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P4a_precursor

Euk-Vir

Sea_otter_poxvirus

P4a_precursor__YP_009480637__Sea_otter_poxvirus__1416741

Identity

Accession:
YP_009480637 ↗
Protein ID:
P4a_precursor
Kingdom:
euk

Quality

72.9 mean pLDDT

Taxonomy

Bamfordvirae› Nucleocytoviricota› Pokkesviricetes› Chitovirales› Poxviridae› Mustelpoxvirus› Sea_otter_poxvirus

TaxID: 1416741

Cluster

Singleton — not in a non-trivial cluster

3D Structure

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Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 42-177_358-431
PDB
Domain cluster: rep: P4a_precursor__YP_010085236__Western_grey_kangaroopox_virus__1566307__D37-168_363-435
Pfam (2)
AccessionNameScoreE-valueQ covHMM cov
PF03395.20 best Pox_P4A 174.0 5.00e-51 69.0% 15.8%
PF03395.20 Pox_P4A 112.5 1.90e-32 35.7% 7.8%
D2 high residues 651-733
PDB
D3 medium residues 195-265
PDB
Domain cluster: rep: core_wall_protein__YP_005296306__Cotia_virus_SPAn232__930275__D180-247
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF03395.20 best Pox_P4A 84.5 5.40e-24 100.0% 8.0%
D4 medium residues 266-338
PDB
Domain cluster: rep: P4a_precursor__YP_010085236__Western_grey_kangaroopox_virus__1566307__D246-346
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF03395.20 best Pox_P4A 52.7 2.20e-14 100.0% 8.3%
CATH (25)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1z47A03 2.40.50.140 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins 0.68 35.0 4.21e-01 87.7% 75.5%
5c7qB00 3.90.79.10 Alpha Beta › Alpha-Beta Complex › Nucleoside Triphosphate Pyrophosphohydrolase › Nucleoside Triphosphate Pyrophosphohydrolase 0.64 36.0 2.66e-01 84.9% 22.8%
1gqyB02 3.40.1190.10 Alpha Beta › 3-Layer(aba) Sandwich › UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase › Mur-like, catalytic domain 0.63 36.0 2.56e-01 95.9% 18.4%
1lomA00 2.30.60.10 Mainly Beta › Roll › HIV-inactivating Protein, Cyanovirin-n › Cyanovirin-N 0.63 35.0 3.15e-01 89.0% 38.6%
4hh2C04 3.30.450.20 Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › PAS domain 0.63 41.0 3.55e-01 86.3% 41.9%
3dorA02 2.30.42.10 Mainly Beta › Roll › Pdz3 Domain › PDZ domain 0.61 52.0 4.59e-01 94.5% 90.7%
1ci3M02 2.40.50.100 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain 0.60 34.0 3.77e-01 89.0% 69.0%
3vcxA02 3.30.720.110 Alpha Beta › 2-Layer Sandwich › Signal recognition particle alu RNA binding heterodimer, srp9/1 › 0.55 32.0 3.53e-01 82.2% 75.5%
1b9mA03 2.40.50.100 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain 0.54 36.0 3.67e-01 90.4% 70.4%
4hh3A01 3.30.450.20 Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › PAS domain 0.54 43.0 3.73e-01 86.3% 64.9%
3nixB00 3.50.50.60 Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain 0.54 40.0 2.55e-01 80.8% 14.7%
1y8tA03 2.30.42.10 Mainly Beta › Roll › Pdz3 Domain › PDZ domain 0.54 45.0 4.30e-01 93.2% 88.6%
1p97A00 3.30.450.20 Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › PAS domain 0.54 42.0 3.66e-01 84.9% 63.2%
3jcuO01 2.40.160.30 Mainly Beta › Beta Barrel › Porin › Photosystem II, cytochrome c-550 precursor 0.53 43.0 3.27e-01 89.0% 51.7%
1s67L00 3.30.450.20 Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › PAS domain 0.52 36.0 3.16e-01 89.0% 44.5%
2xcmC00 2.60.40.790 Mainly Beta › Sandwich › Immunoglobulin-like › 0.52 33.0 3.14e-01 94.5% 51.1%
4f3nA00 3.40.50.12710 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.52 44.0 2.89e-01 100.0% 81.8%
3d2lA02 2.20.25.110 Mainly Beta › Single Sheet › N-terminal domain of TfIIb › S-adenosyl-L-methionine-dependent methyltransferases 0.52 34.0 3.63e-01 90.4% 77.8%
1n02A00 2.30.60.10 Mainly Beta › Roll › HIV-inactivating Protein, Cyanovirin-n › Cyanovirin-N 0.52 38.0 3.44e-01 78.1% 83.3%
3ci0J02 2.10.70.20 Mainly Beta › Ribbon › Complement Module; domain 1 › gspk-gspi-gspj complex like domains 0.52 33.0 3.82e-01 80.8% 96.0%
6k96B02 3.30.360.10 Alpha Beta › 2-Layer Sandwich › Dihydrodipicolinate Reductase; domain 2 › Dihydrodipicolinate Reductase; domain 2 0.51 41.0 3.75e-01 89.0% 89.7%
7jooC01 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.51 39.0 3.62e-01 84.9% 86.6%
3jq0A00 1.25.40.390 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.50 40.0 2.55e-01 93.2% 90.6%
3m4aA03 3.90.15.10 Alpha Beta › Alpha-Beta Complex › Topoisomerase I; Chain A, domain 3 › Topoisomerase I; Chain A, domain 3 0.50 35.0 3.05e-01 74.0% 90.7%
2bhkA00 2.10.90.10 Mainly Beta › Ribbon › Cystine Knot Cytokines, subunit B › Cystine-knot cytokines 0.50 44.0 3.92e-01 97.3% 82.9%
ECOD (25)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
5049432 223.1.1.13 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS_3 0.66 44.0 2.85e-01 89.0% 14.3%
4980664 223.1.1.25 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS_9 0.65 44.0 3.73e-01 87.7% 42.5%
5008603 223.1.1.2 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS 0.63 43.0 3.21e-01 87.7% 27.4%
4988947 223.1.1.2 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS 0.62 42.0 3.38e-01 89.0% 35.2%
3897327 2.1.1.241 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › Rsm22 0.61 37.0 4.25e-01 86.3% 81.8%
3949731 223.1.1.2 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS 0.61 41.0 3.41e-01 86.3% 39.2%
4958946 223.1.1.24 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS_8 0.61 43.0 3.65e-01 87.7% 44.0%
3480307 223.1.1.29 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS_11 0.60 40.0 3.92e-01 89.0% 62.5%
5050614 223.1.1.25 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS_9 0.59 40.0 3.54e-01 86.3% 46.4%
4594302 2.4.1.2 ↗ beta barrels › OB-fold › MOP-like › MOP-like › TOBE_2 0.59 36.0 3.05e-01 87.7% 39.1%
4862817 223.1.1.13 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS_3 0.58 46.0 4.16e-01 86.3% 74.3%
3608238 7.1.1.10 ↗ beta barrels › PDZ domain › PDZ domain › PDZ domain › PDZ_6 0.58 50.0 4.83e-01 94.5% 86.7%
3959531 4.1.1.0 ↗ beta barrels › SH3 › SH3 › SH3 0.58 39.0 3.99e-01 94.5% 72.9%
4984593 223.1.1.25 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS_9 0.54 40.0 3.35e-01 89.0% 43.7%
3578208 4.1.1.0 ↗ beta barrels › SH3 › SH3 › SH3 0.52 35.0 3.92e-01 93.2% 90.9%
4931190 2004.1.1.162 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Rad51 0.52 39.0 2.94e-01 83.6% 80.5%
4357768 101.1.8.0 ↗ alpha arrays › HTH › HTH › DNA breaking-rejoining enzymes 0.52 35.0 2.93e-01 93.2% 39.2%
4236900 2.4.1.2 ↗ beta barrels › OB-fold › MOP-like › MOP-like › TOBE_2 0.51 36.0 2.96e-01 89.0% 41.1%
3191963 206.1.1.0 ↗ a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase 0.51 41.0 2.57e-01 94.5% 95.5%
3217772 4.1.1.0 ↗ beta barrels › SH3 › SH3 › SH3 0.51 30.0 2.91e-01 86.3% 48.2%
5056802 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.51 38.0 2.61e-01 82.2% 38.0%
3217417 5001.1.1.121 ↗ alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › TRAM_LAG1_CLN8 0.51 40.0 2.71e-01 91.8% 58.2%
4403656 11.1.1.42 ↗ beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › PapD_C 0.50 41.0 3.77e-01 89.0% 76.8%
3942573 4.1.1.0 ↗ beta barrels › SH3 › SH3 › SH3 0.50 32.0 3.48e-01 90.4% 79.3%
5049412 302.1.1.1 ↗ a+b two layers › Reverse ferredoxin › Lesion bypass DNA polymerase (Y-family), little finger domain › Lesion bypass DNA polymerase (Y-family), little finger domain › IMS_C 0.50 35.0 2.98e-01 98.6% 42.4%
D5 medium residues 521-601_638-649
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF03395.20 best Pox_P4A 124.0 6.40e-36 97.9% 9.7%
CATH (19)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2rk9B00 3.10.180.10 Alpha Beta › Roll › 2,3-Dihydroxybiphenyl 1,2-Dioxygenase; domain 1 › 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1 0.70 37.0 3.45e-01 97.8% 41.0%
3caxA02 3.30.450.20 Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › PAS domain 0.67 34.0 2.94e-01 89.2% 32.6%
1s3rA02 3.30.1040.20 Alpha Beta › 2-Layer Sandwich › Carboxypeptidase Inhibitor; Chain A › 0.66 33.0 4.30e-01 88.2% 86.8%
4akrA02 3.90.1150.210 Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › F-actin capping protein, beta subunit 0.63 39.0 3.32e-01 100.0% 39.5%
3ecrB03 3.30.160.40 Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › Porphobilinogen deaminase, C-terminal domain 0.62 33.0 3.20e-01 100.0% 45.1%
3b5hA01 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.62 37.0 4.01e-01 89.2% 68.3%
2rs7A01 3.30.160.20 Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › 0.62 36.0 3.98e-01 100.0% 71.6%
3hn3A02 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.56 36.0 3.46e-01 91.4% 56.7%
4bxiA00 3.30.565.10 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain 0.55 48.0 4.12e-01 100.0% 61.0%
6rh8A02 3.30.565.10 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain 0.55 49.0 4.13e-01 100.0% 90.5%
3a0rA03 3.30.565.10 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain 0.54 47.0 4.04e-01 100.0% 61.0%
6lgqC01 3.30.565.10 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain 0.53 46.0 4.06e-01 98.9% 65.6%
3d36B01 3.30.565.10 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain 0.52 47.0 3.92e-01 100.0% 82.5%
3tekA00 3.30.470.50 Alpha Beta › 2-Layer Sandwich › D-amino Acid Aminotransferase; Chain A, domain 1 › 0.51 40.0 3.56e-01 86.0% 82.7%
8g3lE01 3.30.565.10 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain 0.51 45.0 3.68e-01 100.0% 76.4%
2f1dA01 3.30.230.40 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 › Imidazole glycerol phosphate dehydratase; domain 1 0.51 31.0 3.22e-01 87.1% 64.0%
3uaqB01 2.40.128.250 Mainly Beta › Beta Barrel › Lipocalin › 0.51 34.0 3.29e-01 100.0% 59.1%
1b3qB02 3.30.565.10 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain 0.50 46.0 3.63e-01 100.0% 73.5%
4fppA02 3.30.565.10 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain 0.50 45.0 3.96e-01 100.0% 70.1%
ECOD (28)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3894031 330.1.1.6 ↗ a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like › Staufen_C 0.80 40.0 4.22e-01 100.0% 52.9%
3670595 330.1.1.0 ↗ a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like 0.78 40.0 4.02e-01 100.0% 48.4%
3809302 330.1.1.1 ↗ a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like › dsrm 0.76 40.0 4.18e-01 100.0% 55.3%
3420092 330.1.1.1 ↗ a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like › dsrm 0.74 39.0 4.17e-01 100.0% 58.7%
4026006 330.1.1.0 ↗ a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like 0.72 40.0 4.34e-01 100.0% 63.7%
3435911 330.1.1.1 ↗ a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like › dsrm 0.72 38.0 3.59e-01 100.0% 42.7%
3592741 330.1.1.0 ↗ a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like 0.68 37.0 3.90e-01 100.0% 58.8%
3624927 330.1.1.1 ↗ a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like › dsrm 0.67 39.0 3.80e-01 100.0% 51.4%
3959921 243.3.1.0 ↗ a+b two layers › Cystatin-like › Cystatin/monellin › Cystatin/monellin 0.65 35.0 3.80e-01 91.4% 62.0%
3534592 375.1.1.0 ↗ few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related 0.64 32.0 4.17e-01 89.2% 83.6%
4466453 63.1.1.5 ↗ beta barrels › Mannose 6-phosphate receptor domain › Mannose 6-phosphate receptor domain › Mannose 6-phosphate receptor domain › ATG27 0.63 36.0 3.07e-01 90.3% 34.9%
4983717 225.1.1.3 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c 0.62 56.0 4.74e-01 100.0% 65.8%
3606814 896.1.1.0 ↗ a+b two layers › SRP9/14-like › Signal recognition particle alu RNA binding heterodimer SRP9/14-related › Signal recognition particle alu RNA binding heterodimer SRP9/14-related 0.59 33.0 3.65e-01 97.8% 66.7%
4160946 212.1.1.9 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_mis_repair 0.56 42.0 4.00e-01 100.0% 67.3%
3959629 225.1.1.0 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 0.55 47.0 4.58e-01 100.0% 83.8%
3271910 4958.1.1.0 ↗ a+b complex topology › second helical domain in RNA-polymerase beta-prime subunit › second helical domain in RNA-polymerase beta-prime subunit › second helical domain in RNA-polymerase beta-prime subunit 0.54 47.0 3.80e-01 94.6% 87.4%
4943593 225.1.1.0 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 0.53 49.0 4.24e-01 100.0% 67.9%
3456962 304.8.1.45 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › bHLH-TF_ACT-like_plant 0.53 32.0 3.37e-01 83.9% 65.5%
4962782 225.1.1.3 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c 0.53 49.0 4.16e-01 100.0% 67.6%
3978963 225.1.1.3 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c 0.53 47.0 4.10e-01 100.0% 66.9%
4398167 304.8.1.2 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › ACT 0.52 31.0 3.22e-01 84.9% 61.4%
5039855 225.1.1.3 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c 0.52 47.0 4.03e-01 100.0% 66.0%
5047927 11.1.1.0 ↗ beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like 0.52 40.0 3.76e-01 91.4% 67.3%
4144295 225.1.1.3 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c 0.52 47.0 3.91e-01 100.0% 60.6%
5044862 11.1.1.0 ↗ beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like 0.52 41.0 3.74e-01 95.7% 65.0%
3367684 304.8.1.45 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › bHLH-TF_ACT-like_plant 0.51 32.0 3.32e-01 83.9% 67.1%
5065474 225.1.1.3 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c 0.51 46.0 3.92e-01 100.0% 64.0%
3817811 304.8.1.0 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.50 30.0 3.15e-01 83.9% 63.5%
D6 medium residues 747-901
PDB