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NSP3

Euk-Vir

Bat_rotavirus

NSP3__YP_009551531__Bat_rotavirus__1340801

Identity

Accession:
YP_009551531 ↗
Protein ID:
NSP3
Kingdom:
euk

Quality

75.2 mean pLDDT

Cluster

Singleton — not in a non-trivial cluster

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 218-309
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF01665.21 best Rota_NSP3 39.8 4.00e-10 82.6% 22.5%
CATH (29)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1lj2A00 1.20.5.970 Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › Nonstructural RNA-binding protein 0.91 73.0 6.91e-01 83.7% 75.5%
4p9tA01 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.76 62.0 5.58e-01 84.8% 80.8%
2efkA01 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.74 58.0 4.21e-01 85.9% 89.3%
4heoA00 1.10.8.10 Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Ubiquitin-associated (UBA) domain 0.73 44.0 5.40e-01 76.1% 100.0%
4jioA01 1.20.120.560 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › alix/aip1 in complex with the ypdl late domain 0.71 59.0 4.87e-01 90.2% 91.3%
4nqiD00 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.70 56.0 4.18e-01 85.9% 83.6%
2ap3A00 1.20.120.570 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › YkyA-like 0.68 54.0 4.22e-01 84.8% 64.6%
3dfzA02 1.10.8.610 Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › SirC, precorrin-2 dehydrogenase, C-terminal helical domain-like 0.67 43.0 4.79e-01 77.2% 81.1%
3hwcA03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.67 58.0 4.53e-01 97.8% 73.3%
4gxbA02 1.20.80.60 Mainly Alpha › Up-down Bundle › Acyl-CoA Binding Protein › 0.66 39.0 4.61e-01 72.8% 87.1%
2oo2A00 1.20.1270.90 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › AF1782-like 0.66 51.0 5.52e-01 84.8% 100.0%
2zxqA06 1.20.1270.70 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Designed single chain three-helix bundle 0.65 44.0 5.07e-01 72.8% 98.5%
3nhiA01 1.10.238.20 Mainly Alpha › Orthogonal Bundle › Recoverin; domain 1 › Pheromone/general odorant binding protein domain 0.63 48.0 4.15e-01 82.6% 62.4%
2ex3B02 1.20.1270.230 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › DNA terminal protein Gp3, priming domain 0.60 41.0 4.37e-01 72.8% 81.5%
6ygiB01 1.10.4090.10 Mainly Alpha › Orthogonal Bundle › Hepatitis B viral capsid (hbcag) fold › Viral capsid, core domain supefamily, Hepatitis B virus 0.60 42.0 3.61e-01 87.0% 46.6%
2oezA02 1.10.3900.10 Mainly Alpha › Orthogonal Bundle › YacF-like › YacF-like 0.57 43.0 3.58e-01 81.5% 74.8%
6k9pB02 1.20.1300.20 Mainly Alpha › Up-down Bundle › 3 helical TM bundles of succinate and fumarate reductases › Peptidase C65 Otubain, subdomain 2 0.56 44.0 3.83e-01 87.0% 58.6%
1dowA00 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.56 48.0 3.67e-01 92.4% 46.8%
3c8tA01 1.10.275.10 Mainly Alpha › Orthogonal Bundle › Fumarase C; Chain B, domain 1 › Fumarase/aspartase (N-terminal domain) 0.55 46.0 4.54e-01 92.4% 99.0%
3uumA00 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.54 43.0 3.98e-01 87.0% 95.1%
3l8rA00 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.53 42.0 4.10e-01 85.9% 100.0%
2w02B01 1.10.150.640 Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › AcsD, thumb domain, helical bundle 0.53 31.0 3.41e-01 76.1% 71.6%
5cbgA00 1.10.287.70 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.53 38.0 3.72e-01 76.1% 99.0%
5grqA00 1.10.8.810 Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Daxx helical bundle domain 0.52 39.0 3.96e-01 78.3% 82.2%
7y11B01 1.10.8.20 Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › N-terminal domain of phosphatidylinositol transfer protein sec14p 0.52 33.0 3.85e-01 71.7% 93.7%
2yviA00 1.10.533.10 Mainly Alpha › Orthogonal Bundle › Death Domain, Fas › Death Domain, Fas 0.52 37.0 3.75e-01 75.0% 97.8%
2fji101 1.10.357.50 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › 0.52 48.0 3.61e-01 100.0% 58.4%
4l0fA00 1.10.630.10 Mainly Alpha › Orthogonal Bundle › Cytochrome p450 › Cytochrome P450 0.50 42.0 2.77e-01 94.6% 48.3%
2odvA01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.50 43.0 4.01e-01 93.5% 100.0%
ECOD (17)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
5059486 109.3.1.0 alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat 0.80 73.0 5.47e-01 100.0% 43.1%
5060017 632.11.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like 0.76 52.0 6.15e-01 75.0% 100.0%
3398320 632.7.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Heat shock protein 70kD (HSP70), C-terminal subdomain › Heat shock protein 70kD (HSP70), C-terminal subdomain 0.74 53.0 5.97e-01 75.0% 100.0%
5035838 632.22.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats 0.72 56.0 5.70e-01 82.6% 94.4%
3988174 632.19.1.3 alpha bundles › immunoglobulin/albumin-binding domain-like › Choline binding protein A › Choline binding protein A › DUF1542 0.71 59.0 6.18e-01 88.0% 100.0%
5014264 632.11.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like 0.69 55.0 5.64e-01 84.8% 93.3%
3928004 192.29.1.0 alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) 0.69 54.0 5.46e-01 82.6% 91.1%
4492498 632.7.1.1 alpha bundles › immunoglobulin/albumin-binding domain-like › Heat shock protein 70kD (HSP70), C-terminal subdomain › Heat shock protein 70kD (HSP70), C-terminal subdomain › HSP70 0.69 54.0 5.69e-01 87.0% 96.2%
4978779 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.68 58.0 5.05e-01 95.7% 82.1%
3466449 632.1.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain 0.67 51.0 5.09e-01 80.4% 100.0%
4237257 632.15.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Staphylococcal complement inhibitor (SCIN) › Staphylococcal complement inhibitor (SCIN) 0.66 52.0 5.31e-01 87.0% 100.0%
3396625 4177.1.1.12 alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › FAM92 0.66 56.0 4.21e-01 94.6% 85.2%
3391070 632.1.1.3 alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain › Alpha-mann_mid 0.63 53.0 5.01e-01 91.3% 86.4%
3335320 5054.1.1.1 alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels › Lig_chan 0.62 40.0 4.11e-01 83.7% 66.7%
3592972 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.62 55.0 4.24e-01 96.7% 84.6%
3644416 4268.2.1.2 alpha duplicates or obligate multimers › EspA/CesA-like › EspA chaperone CesA › EspA chaperone CesA › Rx_N 0.61 48.0 4.68e-01 87.0% 78.1%
4975739 2004.1.1.0 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.59 51.0 3.40e-01 97.8% 36.1%
D2 medium residues 7-89
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF01665.21 best Rota_NSP3 134.3 7.00e-39 100.0% 26.7%
CATH (17)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1knzA01 6.10.280.20 Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Rotavirus non-structural protein NSP3, N-terminal domain 0.92 76.0 6.98e-01 86.7% 69.6%
2ic6A00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.76 44.0 4.74e-01 100.0% 67.6%
3vm9A02 6.10.140.2110 Special › Helix non-globular › Helix Hairpins › 0.76 39.0 4.59e-01 97.6% 71.9%
2bnlC00 1.10.490.10 Mainly Alpha › Orthogonal Bundle › Globin-like › Globins 0.74 50.0 4.23e-01 79.5% 42.5%
3lnnB03 1.10.287.470 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin 0.74 36.0 4.03e-01 95.2% 59.7%
4ioeA00 1.10.287.850 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HP0062-like domain 0.71 54.0 5.35e-01 100.0% 77.0%
1f45B00 1.20.1250.10 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › 0.62 42.0 3.58e-01 94.0% 43.6%
16vpA00 1.10.1290.10 Mainly Alpha › Orthogonal Bundle › Conserved core of transcriptional regulatory protein vp16 › Alpha trans-inducing (Alpha-TIF) 0.62 53.0 3.66e-01 98.8% 57.9%
1b04A03 1.10.287.610 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin 0.59 33.0 3.71e-01 84.3% 71.0%
1sumB01 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.58 40.0 3.75e-01 94.0% 56.1%
2b5uA02 1.10.287.620 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix Hairpins 0.58 52.0 4.19e-01 100.0% 51.6%
2odvA01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.57 42.0 3.82e-01 96.4% 58.0%
3fb2A01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.56 40.0 3.78e-01 92.8% 60.0%
1kmiZ02 1.10.287.500 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin 0.56 50.0 4.27e-01 100.0% 84.3%
1hwyA03 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.55 45.0 3.13e-01 91.6% 62.0%
2gl2B00 1.10.287.1700 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.55 46.0 4.21e-01 98.8% 70.6%
3spcA02 1.10.287.70 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.54 48.0 4.19e-01 98.8% 74.0%
ECOD (27)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
7720 4060.1.1.1 a+b duplicates or obligate multimers › NSP3 homodimer › NSP3 homodimer › NSP3 homodimer › Rota_NSP3 0.92 76.0 5.97e-01 86.7% 46.1%
4092193 3755.4.1.53 alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › CemA 0.75 54.0 4.37e-01 100.0% 40.6%
3264568 3748.1.1.3 extended segments › 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain › 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain › 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain › eIF3h_C 0.71 58.0 5.42e-01 100.0% 71.4%
4996194 5058.1.1.0 alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region 0.69 47.0 4.63e-01 75.9% 65.6%
3718093 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.69 49.0 3.95e-01 100.0% 38.7%
4179286 547.1.1.1 alpha duplicates or obligate multimers › Glutamyl tRNA-reductase dimerization domain › Glutamyl tRNA-reductase dimerization domain › Glutamyl tRNA-reductase dimerization domain › GlutR_dimer 0.68 50.0 5.04e-01 81.9% 76.5%
3654648 103.9.1.0 alpha arrays › RuvA-C › RanGAP2 N-terminal domain › RanGAP2 N-terminal domain 0.68 43.0 4.58e-01 72.3% 75.7%
3209229 3877.1.1.1 alpha bundles › Membrane protein insertase YidC-related › Membrane protein insertase YidC-related › Membrane protein insertase YidC › 60KD_IMP 0.67 53.0 3.70e-01 84.3% 75.7%
4579424 2003.1.1.0 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains 0.67 49.0 3.57e-01 81.9% 27.1%
5005807 2003.1.1.24 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › Shikimate_DH 0.66 54.0 3.81e-01 90.4% 71.3%
2698234 192.24.1.1 alpha bundles › Long alpha-hairpin › RPC62 helical hairpin domain › RPC62 helical hairpin domain › RPC3_helical 0.65 48.0 4.46e-01 95.2% 60.2%
4960231 4323.1.1.0 alpha bundles › helical bundle domain in vacuolar ATP synthase subunit C › helical bundle domain in vacuolar ATP synthase subunit C › helical bundle domain in vacuolar ATP synthase subunit C 0.65 50.0 4.09e-01 100.0% 46.2%
5021813 5058.1.1.101 alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › DUF1622 0.64 44.0 4.08e-01 94.0% 56.2%
5060042 150.1.1.0 alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin 0.64 49.0 4.16e-01 100.0% 49.3%
3484968 109.4.1.192 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_8 0.64 48.0 3.42e-01 78.3% 29.1%
3600869 3567.1.1.0 a+b duplicates or obligate multimers › MPER trimer › MPER trimer › MPER trimer 0.63 49.0 4.36e-01 100.0% 59.1%
3923888 4177.1.1.5 alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › Vps5 0.63 55.0 4.09e-01 100.0% 52.3%
3945729 604.32.1.0 alpha bundles › Spectrin repeat-like › Recombination protein uvsY › Recombination protein uvsY 0.59 52.0 4.56e-01 100.0% 67.7%
3746549 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.58 44.0 3.85e-01 81.9% 72.0%
4980864 604.5.1.2 alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › PhoU 0.57 41.0 3.60e-01 94.0% 50.4%
4934657 4323.1.1.0 alpha bundles › helical bundle domain in vacuolar ATP synthase subunit C › helical bundle domain in vacuolar ATP synthase subunit C › helical bundle domain in vacuolar ATP synthase subunit C 0.57 46.0 3.70e-01 100.0% 44.2%
4982694 3843.1.1.35 alpha complex topology › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › DUF1634 0.56 42.0 3.98e-01 78.3% 69.4%
3711734 3755.3.1.297 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › KIF9 0.56 51.0 4.06e-01 100.0% 78.2%
4210642 3755.1.1.12 alpha bundles › YscO-like › Putative type III secretion protein YscO-related › Putative type III secretion protein YscO-related › CheZ 0.56 49.0 4.28e-01 100.0% 65.4%
4408604 150.5.1.0 alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › ESAT-6 like › ESAT-6 like 0.53 47.0 3.39e-01 100.0% 58.4%
1019364 604.5.1.2 alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › PhoU 0.53 40.0 3.66e-01 85.5% 61.3%
3506760 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.52 45.0 3.97e-01 100.0% 65.4%