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ORF52
Euk-VirCallitrichine_gammaherpesvirus_3
ORF52__NP_733906__Callitrichine_gammaherpesvirus_3__106331
Identity
- Accession:
- NP_733906 ↗
- Protein ID:
- ORF52
- Kingdom:
- euk
Quality
78.1
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Lymphocryptovirus›
callitrichine_gammaherpesvirus_3
TaxID: 106331
Cluster
View cluster (37 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 4-193
Domain cluster:
rep: BMRF2__YP_001129455__Human_herpesvirus_4_type_2__12509__D4-191
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF04633.18 best | Herpes_BMRF2 | 166.0 | 2.00e-48 | 99.5% | 53.6% |
D2
high
residues 207-354
Domain cluster:
rep: ORF58__YP_009173938__Felis_catus_gammaherpesvirus_1__1452540__D210-353
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF04633.18 best | Herpes_BMRF2 | 57.9 | 1.60e-15 | 99.3% | 38.4% |
CATH (44)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2xgcA02 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.72 | 40.0 | 4.29e-01 | 95.3% | 62.5% |
| 1k90B03 | 1.20.140.60 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › | 0.70 | 34.0 | 3.81e-01 | 92.6% | 58.3% |
| 2qvaA01 | 1.20.58.190 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 1 | 0.69 | 41.0 | 4.36e-01 | 93.9% | 66.7% |
| 4ymuD00 | 1.10.3720.10 | Mainly Alpha › Orthogonal Bundle › MetI-like fold › MetI-like | 0.68 | 50.0 | 4.45e-01 | 77.0% | 81.9% |
| 1avoB00 | 1.20.120.180 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Proteasome activator pa28, C-terminal domain | 0.65 | 34.0 | 3.51e-01 | 79.1% | 52.1% |
| 5c4yA00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.65 | 40.0 | 4.22e-01 | 94.6% | 66.9% |
| 6p73A02 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.65 | 36.0 | 3.70e-01 | 94.6% | 55.2% |
| 3wvoC02 | 1.10.132.100 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › | 0.64 | 42.0 | 4.47e-01 | 98.0% | 74.6% |
| 3i9yA00 | 1.20.58.920 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.63 | 47.0 | 3.97e-01 | 75.7% | 100.0% |
| 2gsqA02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.63 | 37.0 | 4.29e-01 | 93.2% | 80.6% |
| 7d5qA01 | 1.20.1250.20 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains | 0.63 | 55.0 | 5.19e-01 | 95.9% | 82.4% |
| 7zh0A01 | 1.20.1250.20 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains | 0.62 | 56.0 | 4.11e-01 | 98.6% | 63.2% |
| 2i0mA01 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.61 | 39.0 | 4.49e-01 | 96.6% | 88.7% |
| 1b5lA00 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.61 | 43.0 | 4.31e-01 | 72.3% | 100.0% |
| 3ezhA00 | 1.20.120.960 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Histidine kinase NarX, sensor domain | 0.60 | 44.0 | 4.95e-01 | 75.7% | 97.4% |
| 4yjwA00 | 1.20.120.930 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Uncharacterised protein PF12889, N-terminal DUF3829 | 0.60 | 45.0 | 4.51e-01 | 78.4% | 98.0% |
| 1jmwA00 | 1.20.120.30 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Aspartate receptor, ligand-binding domain | 0.60 | 46.0 | 4.68e-01 | 80.4% | 96.6% |
| 1u8bA02 | 1.10.10.60 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Homeodomain-like | 0.59 | 25.0 | 3.74e-01 | 93.2% | 93.4% |
| 1tqgA00 | 1.20.120.160 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain | 0.58 | 40.0 | 4.75e-01 | 83.1% | 100.0% |
| 4v1gA00 | 1.20.20.10 | Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C | 0.58 | 31.0 | 4.01e-01 | 76.4% | 90.6% |
| 3kyiA00 | 1.20.120.160 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain | 0.57 | 40.0 | 4.29e-01 | 72.3% | 82.8% |
| 2hydA01 | 1.20.1560.10 | Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain | 0.56 | 53.0 | 4.03e-01 | 100.0% | 50.2% |
| 4iggB02 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.56 | 41.0 | 4.50e-01 | 75.7% | 97.5% |
| 4cqiA00 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.56 | 38.0 | 4.39e-01 | 89.2% | 96.3% |
| 3ljbA00 | 1.20.120.1240 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Dynamin, middle domain | 0.56 | 49.0 | 4.28e-01 | 100.0% | 64.4% |
| 3owaB04 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.55 | 43.0 | 4.25e-01 | 81.1% | 80.9% |
| 3caxA01 | 1.20.120.520 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › nmb1532 protein domain like | 0.55 | 43.0 | 3.83e-01 | 83.1% | 92.2% |
| 8i3jA01 | 1.20.920.20 | Mainly Alpha › Up-down Bundle › Histone Acetyltransferase; Chain A › | 0.55 | 43.0 | 3.63e-01 | 82.4% | 64.1% |
| 1b68A00 | 1.20.120.20 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Apolipoprotein | 0.55 | 41.0 | 4.24e-01 | 77.0% | 99.3% |
| 4nx9A01 | 1.20.1330.10 | Mainly Alpha › Up-down Bundle › f41 fragment of flagellin, N-terminal domain › f41 fragment of flagellin, N-terminal domain | 0.55 | 42.0 | 4.21e-01 | 80.4% | 97.4% |
| 3fseB02 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.55 | 45.0 | 4.65e-01 | 91.2% | 89.6% |
| 3ajmB02 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.54 | 39.0 | 4.07e-01 | 73.0% | 86.5% |
| 2xq9A02 | 1.20.58.390 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Neurotransmitter-gated ion-channel transmembrane domain | 0.54 | 39.0 | 4.27e-01 | 74.3% | 98.3% |
| 2odvA01 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.54 | 36.0 | 4.08e-01 | 95.9% | 91.1% |
| 1ileA03 | 1.10.730.10 | Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1 | 0.53 | 48.0 | 4.40e-01 | 98.0% | 75.9% |
| 2bg9C02 | 1.20.58.390 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Neurotransmitter-gated ion-channel transmembrane domain | 0.52 | 39.0 | 3.85e-01 | 78.4% | 96.2% |
| 1fftC00 | 1.20.120.80 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c oxidase, subunit III, four-helix bundle | 0.52 | 46.0 | 4.31e-01 | 98.6% | 98.9% |
| 6t0bc02 | 1.20.120.80 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c oxidase, subunit III, four-helix bundle | 0.51 | 45.0 | 4.22e-01 | 98.6% | 98.4% |
| 2uuiA00 | 1.20.120.550 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Membrane associated eicosanoid/glutathione metabolism-like domain | 0.51 | 38.0 | 3.82e-01 | 77.0% | 87.1% |
| 7p3rA01 | 1.20.1170.10 | Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; › | 0.51 | 46.0 | 3.48e-01 | 95.9% | 96.0% |
| 2e87A01 | 1.20.120.1190 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › | 0.51 | 39.0 | 3.81e-01 | 79.7% | 98.1% |
| 3mpxA01 | 1.20.900.10 | Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain | 0.50 | 41.0 | 3.72e-01 | 87.8% | 86.4% |
| 3qweA00 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.50 | 40.0 | 3.22e-01 | 81.8% | 73.8% |
| 3zdqA01 | 1.20.1560.10 | Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain | 0.50 | 46.0 | 3.53e-01 | 100.0% | 45.3% |
ECOD (38)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3977082 | 150.1.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin | 0.70 | 39.0 | 4.21e-01 | 93.9% | 64.0% |
| 3927148 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.68 | 32.0 | 2.85e-01 | 79.7% | 29.8% |
| 4008711 | 1075.3.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC importer transmembrane domain fold › Type I ABC importer transmembrane domain fold › BPD_transp_1 | 0.66 | 49.0 | 4.25e-01 | 77.0% | 83.1% |
| 4667108 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.64 | 55.0 | 4.92e-01 | 93.2% | 73.7% |
| 3188194 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.63 | 56.0 | 4.83e-01 | 94.6% | 80.4% |
| 3940171 | 633.23.1.0 ↗ | alpha bundles › Bromodomain-like › Claudin › Claudin | 0.62 | 41.0 | 4.25e-01 | 93.9% | 70.0% |
| 3632884 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.61 | 55.0 | 5.00e-01 | 99.3% | 76.1% |
| 3974601 | 601.3.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine-containing phosphotransfer domain, HPT domain › Histidine-containing phosphotransfer domain, HPT domain | 0.61 | 43.0 | 4.97e-01 | 79.1% | 97.3% |
| 4154382 | 3684.1.1.0 ↗ | alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like | 0.61 | 47.0 | 4.46e-01 | 79.7% | 80.3% |
| 3286989 | 5051.1.1.9 ↗ | alpha complex topology › Sodium:neurotransmitter symporter family (SNF)-like › Sodium:neurotransmitter symporter family (SNF)-like › Sodium:neurotransmitter symporter family (SNF)-like › Transp_cyt_pur | 0.61 | 53.0 | 3.81e-01 | 96.6% | 53.9% |
| 3919843 | 604.1.1.124 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin_6 | 0.60 | 44.0 | 4.73e-01 | 95.3% | 86.9% |
| 3740557 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.60 | 54.0 | 4.77e-01 | 100.0% | 72.6% |
| 4944676 | 632.22.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats | 0.59 | 36.0 | 4.04e-01 | 81.8% | 77.4% |
| 3417771 | 1075.4.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane | 0.58 | 55.0 | 4.69e-01 | 100.0% | 69.8% |
| 3373543 | 1075.4.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane | 0.58 | 52.0 | 3.27e-01 | 100.0% | 19.9% |
| 3297392 | 3567.1.1.80 ↗ | a+b duplicates or obligate multimers › MPER trimer › MPER trimer › MPER trimer › DUF747 | 0.57 | 44.0 | 3.34e-01 | 80.4% | 93.2% |
| 3393033 | 5054.1.1.63 ↗ | alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels › Ion_trans, YVC1_C | 0.56 | 43.0 | 3.24e-01 | 79.7% | 36.1% |
| 3928548 | 601.4.1.48 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains › Cornichon | 0.56 | 42.0 | 4.33e-01 | 79.1% | 97.9% |
| 4342285 | 1075.4.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane | 0.56 | 52.0 | 3.97e-01 | 100.0% | 48.3% |
| 3946069 | 1079.1.1.1 ↗ | alpha complex topology › Transmembrane reductase CcdA › Transmembrane reductase CcdA › Transmembrane reductase CcdA › DsbD | 0.55 | 49.0 | 4.42e-01 | 100.0% | 82.3% |
| 3608570 | 601.19.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Apolipoprotein › Apolipoprotein | 0.55 | 43.0 | 4.00e-01 | 91.9% | 64.2% |
| 3177832 | 174.1.1.62 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › PF27705 | 0.55 | 43.0 | 4.18e-01 | 79.7% | 96.2% |
| 3638803 | 6155.1.1.2 ↗ | alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter › PQ-loop | 0.55 | 38.0 | 3.84e-01 | 95.9% | 69.3% |
| 4012748 | 4121.1.1.0 ↗ | a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like | 0.55 | 45.0 | 3.48e-01 | 97.3% | 40.6% |
| 5047855 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.55 | 40.0 | 4.13e-01 | 77.0% | 97.2% |
| 3552989 | 604.8.1.1 ↗ | alpha bundles › Spectrin repeat-like › Smac/diablo › Smac/diablo › Smac_DIABLO | 0.55 | 44.0 | 4.12e-01 | 98.0% | 69.0% |
| 3591771 | 611.8.1.0 ↗ | alpha bundles › N-cbl like › C-terminal domain of E3 ubiquitin-protein ligase ARIH1 › C-terminal domain of E3 ubiquitin-protein ligase ARIH1 | 0.54 | 38.0 | 3.80e-01 | 70.9% | 92.7% |
| 3968781 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.53 | 35.0 | 3.61e-01 | 79.1% | 69.0% |
| 4971764 | 3567.1.1.0 ↗ | a+b duplicates or obligate multimers › MPER trimer › MPER trimer › MPER trimer | 0.53 | 48.0 | 4.32e-01 | 98.6% | 72.7% |
| 4933354 | 3755.3.1.637 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › DUF7121 | 0.53 | 36.0 | 3.06e-01 | 80.4% | 43.3% |
| 3799733 | 174.1.1.0 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain | 0.52 | 41.0 | 3.98e-01 | 83.8% | 82.9% |
| 3713898 | 3684.1.1.0 ↗ | alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like | 0.52 | 38.0 | 3.40e-01 | 81.8% | 55.5% |
| 2774528 | 3286.1.1.1 ↗ | alpha complex topology › Glypican insertion domain › Glypican insertion domain › Glypican insertion domain › Glypican | 0.52 | 32.0 | 3.29e-01 | 94.6% | 62.3% |
| 3212031 | 1075.4.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane | 0.52 | 48.0 | 3.03e-01 | 100.0% | 21.0% |
| 3446311 | 1075.4.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane | 0.51 | 47.0 | 3.69e-01 | 100.0% | 51.7% |
| 4665474 | 4177.2.1.4 ↗ | alpha duplicates or obligate multimers › BAR/IMD domain-like › Inhibitor of kappaB kinase beta dimerization domain › Inhibitor of kappaB kinase beta dimerization domain › ATG17_like | 0.51 | 40.0 | 3.30e-01 | 81.8% | 85.9% |
| 3486435 | 5059.1.1.0 ↗ | alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter | 0.51 | 44.0 | 3.55e-01 | 94.6% | 78.2% |
| 3969687 | 3755.3.1.461 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › MksF | 0.50 | 43.0 | 3.56e-01 | 91.9% | 89.6% |