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ORF1a
Euk-VirAstrovirus_MLB3
ORF1a__YP_006905852__Astrovirus_MLB3__1247114
Identity
- Accession:
- YP_006905852 ↗
- Protein ID:
- ORF1a
- Kingdom:
- euk
Quality
69.2
mean pLDDT
Taxonomy
TaxID: 1247114
Cluster
View cluster (8 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 9-114
Domain cluster:
rep: ORF1a__YP_009010969__Porcine_astrovirus_5__1093928__D1-101
D2
high
residues 222-335
Domain cluster:
rep: non-structural_protein__YP_003275952__HMO_Astrovirus_A__682382__D294-402
CATH (35)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3l39A01 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.70 | 55.0 | 4.50e-01 | 81.6% | 96.5% |
| 1vmgA00 | 1.10.287.1080 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › MazG-like | 0.66 | 39.0 | 4.51e-01 | 78.1% | 80.5% |
| 4e4eA01 | 1.10.287.990 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Fe,Mn superoxide dismutase (SOD) domain | 0.65 | 35.0 | 4.19e-01 | 73.7% | 80.3% |
| 7p3rA01 | 1.20.1170.10 | Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; › | 0.65 | 46.0 | 3.33e-01 | 73.7% | 99.7% |
| 3p5nA00 | 1.10.1760.20 | Mainly Alpha › Orthogonal Bundle › Arp2/3 complex 21 kDa subunit ARPC3 › | 0.64 | 47.0 | 4.18e-01 | 77.2% | 69.6% |
| 4gzrB00 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.63 | 39.0 | 4.70e-01 | 73.7% | 92.2% |
| 5dsgA01 | 1.10.530.40 | Mainly Alpha › Orthogonal Bundle › Lysozyme › | 0.63 | 44.0 | 4.58e-01 | 82.5% | 78.3% |
| 2c41C01 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.62 | 47.0 | 4.33e-01 | 80.7% | 87.9% |
| 2c2jA00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.61 | 47.0 | 4.21e-01 | 82.5% | 85.5% |
| 3hiuD00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.61 | 47.0 | 4.32e-01 | 82.5% | 84.2% |
| 3f4mA00 | 1.20.1440.160 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › Tumor necrosis factor alpha-induced protein 8-like | 0.61 | 50.0 | 4.54e-01 | 89.5% | 87.7% |
| 2yjkC00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.61 | 46.0 | 4.20e-01 | 81.6% | 83.4% |
| 152lA00 | 1.10.530.40 | Mainly Alpha › Orthogonal Bundle › Lysozyme › | 0.60 | 46.0 | 4.10e-01 | 98.2% | 56.1% |
| 1nfvA00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.60 | 49.0 | 4.36e-01 | 89.5% | 85.8% |
| 2fji101 | 1.10.357.50 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › | 0.60 | 49.0 | 3.98e-01 | 86.8% | 84.2% |
| 2lseA00 | 1.20.120.1360 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › | 0.60 | 41.0 | 4.34e-01 | 70.2% | 86.1% |
| 2cmrA00 | 1.20.58.1860 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.60 | 48.0 | 4.03e-01 | 86.0% | 91.7% |
| 2jqqA00 | 1.20.58.1240 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.60 | 45.0 | 4.12e-01 | 80.7% | 96.8% |
| 7m2wE01 | 1.20.120.1900 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Gamma-tubulin complex, C-terminal domain | 0.59 | 42.0 | 3.12e-01 | 74.6% | 96.1% |
| 1s3qG00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.58 | 49.0 | 4.44e-01 | 94.7% | 85.9% |
| 4x5mA00 | 1.20.1280.290 | Mainly Alpha › Up-down Bundle › Monooxygenase › | 0.57 | 37.0 | 4.10e-01 | 85.1% | 84.9% |
| 1oahA02 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.57 | 37.0 | 3.48e-01 | 78.1% | 52.8% |
| 3l1nA02 | 1.20.1280.140 | Mainly Alpha › Up-down Bundle › Monooxygenase › | 0.56 | 40.0 | 4.51e-01 | 84.2% | 100.0% |
| 2qgmA03 | 1.20.1440.30 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › Biosynthetic Protein domain | 0.55 | 42.0 | 4.23e-01 | 79.8% | 90.5% |
| 2yxhA00 | 1.10.287.1080 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › MazG-like | 0.55 | 40.0 | 4.07e-01 | 94.7% | 77.0% |
| 3agtA00 | 1.20.120.50 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Hemerythrin-like | 0.55 | 43.0 | 4.10e-01 | 83.3% | 78.9% |
| 1a36A04 | 1.10.132.10 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › | 0.54 | 42.0 | 3.62e-01 | 82.5% | 69.1% |
| 2b5dX01 | 3.20.110.10 | Alpha Beta › Alpha-Beta Barrel › 7-stranded beta/alpha barrel › Glycoside hydrolase 38, N terminal domain | 0.53 | 44.0 | 3.05e-01 | 91.2% | 88.6% |
| 1ku9A02 | 1.10.287.450 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.53 | 30.0 | 3.86e-01 | 72.8% | 98.4% |
| 1yg2A02 | 6.10.140.190 | Special › Helix non-globular › Helix Hairpins › | 0.53 | 39.0 | 4.36e-01 | 83.3% | 98.9% |
| 4h3tA02 | 1.10.132.100 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › | 0.53 | 38.0 | 3.58e-01 | 75.4% | 93.6% |
| 1yfmA01 | 1.10.275.10 | Mainly Alpha › Orthogonal Bundle › Fumarase C; Chain B, domain 1 › Fumarase/aspartase (N-terminal domain) | 0.52 | 39.0 | 3.79e-01 | 81.6% | 69.8% |
| 2b5uA02 | 1.10.287.620 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix Hairpins | 0.51 | 36.0 | 3.20e-01 | 73.7% | 88.2% |
| 4aflA00 | 6.10.140.1740 | Special › Helix non-globular › Helix Hairpins › | 0.51 | 38.0 | 4.01e-01 | 78.1% | 92.2% |
| 4gc0A01 | 1.20.1250.20 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains | 0.51 | 36.0 | 2.93e-01 | 76.3% | 95.2% |
ECOD (38)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 5067848 | 5067.1.1.4 ↗ | alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › MMPL | 0.78 | 65.0 | 5.23e-01 | 89.5% | 73.0% |
| 3603202 | 5067.1.1.4 ↗ | alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › MMPL | 0.77 | 63.0 | 4.35e-01 | 88.6% | 40.0% |
| 2722819 | 3758.2.1.1 ↗ | alpha bundles › Bacterial hemolysins-like › Biopolymer transport protein ExbB › Biopolymer transport protein ExbB › MotA_ExbB | 0.73 | 51.0 | 4.00e-01 | 72.8% | 69.9% |
| 3782664 | 5067.1.1.0 ↗ | alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain | 0.71 | 58.0 | 4.56e-01 | 88.6% | 65.7% |
| 4986508 | 5067.1.1.4 ↗ | alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › MMPL | 0.71 | 58.0 | 4.07e-01 | 88.6% | 41.6% |
| 3509413 | 601.54.1.4 ↗ | alpha bundles › Four-helical up-and-down bundle › low CO2-inducible protein LCI1 › low CO2-inducible protein LCI1 › UPF0220 | 0.71 | 50.0 | 4.73e-01 | 72.8% | 93.3% |
| 4557092 | 633.23.1.32 ↗ | alpha bundles › Bromodomain-like › Claudin › Claudin › CASP_dom | 0.70 | 50.0 | 4.55e-01 | 72.8% | 94.6% |
| 3503767 | 633.21.1.0 ↗ | alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 | 0.69 | 48.0 | 4.53e-01 | 71.9% | 91.4% |
| 3580491 | 174.1.1.1 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin | 0.68 | 48.0 | 4.27e-01 | 71.9% | 81.2% |
| 3233878 | 633.23.1.0 ↗ | alpha bundles › Bromodomain-like › Claudin › Claudin | 0.68 | 48.0 | 4.67e-01 | 71.9% | 96.0% |
| 3484828 | 150.1.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin | 0.68 | 47.0 | 4.22e-01 | 70.2% | 82.6% |
| 3448339 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.68 | 47.0 | 4.39e-01 | 71.9% | 84.8% |
| 4019714 | 633.21.1.0 ↗ | alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 | 0.66 | 48.0 | 4.80e-01 | 75.4% | 98.3% |
| 3575989 | 5067.1.1.0 ↗ | alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain | 0.66 | 54.0 | 4.50e-01 | 89.5% | 70.7% |
| 3229018 | 633.21.1.0 ↗ | alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 | 0.66 | 47.0 | 4.43e-01 | 72.8% | 91.9% |
| 5066136 | 604.5.1.1 ↗ | alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › PhoU_div | 0.65 | 53.0 | 4.27e-01 | 87.7% | 79.4% |
| 3259976 | 601.1.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin | 0.65 | 52.0 | 4.04e-01 | 84.2% | 94.6% |
| 3516873 | 159.1.1.3 ↗ | alpha bundles › all-alpha NTP pyrophosphatases › all-alpha NTP pyrophosphatases › Hypothetical protein AF_0060 › DUF1599 | 0.65 | 40.0 | 4.61e-01 | 79.8% | 87.5% |
| 4067307 | 3758.2.1.2 ↗ | alpha bundles › Bacterial hemolysins-like › Biopolymer transport protein ExbB › Biopolymer transport protein ExbB | 0.65 | 57.0 | 4.27e-01 | 94.7% | 72.2% |
| 3799907 | 633.21.1.0 ↗ | alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 | 0.64 | 47.0 | 4.51e-01 | 76.3% | 98.5% |
| 4024396 | 174.1.1.0 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain | 0.64 | 46.0 | 4.35e-01 | 73.7% | 91.1% |
| 4013285 | 4121.1.1.0 ↗ | a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like | 0.64 | 49.0 | 3.83e-01 | 80.7% | 53.3% |
| 4958277 | 1075.5.1.0 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter | 0.64 | 50.0 | 4.25e-01 | 85.1% | 75.4% |
| 5001408 | 4995.1.1.0 ↗ | alpha arrays › Methionine synthase domain-like › Methionine synthase domain-like › Methionine synthase domain-like | 0.63 | 43.0 | 4.51e-01 | 83.3% | 79.0% |
| 4997633 | 150.1.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin | 0.61 | 45.0 | 4.36e-01 | 76.3% | 75.2% |
| 4028568 | 633.10.1.0 ↗ | alpha bundles › Bromodomain-like › IVS-encoded protein-like › IVS-encoded protein-like | 0.60 | 47.0 | 4.26e-01 | 82.5% | 89.0% |
| 3943210 | 5079.1.1.1 ↗ | alpha duplicates or obligate multimers › Magnesium transporter MgtE membrane domain › Magnesium transporter MgtE membrane domain › Magnesium transporter MgtE membrane domain › MgtE | 0.60 | 50.0 | 4.24e-01 | 90.4% | 93.7% |
| 4996413 | 3352.1.1.0 ↗ | alpha bundles › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain | 0.60 | 52.0 | 3.62e-01 | 99.1% | 89.9% |
| 4946345 | 3684.1.1.0 ↗ | alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like | 0.57 | 39.0 | 3.67e-01 | 70.2% | 82.1% |
| 3996236 | 5050.1.1.11 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › UNC-93 | 0.57 | 37.0 | 3.06e-01 | 83.3% | 35.7% |
| 3770414 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.56 | 43.0 | 4.51e-01 | 79.8% | 91.4% |
| 3598668 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.56 | 41.0 | 3.41e-01 | 77.2% | 62.4% |
| 4946897 | 150.1.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin | 0.55 | 42.0 | 3.71e-01 | 80.7% | 81.8% |
| 3172226 | 603.1.1.17 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins › SNARE | 0.54 | 43.0 | 3.36e-01 | 85.1% | 71.2% |
| 4188455 | 601.19.1.19 ↗ | alpha bundles › Four-helical up-and-down bundle › Apolipoprotein › Apolipoprotein › ATP-synt_A | 0.53 | 45.0 | 3.65e-01 | 92.1% | 69.1% |
| 4021292 | 4121.1.1.0 ↗ | a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like | 0.53 | 42.0 | 2.83e-01 | 86.0% | 44.9% |
| 3965610 | 3831.1.1.1 ↗ | alpha bundles › Secreted protein of unknown function DUF1311 › Secreted protein of unknown function DUF1311 › Secreted protein of unknown function DUF1311 › LprI | 0.51 | 32.0 | 3.62e-01 | 82.5% | 83.5% |
| 3806504 | 192.22.1.0 ↗ | alpha bundles › Long alpha-hairpin › Ral binding domain of RLIP76 › Ral binding domain of RLIP76 | 0.50 | 39.0 | 3.91e-01 | 81.6% | 83.5% |
D3
high
residues 699-758
D4
medium
residues 390-464
Domain cluster:
rep: ORF1a__YP_009162618__Dromedary_astrovirus__1662272__D428-481
D5
medium
residues 465-544
Domain cluster:
rep: ORF1a__YP_009047079__Human_astrovirus_BF34__1518575__D522-618
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00548.27 best | Peptidase_C3 | 25.0 | 2.30e-05 | 80.0% | 25.3% |