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ORF1a
Euk-VirAstrovirus_wild_boar_WBAstV-1_2011_HUN
ORF1a__YP_005271207__Astrovirus_wild_boar_WBAstV-1_2011_HUN__1137931
Identity
- Accession:
- YP_005271207 ↗
- Protein ID:
- ORF1a
- Kingdom:
- euk
Quality
60.9
mean pLDDT
Taxonomy
Orthornavirae›
Pisuviricota›
Stelpaviricetes›
Stellavirales›
Astroviridae›
Mamastrovirus›
Astrovirus_wild_boar/WBAstV-1/2011/HUN
TaxID: 1137931
Cluster
View cluster (19 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 1-67
D2
medium
residues 254-369
Domain cluster:
rep: nonstructural_protein__YP_009154705__Astrovirus_Er_SZAL6_HUN_2011__1671382__D274-394_416-431
CATH (33)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1u89A00 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.74 | 53.0 | 4.97e-01 | 73.3% | 81.3% |
| 2yfaA02 | 1.20.1440.210 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › | 0.69 | 47.0 | 4.78e-01 | 70.7% | 96.6% |
| 3l39A01 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.68 | 52.0 | 4.39e-01 | 82.8% | 80.0% |
| 3lcnB00 | 1.10.340.40 | Mainly Alpha › Orthogonal Bundle › Endonuclease III; domain 1 › Nuclear abundant poly(A) RNA-bind protein 2, N-terminal domain | 0.66 | 50.0 | 5.42e-01 | 88.8% | 95.9% |
| 1zoyD00 | 1.20.1300.10 | Mainly Alpha › Up-down Bundle › 3 helical TM bundles of succinate and fumarate reductases › Fumarate reductase/succinate dehydrogenase, transmembrane subunit | 0.64 | 44.0 | 4.73e-01 | 91.4% | 80.4% |
| 5gl7A01 | 1.10.730.10 | Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1 | 0.64 | 57.0 | 5.01e-01 | 96.6% | 100.0% |
| 152lA00 | 1.10.530.40 | Mainly Alpha › Orthogonal Bundle › Lysozyme › | 0.62 | 46.0 | 4.09e-01 | 92.2% | 54.3% |
| 1tjoB00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.62 | 48.0 | 4.21e-01 | 81.9% | 78.3% |
| 2icwG01 | 1.20.120.390 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Hla class ii histocompatibility antigen, dr alpha chain. Chain D, domain 1 | 0.62 | 36.0 | 3.51e-01 | 79.3% | 52.4% |
| 3unoE00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.62 | 51.0 | 4.53e-01 | 89.7% | 85.0% |
| 3hiuD00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.62 | 48.0 | 4.38e-01 | 81.9% | 84.9% |
| 1nfvA00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.62 | 51.0 | 4.55e-01 | 90.5% | 83.4% |
| 2oh3A01 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.61 | 47.0 | 4.41e-01 | 82.8% | 93.1% |
| 5u1aL00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.61 | 52.0 | 4.68e-01 | 97.4% | 88.6% |
| 6nsjA00 | 1.25.40.600 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › AmiS/UreI transporter | 0.60 | 52.0 | 4.48e-01 | 94.0% | 88.5% |
| 1s3qG00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.60 | 49.0 | 4.45e-01 | 90.5% | 89.0% |
| 4cmyA00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.60 | 45.0 | 4.10e-01 | 81.0% | 77.9% |
| 1qdmA03 | 1.10.225.10 | Mainly Alpha › Orthogonal Bundle › NK-Lysin › Saposin-like | 0.59 | 37.0 | 4.36e-01 | 80.2% | 92.2% |
| 3acxA00 | 1.10.600.10 | Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase | 0.59 | 53.0 | 4.00e-01 | 99.1% | 94.4% |
| 4dveA00 | 1.10.1760.20 | Mainly Alpha › Orthogonal Bundle › Arp2/3 complex 21 kDa subunit ARPC3 › | 0.58 | 44.0 | 3.78e-01 | 80.2% | 63.5% |
| 2rbdA01 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.57 | 45.0 | 4.13e-01 | 82.8% | 86.7% |
| 2aplA01 | 1.10.8.330 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › PG0816-like | 0.57 | 34.0 | 4.27e-01 | 89.7% | 100.0% |
| 4fxdA04 | 3.90.1600.10 | Alpha Beta › Alpha-Beta Complex › Palm domain of DNA polymerase › B family DNA polymerase, palm domain | 0.55 | 44.0 | 3.99e-01 | 83.6% | 86.3% |
| 3agtA00 | 1.20.120.50 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Hemerythrin-like | 0.55 | 41.0 | 3.96e-01 | 79.3% | 79.7% |
| 4gc0A01 | 1.20.1250.20 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains | 0.55 | 43.0 | 3.50e-01 | 87.9% | 66.7% |
| 3rkgA02 | 1.20.58.340 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Magnesium transport protein CorA, transmembrane region | 0.54 | 42.0 | 3.73e-01 | 82.8% | 85.4% |
| 6vxcA01 | 3.20.70.20 | Alpha Beta › Alpha-Beta Barrel › Anaerobic Ribonucleotide-triphosphate Reductase Large Chain › | 0.53 | 42.0 | 2.61e-01 | 87.1% | 39.9% |
| 2c5uA02 | 1.10.3550.20 | Mainly Alpha › Orthogonal Bundle › eoxyguanosinetriphosphate triphosphohydrolase fold › | 0.52 | 38.0 | 3.66e-01 | 75.0% | 89.3% |
| 2qgmA03 | 1.20.1440.30 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › Biosynthetic Protein domain | 0.52 | 45.0 | 4.56e-01 | 96.6% | 96.6% |
| 4xxiA00 | 1.10.490.20 | Mainly Alpha › Orthogonal Bundle › Globin-like › Phycocyanins | 0.51 | 39.0 | 3.65e-01 | 81.0% | 69.4% |
| 1a36A04 | 1.10.132.10 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › | 0.51 | 39.0 | 3.43e-01 | 81.0% | 68.6% |
| 3gi7A00 | 1.20.1270.180 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.51 | 37.0 | 3.91e-01 | 88.8% | 85.4% |
| 4nswB01 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.50 | 38.0 | 2.95e-01 | 79.3% | 67.6% |
ECOD (36)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4943286 | 633.10.1.0 ↗ | alpha bundles › Bromodomain-like › IVS-encoded protein-like › IVS-encoded protein-like | 0.76 | 52.0 | 4.81e-01 | 70.7% | 76.4% |
| 3484828 | 150.1.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin | 0.71 | 49.0 | 4.46e-01 | 70.7% | 90.3% |
| 3623412 | 5067.1.1.0 ↗ | alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain | 0.71 | 56.0 | 4.48e-01 | 84.5% | 63.0% |
| 3480976 | 601.1.2.100 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › PF31009 | 0.69 | 49.0 | 4.22e-01 | 74.1% | 75.1% |
| 5006070 | 604.5.1.2 ↗ | alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › PhoU | 0.68 | 52.0 | 4.39e-01 | 81.0% | 91.3% |
| 3503767 | 633.21.1.0 ↗ | alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 | 0.67 | 47.0 | 4.42e-01 | 71.6% | 85.7% |
| 4950367 | 622.1.1.0 ↗ | alpha bundles › YvfG-like › HSC20 (HSCB), C-terminal oligomerisation domain › HSC20 (HSCB), C-terminal oligomerisation domain | 0.66 | 47.0 | 4.52e-01 | 72.4% | 75.4% |
| 4958277 | 1075.5.1.0 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter | 0.65 | 53.0 | 4.48e-01 | 88.8% | 77.4% |
| 3373563 | 1075.5.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › MatE | 0.64 | 54.0 | 4.24e-01 | 91.4% | 68.6% |
| 3172226 | 603.1.1.17 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins › SNARE | 0.64 | 47.0 | 3.69e-01 | 76.7% | 80.0% |
| 3590175 | 5065.1.1.3 ↗ | alpha bundles › Type II ABC importer transmembrane domain fold › Type II ABC importer transmembrane domain fold › Type II ABC importer transmembrane domain fold › BPD_transp_2 | 0.64 | 48.0 | 3.67e-01 | 100.0% | 35.4% |
| 3636767 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.63 | 48.0 | 3.96e-01 | 81.9% | 64.7% |
| 5010685 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.62 | 48.0 | 4.40e-01 | 81.9% | 75.3% |
| 4946897 | 150.1.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin | 0.60 | 44.0 | 3.88e-01 | 76.7% | 81.2% |
| 4283454 | 604.8.1.2 ↗ | alpha bundles › Spectrin repeat-like › Smac/diablo › Smac/diablo › Mitofilin | 0.60 | 45.0 | 3.51e-01 | 77.6% | 94.6% |
| 3261143 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.60 | 44.0 | 3.84e-01 | 75.9% | 53.4% |
| 5060485 | 633.7.1.0 ↗ | alpha bundles › Bromodomain-like › Bacillus cereus metalloprotein-like › Bacillus cereus metalloprotein-like | 0.60 | 43.0 | 4.41e-01 | 75.0% | 96.4% |
| 3887521 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.59 | 47.0 | 3.79e-01 | 85.3% | 64.8% |
| 4944462 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.58 | 54.0 | 5.35e-01 | 100.0% | 98.3% |
| 3479320 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.58 | 45.0 | 3.66e-01 | 82.8% | 80.0% |
| 4068116 | 5060.1.1.1 ↗ | alpha bundles › V-type ATP synthase subunit C › V-type ATP synthase subunit C › V-type ATP synthase subunit C › vATP-synt_AC39 | 0.58 | 48.0 | 4.86e-01 | 88.8% | 90.4% |
| 5038657 | 150.1.1.1 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › Ferritin | 0.57 | 48.0 | 4.44e-01 | 97.4% | 89.4% |
| 3913986 | 192.1.1.36 ↗ | alpha bundles › Long alpha-hairpin › GreA transcript cleavage protein, N-terminal domain › GreA transcript cleavage protein, N-terminal domain › BAG6 | 0.56 | 40.0 | 4.27e-01 | 74.1% | 81.9% |
| 4021292 | 4121.1.1.0 ↗ | a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like | 0.56 | 43.0 | 2.90e-01 | 82.8% | 43.4% |
| 5050990 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.56 | 50.0 | 3.92e-01 | 98.3% | 56.7% |
| 5049715 | 592.2.1.0 ↗ | alpha arrays › PWI domain-like › YugE-like › YugE-like | 0.55 | 40.0 | 3.95e-01 | 75.0% | 96.0% |
| 5018387 | 604.18.1.0 ↗ | alpha bundles › Spectrin repeat-like › Triple-helical domain in regulatory ATPase variant A (RavA) › Triple-helical domain in regulatory ATPase variant A (RavA) | 0.55 | 42.0 | 4.41e-01 | 80.2% | 90.5% |
| 3450053 | 3939.1.1.0 ↗ | alpha duplicates or obligate multimers › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain | 0.54 | 42.0 | 3.59e-01 | 82.8% | 65.3% |
| 3800597 | 2002.1.1.150 ↗ | a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels › NAGidase | 0.54 | 48.0 | 3.17e-01 | 100.0% | 30.7% |
| 3998044 | 4177.1.1.8 ↗ | alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › BAR_3 | 0.54 | 41.0 | 3.10e-01 | 79.3% | 67.7% |
| 3607399 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.53 | 43.0 | 3.63e-01 | 88.8% | 73.2% |
| 5026255 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.53 | 40.0 | 3.55e-01 | 81.9% | 73.7% |
| 3191902 | 5001.1.1.0 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like | 0.52 | 46.0 | 3.42e-01 | 99.1% | 85.7% |
| 3630684 | 4177.1.1.2 ↗ | alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › BAR | 0.52 | 43.0 | 3.58e-01 | 91.4% | 80.9% |
| 5048679 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.52 | 45.0 | 4.30e-01 | 98.3% | 81.5% |
| 5079003 | 1076.1.1.3 ↗ | alpha bundles › Intramembrane protease Rce1-related › Intramembrane protease Rce1-related › Intramembrane protease Rce1-related › YhfC | 0.51 | 46.0 | 3.65e-01 | 100.0% | 77.9% |
D3
medium
residues 418-493
Domain cluster:
rep: ORF1a__YP_009162618__Dromedary_astrovirus__1662272__D428-481
D4
medium
residues 494-574
Domain cluster:
rep: ORF1a__YP_009047079__Human_astrovirus_BF34__1518575__D522-618
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF13365.13 best | Trypsin_2 | 28.5 | 3.30e-06 | 65.4% | 29.0% |