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ORF1a
Euk-VirMouse_astrovirus_M-52_USA_2008
ORF1a__YP_004782205__Mouse_astrovirus_M-52_USA_2008__1074210
Identity
- Accession:
- YP_004782205 ↗
- Protein ID:
- ORF1a
- Kingdom:
- euk
Quality
54.5
mean pLDDT
Taxonomy
Orthornavirae›
Pisuviricota›
Stelpaviricetes›
Stellavirales›
Astroviridae›
Mouse_astrovirus_M-52/USA/2008
TaxID: 1074210
Cluster
Singleton — not in a non-trivial cluster
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 91-143
D2
high
residues 415-565
Domain cluster:
rep: 100_kDa_protein__YP_008130303__Citrus_vein_enation_virus__1301220__D379-571
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02907.22 best | Peptidase_S29 | 30.0 | 5.80e-07 | 92.0% | 60.4% |
| PF13365.13 | Trypsin_2 | 43.5 | 8.00e-11 | 80.8% | 98.6% |
D3
high
residues 703-812
Domain cluster:
representative
CATH (17)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2jswA00 | 1.20.1410.10 | Mainly Alpha › Up-down Bundle › I/LWEQ domain › I/LWEQ domain | 0.69 | 52.0 | 4.31e-01 | 78.2% | 60.8% |
| 2wyhB04 | 1.20.1270.50 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Glycoside hydrolase family 38, central domain | 0.69 | 47.0 | 4.92e-01 | 70.0% | 86.1% |
| 8hk0C01 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.67 | 49.0 | 4.46e-01 | 77.3% | 78.7% |
| 4o6yB00 | 1.20.120.1770 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › | 0.65 | 48.0 | 3.96e-01 | 80.0% | 92.9% |
| 2e8gA01 | 1.20.1440.150 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › | 0.65 | 47.0 | 4.58e-01 | 76.4% | 86.3% |
| 3buxB01 | 1.20.930.20 | Mainly Alpha › Up-down Bundle › Transcription Elongation Factor S-II; Chain A › Adaptor protein Cbl, N-terminal domain | 0.63 | 44.0 | 4.20e-01 | 71.8% | 68.2% |
| 5ts9B00 | 1.20.59.10 | Mainly Alpha › Up-down Bundle › Chorismate Mutase Domain, subunit A › Chorismate mutase | 0.63 | 35.0 | 3.05e-01 | 73.6% | 36.6% |
| 1eq1A00 | 1.20.120.20 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Apolipoprotein | 0.62 | 51.0 | 4.51e-01 | 91.8% | 85.5% |
| 3rpmA02 | 1.20.1270.90 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › AF1782-like | 0.61 | 41.0 | 4.53e-01 | 70.0% | 87.1% |
| 1tfkB00 | 1.20.120.650 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Colicin D | 0.59 | 41.0 | 4.52e-01 | 70.9% | 94.2% |
| 4lqqB00 | 1.20.140.30 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › MOB kinase activator | 0.57 | 48.0 | 4.43e-01 | 91.8% | 82.2% |
| 3ay5A01 | 1.20.1420.10 | Mainly Alpha › Up-down Bundle › A middle domain of Talin 1 › Talin, central domain | 0.57 | 42.0 | 3.93e-01 | 76.4% | 79.7% |
| 2gtaA00 | 1.10.287.1080 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › MazG-like | 0.57 | 45.0 | 4.72e-01 | 93.6% | 95.9% |
| 1oedA00 | 1.20.58.390 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Neurotransmitter-gated ion-channel transmembrane domain | 0.56 | 39.0 | 3.77e-01 | 72.7% | 87.4% |
| 2a3qA00 | 1.10.287.1080 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › MazG-like | 0.55 | 46.0 | 4.61e-01 | 90.9% | 88.5% |
| 3ipiA00 | 1.10.600.10 | Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase | 0.54 | 43.0 | 3.22e-01 | 83.6% | 45.5% |
| 6ifsB02 | 1.10.8.100 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › rRNA adenine dimethylase, C-terminal domain | 0.51 | 32.0 | 3.88e-01 | 70.0% | 100.0% |
ECOD (25)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4192155 | 601.1.1.43 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › Serendipity_A | 0.75 | 55.0 | 5.39e-01 | 77.3% | 86.7% |
| 3318429 | 3562.1.1.11 ↗ | alpha bundles › Calcium release-activated calcium channel protein 1 › Calcium release-activated calcium channel protein 1 › Calcium release-activated calcium channel protein 1 › PGG | 0.71 | 49.0 | 4.02e-01 | 70.9% | 60.5% |
| 3970945 | 601.4.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains | 0.71 | 54.0 | 5.33e-01 | 79.1% | 98.3% |
| 4371507 | 632.22.1.1 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats › EzrA | 0.70 | 48.0 | 5.19e-01 | 70.9% | 90.5% |
| 5073702 | 633.29.1.13 ↗ | alpha bundles › Bromodomain-like › Putative uncharacterized protein PAV1-137 › Putative uncharacterized protein PAV1-137 › DUF2096_N | 0.70 | 54.0 | 5.63e-01 | 80.0% | 98.0% |
| 4363280 | 601.1.2.53 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › DGKD_4H | 0.70 | 53.0 | 4.63e-01 | 79.1% | 64.4% |
| 3997336 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.69 | 48.0 | 4.65e-01 | 71.8% | 79.2% |
| 5041273 | 632.22.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats | 0.69 | 47.0 | 4.85e-01 | 70.0% | 87.6% |
| 5001323 | 4333.1.1.2 ↗ | a+b complex topology › DNA methylase specificity domain › DNA methylase specificity domain › DNA methylase specificity domain › TaqI_C | 0.67 | 47.0 | 3.37e-01 | 71.8% | 77.4% |
| 3608693 | 632.1.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain | 0.67 | 46.0 | 4.69e-01 | 70.0% | 87.6% |
| 3377582 | 632.21.1.4 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Helical bundle domain in endo-beta-N-acetylglucosaminidase F2 › Helical bundle domain in endo-beta-N-acetylglucosaminidase F2 › GAUT_1 | 0.67 | 52.0 | 5.52e-01 | 81.8% | 94.7% |
| 3614754 | 5.1.4.301 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › Kelch_1, Kelch_KLHDC2_KLHL20_DRC7 | 0.66 | 50.0 | 3.15e-01 | 78.2% | 22.1% |
| 4272227 | 5059.1.1.1 ↗ | alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › EamA | 0.63 | 50.0 | 3.65e-01 | 84.5% | 100.0% |
| 4644500 | 149.1.1.1 ↗ | alpha arrays › Cytochrome P450 › Cytochrome P450 › Cytochrome P450 › p450 | 0.62 | 48.0 | 3.12e-01 | 81.8% | 66.4% |
| 2583940 | 601.7.1.8 ↗ | alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain › Cas_Csm6_HEPN | 0.61 | 46.0 | 3.96e-01 | 80.0% | 81.6% |
| 4295850 | 5059.1.1.9 ↗ | alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › Sugar_transport | 0.61 | 45.0 | 3.39e-01 | 78.2% | 100.0% |
| 3729721 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.60 | 42.0 | 3.96e-01 | 71.8% | 83.0% |
| 3719881 | 159.1.3.0 ↗ | alpha bundles › all-alpha NTP pyrophosphatases › all-alpha NTP pyrophosphatases › putative NTP pyrophosphohydrolase Exig_1061 | 0.57 | 41.0 | 4.45e-01 | 85.5% | 86.3% |
| 4110524 | 4979.2.1.1 ↗ | alpha arrays › C-terminal domain of Hypothetical protein MPN330-like › XRN2-binding domain (XTBD) › XRN2-binding domain (XTBD) › XTBD | 0.56 | 32.0 | 3.43e-01 | 93.6% | 65.3% |
| 3165101 | 2004.1.1.5 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ABC_tran | 0.51 | 40.0 | 2.96e-01 | 83.6% | 53.6% |
| 3281875 | 191.1.1.48 ↗ | alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › TetR_C_46 | 0.51 | 37.0 | 3.53e-01 | 76.4% | 91.5% |
| 3942352 | 2004.1.1.5 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ABC_tran | 0.51 | 40.0 | 3.25e-01 | 86.4% | 57.3% |
| 5075323 | 2004.1.1.5 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ABC_tran | 0.51 | 39.0 | 3.04e-01 | 83.6% | 62.0% |
| None | — | 0.51 | 39.0 | 3.08e-01 | 83.6% | 53.2% | |
| 5049780 | 101.1.10.0 ↗ | alpha arrays › HTH › HTH › Cyclin-like | 0.50 | 35.0 | 3.34e-01 | 75.5% | 61.7% |
D4
medium
residues 365-402