 3.30.1360.10 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › RNA polymerase, RBP11-like subunit 0.57 37.0 3.66e-01 71.4% 60.0%
2bwnB01 3.90.1150.10 Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1 0.57 39.0 3.38e-01 92.4% 45.3%
1blxA01 3.30.200.20 Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › Phosphorylase Kinase; domain 1 0.57 44.0 4.71e-01 99.0% 95.7%
2uvaG03 3.30.70.3320 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.57 35.0 3.52e-01 89.5% 59.3%
3c0wA01 3.10.28.10 Alpha Beta › Roll › Endonuclease I-creI › Homing endonucleases 0.56 40.0 3.84e-01 87.6% 65.0%
2cdqA03 3.30.70.260 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain 0.56 35.0 3.78e-01 71.4% 77.4%
3gkuA03 3.30.1370.50 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › R3H-like domain 0.56 34.0 4.02e-01 79.0% 90.1%
2dt9A01 3.30.70.260 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain 0.55 32.0 3.64e-01 71.4% 78.4%
3pgvA02 3.30.1240.10 Alpha Beta › 2-Layer Sandwich › Hypothetical Protein, Haloacid Dehalogenase-like Hydrolase; Chain: A; domain 2 › 0.55 37.0 3.84e-01 96.2% 72.3%
3dxqA01 3.30.200.20 Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › Phosphorylase Kinase; domain 1 0.55 41.0 4.55e-01 96.2% 100.0%
2j0wA03 3.30.70.260 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain 0.55 34.0 3.71e-01 71.4% 77.8%
5suhB01 3.30.70.1710 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › BMC (bacterial microcompartment) domain 0.55 37.0 3.87e-01 94.3% 74.7%
5w2fA01 3.30.780.10 Alpha Beta › 2-Layer Sandwich › Translation Initiation Factor Eif1 › SUI1-like domain 0.54 37.0 4.05e-01 71.4% 100.0%
5suhA02 3.30.70.1710 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › BMC (bacterial microcompartment) domain 0.54 37.0 3.80e-01 71.4% 78.6%
3ofgB00 3.30.70.260 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain 0.53 32.0 3.44e-01 77.1% 70.1%
5o5cB02 3.90.1150.10 Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1 0.53 38.0 3.62e-01 100.0% 62.5%
1lfwA03 3.30.70.360 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.53 37.0 3.95e-01 72.4% 85.2%
4hkhA00 2.30.110.20 Mainly Beta › Roll › Pnp Oxidase; Chain A › Hcp1-like 0.53 44.0 4.01e-01 94.3% 89.3%
1y12B00 2.30.110.20 Mainly Beta › Roll › Pnp Oxidase; Chain A › Hcp1-like 0.53 44.0 3.91e-01 93.3% 82.1%
4m1xD00 3.30.1360.240 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › 0.52 33.0 3.80e-01 91.4% 93.1%
3l7yA02 3.30.1240.10 Alpha Beta › 2-Layer Sandwich › Hypothetical Protein, Haloacid Dehalogenase-like Hydrolase; Chain: A; domain 2 › 0.52 37.0 3.70e-01 95.2% 72.5%
2kwaA00 3.30.1360.40 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › 0.51 35.0 3.64e-01 71.4% 74.3%
1r62A00 3.30.565.10 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain 0.51 42.0 3.85e-01 88.6% 95.6%
1s28A00 3.30.1460.10 Alpha Beta › 2-Layer Sandwich › Yope Regulator; Chain: A, › 0.51 43.0 4.01e-01 99.0% 73.8%
5hl8C00 3.30.1360.100 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › General secretion pathway protein M, EpsM 0.51 34.0 3.81e-01 85.7% 91.1%
1ug8A00 3.30.1370.50 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › R3H-like domain 0.51 32.0 3.44e-01 80.0% 75.9%
4rmoA00 3.10.129.130 Alpha Beta › Roll › Thiol Ester Dehydrase; Chain A › 0.50 45.0 3.98e-01 100.0% 96.1%
ECOD (70)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4020561 306.3.1.0 ↗ a+b two layers › Glucose permease domain IIB-like › eIF1-like › eIF1-like 0.65 39.0 4.04e-01 71.4% 62.0%
3171307 306.3.1.1 ↗ a+b two layers › Glucose permease domain IIB-like › eIF1-like › eIF1-like › SUI1 0.65 39.0 3.83e-01 71.4% 53.9%
5054097 305.1.1.10 ↗ a+b two layers › DCoH-like › RBP11-like subunits of RNA polymerase › RBP11-like subunits of RNA polymerase › PF27806 0.65 40.0 4.36e-01 71.4% 75.3%
3651874 306.3.1.1 ↗ a+b two layers › Glucose permease domain IIB-like › eIF1-like › eIF1-like › SUI1 0.65 39.0 4.01e-01 71.4% 62.0%
3268586 306.3.1.1 ↗ a+b two layers › Glucose permease domain IIB-like › eIF1-like › eIF1-like › SUI1 0.65 39.0 4.01e-01 72.4% 62.0%
None — 0.65 48.0 2.91e-01 100.0% 12.1%
3789931 206.1.1.71 ↗ a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase, Kdo 0.65 48.0 3.33e-01 100.0% 24.5%
3246479 206.1.1.71 ↗ a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase, Kdo 0.65 48.0 3.41e-01 100.0% 26.5%
4997133 306.3.1.1 ↗ a+b two layers › Glucose permease domain IIB-like › eIF1-like › eIF1-like › SUI1 0.64 40.0 4.18e-01 81.9% 68.4%
3655967 304.8.1.0 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.62 38.0 4.05e-01 94.3% 68.4%
5075416 242.1.1.7 ↗ a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases › LAGLIDADG_3 0.62 45.0 4.45e-01 85.7% 71.8%
3372798 304.8.1.45 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › bHLH-TF_ACT-like_plant 0.62 38.0 4.25e-01 94.3% 77.6%
4943356 305.1.1.0 ↗ a+b two layers › DCoH-like › RBP11-like subunits of RNA polymerase › RBP11-like subunits of RNA polymerase 0.61 38.0 4.07e-01 71.4% 73.3%
5080958 310.3.1.0 ↗ a+b two layers › RRF/tRNA synthetase additional domain-like › General secretion pathway protein M (EpsM) periplasmic domain-related › General secretion pathway protein M (EpsM) periplasmic domain-related 0.60 38.0 4.50e-01 85.7% 90.7%
5034013 3012.1.1.0 ↗ a+b two layers › Cof C2 cap domain › Cof C2 cap domain › Cof C2 cap domain 0.60 39.0 4.55e-01 85.7% 92.0%
4500961 242.1.1.0 ↗ a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases 0.59 41.0 4.43e-01 85.7% 87.1%
5051463 304.54.1.0 ↗ a+b two layers › Alpha-beta plaits › CcmK-like › CcmK-like 0.59 37.0 4.10e-01 71.4% 81.2%
5077304 310.3.1.0 ↗ a+b two layers › RRF/tRNA synthetase additional domain-like › General secretion pathway protein M (EpsM) periplasmic domain-related › General secretion pathway protein M (EpsM) periplasmic domain-related 0.59 39.0 4.48e-01 84.8% 94.7%
4993129 242.1.1.0 ↗ a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases 0.59 42.0 3.96e-01 86.7% 61.6%
3315331 304.8.1.45 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › bHLH-TF_ACT-like_plant 0.58 37.0 4.08e-01 71.4% 82.5%
4999334 304.165.1.4 ↗ a+b two layers › Alpha-beta plaits › Uncharacterized protein Ta1207 › Uncharacterized protein Ta1207 › HVO_2525_N 0.58 39.0 3.66e-01 84.8% 56.0%
4998391 242.1.1.0 ↗ a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases 0.58 42.0 4.52e-01 87.6% 87.8%
235805 241.1.1.3 ↗ a+b two layers › Type III secretory system chaperone-like › Type III secretory system chaperone › Type III secretory system chaperone › CesT 0.58 42.0 4.04e-01 100.0% 65.0%
5031915 242.1.1.0 ↗ a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases 0.58 39.0 4.29e-01 86.7% 84.7%
4372378 306.3.1.4 ↗ a+b two layers › Glucose permease domain IIB-like › eIF1-like › eIF1-like › PFF1_C 0.58 38.0 4.21e-01 82.9% 83.5%
4961351 242.1.1.10 ↗ a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases › PF26411 0.57 40.0 4.00e-01 86.7% 69.1%
3175703 206.1.1.71 ↗ a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase, Kdo 0.57 45.0 3.08e-01 98.1% 23.5%
3300216 306.3.1.1 ↗ a+b two layers › Glucose permease domain IIB-like › eIF1-like › eIF1-like › SUI1 0.57 39.0 3.97e-01 71.4% 82.9%
3249184 305.2.1.1 ↗ a+b two layers › DCoH-like › Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH) › Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH) › Pterin_4a 0.56 39.0 4.13e-01 92.4% 80.0%
3438815 304.8.1.45 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › bHLH-TF_ACT-like_plant 0.56 36.0 3.90e-01 71.4% 78.8%
4409022 242.1.1.2 ↗ a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases › LAGLIDADG_2 0.56 40.0 3.86e-01 86.7% 65.0%
3959682 304.8.1.0 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.56 37.0 4.32e-01 96.2% 96.0%
3824912 304.8.1.45 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › bHLH-TF_ACT-like_plant 0.56 35.0 3.87e-01 71.4% 81.2%
5051462 306.3.1.0 ↗ a+b two layers › Glucose permease domain IIB-like › eIF1-like › eIF1-like 0.56 40.0 4.48e-01 97.1% 98.8%
4982153 1.1.5.0 ↗ beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel 0.56 46.0 3.46e-01 91.4% 48.9%
4993850 242.1.1.0 ↗ a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases 0.56 41.0 4.34e-01 85.7% 86.3%
4979990 242.1.1.0 ↗ a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases 0.55 40.0 3.76e-01 85.7% 60.8%
3175120 242.1.1.2 ↗ a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases › LAGLIDADG_2 0.55 43.0 4.30e-01 86.7% 80.0%
3462522 304.8.1.0 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.55 36.0 3.39e-01 71.4% 54.4%
3602727 242.1.1.7 ↗ a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases › LAGLIDADG_3 0.55 39.0 4.18e-01 86.7% 86.7%
4317294 207.11.1.1 ↗ beta duplicates or obligate multimers › Single-stranded right-handed beta-helix › Urease accessory protein ureH › Urease accessory protein ureH › UreD 0.55 44.0 3.36e-01 89.5% 83.0%
3367362 304.8.1.45 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › bHLH-TF_ACT-like_plant 0.54 34.0 3.76e-01 71.4% 81.2%
3807253 304.8.1.45 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › bHLH-TF_ACT-like_plant 0.54 34.0 3.77e-01 70.5% 81.2%
3832697 304.8.1.45 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › bHLH-TF_ACT-like_plant 0.54 39.0 4.09e-01 95.2% 84.2%
5000362 306.3.1.1 ↗ a+b two layers › Glucose permease domain IIB-like › eIF1-like › eIF1-like › SUI1 0.54 36.0 3.79e-01 82.9% 74.7%
5027649 242.1.1.7 ↗ a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases › LAGLIDADG_3 0.54 43.0 4.10e-01 83.8% 80.0%
1839315 206.1.1.11 ↗ a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › APH 0.54 44.0 3.18e-01 99.0% 31.1%
3285931 304.8.1.0 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.54 38.0 3.67e-01 96.2% 66.1%
5030027 242.1.1.0 ↗ a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases 0.54 42.0 3.91e-01 82.9% 89.2%
4980724 304.165.1.4 ↗ a+b two layers › Alpha-beta plaits › Uncharacterized protein Ta1207 › Uncharacterized protein Ta1207 › HVO_2525_N 0.54 40.0 3.65e-01 90.5% 57.9%
3369895 304.12.1.0 ↗ a+b two layers › Alpha-beta plaits › Ribosomal protein S6 › Ribosomal protein S6 0.53 40.0 4.25e-01 99.0% 87.4%
5030026 242.1.1.7 ↗ a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases › LAGLIDADG_3 0.53 38.0 4.01e-01 86.7% 85.6%
4498099 207.11.1.1 ↗ beta duplicates or obligate multimers › Single-stranded right-handed beta-helix › Urease accessory protein ureH › Urease accessory protein ureH › UreD 0.53 43.0 3.33e-01 89.5% 86.3%
4611212 207.11.1.1 ↗ beta duplicates or obligate multimers › Single-stranded right-handed beta-helix › Urease accessory protein ureH › Urease accessory protein ureH › UreD 0.53 42.0 3.19e-01 84.8% 81.0%
3325750 304.8.1.45 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › bHLH-TF_ACT-like_plant 0.53 33.0 3.61e-01 70.5% 78.8%
4937023 242.1.1.7 ↗ a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases › LAGLIDADG_3 0.53 40.0 4.11e-01 86.7% 83.0%
3807910 304.8.1.45 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › bHLH-TF_ACT-like_plant 0.53 34.0 3.76e-01 70.5% 85.0%
3667551 304.8.1.0 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.52 39.0 4.14e-01 86.7% 92.2%
2165976 310.3.1.4 ↗ a+b two layers › RRF/tRNA synthetase additional domain-like › General secretion pathway protein M (EpsM) periplasmic domain-related › General secretion pathway protein M (EpsM) periplasmic domain-related › GspL_C 0.52 35.0 3.96e-01 86.7% 91.3%
3317802 304.8.1.45 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › bHLH-TF_ACT-like_plant 0.52 36.0 3.75e-01 71.4% 77.9%
5054060 310.3.1.0 ↗ a+b two layers › RRF/tRNA synthetase additional domain-like › General secretion pathway protein M (EpsM) periplasmic domain-related › General secretion pathway protein M (EpsM) periplasmic domain-related 0.52 39.0 4.29e-01 88.6% 98.8%
4529236 207.11.1.1 ↗ beta duplicates or obligate multimers › Single-stranded right-handed beta-helix › Urease accessory protein ureH › Urease accessory protein ureH › UreD 0.52 40.0 3.11e-01 85.7% 80.0%
3365684 306.6.1.0 ↗ a+b two layers › Glucose permease domain IIB-like › PH0987 N-terminal domain-like › PH0987 N-terminal domain-like 0.52 40.0 4.18e-01 99.0% 86.0%
3367441 304.8.1.0 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.51 35.0 3.60e-01 92.4% 73.7%
3302370 304.8.1.0 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.51 33.0 3.63e-01 72.4% 81.9%
3831627 304.8.1.45 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › bHLH-TF_ACT-like_plant 0.51 32.0 3.56e-01 71.4% 82.5%
4237289 207.11.1.1 ↗ beta duplicates or obligate multimers › Single-stranded right-handed beta-helix › Urease accessory protein ureH › Urease accessory protein ureH › UreD 0.51 41.0 3.16e-01 89.5% 84.6%
4992616 304.165.1.0 ↗ a+b two layers › Alpha-beta plaits › Uncharacterized protein Ta1207 › Uncharacterized protein Ta1207 0.51 39.0 3.55e-01 90.5% 60.7%
3164985 310.3.1.0 ↗ a+b two layers › RRF/tRNA synthetase additional domain-like › General secretion pathway protein M (EpsM) periplasmic domain-related › General secretion pathway protein M (EpsM) periplasmic domain-related 0.50 34.0 3.04e-01 87.6% 46.3%
3810458 304.8.1.0 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.50 37.0 3.84e-01 100.0% 86.3%
D3 medium residues 346-408
PDB
Domain cluster: rep: RNA-dependent_RNA_polymerase__NP_740629__Infectious_bronchitis_virus__11120__D333-394
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF06478.20 best CoV_RPol_N 60.1 2.70e-16 68.2% 12.3%
D4 medium residues 409-470
PDB
Domain cluster: rep: RNA-dependent_RNA_polymerase__YP_009924352__Murine_hepatitis_virus__11138__D393-454
D5 medium residues 471-486_522-602_646-703
PDB
Domain cluster: rep: NIa__YP_003620390__Freesia_mosaic_virus__421012__D109-224
D6 medium residues 487-521_603-645_704-728_761-790
PDB
Domain cluster: representative
CATH (10)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1gx5A03 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.84 52.0 5.45e-01 87.2% 68.0%
6qwtA02 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.82 52.0 5.07e-01 72.9% 59.6%
1khvA03 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.81 54.0 5.52e-01 70.7% 69.2%
1s48A04 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.78 41.0 4.47e-01 89.5% 61.3%
1hi8A03 3.30.70.1600 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.64 51.0 4.64e-01 84.2% 67.6%
1mukA02 3.90.1850.10 Alpha Beta › Alpha-Beta Complex › RNA-directed RNA polymerase lambda-3 › RNA-directed RNA polymerase lambda-3 0.63 58.0 3.87e-01 100.0% 69.2%
4hkqA01 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.60 37.0 3.66e-01 97.0% 56.9%
7uinD01 3.30.70.270 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain 0.52 43.0 3.99e-01 91.0% 69.5%
2nwlC00 1.10.3860.10 Mainly Alpha › Orthogonal Bundle › Proton glutamate symport protein › Sodium:dicarboxylate symporter 0.51 43.0 3.09e-01 93.2% 75.4%
6vudA02 3.30.1360.40 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › 0.50 25.0 3.21e-01 97.0% 84.0%
ECOD (14)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
2994348 304.48.1.9 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_1,CoV_RPol_N 0.98 95.0 5.50e-01 100.0% 32.8%
5366 304.48.1.15 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_3 0.78 73.0 5.11e-01 100.0% 69.6%
4882532 304.48.1.0 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.73 59.0 4.34e-01 85.0% 90.8%
1699894 304.48.2.2 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › 'palm' domain in birnaviruse RNA-dependent RNA polymerase › Permu_RdRp_palm 0.62 56.0 3.68e-01 97.0% 61.3%
4793418 304.48.1.0 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.58 43.0 3.46e-01 78.9% 86.9%
3193439 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.55 45.0 3.50e-01 88.0% 53.3%
4262041 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.55 44.0 3.55e-01 84.2% 80.4%
4434853 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.55 43.0 3.58e-01 84.2% 82.1%
4115819 304.48.1.48 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › GGDEF_2 0.54 38.0 3.51e-01 88.7% 56.5%
4890630 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.53 39.0 3.25e-01 78.2% 54.8%
2636124 304.48.1.0 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.52 39.0 3.25e-01 78.2% 61.1%
4552467 4967.1.1.0 ↗ alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases 0.52 40.0 2.96e-01 81.2% 39.7%
3669878 101.1.2.0 ↗ alpha arrays › HTH › HTH › winged helix domain 0.52 25.0 2.98e-01 89.5% 66.7%
5079009 101.1.2.650 ↗ alpha arrays › HTH › HTH › winged helix domain › DUF7343 0.50 21.0 2.67e-01 72.2% 64.1%