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ORF1a

Euk-Vir

Astrovirus_VA3

ORF1a__YP_006905858__Astrovirus_VA3__683174

Identity

Accession:
YP_006905858 ↗
Protein ID:
ORF1a
Kingdom:
euk

Quality

67.1 mean pLDDT

Taxonomy

Orthornavirae› Pisuviricota› Stelpaviricetes› Stellavirales› Astroviridae› Astrovirus_VA3

TaxID: 683174

Cluster

View cluster (8 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 15-134
PDB
Domain cluster: rep: ORF1a__YP_009010969__Porcine_astrovirus_5__1093928__D1-101
D2 high residues 787-858
PDB
Domain cluster: rep: non-structural_protein__YP_003275952__HMO_Astrovirus_A__682382__D798-855
D3 medium residues 399-425
PDB
D4 medium residues 434-445_520-622
PDB
Domain cluster: rep: ORF1a__YP_009047079__Human_astrovirus_BF34__1518575__D522-618
D5 medium residues 446-519
PDB
Domain cluster: rep: ORF1a__YP_009162618__Dromedary_astrovirus__1662272__D428-481
CATH (55)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2w5eA01 2.40.10.10 Mainly Beta › Beta Barrel › Thrombin, subunit H › Trypsin-like serine proteases 0.97 81.0 8.69e-01 87.8% 98.5%
3k6yA01 2.40.10.10 Mainly Beta › Beta Barrel › Thrombin, subunit H › Trypsin-like serine proteases 0.88 83.0 7.61e-01 100.0% 85.9%
3otpA01 2.40.10.120 Mainly Beta › Beta Barrel › Thrombin, subunit H › 0.88 81.0 5.77e-01 100.0% 39.9%
4yo1A01 2.40.10.10 Mainly Beta › Beta Barrel › Thrombin, subunit H › Trypsin-like serine proteases 0.87 81.0 7.58e-01 100.0% 89.9%
3nziA01 2.40.10.10 Mainly Beta › Beta Barrel › Thrombin, subunit H › Trypsin-like serine proteases 0.86 80.0 7.02e-01 100.0% 82.1%
4ic6C01 2.40.10.10 Mainly Beta › Beta Barrel › Thrombin, subunit H › Trypsin-like serine proteases 0.86 80.0 6.89e-01 100.0% 85.5%
1p3cA02 2.40.10.10 Mainly Beta › Beta Barrel › Thrombin, subunit H › Trypsin-like serine proteases 0.84 76.0 6.62e-01 100.0% 88.2%
5hmaA01 2.40.10.10 Mainly Beta › Beta Barrel › Thrombin, subunit H › Trypsin-like serine proteases 0.83 77.0 7.22e-01 100.0% 95.4%
2r0lA02 2.40.10.10 Mainly Beta › Beta Barrel › Thrombin, subunit H › Trypsin-like serine proteases 0.82 72.0 6.19e-01 95.9% 88.5%
5y2dA01 2.40.10.10 Mainly Beta › Beta Barrel › Thrombin, subunit H › Trypsin-like serine proteases 0.82 76.0 6.32e-01 100.0% 65.0%
8e7cA01 2.40.10.10 Mainly Beta › Beta Barrel › Thrombin, subunit H › Trypsin-like serine proteases 0.81 65.0 6.36e-01 86.5% 97.5%
2aiqA02 2.40.10.10 Mainly Beta › Beta Barrel › Thrombin, subunit H › Trypsin-like serine proteases 0.80 73.0 6.31e-01 100.0% 84.1%
1elvA01 2.40.10.10 Mainly Beta › Beta Barrel › Thrombin, subunit H › Trypsin-like serine proteases 0.80 69.0 6.26e-01 93.2% 90.8%
1mbmA01 2.40.10.10 Mainly Beta › Beta Barrel › Thrombin, subunit H › Trypsin-like serine proteases 0.80 73.0 7.30e-01 100.0% 100.0%
2zu2A01 2.40.10.10 Mainly Beta › Beta Barrel › Thrombin, subunit H › Trypsin-like serine proteases 0.80 73.0 6.62e-01 100.0% 87.8%
2o8mB01 2.40.10.120 Mainly Beta › Beta Barrel › Thrombin, subunit H › 0.78 63.0 6.59e-01 97.3% 97.0%
2ynaA02 2.40.10.10 Mainly Beta › Beta Barrel › Thrombin, subunit H › Trypsin-like serine proteases 0.77 67.0 6.32e-01 95.9% 100.0%
2ijd101 2.40.10.120 Mainly Beta › Beta Barrel › Thrombin, subunit H › 0.76 68.0 5.10e-01 100.0% 42.8%
1wxrA01 2.40.10.120 Mainly Beta › Beta Barrel › Thrombin, subunit H › 0.75 64.0 4.33e-01 100.0% 26.8%
2sfaA01 2.40.10.10 Mainly Beta › Beta Barrel › Thrombin, subunit H › Trypsin-like serine proteases 0.74 66.0 6.13e-01 97.3% 100.0%
3r5lA00 2.30.110.10 Mainly Beta › Roll › Pnp Oxidase; Chain A › Electron Transport, Fmn-binding Protein; Chain A 0.74 60.0 5.16e-01 87.8% 96.6%
4q63A00 2.40.10.430 Mainly Beta › Beta Barrel › Thrombin, subunit H › 0.72 61.0 5.69e-01 94.6% 91.4%
2dpyA00 3.40.50.12240 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.72 57.0 3.51e-01 85.1% 15.6%
4rt0A00 2.40.10.220 Mainly Beta › Beta Barrel › Thrombin, subunit H › predicted glycosyltransferase like domains 0.72 62.0 5.50e-01 97.3% 89.0%
4i86A00 2.40.10.220 Mainly Beta › Beta Barrel › Thrombin, subunit H › predicted glycosyltransferase like domains 0.71 60.0 5.43e-01 94.6% 89.2%
4b6eB01 2.40.10.120 Mainly Beta › Beta Barrel › Thrombin, subunit H › 0.71 64.0 4.61e-01 100.0% 46.0%
3su0A01 2.40.10.120 Mainly Beta › Beta Barrel › Thrombin, subunit H › 0.70 64.0 5.53e-01 100.0% 85.7%
2w5eA02 2.40.10.10 Mainly Beta › Beta Barrel › Thrombin, subunit H › Trypsin-like serine proteases 0.70 56.0 5.62e-01 86.5% 93.2%
1g7sA02 2.40.30.10 Mainly Beta › Beta Barrel › Elongation Factor Tu (Ef-tu); domain 3 › Translation factors 0.66 50.0 4.48e-01 83.8% 80.6%
2pp6A02 2.40.10.210 Mainly Beta › Beta Barrel › Thrombin, subunit H › Phage tail proteins (gpFII-like) 0.64 49.0 5.20e-01 83.8% 100.0%
3zugB02 2.40.30.30 Mainly Beta › Beta Barrel › Elongation Factor Tu (Ef-tu); domain 3 › Riboflavin kinase-like 0.64 48.0 3.99e-01 83.8% 63.4%
1smrA02 2.40.70.10 Mainly Beta › Beta Barrel › Cathepsin D, subunit A; domain 1 › Acid Proteases 0.62 52.0 4.20e-01 97.3% 89.0%
3zn6A02 2.60.40.3410 Mainly Beta › Sandwich › Immunoglobulin-like › 0.62 46.0 4.42e-01 81.1% 89.7%
2f1lA01 2.40.30.60 Mainly Beta › Beta Barrel › Elongation Factor Tu (Ef-tu); domain 3 › RimM 0.62 48.0 4.54e-01 85.1% 84.3%
3tfiA00 3.30.1360.120 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › Probable tRNA modification gtpase trme; domain 1 0.61 43.0 2.81e-01 75.7% 45.0%
4paaA03 3.30.1360.120 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › Probable tRNA modification gtpase trme; domain 1 0.61 43.0 3.19e-01 74.3% 48.1%
2nv4A00 2.40.30.70 Mainly Beta › Beta Barrel › Elongation Factor Tu (Ef-tu); domain 3 › YaeB-like 0.58 48.0 4.01e-01 91.9% 84.8%
3oc5A02 2.60.40.3240 Mainly Beta › Sandwich › Immunoglobulin-like › Vibrio cholerae toxin co-regulated pilus biosynthesis protein F, C-terminal domain 0.58 44.0 3.66e-01 83.8% 90.8%
4fxtA01 2.60.40.1120 Mainly Beta › Sandwich › Immunoglobulin-like › Carboxypeptidase-like, regulatory domain 0.57 45.0 4.35e-01 90.5% 77.9%
6ahuH01 3.30.70.3250 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Ribonuclease P, Pop5 subunit 0.56 39.0 3.63e-01 73.0% 89.5%
2b5iB01 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.55 40.0 3.79e-01 81.1% 97.9%
4ydzA00 2.60.40.790 Mainly Beta › Sandwich › Immunoglobulin-like › 0.54 37.0 3.10e-01 71.6% 65.2%
4mypA00 2.60.40.1850 Mainly Beta › Sandwich › Immunoglobulin-like › 0.54 45.0 3.93e-01 95.9% 90.9%
2fnqA01 2.60.60.20 Mainly Beta › Sandwich › Lipoxygenase-1 › PLAT/LH2 domain 0.54 41.0 3.67e-01 85.1% 100.0%
3sz6A00 2.60.40.1850 Mainly Beta › Sandwich › Immunoglobulin-like › 0.54 45.0 3.95e-01 94.6% 90.5%
4lwoB02 2.70.160.11 Mainly Beta › Distorted Sandwich › Hnrnp arginine n-methyltransferase1 › Hnrnp arginine n-methyltransferase1 0.53 42.0 3.34e-01 91.9% 97.3%
2z30B00 3.30.70.80 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Peptidase S8 propeptide/proteinase inhibitor I9 0.53 37.0 3.88e-01 73.0% 86.2%
3ednA01 3.10.310.10 Alpha Beta › Roll › Diaminopimelate Epimerase; Chain A, domain 1 › Diaminopimelate Epimerase; Chain A, domain 1 0.53 43.0 3.58e-01 90.5% 59.0%
5dn6I00 2.60.15.10 Mainly Beta › Sandwich › ATP Synthase; domain 1 › F0F1 ATP synthase delta/epsilon subunit, N-terminal 0.52 39.0 3.93e-01 79.7% 85.3%
7szeB02 3.90.380.10 Alpha Beta › Alpha-Beta Complex › Naphthalene 1,2-dioxygenase Alpha Subunit; Chain A, domain 1 › Naphthalene 1,2-dioxygenase Alpha Subunit; Chain A, domain 1 0.52 36.0 2.80e-01 73.0% 71.2%
1dmlA00 3.70.10.10 Alpha Beta › Box › Proliferating Cell Nuclear Antigen › 0.52 39.0 2.78e-01 85.1% 89.1%
2j7qA00 3.90.70.120 Alpha Beta › Alpha-Beta Complex › Cathepsin B; Chain A › 0.51 41.0 2.95e-01 89.2% 48.1%
3t0pA02 3.10.150.10 Alpha Beta › Roll › DNA Polymerase III; Chain A, domain 2 › DNA Polymerase III, subunit A, domain 2 0.51 38.0 2.95e-01 83.8% 88.6%
2oolA01 3.30.450.20 Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › PAS domain 0.51 41.0 3.63e-01 87.8% 64.5%
4tr6A01 3.10.150.10 Alpha Beta › Roll › DNA Polymerase III; Chain A, domain 2 › DNA Polymerase III, subunit A, domain 2 0.50 37.0 2.94e-01 82.4% 85.6%
ECOD (53)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
134018 1.1.5.33 ↗ beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel › Trypsin_2 0.95 90.0 6.67e-01 100.0% 45.1%
3650249 1.1.5.33 ↗ beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel › Trypsin_2 0.90 84.0 5.64e-01 100.0% 38.8%
4028467 1.1.5.33 ↗ beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel › Trypsin_2 0.90 84.0 5.50e-01 100.0% 34.5%
5072499 1.1.17.3 ↗ beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel 2 › Trypsin_2 0.89 84.0 5.92e-01 100.0% 39.5%
3284172 1.1.17.3 ↗ beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel 2 › Trypsin_2 0.89 83.0 5.85e-01 100.0% 36.6%
3682203 1.1.17.3 ↗ beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel 2 › Trypsin_2 0.88 82.0 5.80e-01 100.0% 52.7%
140973 1.1.17.3 ↗ beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel 2 › Trypsin_2 0.88 83.0 5.66e-01 100.0% 34.8%
3545090 1.1.5.33 ↗ beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel › Trypsin_2 0.88 82.0 5.66e-01 100.0% 37.3%
3428387 1.1.17.0 ↗ beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel 2 0.87 81.0 5.93e-01 100.0% 51.1%
3957702 1.1.5.33 ↗ beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel › Trypsin_2 0.86 80.0 6.39e-01 100.0% 62.2%
3950281 1.1.5.33 ↗ beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel › Trypsin_2 0.86 79.0 5.48e-01 100.0% 37.3%
5063379 1.1.17.3 ↗ beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel 2 › Trypsin_2 0.85 79.0 5.78e-01 100.0% 44.4%
3281996 1.1.17.3 ↗ beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel 2 › Trypsin_2 0.85 78.0 5.50e-01 100.0% 41.9%
3649347 1.1.5.33 ↗ beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel › Trypsin_2 0.84 78.0 6.12e-01 100.0% 73.1%
3443107 1.1.17.3 ↗ beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel 2 › Trypsin_2 0.84 79.0 5.41e-01 100.0% 36.9%
3925093 1.1.17.0 ↗ beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel 2 0.81 73.0 4.91e-01 100.0% 48.9%
260 1.1.5.22 ↗ beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel › Peptidase_S32 0.80 73.0 5.27e-01 100.0% 38.4%
1099000 1.1.5.19 ↗ beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel › Peptidase_C30 0.79 73.0 5.33e-01 100.0% 46.5%
4852372 1.1.5.19 ↗ beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel › Peptidase_C30 0.79 72.0 5.26e-01 100.0% 46.6%
3752007 1.1.17.1 ↗ beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel 2 › Trypsin 0.77 70.0 4.86e-01 100.0% 39.1%
3970225 1.1.13.68 ↗ beta barrels › cradle loop barrel › RIFT-related › Phage tail proteins › PF27125 0.75 61.0 5.72e-01 87.8% 96.7%
3967745 1.1.7.17 ↗ beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C › ATP-synt_ab_N 0.75 59.0 5.87e-01 83.8% 86.7%
4125814 1.1.7.17 ↗ beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C › ATP-synt_ab_N 0.74 59.0 5.95e-01 85.1% 84.0%
3893654 1.1.7.69 ↗ beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C › MOV-10_beta-barrel 0.74 60.0 5.18e-01 87.8% 72.2%
4010630 2004.1.1.10 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ATP-synt_ab 0.74 59.0 3.61e-01 85.1% 15.3%
4472606 1.1.13.55 ↗ beta barrels › cradle loop barrel › RIFT-related › Phage tail proteins › DUF4873 0.74 62.0 5.63e-01 93.2% 87.0%
3956293 1.1.5.75 ↗ beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel › DUF4873 0.73 62.0 5.62e-01 93.2% 85.0%
4061526 1.1.7.7 ↗ beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C › FAD_binding_6 0.73 58.0 5.27e-01 86.5% 87.0%
2060704 1.1.5.13 ↗ beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel › Peptidase_S6 0.73 66.0 4.48e-01 100.0% 28.8%
1291989 1.1.5.42 ↗ beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel › PilZ-like 0.72 61.0 5.70e-01 94.6% 91.4%
3290002 1.1.5.15 ↗ beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel › F420H2_quin_red 0.72 57.0 4.53e-01 86.5% 74.0%
4105189 1.1.5.25 ↗ beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel › PilZ 0.71 62.0 5.66e-01 94.6% 93.7%
3943844 1.1.5.25 ↗ beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel › PilZ 0.71 60.0 5.46e-01 94.6% 88.0%
3289833 1.1.5.15 ↗ beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel › F420H2_quin_red 0.71 57.0 4.62e-01 89.2% 77.9%
1161323 1.1.5.14 ↗ beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel › Peptidase_S29 0.71 64.0 4.75e-01 100.0% 51.4%
3953207 1.1.5.15 ↗ beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel › F420H2_quin_red 0.70 58.0 5.08e-01 89.2% 100.0%
3947980 1.1.5.25 ↗ beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel › PilZ 0.70 60.0 5.47e-01 95.9% 92.0%
4947671 1.1.7.0 ↗ beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C 0.70 54.0 5.33e-01 83.8% 93.8%
3976283 1.1.13.32 ↗ beta barrels › cradle loop barrel › RIFT-related › Phage tail proteins › DUF1480 0.68 54.0 5.34e-01 87.8% 100.0%
4381495 1.1.7.11 ↗ beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C › RimM 0.65 50.0 4.77e-01 85.1% 83.3%
4682440 1.1.7.11 ↗ beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C › RimM 0.64 50.0 4.66e-01 85.1% 78.9%
4391995 1.1.7.11 ↗ beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C › RimM 0.64 50.0 4.80e-01 85.1% 88.2%
1005556 10.2.1.65 ↗ beta sandwiches › jelly-roll › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Nucleoplasmin-like/VP (viral coat and capsid proteins) › VP17_central_barrel 0.61 46.0 4.38e-01 82.4% 86.4%
3271989 11.1.1.0 ↗ beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like 0.60 45.0 4.25e-01 82.4% 100.0%
4405079 1.1.7.11 ↗ beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C › RimM 0.59 46.0 4.28e-01 86.5% 81.1%
4325609 11.1.4.122 ↗ beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Prealbumin-like › PTR2 0.56 45.0 4.30e-01 95.9% 74.4%
4096531 11.1.4.13 ↗ beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Prealbumin-like › P_gingi_FimA 0.54 45.0 3.60e-01 95.9% 72.5%
223262 304.7.1.0 ↗ a+b two layers › Alpha-beta plaits › Protease propeptides/inhibitors › Protease propeptides/inhibitors 0.54 37.0 3.98e-01 73.0% 87.7%
3251645 11.1.1.0 ↗ beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like 0.54 40.0 3.73e-01 79.7% 95.8%
3288251 331.3.1.9 ↗ a+b two layers › TBP-like › Bet v1-like › Bet v1-like › AHSA1 0.53 45.0 3.60e-01 97.3% 54.8%
4006143 3943.1.1.5 ↗ beta sandwiches › Flagellar hook-associated protein 1 beta-sandwich domains › Flagellar hook-associated protein 1 beta-sandwich domains › Flagellar hook-associated protein 1 beta-sandwich domains › WZC_N 0.52 38.0 3.51e-01 100.0% 60.0%
3268316 11.1.1.0 ↗ beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like 0.51 37.0 3.62e-01 77.0% 75.0%
3889564 331.18.1.4 ↗ a+b two layers › TBP-like › C-terminal TBP-like domain of Roc › C-terminal TBP-like domain of Roc › COR-B 0.51 43.0 3.46e-01 97.3% 95.6%