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NSP6
Euk-VirDuck_coronavirus
NSP6__YP_009825034__Duck_coronavirus__300188
Identity
- Accession:
- YP_009825034 ↗
- Protein ID:
- NSP6
- Kingdom:
- euk
Quality
75.0
mean pLDDT
Taxonomy
Orthornavirae›
Pisuviricota›
Pisoniviricetes›
Nidovirales›
Coronaviridae›
Gammacoronavirus›
Duck_coronavirus
TaxID: 300188
Cluster
View cluster (35 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 58-226
Domain cluster:
rep: coronavirus_nsp3_-HD2-__NP_740624__Infectious_bronchitis_virus__11120__D59-225
D2
high
residues 231-293
Domain cluster:
rep: nsp6__YP_009924414__Rabbit_coronavirus_HKU14__1160968__D233-286
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF19213.6 best | CoV_NSP6 | 76.0 | 8.00e-21 | 100.0% | 23.6% |
D3
medium
residues 1-57
Domain cluster:
representative
CATH (45)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3ermB00 | 1.10.10.710 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › PSPTO_1197 like | 0.87 | 66.0 | 6.35e-01 | 94.7% | 71.9% |
| 2rdcA00 | 1.10.287.800 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › protein ne1242 | 0.85 | 66.0 | 4.92e-01 | 82.5% | 37.6% |
| 2no4A02 | 1.10.150.240 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 | 0.79 | 63.0 | 5.73e-01 | 94.7% | 65.3% |
| 2uv8A07 | 6.10.140.1410 | Special › Helix non-globular › Helix Hairpins › | 0.77 | 65.0 | 5.69e-01 | 94.7% | 64.7% |
| 2vkzA02 | 3.40.47.10 | Alpha Beta › 3-Layer(aba) Sandwich › Peroxisomal Thiolase; Chain A, domain 1 › Thiolase/Chalcone synthase | 0.77 | 65.0 | 4.17e-01 | 94.7% | 21.0% |
| 1or7B01 | 1.10.1740.10 | Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › RNA polymerase sigma factor, region 2, helix turn helix motif | 0.76 | 58.0 | 4.95e-01 | 84.2% | 51.1% |
| 4l8iB00 | 1.10.132.20 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor | 0.75 | 64.0 | 5.10e-01 | 94.7% | 49.1% |
| 1tjlA00 | 1.20.120.910 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › DksA, coiled-coil domain | 0.75 | 57.0 | 4.16e-01 | 80.7% | 37.2% |
| 2e62A01 | 6.10.140.420 | Special › Helix non-globular › Helix Hairpins › | 0.74 | 57.0 | 5.94e-01 | 84.2% | 94.2% |
| 3umbA02 | 1.10.150.240 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 | 0.74 | 63.0 | 5.64e-01 | 94.7% | 67.1% |
| 2iw3A02 | 1.20.1390.20 | Mainly Alpha › Up-down Bundle › PWI domain › | 0.74 | 50.0 | 4.23e-01 | 71.9% | 44.4% |
| 3besR03 | 6.10.140.1480 | Special › Helix non-globular › Helix Hairpins › | 0.73 | 53.0 | 5.41e-01 | 78.9% | 82.1% |
| 2o7gA00 | 1.10.1740.10 | Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › RNA polymerase sigma factor, region 2, helix turn helix motif | 0.73 | 54.0 | 4.72e-01 | 80.7% | 52.3% |
| 5u4nA00 | 3.20.20.70 | Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Aldolase class I | 0.73 | 64.0 | 3.91e-01 | 100.0% | 38.3% |
| 1skvA00 | 1.10.287.660 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.72 | 58.0 | 5.54e-01 | 84.2% | 78.1% |
| 3q1pA01 | 6.10.250.1120 | Special › Helix non-globular › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › | 0.72 | 42.0 | 4.96e-01 | 84.2% | 87.2% |
| 1gvfB00 | 3.20.20.70 | Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Aldolase class I | 0.71 | 62.0 | 3.97e-01 | 100.0% | 29.1% |
| 1bhaA00 | 1.10.287.170 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.71 | 53.0 | 5.06e-01 | 82.5% | 68.7% |
| 2bg1A01 | 3.90.1310.40 | Alpha Beta › Alpha-Beta Complex › Penicillin-binding protein 2a (Domain 2) › | 0.71 | 57.0 | 5.19e-01 | 89.5% | 67.5% |
| 3dcfA02 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.70 | 56.0 | 4.20e-01 | 94.7% | 35.2% |
| 3b0cW00 | 1.10.20.10 | Mainly Alpha › Orthogonal Bundle › Histone, subunit A › Histone, subunit A | 0.69 | 58.0 | 5.39e-01 | 94.7% | 74.0% |
| 4l0rB00 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.69 | 56.0 | 5.16e-01 | 87.7% | 72.6% |
| 4okvE00 | 6.10.140.1890 | Special › Helix non-globular › Helix Hairpins › | 0.67 | 53.0 | 5.18e-01 | 94.7% | 80.0% |
| 1t72A02 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.67 | 54.0 | 4.57e-01 | 94.7% | 53.1% |
| 1zpyA00 | 6.10.140.1960 | Special › Helix non-globular › Helix Hairpins › | 0.67 | 54.0 | 4.59e-01 | 87.7% | 56.0% |
| 4abmD00 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.65 | 52.0 | 4.72e-01 | 87.7% | 68.8% |
| 3h36A00 | 1.10.10.400 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Polyribonucleotide nucleotidyltransferase, RNA-binding domain | 0.65 | 51.0 | 4.62e-01 | 86.0% | 65.4% |
| 4hehA01 | 1.10.1240.10 | Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › Methionine synthase domain | 0.65 | 46.0 | 4.04e-01 | 82.5% | 50.6% |
| 3icxA01 | 1.10.287.660 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.65 | 56.0 | 5.10e-01 | 94.7% | 77.3% |
| 6k9pB02 | 1.20.1300.20 | Mainly Alpha › Up-down Bundle › 3 helical TM bundles of succinate and fumarate reductases › Peptidase C65 Otubain, subdomain 2 | 0.64 | 53.0 | 3.87e-01 | 91.2% | 40.1% |
| 2mtqA00 | 1.20.58.130 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.63 | 44.0 | 4.09e-01 | 75.4% | 57.5% |
| 1v4aA01 | 1.10.4050.10 | Mainly Alpha › Orthogonal Bundle › Nucleotidyltransferase substrate binding subunit/domain fold › Glutamine synthase adenylyltransferase GlnE | 0.63 | 46.0 | 3.79e-01 | 78.9% | 44.0% |
| 1urfA00 | 1.10.287.160 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat | 0.63 | 50.0 | 4.45e-01 | 87.7% | 61.7% |
| 8igrI01 | 2.40.270.10 | Mainly Beta › Beta Barrel › Dna-directed Rna Polymerase Ii 140kd Polypeptide; Chain: B; Domain 6 › DNA-directed RNA polymerase, subunit 2, domain 6 | 0.62 | 54.0 | 3.86e-01 | 100.0% | 77.8% |
| 2nrkA00 | 3.30.460.10 | Alpha Beta › 2-Layer Sandwich › Beta Polymerase; domain 2 › Beta Polymerase, domain 2 | 0.61 | 43.0 | 3.15e-01 | 82.5% | 26.1% |
| 1f68A00 | 1.20.920.10 | Mainly Alpha › Up-down Bundle › Histone Acetyltransferase; Chain A › Bromodomain-like | 0.61 | 55.0 | 4.49e-01 | 100.0% | 100.0% |
| 2rgnB01 | 1.20.900.10 | Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain | 0.61 | 53.0 | 3.60e-01 | 96.5% | 64.7% |
| 1vfiA00 | 1.10.246.100 | Mainly Alpha › Orthogonal Bundle › Serum Albumin; Chain A, Domain 1 › Vanadium-binding protein 2 | 0.60 | 49.0 | 4.18e-01 | 91.2% | 76.8% |
| 1zs3A00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.60 | 53.0 | 3.79e-01 | 100.0% | 63.7% |
| 2yevA02 | 1.10.287.70 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.60 | 41.0 | 3.81e-01 | 75.4% | 55.4% |
| 2v6eA01 | 1.10.287.3180 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.59 | 45.0 | 4.16e-01 | 87.7% | 64.0% |
| 3hwrA02 | 1.10.1040.10 | Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 | 0.58 | 46.0 | 3.57e-01 | 87.7% | 41.1% |
| 3t69A02 | 3.30.420.310 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › 2-keto-3-deoxy-galactonokinase, C-terminal domain | 0.58 | 49.0 | 3.37e-01 | 100.0% | 59.7% |
| 3sqiA01 | 1.10.150.540 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › | 0.56 | 44.0 | 3.65e-01 | 84.2% | 52.5% |
| 3fkjA02 | 1.10.10.2240 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › | 0.53 | 37.0 | 3.62e-01 | 73.7% | 76.6% |
ECOD (39)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 185221 | 3502.1.1.1 ↗ | alpha bundles › uncharacterized conserved protein › uncharacterized conserved protein › uncharacterized conserved protein › YebG | 0.89 | 69.0 | 6.53e-01 | 96.5% | 70.1% |
| 3518379 | 3502.1.1.1 ↗ | alpha bundles › uncharacterized conserved protein › uncharacterized conserved protein › uncharacterized conserved protein › YebG | 0.83 | 63.0 | 6.40e-01 | 94.7% | 83.6% |
| 5072135 | 2498.1.1.10 ↗ | mixed a+b and a/b › Zincin-like › "Metalloproteases (""zincins"") catalytic domain" › "Metalloproteases (""zincins"") catalytic domain" › Peptidase_M48 | 0.79 | 70.0 | 4.81e-01 | 100.0% | 30.8% |
| 3278617 | 5063.1.1.0 ↗ | alpha bundles › Photosystem I reaction center subunit X, PsaK › Photosystem I reaction center subunit X, PsaK › Photosystem I reaction center subunit X, PsaK | 0.79 | 61.0 | 6.48e-01 | 94.7% | 96.0% |
| 5050325 | 4333.1.1.0 ↗ | a+b complex topology › DNA methylase specificity domain › DNA methylase specificity domain › DNA methylase specificity domain | 0.78 | 66.0 | 4.14e-01 | 93.0% | 18.6% |
| 3705250 | 708.1.1.0 ↗ | beta complex topology › ETN0001 domain-like › ETN0001 domain-like › NAC/WRKY/GCM/WOPR domain | 0.78 | 69.0 | 4.83e-01 | 100.0% | 41.7% |
| 3770340 | 5041.1.1.2 ↗ | extended segments › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C › TMEM169 | 0.77 | 69.0 | 5.63e-01 | 100.0% | 70.5% |
| 5004053 | 5058.1.1.0 ↗ | alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region | 0.77 | 71.0 | 5.79e-01 | 100.0% | 59.0% |
| 5054424 | 5058.1.1.2 ↗ | alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › MS_channel_1st | 0.76 | 62.0 | 5.55e-01 | 91.2% | 63.7% |
| 3239014 | 198.1.1.0 ↗ | alpha arrays › Saposin-like › Saposin-like › Saposin-like | 0.76 | 57.0 | 4.58e-01 | 80.7% | 44.0% |
| 4951179 | 5058.1.1.2 ↗ | alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › MS_channel_1st | 0.76 | 69.0 | 5.66e-01 | 100.0% | 67.0% |
| 3242033 | 198.1.1.0 ↗ | alpha arrays › Saposin-like › Saposin-like › Saposin-like | 0.75 | 59.0 | 4.90e-01 | 86.0% | 50.0% |
| 197868 | 614.1.1.0 ↗ | alpha duplicates or obligate multimers › L27 domain › L27 domain › L27 domain | 0.74 | 53.0 | 5.58e-01 | 77.2% | 88.2% |
| 5058468 | 5058.1.1.0 ↗ | alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region | 0.74 | 66.0 | 6.06e-01 | 100.0% | 76.0% |
| 5012157 | 605.1.1.354 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › MS_channel_1st_1 | 0.74 | 66.0 | 5.77e-01 | 100.0% | 70.6% |
| 3597348 | 207.1.1.0 ↗ | beta duplicates or obligate multimers › Single-stranded right-handed beta-helix › Leucine-rich repeats › Leucine-rich repeats | 0.74 | 63.0 | 3.99e-01 | 100.0% | 88.2% |
| 3319313 | 2006.1.4.33 ↗ | a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like › Tim17 | 0.73 | 63.0 | 4.99e-01 | 100.0% | 47.2% |
| 5018642 | 5058.1.1.2 ↗ | alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › MS_channel_1st | 0.73 | 64.0 | 5.23e-01 | 96.5% | 66.7% |
| 5047182 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.72 | 60.0 | 5.75e-01 | 93.0% | 81.5% |
| 4403895 | 2004.1.1.795 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › PF27377 | 0.71 | 64.0 | 4.30e-01 | 100.0% | 32.7% |
| 3690556 | 148.1.1.0 ↗ | alpha arrays › Histone-like › Histone-related › Histone | 0.71 | 58.0 | 5.73e-01 | 91.2% | 86.7% |
| 2122153 | 3831.1.1.1 ↗ | alpha bundles › Secreted protein of unknown function DUF1311 › Secreted protein of unknown function DUF1311 › Secreted protein of unknown function DUF1311 › LprI | 0.71 | 48.0 | 4.27e-01 | 71.9% | 47.7% |
| 4632127 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.70 | 60.0 | 5.36e-01 | 100.0% | 70.6% |
| 3230904 | 2484.1.1.26 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › Piwi | 0.69 | 60.0 | 3.76e-01 | 100.0% | 27.5% |
| 4267174 | 614.1.1.24 ↗ | alpha duplicates or obligate multimers › L27 domain › L27 domain › L27 domain › GlutR_dimer | 0.69 | 53.0 | 4.97e-01 | 96.5% | 68.0% |
| 3229793 | 198.1.1.0 ↗ | alpha arrays › Saposin-like › Saposin-like › Saposin-like | 0.68 | 56.0 | 4.97e-01 | 93.0% | 63.5% |
| 3643105 | 6026.1.1.1 ↗ | alpha duplicates or obligate multimers › cwf21 domain › cwf21 domain › cwf21 domain › cwf21 | 0.68 | 59.0 | 4.35e-01 | 100.0% | 46.5% |
| 4001318 | 603.1.1.0 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins | 0.68 | 53.0 | 4.88e-01 | 93.0% | 65.3% |
| 3973864 | 6026.1.1.2 ↗ | alpha duplicates or obligate multimers › cwf21 domain › cwf21 domain › cwf21 domain › GlpM | 0.67 | 55.0 | 4.63e-01 | 100.0% | 51.4% |
| 3285244 | 5063.1.1.19 ↗ | alpha bundles › Photosystem I reaction center subunit X, PsaK › Photosystem I reaction center subunit X, PsaK › Photosystem I reaction center subunit X, PsaK › DUF2277 | 0.66 | 47.0 | 5.08e-01 | 80.7% | 100.0% |
| 4558943 | 5045.1.1.1 ↗ | alpha bundles › F1F0 ATP synthase subunit A › F1F0 ATP synthase subunit A › F1F0 ATP synthase subunit A › ATP-synt_A | 0.65 | 53.0 | 3.55e-01 | 93.0% | 76.2% |
| 3209368 | 148.1.3.0 ↗ | alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain | 0.65 | 53.0 | 3.26e-01 | 94.7% | 53.6% |
| 4211233 | 4120.1.1.60 ↗ | few secondary structure elements › Tim10/DDP › Tim10/DDP › Tim10/DDP › GlutR_dimer | 0.65 | 52.0 | 4.81e-01 | 100.0% | 68.8% |
| 3227678 | 632.1.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain | 0.65 | 55.0 | 4.58e-01 | 94.7% | 82.0% |
| 4564711 | 547.1.1.1 ↗ | alpha duplicates or obligate multimers › Glutamyl tRNA-reductase dimerization domain › Glutamyl tRNA-reductase dimerization domain › Glutamyl tRNA-reductase dimerization domain › GlutR_dimer | 0.64 | 50.0 | 4.66e-01 | 89.5% | 68.0% |
| 3697466 | 1075.5.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › MatE | 0.63 | 57.0 | 3.72e-01 | 100.0% | 30.4% |
| 4323124 | 109.3.1.2 ↗ | alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat › Ank,Ank_2 | 0.62 | 50.0 | 3.16e-01 | 91.2% | 21.5% |
| 3971539 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.61 | 51.0 | 4.73e-01 | 94.7% | 73.3% |
| 5043869 | 3456.1.1.1 ↗ | extended segments › NADH-quinone oxidoreductase subunit A › NADH-quinone oxidoreductase subunit A › NADH-quinone oxidoreductase subunit A › Oxidored_q4 | 0.61 | 49.0 | 4.09e-01 | 93.0% | 51.4% |