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ORF27
Euk-VirHuman_gammaherpesvirus_8
ORF27__YP_001129380__Human_gammaherpesvirus_8__37296
Identity
- Accession:
- YP_001129380 ↗
- Protein ID:
- ORF27
- Kingdom:
- euk
Quality
63.4
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Rhadinovirus›
Human_gammaherpesvirus_8
TaxID: 37296
Cluster
Singleton — not in a non-trivial cluster
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 41-98
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF25730.2 best | Herpes_BDLF2 | 41.2 | 1.70e-10 | 100.0% | 21.1% |
CATH (46)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2ic6A00 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.80 | 60.0 | 5.58e-01 | 79.3% | 80.3% |
| 1nt2B02 | 1.10.287.660 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.79 | 59.0 | 5.63e-01 | 79.3% | 74.6% |
| 2ib0A01 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.78 | 56.0 | 4.21e-01 | 75.9% | 32.6% |
| 3favD00 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.77 | 57.0 | 5.12e-01 | 77.6% | 59.0% |
| 1tf5A04 | 1.10.3060.10 | Mainly Alpha › Orthogonal Bundle › Helical scaffold and wing domains of SecA › Helical scaffold and wing domains of SecA | 0.76 | 54.0 | 3.70e-01 | 74.1% | 37.9% |
| 2wmmA01 | 1.20.5.420 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › Immunoglobulin FC, subunit C | 0.73 | 41.0 | 4.47e-01 | 75.9% | 67.3% |
| 3vfzB00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.73 | 51.0 | 5.03e-01 | 74.1% | 82.5% |
| 6t0bc01 | 1.10.287.70 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.73 | 51.0 | 4.67e-01 | 79.3% | 55.1% |
| 2lzfA00 | 1.10.287.3030 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.72 | 51.0 | 4.86e-01 | 74.1% | 94.1% |
| 2lhrA00 | 1.20.58.1270 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.70 | 55.0 | 4.92e-01 | 84.5% | 67.9% |
| 2zgyA02 | 3.30.420.40 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain | 0.69 | 61.0 | 4.57e-01 | 98.3% | 45.0% |
| 6q3wB02 | 3.30.70.890 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › GHMP kinase, C-terminal domain | 0.69 | 58.0 | 4.24e-01 | 96.6% | 36.1% |
| 7s3lA01 | 3.90.1200.10 | Alpha Beta › Alpha-Beta Complex › Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2 › Aminoglycoside phosphotransferase (APH), C-terminal lobe | 0.68 | 58.0 | 4.17e-01 | 94.8% | 58.2% |
| 3m71A00 | 1.50.10.150 | Mainly Alpha › Alpha/alpha barrel › Glycosyltransferase › Voltage-dependent anion channel | 0.67 | 59.0 | 3.68e-01 | 96.6% | 24.4% |
| 1br0A00 | 1.20.58.70 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.66 | 54.0 | 4.38e-01 | 94.8% | 90.0% |
| 2kiwA01 | 1.10.150.130 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Tyrosine recombinase, N-terminal domain | 0.66 | 53.0 | 4.69e-01 | 89.7% | 77.9% |
| 1zkeA00 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.66 | 53.0 | 4.84e-01 | 93.1% | 75.3% |
| 1j1jA02 | 1.20.58.200 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 2 | 0.66 | 55.0 | 4.90e-01 | 94.8% | 90.6% |
| 2nx4C00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.66 | 54.0 | 3.91e-01 | 98.3% | 39.6% |
| 2l37A00 | 6.10.250.890 | Special › Helix non-globular › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › | 0.65 | 39.0 | 4.47e-01 | 74.1% | 81.4% |
| 1b10A00 | 1.10.790.10 | Mainly Alpha › Orthogonal Bundle › Major Prion Protein › Prion/Doppel protein, beta-ribbon domain | 0.65 | 54.0 | 4.64e-01 | 100.0% | 81.7% |
| 1owlA02 | 1.25.40.80 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.65 | 55.0 | 4.35e-01 | 96.6% | 54.5% |
| 5ffdA00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.65 | 54.0 | 4.10e-01 | 93.1% | 68.6% |
| 2jqqA00 | 1.20.58.1240 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.65 | 56.0 | 4.09e-01 | 96.6% | 60.4% |
| 2rkkA01 | 1.25.40.270 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Vacuolar protein sorting-associated protein vta1 | 0.64 | 55.0 | 4.00e-01 | 94.8% | 73.1% |
| 3v5uA01 | 6.10.280.80 | Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › NCX, peripheral helical region | 0.64 | 49.0 | 4.57e-01 | 84.5% | 69.7% |
| 2ff4A02 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.64 | 52.0 | 3.59e-01 | 87.9% | 41.2% |
| 2co9A00 | 1.10.30.10 | Mainly Alpha › Orthogonal Bundle › DNA Binding (I), subunit A › High mobility group box domain | 0.64 | 45.0 | 3.81e-01 | 75.9% | 60.8% |
| 2p4vA01 | 1.10.287.180 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Transcription elongation factor, GreA/GreB, N-terminal domain | 0.64 | 49.0 | 4.51e-01 | 87.9% | 63.2% |
| 4kkiA01 | 1.50.10.20 | Mainly Alpha › Alpha/alpha barrel › Glycosyltransferase › | 0.64 | 51.0 | 3.26e-01 | 89.7% | 53.7% |
| 1gt0D00 | 1.10.30.10 | Mainly Alpha › Orthogonal Bundle › DNA Binding (I), subunit A › High mobility group box domain | 0.63 | 44.0 | 3.98e-01 | 72.4% | 75.9% |
| 2i7uA00 | 6.10.250.1010 | Special › Helix non-globular › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › | 0.63 | 45.0 | 4.46e-01 | 77.6% | 77.4% |
| 2yevA02 | 1.10.287.70 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.63 | 43.0 | 4.02e-01 | 77.6% | 56.8% |
| 1vt0k00 | 1.10.3230.20 | Mainly Alpha › Orthogonal Bundle › Hypothetical protein yqbg › P22 tail accessory factor (Gp4) | 0.62 | 46.0 | 3.53e-01 | 82.8% | 33.8% |
| 2mpkA00 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.61 | 46.0 | 4.32e-01 | 84.5% | 95.9% |
| 4gf0A02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.60 | 42.0 | 3.43e-01 | 74.1% | 41.6% |
| 1lfuP00 | 1.10.10.60 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Homeodomain-like | 0.59 | 45.0 | 4.14e-01 | 86.2% | 80.5% |
| 1y71A00 | 2.30.30.430 | Mainly Beta › Roll › SH3 type barrels. › Kinase associated protein B domain | 0.59 | 42.0 | 3.45e-01 | 74.1% | 89.0% |
| 2lpeA01 | 6.10.140.1120 | Special › Helix non-globular › Helix Hairpins › | 0.59 | 44.0 | 4.08e-01 | 84.5% | 66.7% |
| 3eabE00 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.59 | 49.0 | 4.30e-01 | 93.1% | 100.0% |
| 2e5vA03 | 1.20.58.100 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain | 0.56 | 44.0 | 3.76e-01 | 87.9% | 64.9% |
| 3s6jE02 | 1.10.150.240 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 | 0.55 | 44.0 | 4.15e-01 | 87.9% | 82.6% |
| 1wpaA01 | 6.10.140.340 | Special › Helix non-globular › Helix Hairpins › | 0.55 | 48.0 | 4.02e-01 | 96.6% | 82.8% |
| 6igxD01 | 1.25.10.10 | Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant | 0.54 | 45.0 | 2.93e-01 | 91.4% | 23.3% |
| 2x6hA01 | 1.25.40.70 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Phosphatidylinositol 3-kinase, accessory domain (PIK) | 0.53 | 44.0 | 3.08e-01 | 89.7% | 36.6% |
| 1nklA00 | 1.10.225.10 | Mainly Alpha › Orthogonal Bundle › NK-Lysin › Saposin-like | 0.52 | 35.0 | 3.32e-01 | 72.4% | 84.6% |
ECOD (31)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3237156 | 604.12.1.4 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › ATG1-like_MIT1 | 0.84 | 73.0 | 5.43e-01 | 93.1% | 83.0% |
| 3569625 | 604.12.1.4 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › ATG1-like_MIT1 | 0.83 | 73.0 | 5.26e-01 | 93.1% | 79.3% |
| 3929097 | 4163.1.1.0 ↗ | alpha bundles › GINS helical bundle-like › GINS helical bundle-like › PSF1 N-terminal domain-like | 0.83 | 70.0 | 5.27e-01 | 91.4% | 70.0% |
| 3575911 | 2007.2.3.21 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › Y_phosphatase, PTP-SAK | 0.81 | 66.0 | 4.11e-01 | 89.7% | 96.8% |
| 3519581 | 604.12.1.4 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › ATG1-like_MIT1 | 0.81 | 69.0 | 5.18e-01 | 93.1% | 81.5% |
| 4938271 | 605.6.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › HP1531-like › HP1531-like | 0.78 | 64.0 | 5.52e-01 | 89.7% | 60.0% |
| 3795197 | 2007.2.3.1 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › Y_phosphatase | 0.78 | 59.0 | 3.65e-01 | 81.0% | 96.7% |
| 3611632 | 192.7.1.0 ↗ | alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm | 0.77 | 57.0 | 4.76e-01 | 79.3% | 50.0% |
| 4993232 | 605.6.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › HP1531-like › HP1531-like | 0.75 | 59.0 | 5.70e-01 | 86.2% | 81.5% |
| 4022479 | 5059.1.1.6 ↗ | alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › CSG2 | 0.74 | 65.0 | 3.89e-01 | 94.8% | 58.7% |
| 3533358 | 190.1.1.1 ↗ | alpha arrays › HMG-box-like › HMG-box › HMG-box › HMG_box | 0.74 | 54.0 | 4.47e-01 | 75.9% | 68.4% |
| 4058767 | 7015.1.1.0 ↗ | alpha bundles › Palmitoyltransferase DHHC transmembrane domain › Palmitoyltransferase DHHC transmembrane domain › Palmitoyltransferase DHHC transmembrane domain | 0.74 | 62.0 | 4.74e-01 | 96.6% | 83.6% |
| 4344838 | 190.1.1.1 ↗ | alpha arrays › HMG-box-like › HMG-box › HMG-box › HMG_box | 0.73 | 52.0 | 4.67e-01 | 75.9% | 81.2% |
| 3362890 | 7519.1.1.0 ↗ | a/b three-layered sandwiches › ATP synthase (F1-ATPase), gamma subunit › ATP synthase (F1-ATPase), gamma subunit › ATP synthase (F1-ATPase), gamma subunit | 0.72 | 53.0 | 4.44e-01 | 84.5% | 47.4% |
| 3706210 | 7015.1.1.1 ↗ | alpha bundles › Palmitoyltransferase DHHC transmembrane domain › Palmitoyltransferase DHHC transmembrane domain › Palmitoyltransferase DHHC transmembrane domain › DHHC | 0.71 | 55.0 | 3.69e-01 | 84.5% | 39.1% |
| 4384067 | 632.7.1.37 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Heat shock protein 70kD (HSP70), C-terminal subdomain › Heat shock protein 70kD (HSP70), C-terminal subdomain › LETM1_RBD | 0.67 | 50.0 | 4.02e-01 | 84.5% | 41.8% |
| 3506862 | 611.3.1.0 ↗ | alpha bundles › N-cbl like › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0.63 | 44.0 | 4.06e-01 | 75.9% | 62.5% |
| 3341091 | 101.35.1.6 ↗ | alpha arrays › HTH › DNA repair regulatory protein RecX › DNA repair regulatory protein RecX › A_thal_3526 | 0.63 | 47.0 | 4.60e-01 | 82.8% | 83.1% |
| 1174239 | 129.1.1.3 ↗ | alpha arrays › 6-phosphogluconate dehydrogenase C-terminal domain-like › 6-phosphogluconate dehydrogenase C-terminal domain-like › 6-phosphogluconate dehydrogenase C-terminal domain-like › UDPG_MGDP_dh | 0.63 | 48.0 | 3.94e-01 | 84.5% | 80.0% |
| 4379330 | 632.2.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Bacterial immunoglobulin/albumin-binding domains › Bacterial immunoglobulin/albumin-binding domains | 0.63 | 44.0 | 4.36e-01 | 74.1% | 85.0% |
| 3257744 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.62 | 55.0 | 3.75e-01 | 100.0% | 44.3% |
| 3010699 | 3276.1.1.0 ↗ | alpha arrays › N-terminal domain in MogR repressor › N-terminal domain in MogR repressor › N-terminal domain in MogR repressor | 0.62 | 51.0 | 5.04e-01 | 89.7% | 90.2% |
| 3486304 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.60 | 45.0 | 3.87e-01 | 84.5% | 59.0% |
| 4225349 | 3455.1.1.0 ↗ | alpha arrays › WY-domain in RXLR effectors › WY-domain in RXLR effectors › WY-domain in RXLR effectors | 0.59 | 47.0 | 4.36e-01 | 87.9% | 100.0% |
| 3277954 | 2008.1.1.67 ↗ | a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › RecC_C | 0.58 | 44.0 | 2.75e-01 | 81.0% | 48.9% |
| 3404059 | 3919.1.1.0 ↗ | alpha duplicates or obligate multimers › N-terminal domain of COMMD9 › N-terminal domain of COMMD9 › N-terminal domain of COMMD9 | 0.58 | 51.0 | 4.06e-01 | 98.3% | 55.7% |
| 4408728 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.56 | 45.0 | 4.16e-01 | 87.9% | 73.3% |
| 5042310 | 195.1.1.1 ↗ | alpha complex topology › NusB-like › NusB-like › NusB-like › NusB | 0.55 | 48.0 | 3.71e-01 | 98.3% | 99.3% |
| 3532935 | 109.4.1.1965 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PF28295 | 0.55 | 48.0 | 2.96e-01 | 98.3% | 18.3% |
| 3926720 | 130.1.1.0 ↗ | alpha arrays › LEM/SAP HeH motif-like › LEM/SAP HeH motif › LEM/SAP HeH motif | 0.53 | 36.0 | 3.56e-01 | 72.4% | 67.7% |
| 4580956 | 2484.1.1.222 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › UPF0236 | 0.52 | 42.0 | 2.92e-01 | 98.3% | 28.9% |
D2
high
residues 124-268