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ORF50
Euk-VirRetroperitoneal_fibromatosis-associated_herpesvirus
ORF50__YP_010084411__Retroperitoneal_fibromatosis-associated_herpesvirus__111469
Identity
- Accession:
- YP_010084411 ↗
- Protein ID:
- ORF50
- Kingdom:
- euk
Quality
59.0
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Rhadinovirus›
Retroperitoneal_fibromatosis-associated_herpesvirus
TaxID: 111469
Cluster
View cluster (4 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 9-108_206-222
Domain cluster:
representative
CATH (44)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2mtqA00 | 1.20.58.130 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.69 | 42.0 | 5.17e-01 | 89.7% | 98.6% |
| 4l8iB00 | 1.10.132.20 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor | 0.68 | 47.0 | 4.80e-01 | 70.1% | 95.5% |
| 5hn9C00 | 1.10.600.10 | Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase | 0.68 | 49.0 | 3.54e-01 | 75.2% | 38.6% |
| 2l3lA01 | 1.20.58.1250 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Tubulin Binding Cofactor C, N-terminal domain | 0.67 | 45.0 | 4.67e-01 | 90.6% | 74.5% |
| 2d9dA00 | 1.20.58.120 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain | 0.65 | 44.0 | 4.92e-01 | 89.7% | 89.9% |
| 4wzxA01 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.65 | 41.0 | 4.89e-01 | 87.2% | 100.0% |
| 3vuqB00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.64 | 53.0 | 4.69e-01 | 90.6% | 68.8% |
| 8e9gK01 | 1.10.287.3510 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.64 | 42.0 | 4.63e-01 | 88.0% | 84.6% |
| 1y4cA03 | 1.20.120.660 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › IL-4 antagonist (De novo design) like domain | 0.64 | 46.0 | 4.66e-01 | 90.6% | 77.0% |
| 2b1eA02 | 1.20.1310.30 | Mainly Alpha › Up-down Bundle › 5 helical Cullin repeat like › | 0.63 | 49.0 | 4.52e-01 | 82.9% | 68.9% |
| 3ztaA00 | 1.10.490.130 | Mainly Alpha › Orthogonal Bundle › Globin-like › | 0.62 | 51.0 | 4.89e-01 | 90.6% | 83.5% |
| 1lm3B00 | 1.20.120.10 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c/b562 | 0.61 | 43.0 | 4.48e-01 | 88.9% | 80.2% |
| 3t6gB00 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.60 | 48.0 | 4.63e-01 | 91.5% | 73.9% |
| 3pubA01 | 1.10.10.2400 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Lepidopteran low molecular weight (30 kD) lipoprotein, N-terminal domain | 0.60 | 36.0 | 4.31e-01 | 80.3% | 93.2% |
| 3lsjA02 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.60 | 51.0 | 4.66e-01 | 92.3% | 92.2% |
| 1ugoA00 | 1.20.58.120 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain | 0.60 | 41.0 | 4.45e-01 | 74.4% | 83.8% |
| 3peuB00 | 1.25.40.510 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › GLE1-like | 0.60 | 51.0 | 3.82e-01 | 93.2% | 59.7% |
| 2lhrA00 | 1.20.58.1270 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.60 | 34.0 | 4.05e-01 | 76.1% | 83.3% |
| 5h5mA02 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.60 | 49.0 | 4.79e-01 | 87.2% | 86.2% |
| 3kavA00 | 1.20.1270.360 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.60 | 42.0 | 4.44e-01 | 92.3% | 83.3% |
| 3fbzA01 | 1.20.58.800 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.60 | 41.0 | 4.40e-01 | 71.8% | 87.3% |
| 1sj8A02 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.60 | 46.0 | 4.62e-01 | 82.9% | 93.4% |
| 2h7oA01 | 1.20.120.1330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Rac1-binding domain, N-terminal GTPase binding subdomain | 0.59 | 49.0 | 4.87e-01 | 88.9% | 96.7% |
| 4iu9B02 | 1.20.1250.20 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains | 0.59 | 43.0 | 3.60e-01 | 75.2% | 83.3% |
| 2mx8A01 | 1.10.274.70 | Mainly Alpha › Orthogonal Bundle › Enzyme I; Chain A, domain 2 › Spidroin, N-terminal domain | 0.59 | 49.0 | 4.96e-01 | 90.6% | 94.7% |
| 2w31A00 | 1.10.490.10 | Mainly Alpha › Orthogonal Bundle › Globin-like › Globins | 0.58 | 47.0 | 4.42e-01 | 90.6% | 76.3% |
| 1or4B00 | 1.10.490.10 | Mainly Alpha › Orthogonal Bundle › Globin-like › Globins | 0.58 | 47.0 | 4.29e-01 | 89.7% | 72.8% |
| 2juaA00 | 1.20.1480.30 | Mainly Alpha › Up-down Bundle › hypothetical protein mp506/mpn330, domain 1 › Designed four-helix bundle protein | 0.57 | 44.0 | 4.62e-01 | 96.6% | 92.2% |
| 1txuA02 | 1.20.1050.80 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › VPS9 domain | 0.56 | 48.0 | 4.31e-01 | 93.2% | 74.4% |
| 1rx0A03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.55 | 47.0 | 4.28e-01 | 91.5% | 76.1% |
| 1o5hA00 | 1.20.120.680 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Formiminotetrahydrofolate cyclodeaminase monomer, up-and-down helical bundle | 0.55 | 45.0 | 3.86e-01 | 89.7% | 82.5% |
| 1wtyA00 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.55 | 42.0 | 4.30e-01 | 88.9% | 81.9% |
| 1sumB01 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.55 | 42.0 | 4.39e-01 | 88.9% | 88.8% |
| 1bbhA00 | 1.20.120.10 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c/b562 | 0.54 | 43.0 | 4.20e-01 | 89.7% | 76.3% |
| 2fd5A02 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.52 | 43.0 | 4.19e-01 | 91.5% | 97.7% |
| 2d2sA01 | 1.20.58.1210 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Exo84p, N-terminal helical domain | 0.52 | 41.0 | 4.12e-01 | 89.7% | 83.6% |
| 6s6hA01 | 1.10.10.2830 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › | 0.52 | 35.0 | 3.66e-01 | 88.9% | 74.3% |
| 4id0A02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.52 | 41.0 | 4.18e-01 | 84.6% | 92.9% |
| 4ikhA02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.51 | 38.0 | 3.71e-01 | 79.5% | 71.7% |
| 8hk0B03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.51 | 43.0 | 4.09e-01 | 90.6% | 85.5% |
| 3ismC01 | 1.25.40.240 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Ku, C-terminal domain | 0.51 | 42.0 | 3.84e-01 | 89.7% | 74.0% |
| 3a8pA02 | 6.10.140.680 | Special › Helix non-globular › Helix Hairpins › | 0.50 | 40.0 | 4.06e-01 | 85.5% | 93.9% |
| 8befJ01 | 1.20.120.1200 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ | 0.50 | 42.0 | 3.70e-01 | 89.7% | 99.4% |
| 4aciA00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.50 | 41.0 | 3.68e-01 | 91.5% | 73.3% |
ECOD (41)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 5053257 | 601.28.1.1 ↗ | alpha bundles › Four-helical up-and-down bundle › VPS28 C-terminal domain-like › VPS28 C-terminal domain-like › VPS28 | 0.69 | 42.0 | 4.61e-01 | 88.0% | 74.7% |
| 3395229 | 192.15.1.115 ↗ | alpha bundles › Long alpha-hairpin › Endosomal sorting complex assembly domains › Endosomal sorting complex assembly domains › Use1 | 0.68 | 41.0 | 5.10e-01 | 84.6% | 100.0% |
| 3993765 | 627.1.1.0 ↗ | alpha complex topology › VPS9 domain › VPS9 domain › VPS9 domain | 0.68 | 46.0 | 5.28e-01 | 79.5% | 96.5% |
| 5020412 | 601.4.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains | 0.66 | 49.0 | 5.13e-01 | 77.8% | 97.1% |
| 5074606 | 601.28.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › VPS28 C-terminal domain-like › VPS28 C-terminal domain-like | 0.65 | 41.0 | 4.43e-01 | 89.7% | 74.0% |
| 3974771 | 1075.1.2.0 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type II ABC exporter transmembrane domain-related › MacB transmembrane domain | 0.65 | 50.0 | 4.18e-01 | 82.1% | 82.9% |
| 4970859 | 601.28.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › VPS28 C-terminal domain-like › VPS28 C-terminal domain-like | 0.65 | 41.0 | 4.34e-01 | 88.9% | 73.0% |
| 2539030 | 601.2.1.4 ↗ | alpha bundles › Four-helical up-and-down bundle › Cytochromes › Cytochromes › Cytochrom_C_2 | 0.63 | 43.0 | 4.47e-01 | 89.7% | 73.9% |
| 1546262 | 601.19.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Apolipoprotein › Apolipoprotein | 0.63 | 45.0 | 3.88e-01 | 73.5% | 87.8% |
| 3795454 | 109.12.1.4 ↗ | alpha superhelices › Repetitive alpha hairpins › C-terminal domain of Ku80 › C-terminal domain of Ku80 › ZSWIM4-8_C | 0.63 | 49.0 | 5.04e-01 | 85.5% | 86.4% |
| 4979026 | 633.21.1.0 ↗ | alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 | 0.62 | 48.0 | 4.62e-01 | 97.4% | 72.3% |
| 3334062 | 604.12.1.0 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain | 0.62 | 41.0 | 4.65e-01 | 88.0% | 94.0% |
| 5032163 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.62 | 43.0 | 3.61e-01 | 71.8% | 75.1% |
| 3458159 | 192.29.1.54 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › BPS1 | 0.62 | 46.0 | 3.76e-01 | 77.8% | 96.7% |
| 3264063 | 109.4.1.103 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › GLE1 | 0.61 | 53.0 | 3.82e-01 | 93.2% | 64.8% |
| 3582053 | 601.1.2.64 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › Talin_VBS2 | 0.61 | 45.0 | 4.69e-01 | 88.0% | 84.8% |
| 3738901 | 109.10.1.1 ↗ | alpha superhelices › Repetitive alpha hairpins › Translin › Translin › Translin | 0.61 | 49.0 | 3.97e-01 | 84.6% | 66.0% |
| 5069603 | 601.18.1.30 ↗ | alpha bundles › Four-helical up-and-down bundle › Oxygen-evolving enhancer protein 3 › Oxygen-evolving enhancer protein 3 › Cytochrom_C_asm | 0.61 | 47.0 | 4.60e-01 | 89.7% | 75.2% |
| 3732719 | 601.1.1.25 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › GIT1_C | 0.60 | 46.0 | 4.39e-01 | 90.6% | 69.6% |
| 3841137 | 109.4.1.662 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › MEKK4_N | 0.59 | 49.0 | 4.03e-01 | 91.5% | 79.1% |
| 3819922 | 633.4.1.1 ↗ | alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI | 0.58 | 46.0 | 4.35e-01 | 93.2% | 69.7% |
| 4020563 | 601.16.1.3 ↗ | alpha bundles › Four-helical up-and-down bundle › FAT domain of focal adhesion kinase › FAT domain of focal adhesion kinase › GIT1_C | 0.57 | 47.0 | 4.55e-01 | 90.6% | 78.5% |
| 3385722 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.57 | 42.0 | 3.58e-01 | 76.1% | 80.5% |
| 3502050 | 109.4.1.259 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Tra1_ring | 0.57 | 50.0 | 3.91e-01 | 98.3% | 66.4% |
| 5024540 | 2498.1.1.0 ↗ | mixed a+b and a/b › Zincin-like › "Metalloproteases (""zincins"") catalytic domain" › "Metalloproteases (""zincins"") catalytic domain" | 0.56 | 40.0 | 3.75e-01 | 73.5% | 85.5% |
| 3623264 | 109.4.1.844 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › ZSWIM4-8_C | 0.56 | 47.0 | 3.83e-01 | 90.6% | 70.5% |
| 5022737 | 1030.1.1.1 ↗ | alpha duplicates or obligate multimers › Crispr-associated protein Csm2 › Crispr-associated protein Csm2 › Crispr-associated protein Csm2 › Csm2_III-A | 0.56 | 44.0 | 3.95e-01 | 83.8% | 63.3% |
| 3584294 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.56 | 46.0 | 3.45e-01 | 90.6% | 72.6% |
| 3576407 | 622.4.1.0 ↗ | alpha bundles › YvfG-like › Mite allergen Der p 5-related › Mite allergen Der p 5-related | 0.56 | 46.0 | 4.72e-01 | 88.9% | 96.5% |
| 3410491 | 109.4.1.32 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › MIF4G | 0.55 | 45.0 | 3.58e-01 | 91.5% | 49.6% |
| 3174899 | 627.1.1.1 ↗ | alpha complex topology › VPS9 domain › VPS9 domain › VPS9 domain › VPS9 | 0.55 | 47.0 | 4.01e-01 | 93.2% | 61.6% |
| 3708353 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.55 | 44.0 | 3.90e-01 | 88.9% | 70.0% |
| 3441947 | 109.4.1.474 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Cnd1_N | 0.55 | 44.0 | 3.75e-01 | 88.9% | 86.3% |
| 3404486 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.54 | 45.0 | 3.87e-01 | 90.6% | 70.0% |
| 3608069 | 109.24.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › Helical domain in dedicator of cytokinesis protein 9 › Helical domain in dedicator of cytokinesis protein 9 | 0.53 | 40.0 | 4.02e-01 | 79.5% | 86.4% |
| 5000552 | 604.12.1.0 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain | 0.52 | 41.0 | 4.40e-01 | 95.7% | 97.0% |
| 3515234 | 109.3.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat | 0.52 | 43.0 | 4.01e-01 | 89.7% | 87.6% |
| 3189734 | 109.4.1.70 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › CID | 0.52 | 42.0 | 4.01e-01 | 88.0% | 83.6% |
| 4011264 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.51 | 42.0 | 3.97e-01 | 88.0% | 83.6% |
| 3659570 | 109.4.1.474 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Cnd1_N | 0.51 | 44.0 | 3.32e-01 | 99.1% | 83.2% |
| 3207611 | 109.4.1.1587 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › MOR2-PAG1_N, MOR2-PAG1_mid | 0.50 | 44.0 | 2.68e-01 | 97.4% | 25.2% |
D2
medium
residues 109-205
Domain cluster:
rep: ORF50__YP_010084594__Macaca_nemestrina_rhadinovirus_2__123630__D113-208
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF03326.19 best | Herpes_TAF50 | 129.2 | 3.20e-37 | 100.0% | 17.9% |
D3
medium
residues 223-234_256-331
Domain cluster:
rep: ORF50__YP_001129401__Human_gammaherpesvirus_8__37296__D258-336
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF03326.19 best | Herpes_TAF50 | 23.9 | 2.50e-05 | 88.6% | 13.3% |