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ORF1a
Euk-VirFeline_astrovirus_D1
ORF1a__YP_009052460__Feline_astrovirus_D1__1538452
Identity
- Accession:
- YP_009052460 ↗
- Protein ID:
- ORF1a
- Kingdom:
- euk
Quality
70.4
mean pLDDT
Taxonomy
Orthornavirae›
Pisuviricota›
Stelpaviricetes›
Stellavirales›
Astroviridae›
Mamastrovirus›
Feline_astrovirus_D1
TaxID: 1538452
Cluster
View cluster (19 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 6-121
Domain cluster:
rep: ORF1a__YP_009010969__Porcine_astrovirus_5__1093928__D1-101
CATH (7)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 8gjaD01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.57 | 41.0 | 3.20e-01 | 76.7% | 86.3% |
| 3ub1A01 | 3.10.450.540 | Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › | 0.56 | 40.0 | 3.82e-01 | 75.0% | 91.9% |
| 1so7A00 | 2.120.10.10 | Mainly Beta › 6 Propeller › Neuraminidase › | 0.53 | 45.0 | 3.24e-01 | 94.0% | 90.0% |
| 4yy8A02 | 2.120.10.80 | Mainly Beta › 6 Propeller › Neuraminidase › Kelch-type beta propeller | 0.53 | 44.0 | 3.27e-01 | 89.7% | 69.8% |
| 1s4uX00 | 2.130.10.10 | Mainly Beta › 7 Propeller › Methylamine Dehydrogenase; Chain H › YVTN repeat-like/Quinoprotein amine dehydrogenase | 0.53 | 44.0 | 3.16e-01 | 91.4% | 46.1% |
| 5idmA00 | 3.30.565.10 | Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain | 0.53 | 37.0 | 3.23e-01 | 72.4% | 79.1% |
| 6my0A02 | 2.30.30.30 | Mainly Beta › Roll › SH3 type barrels. › | 0.52 | 24.0 | 3.07e-01 | 75.0% | 73.8% |
ECOD (20)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3597599 | 214.1.1.0 ↗ | a+b two layers › SH2 › SH2 › SH2 | 0.65 | 33.0 | 3.52e-01 | 75.0% | 55.0% |
| 4149678 | 243.3.1.0 ↗ | a+b two layers › Cystatin-like › Cystatin/monellin › Cystatin/monellin | 0.59 | 41.0 | 4.51e-01 | 70.7% | 92.2% |
| 3419181 | 5.1.3.144 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 6-bladed › b-prop_At3g26010-like | 0.57 | 45.0 | 3.34e-01 | 84.5% | 50.5% |
| 3447653 | 5.1.3.0 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 6-bladed | 0.56 | 44.0 | 3.29e-01 | 84.5% | 49.8% |
| 3937740 | 220.1.1.11 ↗ | beta barrels › PH domain-like › PH domain-like › PH domain-like › Rpn13_ADRM1_Pru | 0.56 | 39.0 | 3.74e-01 | 71.6% | 97.7% |
| 3290294 | 243.3.1.0 ↗ | a+b two layers › Cystatin-like › Cystatin/monellin › Cystatin/monellin | 0.55 | 39.0 | 4.16e-01 | 72.4% | 89.0% |
| 4293623 | 5.1.4.1 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › WD40 | 0.55 | 47.0 | 3.14e-01 | 94.0% | 63.0% |
| 4888761 | 5.1.4.1 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › WD40 | 0.54 | 46.0 | 3.90e-01 | 91.4% | 75.8% |
| 3594746 | 5.1.4.0 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed | 0.54 | 46.0 | 3.36e-01 | 94.0% | 46.5% |
| 3286278 | 4210.1.1.0 ↗ | a+b two layers › WGR domain › WGR domain › WGR domain | 0.53 | 32.0 | 3.72e-01 | 88.8% | 85.0% |
| 3805876 | 5.1.3.67 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 6-bladed › FBA_1 | 0.53 | 42.0 | 3.08e-01 | 84.5% | 37.8% |
| 1291144 | 9.1.1.27 ↗ | beta barrels › Lipocalins/Streptavidin › Lipocalins › Lipocalins › MoaF_C | 0.53 | 37.0 | 3.77e-01 | 73.3% | 75.2% |
| 3494479 | 5.1.4.6 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › WD40,ANAPC4_WD40 | 0.52 | 43.0 | 2.92e-01 | 91.4% | 38.9% |
| 3488451 | 5.1.4.0 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed | 0.52 | 46.0 | 3.15e-01 | 98.3% | 88.2% |
| 3554960 | 5.1.4.169 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › Beta-prop_RSE1_2nd | 0.51 | 40.0 | 2.93e-01 | 84.5% | 52.2% |
| 3596057 | 219.1.1.0 ↗ | a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases | 0.51 | 37.0 | 3.14e-01 | 76.7% | 79.0% |
| 4967639 | 314.1.1.0 ↗ | a+b three layers › Class II aaRS and biotin synthetases › Class II aaRS and biotin synthetases › Class II aaRS and biotin synthetases | 0.51 | 35.0 | 2.54e-01 | 70.7% | 25.7% |
| 3959126 | 219.1.1.13 ↗ | a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Transglut_core | 0.51 | 40.0 | 3.49e-01 | 85.3% | 83.3% |
| 3242737 | 5.1.5.47 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 8-bladed › BCAS3_WD40 | 0.51 | 45.0 | 2.95e-01 | 100.0% | 45.6% |
| 4030001 | 5.1.4.621 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › Mcl1_mid | 0.51 | 45.0 | 2.79e-01 | 98.3% | 75.3% |
D2
high
residues 439-582
Domain cluster:
rep: 100_kDa_protein__YP_008130303__Citrus_vein_enation_virus__1301220__D379-571
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF05579.20 best | Peptidase_S32 | 31.6 | 1.40e-07 | 100.0% | 40.7% |
| PF13365.13 | Trypsin_2 | 56.0 | 1.10e-14 | 85.4% | 100.0% |
D3
high
residues 722-831
Domain cluster:
representative
CATH (24)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1avoB00 | 1.20.120.180 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Proteasome activator pa28, C-terminal domain | 0.72 | 50.0 | 4.63e-01 | 71.8% | 87.9% |
| 2okuA00 | 1.20.120.470 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Acyl-CoA dehydrogenase, C-terminal domain | 0.71 | 50.0 | 4.83e-01 | 71.8% | 72.1% |
| 2qkwA00 | 1.20.1270.140 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › AvrPto | 0.70 | 49.0 | 5.15e-01 | 72.7% | 93.1% |
| 1k04A02 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.70 | 48.0 | 4.96e-01 | 70.9% | 88.5% |
| 2uuiA00 | 1.20.120.550 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Membrane associated eicosanoid/glutathione metabolism-like domain | 0.69 | 47.0 | 4.20e-01 | 70.0% | 60.6% |
| 2jswA00 | 1.20.1410.10 | Mainly Alpha › Up-down Bundle › I/LWEQ domain › I/LWEQ domain | 0.69 | 50.0 | 4.20e-01 | 76.4% | 60.3% |
| 2l6hA00 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.68 | 52.0 | 4.68e-01 | 80.9% | 77.3% |
| 1m56C02 | 1.20.120.80 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c oxidase, subunit III, four-helix bundle | 0.68 | 52.0 | 4.31e-01 | 80.9% | 69.9% |
| 3t6gB00 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.67 | 51.0 | 4.83e-01 | 80.9% | 90.3% |
| 3rguB00 | 1.20.5.420 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › Immunoglobulin FC, subunit C | 0.67 | 47.0 | 5.16e-01 | 72.7% | 97.7% |
| 3qa8A04 | 1.20.1270.250 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.64 | 44.0 | 3.51e-01 | 70.9% | 76.8% |
| 4gyvE00 | 1.20.900.10 | Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain | 0.64 | 46.0 | 3.75e-01 | 76.4% | 87.0% |
| 6xz3A01 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.62 | 48.0 | 4.75e-01 | 84.5% | 100.0% |
| 1st6A02 | 1.20.120.810 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Vinculin, Vh2 four-helix bundle | 0.59 | 50.0 | 3.91e-01 | 92.7% | 95.8% |
| 1wu3I00 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.57 | 46.0 | 4.12e-01 | 89.1% | 99.4% |
| 8b6jF01 | 1.10.287.20 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Ubiquinol-cytochrome C reductase hinge domain | 0.56 | 34.0 | 4.08e-01 | 93.6% | 97.0% |
| 4nqfA00 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.55 | 46.0 | 4.24e-01 | 92.7% | 97.2% |
| 3piwA00 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.55 | 41.0 | 3.67e-01 | 78.2% | 100.0% |
| 1td6A01 | 1.20.1480.10 | Mainly Alpha › Up-down Bundle › hypothetical protein mp506/mpn330, domain 1 › hypothetical protein mp506/mpn330, domain 1 | 0.54 | 36.0 | 3.78e-01 | 83.6% | 72.5% |
| 1xqoA01 | 1.10.1670.10 | Mainly Alpha › Orthogonal Bundle › Endonuclease Iii, domain 2 › Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal) | 0.54 | 33.0 | 3.25e-01 | 94.5% | 55.9% |
| 4gdxA02 | 1.10.246.130 | Mainly Alpha › Orthogonal Bundle › Serum Albumin; Chain A, Domain 1 › Gamma-glutamyltranspeptidase, large (L) subunit, C-terminal domain | 0.52 | 36.0 | 3.60e-01 | 70.0% | 78.4% |
| 3ptjA00 | 3.10.310.50 | Alpha Beta › Roll › Diaminopimelate Epimerase; Chain A, domain 1 › | 0.52 | 38.0 | 3.46e-01 | 77.3% | 69.9% |
| 6i3mE01 | 1.20.120.420 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › translation initiation factor eif-2b, domain 1 | 0.52 | 40.0 | 3.79e-01 | 83.6% | 90.5% |
| 3fnrA01 | 1.10.730.10 | Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1 | 0.52 | 40.0 | 3.67e-01 | 81.8% | 67.6% |
ECOD (18)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3497347 | 601.1.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin | 0.66 | 50.0 | 4.86e-01 | 80.0% | 86.4% |
| 3632799 | 632.1.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain | 0.66 | 47.0 | 4.38e-01 | 73.6% | 77.8% |
| 5026634 | 4957.1.1.0 ↗ | a+b complex topology › helical domain in yeast RNA-polymerases › third helical domain in yeast RNA-polymerase II beta-prime subunit › third helical domain in yeast RNA-polymerase II beta-prime subunit | 0.65 | 35.0 | 3.87e-01 | 71.8% | 63.3% |
| 3436259 | 632.15.1.5 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Staphylococcal complement inhibitor (SCIN) › Staphylococcal complement inhibitor (SCIN) › Rx_N | 0.64 | 46.0 | 4.47e-01 | 73.6% | 75.0% |
| 3862608 | 601.1.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin | 0.64 | 48.0 | 4.83e-01 | 80.0% | 100.0% |
| 3839677 | 5068.1.1.1 ↗ | alpha bundles › a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) › a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) › a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) › Cytochrom_B_C | 0.63 | 44.0 | 4.43e-01 | 72.7% | 76.5% |
| 3956181 | 3291.1.1.0 ↗ | alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related | 0.62 | 45.0 | 4.24e-01 | 76.4% | 74.1% |
| 3918077 | 601.1.2.83 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › Dynactin | 0.60 | 43.0 | 3.95e-01 | 75.5% | 59.3% |
| 1442264 | 3323.1.1.1 ↗ | alpha bundles › Inserted helical domain in fatty acid synthase subunit beta › Inserted helical domain in fatty acid synthase subunit beta › Inserted helical domain in fatty acid synthase subunit beta › Fas1-AflB-like_hel | 0.59 | 51.0 | 4.26e-01 | 95.5% | 99.0% |
| 3739998 | 5068.1.1.1 ↗ | alpha bundles › a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) › a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) › a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) › Cytochrom_B_C | 0.59 | 41.0 | 4.00e-01 | 73.6% | 73.6% |
| 3490874 | 5068.1.1.1 ↗ | alpha bundles › a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) › a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) › a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) › Cytochrom_B_C | 0.57 | 40.0 | 4.14e-01 | 73.6% | 80.0% |
| 5081674 | 102.2.1.0 ↗ | alpha arrays › HhH/H2TH › H2TH › H2TH | 0.55 | 37.0 | 4.23e-01 | 74.5% | 95.0% |
| 3730111 | 601.1.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin | 0.53 | 43.0 | 3.62e-01 | 90.9% | 92.2% |
| 4980719 | 1075.1.1.0 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type II ABC exporter transmembrane domain-related › ABCG5/ABCG8 transmembrane domain | 0.53 | 44.0 | 3.51e-01 | 92.7% | 92.7% |
| 4258355 | 191.1.1.12 ↗ | alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › TetR_C_8 | 0.52 | 37.0 | 3.72e-01 | 74.5% | 92.2% |
| 4281990 | 192.4.1.0 ↗ | alpha bundles › Long alpha-hairpin › Ribosomal protein L29 (L29p) › Ribosomal protein L29 (L29p) | 0.52 | 36.0 | 3.16e-01 | 70.9% | 65.3% |
| 3281875 | 191.1.1.48 ↗ | alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › TetR_C_46 | 0.52 | 40.0 | 3.81e-01 | 82.7% | 93.8% |
| 3555324 | 102.2.1.0 ↗ | alpha arrays › HhH/H2TH › H2TH › H2TH | 0.51 | 36.0 | 3.66e-01 | 80.9% | 73.6% |
D4
medium
residues 271-386
Domain cluster:
rep: non-structural_protein__YP_003275952__HMO_Astrovirus_A__682382__D294-402