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ORF53_gene_product

Euk-Vir

Equid_alphaherpesvirus_8

ORF53_gene_product__YP_006273033__Equid_alphaherpesvirus_8__39637

Identity

Accession:: YP_006273033 ↗
Protein ID:: ORF53_gene_product
Kingdom:: euk

Quality

71.8 mean pLDDT

Taxonomy

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Varicellovirus› Equid_alphaherpesvirus_8

TaxID: 39637

Cluster

View cluster (36 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 67-264

PDB

Domain cluster: rep: MK064563__AZI75768.1__SBFV2-gp01__00001__D223-383

Pfam (2)

Accession	Name	Score	E-value	Q cov	HMM cov
PF02399.22 best	Herpes_ori_bp	326.3	5.60e-97	100.0%	24.1%
PF00270.36	DEAD	27.3	3.90e-06	78.3%	89.2%

D2 medium residues 265-276_404-447_508-569

PDB

Domain cluster: representative

Pfam (2)

Accession	Name	Score	E-value	Q cov	HMM cov
PF02399.22 best	Herpes_ori_bp	61.1	8.90e-17	52.5%	7.3%
PF02399.22	Herpes_ori_bp	69.1	3.30e-19	41.5%	5.5%

CATH (28)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3p94A00	3.40.50.1110	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › SGNH hydrolase	0.57	46.0	3.84e-01	86.4%	52.5%
3gffA00	3.40.50.1820	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain	0.57	40.0	2.99e-01	79.7%	27.8%
6n2aB02	3.20.20.10	Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Alanine racemase	0.56	45.0	3.57e-01	83.9%	52.8%
4ltyA01	3.60.21.10	Alpha Beta › 4-Layer Sandwich › Purple Acid Phosphatase; chain A, domain 2 › Metallo-dependent phosphatases	0.56	47.0	3.62e-01	93.2%	73.0%
2j62A02	3.20.20.80	Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Glycosidases	0.55	46.0	3.44e-01	91.5%	48.1%
3of5B00	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.55	40.0	3.29e-01	76.3%	73.3%
2e0nA01	3.40.1010.10	Alpha Beta › 3-Layer(aba) Sandwich › Cobalt-precorrin-4 Transmethylase; domain 1 › Tetrapyrrole methylase, N-terminal domain	0.54	40.0	4.05e-01	78.0%	100.0%
1yhtA00	3.20.20.80	Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Glycosidases	0.54	45.0	3.27e-01	92.4%	65.4%
1ispA00	3.40.50.1820	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain	0.54	43.0	3.79e-01	87.3%	88.8%
4jgiB02	3.40.50.280	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Cobalamin-binding domain	0.53	42.0	4.15e-01	83.1%	88.1%
7l9pE01	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.53	41.0	3.44e-01	83.1%	80.2%
7wmzC01	3.20.20.220	Alpha Beta › Alpha-Beta Barrel › TIM Barrel ›	0.53	45.0	3.42e-01	92.4%	75.6%
4p02A02	3.90.550.10	Alpha Beta › Alpha-Beta Complex › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A	0.53	44.0	3.53e-01	92.4%	83.9%
8gr2A01	3.40.50.1110	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › SGNH hydrolase	0.52	44.0	3.74e-01	91.5%	93.3%
3oqvA00	3.40.50.11710	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Cyclodipeptide synthase	0.52	44.0	3.62e-01	91.5%	86.7%
3o8lA02	3.40.50.460	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Phosphofructokinase domain	0.52	45.0	4.13e-01	94.1%	78.7%
4h2dA00	3.40.50.360	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Flavodoxin domain	0.52	39.0	3.59e-01	90.7%	59.5%
6zb8A01	3.20.20.80	Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Glycosidases	0.52	42.0	3.12e-01	91.5%	64.7%
4dgkA01	3.50.50.60	Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain	0.52	33.0	2.95e-01	71.2%	46.5%
2eplX02	3.20.20.80	Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Glycosidases	0.52	43.0	3.23e-01	91.5%	68.6%
2basB01	3.20.20.450	Alpha Beta › Alpha-Beta Barrel › TIM Barrel › EAL domain	0.51	42.0	3.48e-01	90.7%	66.4%
2j0wA01	3.40.1160.10	Alpha Beta › 3-Layer(aba) Sandwich › Carbamate kinase › Acetylglutamate kinase-like	0.51	40.0	3.40e-01	83.1%	84.8%
2ebjA00	3.40.630.20	Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Peptidase C15, pyroglutamyl peptidase I-like	0.51	42.0	3.59e-01	89.0%	92.7%
4hylA00	3.30.750.24	Alpha Beta › 2-Layer Sandwich › Transcription Regulator spoIIAA › STAS domain	0.51	39.0	3.97e-01	83.1%	83.2%
6ketA01	3.20.20.30	Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Luciferase-like domain	0.51	42.0	3.08e-01	91.5%	75.7%
6se1A01	3.40.50.1110	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › SGNH hydrolase	0.51	43.0	3.46e-01	94.9%	82.4%
1thtA00	3.40.50.1820	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain	0.50	39.0	2.92e-01	81.4%	75.5%
2zyhA01	3.40.50.1820	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain	0.50	41.0	3.44e-01	90.7%	98.6%

ECOD (34)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3438965	2005.1.1.0 ↗	a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains	0.63	44.0	4.78e-01	91.5%	85.0%
3414798	2004.1.1.534 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › PF30386	0.61	40.0	3.34e-01	85.6%	38.0%
None	—		0.58	49.0	3.65e-01	91.5%	91.9%
5064865	2004.1.1.146 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ATPase	0.58	43.0	3.42e-01	78.8%	74.3%
3690787	2004.1.1.19 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Ras	0.58	39.0	3.81e-01	85.6%	61.5%
3671086	2007.5.1.8 ↗	a/b three-layered sandwiches › Flavodoxin-like › SGNH hydrolase › SGNH hydrolase › Lipase_GDSL_2	0.57	45.0	3.74e-01	83.9%	58.1%
5030722	7516.1.1.26 ↗	a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Glyco_tranf_2_3	0.56	45.0	3.10e-01	86.4%	93.4%
4108481	2484.1.1.40 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RuvX	0.56	46.0	4.40e-01	94.1%	76.8%
3693859	2002.1.1.291 ↗	a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels › TIM-barrel_MTC6	0.55	45.0	3.34e-01	89.8%	72.9%
4125316	2004.1.1.201 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_26	0.54	46.0	3.53e-01	92.4%	85.6%
5002326	2002.1.1.57 ↗	a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels › URO-D	0.54	44.0	3.18e-01	90.7%	57.5%
4470791	2004.1.1.201 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_26	0.53	44.0	3.60e-01	89.0%	95.5%
1842575	7512.1.1.13 ↗	a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › PS_pyruv_trans	0.53	41.0	3.55e-01	82.2%	79.1%
3797861	7516.1.1.37 ↗	a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › CHGN	0.53	45.0	3.35e-01	93.2%	88.4%
4024446	2003.1.6.1 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › Tubulin nucleotide-binding domain-like › Tubulin	0.53	43.0	3.34e-01	89.0%	92.7%
3378278	2003.1.5.31 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › GRAS	0.53	44.0	3.07e-01	92.4%	57.3%
3255723	2005.1.1.0 ↗	a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains	0.52	44.0	4.12e-01	90.7%	91.0%
4989351	2002.1.1.60 ↗	a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels › AP_endonuc_2	0.52	43.0	3.43e-01	91.5%	72.5%
4029034	7579.1.1.73 ↗	a/b three-layered sandwiches › alpha/beta-Hydrolases › alpha/beta-Hydrolases › alpha/beta-Hydrolases › DUF900	0.52	41.0	3.07e-01	84.7%	85.6%
3664522	2003.1.5.31 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › GRAS	0.52	45.0	3.08e-01	97.5%	32.0%
3798398	7516.1.1.0 ↗	a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases	0.52	43.0	3.22e-01	93.2%	84.8%
4949481	2002.1.1.60 ↗	a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels › AP_endonuc_2	0.51	42.0	3.35e-01	88.1%	59.6%
5082437	2002.1.1.120 ↗	a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels › Radical_SAM	0.51	44.0	3.40e-01	97.5%	68.1%
4882846	2002.1.1.33 ↗	a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels › Glyco_hydro_20	0.51	35.0	3.93e-01	86.4%	93.3%
3431672	2002.1.1.189 ↗	a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels › PRMT5_TIM	0.51	42.0	3.17e-01	90.7%	54.8%
4001806	2005.1.1.36 ↗	a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains › SLC12	0.51	43.0	3.81e-01	92.4%	72.0%
3971957	7579.1.1.0 ↗	a/b three-layered sandwiches › alpha/beta-Hydrolases › alpha/beta-Hydrolases › alpha/beta-Hydrolases	0.51	42.0	3.17e-01	90.7%	82.3%
4034024	2007.2.1.2 ↗	a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › Flavoproteins › Flavodoxin_2	0.51	40.0	3.46e-01	92.4%	53.9%
4944911	7516.1.1.2 ↗	a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Glycos_transf_2	0.51	40.0	2.85e-01	85.6%	92.1%
2715153	2002.1.1.8 ↗	a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels › Cellulase	0.51	42.0	3.03e-01	92.4%	62.8%
4933955	7592.1.1.6 ↗	a/b three-layered sandwiches › CARF (CRISPR-associated Rossmann fold) domains › CARF (CRISPR-associated Rossmann fold) domains › CARF (CRISPR-associated Rossmann fold) domains › Csa3_N	0.51	43.0	3.97e-01	92.4%	80.0%
3501422	7512.1.1.3 ↗	a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › Glycos_transf_1	0.51	42.0	3.52e-01	91.5%	82.4%
5074182	2002.1.1.0 ↗	a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels	0.51	39.0	3.24e-01	83.1%	58.6%
3652406	7512.1.1.32 ↗	a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › Glyco_trans_1_4	0.50	42.0	3.59e-01	92.4%	75.5%

D3 medium residues 570-721

PDB

Domain cluster: rep: DNA_replication_origin-binding_helicase__YP_009042071__Fruit_bat_alphaherpesvirus_1__1343901__D544-675_809-842

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF02399.22 best	Herpes_ori_bp	130.8	7.30e-38	99.3%	17.8%